The DOI matches its Crossref record; 30 of the 32 references it cites were found in a registry or an index.
A CD36-initiated Signaling Cascade Mediates Inflammatory Effects of β-Amyloid
Open accessAbstract
beta-Amyloid accumulation is associated with pathologic changes in the brain in Alzheimer's disease and has recently been identified in plaques of another chronic inflammatory disorder, atherosclerosis. The class B scavenger receptor, CD36, mediates binding of fibrillar beta-amyloid to cells of the monocyte/macrophage lineage, including brain macrophages (microglia). In this study, we demonstrate that in microglia and other tissue macrophages, beta-amyloid initiates a CD36-dependent signaling cascade involving the Src kinase family members, Lyn and Fyn, and the mitogen-activated protein kinase, p44/42. Interruption of this signaling cascade, through targeted disruption of Src kinases downstream of CD36, inhibits macrophage inflammatory responses to beta-amyloid, including reactive oxygen and chemokine production, and results in decreased recruitment of microglia to sites of amyloid deposition in vivo. The finding that engagement of CD36 by beta-amyloid initiates a Src kinase-dependent production of inflammatory mediators in cells of the macrophage lineage reveals a novel receptor-mediated pro-inflammatory signaling pathway of potential therapeutic importance.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Through these additional substrates, BACE1 has been implicated in inflammation, cardiovascular function, glucose homeostasis, and insulin signaling”
From BACE1: More than just a β‐secretase (2022) · cites this paper as [35]
Experimental — accuracy not yet measuredIn the citing paper
“Furthermore, CD36 mediates fAβ-induced signal cascade which leads to the production of ROS and chemokines [366].”
From Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020) · cites this paper as [366]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Atherosclerosis--an inflammatory disease
Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725
Inflammation and Alzheimer’s disease
Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514
CELLULAR FUNCTIONS REGULATED BY SRC FAMILY KINASES
Thomas, S. Μ., & Brugge, J. S. (1997) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.13.1.513 · Cited by 2,537
CD36 is a receptor for oxidized low density lipoprotein
Endemann, G., Stanton, L. W., Madden, K. S., Bryant, C. M., White, R. T., & Protter, A. A. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50272-1 · Cited by 1,282
A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection
Suzuki, H. I., Kurihara, Y., Takeya, M., Kamada, N., Kataoka, M., Jishage, K., Ueda, O., Sakaguchi, H., Higashi, T., Suzuki, T., et al. (1997) · Nature · doi:10.1038/386292a0 · Cited by 1,226
Febbraio, M., Hajjar, D., & Silverstein, R. (2001) · Journal of Clinical Investigation · doi:10.1172/jci14006 · Cited by 1,171
Febbraio, M., Podrez, E. A., Smith, J. D., Hajjar, D. P., Hazen, S. L., Hoff, H. F., Sharma, K., & Silverstein, R. L. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9259 · Cited by 1,037
Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1
Jiménez, B., Volpert, O. V., Crawford, S. E., Febbraio, M., Silverstein, R. L., & Bouck, N. (2000) · Nature Medicine · doi:10.1038/71517 · Cited by 1,014
MICROGLIA AS MEDIATORS OF INFLAMMATORY AND DEGENERATIVE DISEASES
González-Scarano, F., & Baltuch, G. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.219 · Cited by 984
Scavenger receptor-mediated adhesion of microglia to β-amyloid fibrils
Khoury, J. E., Hickman, S. E., Thomas, C. A., Cao, L., Silverstein, S. C., & Loike, J. D. (1996) · Nature · doi:10.1038/382716a0 · Cited by 727
Self-citation
Flagged first, then by citations
2 of the 32 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Frautschy, 1998, Am. J. Pathol., 152, 307
