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Cited by 1,750

The DOI matches its Crossref record.

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

Open access
Cordon-Cardo, C, O'Brien, J P, Casals, D, Rittman-Grauer, L, Biedler, J L, Melamed, M R, Bertino, J R·1989·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.86.2.695
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Abstract

Endothelial cells of human capillary blood vessels at the blood-brain and other blood-tissue barrier sites express P-glycoprotein as detected by mouse monoclonal antibodies against the human multidrug-resistance gene product. This pattern of endothelial cell expression may indicate a physiological role for P-glycoprotein in regulating the entry of certain molecules into the central nervous system and other anatomic compartments, such as the testes. These tissues, which limit the access of systemic drugs, are known pharmacologic sanctuaries for metastatic cancer. P-glycoprotein expression in capillary endothelium of brain and testes and not other tissues (i.e., kidney and placenta) may in part explain this phenomenon and could have important implications in cancer chemotherapy.

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Metadata

Authors
Cordon-Cardo, C., O'Brien, J. P., Casals, D., Rittman-Grauer, L., Biedler, J. L., Melamed, M. R., & Bertino, J. R.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
1989-01
Volume
86
Issue
2
Pages
695-698
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.86.2.695
OpenAlex
W2078877172
Cited by
1,750
References
0
FWCI
17.91
Type
journal article
Language
en
Open access
green

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