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Neuronal defects and delayed wound healing in mice lacking fibroblast growth factor 2
Open accessAbstract
Basic fibroblast growth factor (FGF2) is a wide-spectrum mitogenic, angiogenic, and neurotrophic factor that is expressed at low levels in many tissues and cell types and reaches high concentrations in brain and pituitary. FGF2 has been implicated in a multitude of physiological and pathological processes, including limb development, angiogenesis, wound healing, and tumor growth, but its physiological role is still unclear. To determine the function of FGF2 in vivo , we have generated FGF2 knockout mice, lacking all three FGF2 isoforms, by homologous recombination in embryonic stem cells. FGF2 −/− mice are viable, fertile and phenotypically indistinguishable from FGF2 +/+ littermates by gross examination. However, abnormalities in the cytoarchitecture of the neocortex, most pronounced in the frontal motor-sensory area, can be detected by histological and immunohistochemical methods. A significant reduction in neuronal density is observed in most layers of the motor cortex in the FGF2 −/− mice, with layer V being the most affected. Cell density is normal in other regions of the brain such as the striatum and the hippocampus. In addition, the healing of excisional skin wounds is delayed in mice lacking FGF2. These results indicate that FGF2, although not essential for embryonic development, plays a specific role in cortical neurogenesis and skin wound healing in mice, which, in spite of the apparent redundancy of FGF signaling, cannot be carried out by other FGF family members.
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Angiogenesis: regulators and clinical applications
Liekens, S., De Clercq, E., & Neyts, J. (2001) · Biochemical Pharmacology · doi:10.1016/s0006-2952(00)00529-3 · Cited by 748
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Miller, F. D., & Gauthier, A. S. (2007) · Neuron · doi:10.1016/j.neuron.2007.04.019 · Cited by 588
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Montero, A., Okada, Y., Tomita, M., Ito, M., Tsurukami, H., Nakamura, T., Doetschman, T., Coffin, J. D., & Hurley, M. M. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8641 · Cited by 483
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Richardson, R., Slanchev, K., Kraus, C., Knyphausen, P., Eming, S., & Hammerschmidt, M. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.16 · Cited by 299
Fibroblast Growth Factors In The Developing Central Nervous System
Ford‐Perriss, M., Abud, H., & Murphy, M. (2001) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.2001.03477.x · Cited by 264
Fibroblast growth factors: key players in regeneration and tissue repair.
Maddaluno, L., Urwyler, C., & Werner, S. (2017) · Development · doi:10.1242/dev.152587 · Cited by 241
Armstrong, R. C., Le, T. Q., Frost, E. E., Borke, R. C., & Vana, A. C. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-19-08574.2002 · Cited by 178
Zhao, M., Li, D., Shimazu, K., Zhou, Y.-X., Lu, B., & Deng, C.-X. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.10.019 · Cited by 171
Yu, C., Wang, F., Jin, C., Huang, X., Miller, D. L., Basilico, C., & McKeehan, W. L. (2003) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63522-5 · Cited by 167
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Iwata, Y., Yoshizaki, A., Komura, K., Shimizu, K., Ogawa, F., Hara, T., Muroi, E., Bae, S., Takenaka, M., Yukami, T., et al. (2009) · The American Journal of Pathology · doi:10.2353/ajpath.2009.080355 · Cited by 107
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Steiling, H., & Werner, S. (2003) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2003.08.003 · Cited by 86
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Xie, J. L., Bian, H. N., Qi, S. H., Chen, H. D., Li, H. D., Xu, Y. B., Li, T. Z., Liu, X. S., Liang, H. Z., Xin, B. R., et al. (2008) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2008.00405.x · Cited by 83
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Fagel, D. M., Ganat, Y., Cheng, E., Silbereis, J., Ohkubo, Y., Ment, L. R., & Vaccarino, F. M. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4516-08.2009 · Cited by 82
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Murawala, P., Tanaka, E. M., & Currie, J. D. (2012) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2012.09.013 · Cited by 71
Metadata
- Authors
- Ortega, S., Ittmann, M., Tsang, S. H., Ehrlich, M., & Basilico, C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1998-05-12
- Volume
- 95
- Issue
- 10
- Pages
- 5672-5677
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2044788795
- Cited by
- 593
- References
- 0
- FWCI
- 11.14
- Type
- journal article
- Language
- en
- Open access
- green
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