- Sakaguchi, 1998, Lab. Invest., 78, 423
Cited by
Sorted by citations
The NALP3 inflammasome is involved in the innate immune response to amyloid-β
Halle, A., Hornung, V., Petzold, G. C., Stewart, C. R., Monks, B. G., Reinheckel, T., Fitzgerald, K. A., Latz, E., Moore, K. J., & Golenbock, D. T. (2008) · Nature Immunology · doi:10.1038/ni.1636 · Cited by 2,441
Self-citationNeurovascular regulation in the normal brain and in Alzheimer's disease
Iadecola, C. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1387 · Cited by 2,213
Stewart, C. R., Stuart, L. M., Wilkinson, K., van Gils, J. M., Deng, J., Halle, A., Rayner, K. J., Boyer, L., Zhong, R., Frazier, W. A., et al. (2010) · Nature Immunology · doi:10.1038/ni.1836 · Cited by 1,513
Self-citationCD36, a Scavenger Receptor Involved in Immunity, Metabolism, Angiogenesis, and Behavior
Silverstein, R. L., & Febbraio, M. (2009) · Science Signaling · doi:10.1126/scisignal.272re3 · Cited by 1,141
Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease
Guo, T., Zhang, D., Zeng, Y., Huang, T. Y., Xu, H., & Zhao, Y. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00391-7 · Cited by 994
Autophagy‐based unconventional secretory pathway for extracellular delivery of IL‐1β
Dupont, N., Jiang, S., Pilli, M., Ornatowski, W., Bhattacharya, D., & Deretic, V. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.398 · Cited by 967
Sheedy, F. J., Grebe, A., Rayner, K. J., Kalantari, P., Ramkhelawon, B., Carpenter, S. B., Becker, C. E., Ediriweera, H. N., Mullick, A. E., Golenbock, D. T., et al. (2013) · Nature Immunology · doi:10.1038/ni.2639 · Cited by 935
Self-citationScavenger receptors in homeostasis and immunity
Canton, J., Neculai, D., & Grinstein, S. (2013) · Nature Reviews Immunology · doi:10.1038/nri3515 · Cited by 838
Cytokine networks in neuroinflammation
Becher, B., Spath, S., & Goverman, J. M. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.123 · Cited by 707
Savelieff, M. G., Nam, G., Kang, J., Lee, H. J., Lee, M., & Lim, M. H. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00138 · Cited by 612
Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer’s disease
Cai, Z., Hussain, M. D., & Yan, L.-J. (2014) · International Journal of Neuroscience · doi:10.3109/00207454.2013.833510 · Cited by 583
Scavenger Receptors in Atherosclerosis: Beyond Lipid Uptake
Moore, K. J., & Freeman, M. W. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000229218.97976.43 · Cited by 562
Self-citationCD36, a scavenger receptor implicated in atherosclerosis
Park, Y. M. (2014) · Experimental & Molecular Medicine · doi:10.1038/emm.2014.38 · Cited by 517
A CD36-dependent signaling cascade is necessary for macrophage foam cell formation
Rahaman, S. O., Lennon, D. J., Febbraio, M., Podrez, E. A., Hazen, S. L., & Silverstein, R. L. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.06.007 · Cited by 519
A Cell Surface Receptor Complex for Fibrillar β-Amyloid Mediates Microglial Activation
Bamberger, M. E., Harris, M. E., McDonald, D. R., Husemann, J., & Landreth, G. E. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-07-02665.2003 · Cited by 501
CD36 Mediates the Innate Host Response to β-Amyloid
El Khoury, J. B., Moore, K. J., Means, T. K., Leung, J., Terada, K., Toft, M., Freeman, M. W., & Luster, A. D. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021546 · Cited by 483
Self-citationSynuclein activates microglia in a model of Parkinson's disease
Su, X., Maguire-Zeiss, K. A., Giuliano, R., Prifti, L., Venkatesh, K., & Federoff, H. J. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.04.006 · Cited by 474
Microglial Phagocytosis of Fibrillar β-Amyloid through a β1Integrin-Dependent Mechanism
Koenigsknecht-Talboo, J., & Landreth, G. E. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2557-04.2004 · Cited by 457
Ursolic acid: An anti‐ and pro‐inflammatory triterpenoid
