Cited by 116Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsAlzheimer's disease research and treatments

Glutamatergic regulation prevents hippocampal-dependent age-related cognitive decline through dendritic spine clustering

Open access
Pereira, Ana C., Lambert, Hilary K., Grossman, Yael S., Dumitriu, Dani, Waldman, Rachel, Jannetty, Sophia K., Calakos, Katina, Janssen, William G. +2 more·2014·Proceedings of the National Academy of Sciences

Abstract

Significance: Aging is often accompanied by cognitive decline. It is of critical importance to understand the synaptic susceptibilities of the glutamatergic neural circuits to age-related cognitive decline and to intervene in this process. Maintenance of synaptic health in the face of aging is a crucially important therapeutic goal. We show that the glutamate modulator, riluzole, prevents age-related memory loss and induces clustering of dendritic spines. Clustering is a critical element of synaptic plasticity that has been previously demonstrated to increase synaptic strength. This study further elucidates neuroplastic changes in the neurocircuits vulnerable to aging and advances therapeutic development to prevent and treat age-related cognitive decline.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1073/pnas.1421285111

Cites

51 of 51 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • During aging in the rat, treatment with riluzole retards aging in the hippocampus as measured by preservation of spatial memory and thin spines found in young hippocampal neurons.

    “During aging in the rat, treatment with riluzole, which is known to retard glutamate release and promote glutamate reuptake by astrocytes, retards aging in the hippocampus as measured by preservation of spatial memory and thin spines that are found in young hippocampal neurons.”

    From Neurobiological and Systemic Effects of Chronic Stress (2017) · cites this paper as [54]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Pereira, A. C., Lambert, H. K., Grossman, Y. S., Dumitriu, D., Waldman, R., Jannetty, S. K., Calakos, K., Janssen, W. G., McEwen, B. S., & Morrison, J. H.
Affiliations
  • Rockefeller University (US)
  • Icahn School of Medicine at Mount Sinai (US)
  • Fishberg Department of Neuroscience and Kastor Neurobiology of Aging Laboratories,
Venue
Proceedings of the National Academy of Sciences
Published
2014-12-15
Volume
111
Issue
52
Pages
18733-18738
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2072639715
Cited by
116
References
51
Citations by year
2026: 4 · 2025: 6 · 2024: 4 · 2023: 9 · 2022: 13 · 2021: 12 · 2020: 13 · 2019: 13 · 2018: 6 · 2017: 13 · 2016: 15 · 2015: 8
FWCI
5.44
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
  • Dana Foundation (no number)
  • Stavros Niarchos Foundation (SNF) (no number)
  • HHS | NIH | National Center for Advancing Translational Sciences (NCATS) (8 UL1 TR000043)
  • HHS | NIH | National Institute on Aging (U.S. National Institute on Aging) (R37 AG06647)
  • Alzheimer Drug Discovery Foundation (ADDF) (20120703)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
age-related cognitive decline, riluzole, glutamatergic synapses, hippocampal CA1, synaptic plasticity, glutamate uptake, extrasynaptic NMDA receptors, memory, synaptic loss, neuroprotection
MeSH terms
Aging, Animals, Cognition, Dendrites, Male, Memory, Synaptic Transmission, Synapses, Receptors, N-Methyl-D-Aspartate, Rats, Sprague-Dawley, Prefrontal Cortex, Neuroprotective Agents, Glutamic Acid, Riluzole, Rats, CA1 Region, Hippocampal

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review