Retrospective Analysis of a Local Cessation of Vaccination against Poliomyelitis: a Possible Scenario for the Future
Open accessAbstract
The global eradication of poliomyelitis will require substantial changes in immunization practices. One of the proposed scenarios includes cessation of vaccination with live oral poliovirus vaccine (OPV) and the creation of an OPV stockpile for emergency response in case of the reintroduction of poliovirus into circulation. We describe here a retrospective analysis of the cessation of OPV usage in a region of the Byelorussian Republic of the former Soviet Union in 1963 to 1966. During this period, a widespread circulation and evolution of independent lineages of vaccine-derived polioviruses took place in the region. Some of these lineages appeared to originate from OPV given to 40 children in the community during this period of essentially no vaccinations. The data demonstrate very high risks associated with both the local cessation of OPV vaccination and the proposed use of OPV to control a possible reemergence of poliovirus in the postvaccination period. The high transmissibility of OPV-derived viruses in nonimmune population, documented here, and the known existence of long-term OPV excretors should be also considered in assessing risks of the synchronized global cessation of OPV usage.
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In 1968, a large poliomyelitis outbreak (464 cases) in Poland immediately followed a field trial of the experimental type 3 oral poliovaccine strain, USOL-D-bac.
“In 1968, a large poliomyelitis outbreak (464 cases) in Poland immediately followed a field trial of the experimental type 3 oral poliovaccine strain, USOL-D-bac (101).”
From VACCINE-DERIVED POLIOVIRUSES AND THE ENDGAME STRATEGY FOR GLOBAL POLIO ERADICATION (2005) · cites this paper as [101]
The combined epidemiologic and virologic findings show that derivatives of the USOL-D-bac vaccine strain had spread extensively by person-to-person transmission for ~13 months.
“however, the combined epidemiologic (101) and virologic (118) findings show that derivatives of the USOL-D-bac vaccine strain had spread extensively by person-to-person transmission for ∼ 13months.”
From VACCINE-DERIVED POLIOVIRUSES AND THE ENDGAME STRATEGY FOR GLOBAL POLIO ERADICATION (2005) · cites this paper as [101]
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Self-citation
- Authors
- Korotkova, E. A., Park, R., Cherkasova, E. A., Lipskaya, G. Y., Chumakov, K. M., Feldman, E. V., Kew, O. M., & Agol, V. I.
- Affiliations
- Lomonosov Moscow State University (RU)
- Centers for Disease Control and Prevention (US)
- Center for Biologics Evaluation and Research (US)
- Republican Research and Practical Center for Epidemiology and Microbiology (BY)
- Corresponding author
- Agol, Vadim I.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2003-12
- Volume
- 77
- Issue
- 23
- Pages
- 12460-12465
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- PMC
- PMC262597
- OpenAlex
- W2157871996
- Cited by
- 73
- References
- 34
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 3 · 2015: 3 · 2014: 6 · 2013: 2 · 2012: 2
- FWCI
- 4.61
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Journal of Virology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- World Health Organization
- Russian Foundation for Basic Research
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Social Sciences › Health › Vaccine Coverage and Hesitancy
- Keywords
- poliomyelitis, vaccine-derived poliovirus, poliovirus evolution, polio eradication, former Soviet Union
- MeSH terms
- Republic of Belarus, Child, Humans, Poliovirus Vaccine, Oral, Retrospective Studies, Genome, Viral, Immunization Programs, Poliovirus, Evolution, Molecular
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