Ikeda, Y., Murakami, A., & Ohigashi, H. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700389 · Cited by 418
Stuart, L. M., Deng, J., Silver, J. M., Takahashi, K., Tseng, A. A., Hennessy, E. J., Ezekowitz, R. A. B., & Moore, K. J. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200501113 · Cited by 423
Self-citationPhosphorylation of Tau by Fyn: Implications for Alzheimer's Disease
Lee, G. S., Thangavel, R., Sharma, V. M., Litersky, J. M., Bhaskar, K., Fang, S. M., Lana, H., Andreadis, A., Hoesen, G. W. V., & Ksiȩżak-Reding, H. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4162-03.2004 · Cited by 434
Park, Y. M., Febbraio, M., & Silverstein, R. L. (2008) · Journal of Clinical Investigation · doi:10.1172/jci35535 · Cited by 407
Wan, E. Y., Yeap, X. Y., Dehn, S., Terry, R. L., Novak, M. L., Zhang, S., Iwata, S., Han, X., Homma, S., Drosatos, K., et al. (2013) · Circulation Research · doi:10.1161/circresaha.113.301198 · Cited by 401
Moore, K. J., Kunjathoor, V. V., Koehn, S. L., Manning, J. J., Tseng, A. A., Silver, J. M., McKee, M. L., & Freeman, M. W. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24061 · Cited by 371
Self-citationvan Gils, J. M., Derby, M. C., Fernandes, L. R., Ramkhelawon, B., Ray, T. D., Rayner, K. J., Parathath, S., Distel, E., Feig, J. L., Alvarez-Leite, J. I., et al. (2012) · Nature Immunology · doi:10.1038/ni.2205 · Cited by 365
Self-citationDoens, D., & Fernández, P. L. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-48 · Cited by 348
Salminen, A., Ojala, J. O., Kauppinen, A., Kaarniranta, K., & Suuronen, T. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.01.001 · Cited by 360
Biochemistry and cell biology of mammalian scavenger receptors
Murphy, J. E., Tedbury, P. R., Homer‐Vanniasinkam, S., Walker, J. H., & Ponnambalam, S. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.03.036 · Cited by 331
Fyn inhibition rescues established memory and synapse loss in Alzheimer mice
Kaufman, A. C., Salazar, S. V., Haas, L. T., Yang, J., Kostylev, M. A., Jeng, A. T., Robinson, S. A., Gunther, E. C., van Dyck, C. H., Nygaard, H. B., et al. (2015) · Annals of Neurology · doi:10.1002/ana.24394 · Cited by 314
IFN-γ receptor signaling mediates spinal microglia activation driving neuropathic pain
Tsuda, M., Masuda, T., Kitano, J., Shimoyama, H., Tozaki‐Saitoh, H., & Inoue, K. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810420106 · Cited by 296
Alzheimer’s disease: pathological mechanisms and the beneficial role of melatonin
Rosales‐Corral, S., Acuña-Castroviejo, D., Coto‐Montes, A. M., Boga, J. A., Manchester, L. C., Fuentes‐Broto, L., Korkmaz, A., Ma, S., Tan, D. X., & Reiter, R. J. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00937.x · Cited by 299
Pan, X.-D., Zhu, Y.-G., Lin, N., Zhang, J., Ye, Q.-Y., Huang, H.-P., & Chen, X.-C. (2011) · Molecular Neurodegeneration · doi:10.1186/1750-1326-6-45 · Cited by 292
Isenberg, J. S., Ridnour, L. A., Dimitry, J. M., Frazier, W. A., Wink, D. A., & Roberts, D. D. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605040200 · Cited by 291
Amyloids — a functional coat for microorganisms
Gebbink, M. F. B. G., Claessen, D., Bouma, B., Dijkhuizen, L., & Wösten, H. A. B. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1127 · Cited by 287
Microglia and neuropathic pain
Inoue, K., & Tsuda, M. (2009) · Glia · doi:10.1002/glia.20871 · Cited by 294
Systemic inflammation during midlife and cognitive change over 20 years: The ARIC Study
Walker, K. A., Gottesman, R. F., Wu, A., Knopman, D. S., Gross, A. L., Mosley, T. H., Selvin, E., & Windham, B. G. (2019) · Neurology · doi:10.1212/wnl.0000000000007094 · Cited by 282
Manning, J. J., Moore, K. J., Seimon, T. A., Bell, S. A., Sharuk, M., Alvarez-Leite, J. I., de Winther, M. P. J., Tabas, I. A., & Freeman, M. W. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.176644 · Cited by 266
