Stress-induced remodeling of hippocampal CA3 pyramidal neurons
Abstract
The discovery of steroid hormone receptors in brain regions that mediate virtually every aspect of brain function has broadened the definition of 'neuroendocrinology' to include the reciprocal communication between the brain and the body via hormonal and neural pathways. The brain is the central organ of stress and adaptation to stress because it perceives and determines what is threatening, as well as determining the behavioral and physiological responses to the stressor. The adult and developing brain possess remarkable structural and functional plasticity in response to stress, including neurogenesis leading to neuronal replacement, dendritic remodeling, and synapse turnover. Stress causes an imbalance of neural circuitry subserving cognition, decision-making, anxiety and mood that can alter expression of those behaviors and behavioral states. The two Brain Research papers noted in this review played an important role in triggering these advances. This article is part of a Special Issue entitled SI:50th Anniversary Issue.
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In the hippocampus, stress and glucocorticoids cause dendritic shrinkage and loss of spines.
“In the hippocampus, stress and glucocorticoids were first shown to cause dendritic shrinkage and loss of spines.”
From Neurobiological and Systemic Effects of Chronic Stress (2017) · cites this paper as [15]
Chronic restraint stress causes shrinkage of apical dendrites of hippocampal CA3 neurons.
“Initial studies of restraint stress which, when chronic, causes shrinkage of apical dendrites of hippocampal CA3 neurons”
From Neurobiological and Systemic Effects of Chronic Stress (2017) · cites this paper as [15]
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- Authors
- McEwen, B. S.
- Affiliations
- Rockefeller University (US)
- Corresponding author
- McEwen, Bruce S.
- ORCID
- McEwen, Bruce S.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2016-08
- Volume
- 1645
- Pages
- 50-54
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2214953116
- Cited by
- 105
- References
- 89
- Citations by year
- 2026: 9 · 2025: 10 · 2024: 9 · 2023: 8 · 2022: 7 · 2021: 14 · 2020: 12 · 2019: 14 · 2018: 12 · 2017: 5 · 2016: 5
- FWCI
- 0.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- NIH (MH41256)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- stress, hippocampal CA3, pyramidal neurons, dendritic remodeling, neuroplasticity, neuroendocrinology, steroid hormone receptors, stress adaptation, anxiety, mood, neurogenesis
- MeSH terms
- Adaptation, Physiological, Animals, Humans, Neuroendocrinology, Neuronal Plasticity, Stress, Psychological, Pyramidal Cells, History, 20th Century, CA3 Region, Hippocampal
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