Self-citationCerebrovascular atherosclerosis correlates with Alzheimer pathology in neurodegenerative dementias
Yarchoan, M. M., Xie, S. X., Kling, M. A., Toledo, J. B., Wolk, D. A., Lee, E. B., Deerlin, V. M. V., Lee, V. M. Y., Trojanowski, J. Q., & Arnold, S. E. (2012) · Brain · doi:10.1093/brain/aws271 · Cited by 268
Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia
Panicker, N., Sarkar, S., Harischandra, D. S., Neal, M. P., Kam, T., Jin, H., Saminathan, H., Langley, M. R., Charli, A., Samidurai, M., et al. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20182191 · Cited by 257
Amyloid-β Receptors: The Good, the Bad, and the Prion Protein
Jarosz-Griffiths, H. H., Noble, E., Rushworth, J. V., & Hooper, N. M. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.r115.702704 · Cited by 256
CD36: Implications in cardiovascular disease
Febbraio, M., & Silverstein, R. L. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.03.012 · Cited by 254
Microglial Aβ Receptors in Alzheimer’s Disease
Yu, Y., & Ye, R. D. (2015) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-014-0101-6 · Cited by 247
Tampakakis, E., Puckett, L. L., Tai, M., Stewart, C. R., Hickman, S. E., Moore, K. J., El Khoury, J., Means, T. K., Mylonakis, E. E., Colvin, R. A., et al. (2009) · Digital Access to Scholarship at Harvard (DASH) (Harvard University) · Cited by 246
Self-citationAmyloid β-Protein Toxicity and the Pathogenesis of Alzheimer Disease
Yankner, B. A., & Lu, T. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.r800018200 · Cited by 229
Arai, S., Kitada, K., Yamazaki, T., Takai, R., Zhang, X., Tsugawa, Y., Sugisawa, R., Matsumoto, A., Mori, M., Yoshihara, Y., et al. (2016) · Nature Medicine · doi:10.1038/nm.4012 · Cited by 229
The microglial phagocytic role with specific plaque types in the Alzheimer disease brain
D’Andrea, M. R., Cole, G. M., & Ard, M. D. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.12.026 · Cited by 215
Kuchibhotla, S., Vanegas, D., Kennedy, D. J., Guy, E. C., Nimako, G., Morton, R. E., & Febbraio, M. (2007) · Cardiovascular Research · doi:10.1093/cvr/cvm093 · Cited by 221
Apoptotic cell recognition receptors and scavenger receptors
Penberthy, K. K., & Ravichandran, K. S. (2015) · Immunological Reviews · doi:10.1111/imr.12376 · Cited by 209
Chen, K., Febbraio, M., Li, W., & Silverstein, R. L. (2008) · Circulation Research · doi:10.1161/circresaha.108.172064 · Cited by 202
Oxidized low density lipoprotein and innate immune receptors
Miller, Y. I., Chang, M.-K., Binder, C. J., Shaw, P. X., & Witztum, J. L. (2003) · Current Opinion in Lipidology · doi:10.1097/00041433-200310000-00004 · Cited by 200
Biochemical diversity of odor detection
Vogt, R. G. (2003) · Elsevier eBooks · doi:10.1016/b978-012107151-6/50016-5 · Cited by 202
Relationship Between Amyloid-β Deposition and Blood–Brain Barrier Dysfunction in Alzheimer’s Disease
Wang, D., Chen, F., Han, Z., Yin, Z., Ge, X., & Lei, P. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.695479 · Cited by 208
Cho, S., Park, E., Febbraio, M., Anrather, J., Park, L., Racchumi, G., Silverstein, R. L., & Iadecola, C. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0035-05.2005 · Cited by 195
The Alzheimer’s Disease Amyloid-Beta Hypothesis in Cardiovascular Aging and Disease
Stakos, D. A., Stamatelopoulos, K., Bampatsias, D., Sachse, M., Zormpas, E., Vlachogiannis, N. I., Tual-Chalot, S., & Stellos, K. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.12.033 · Cited by 188
Microglial Scavenger Receptors and Their Roles in the Pathogenesis of Alzheimer's Disease
Wilkinson, K., & Khoury, J. B. E. (2012) · International Journal of Alzheimer s Disease · doi:10.1155/2012/489456 · Cited by 197
Baranova, I. N., Kurlander, R. J., Bocharov, A. V., Vishnyakova, T. G., Chen, Z., Remaley, A. T., Csákó, G., Patterson, A. P., & Eggerman, T. L. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.10.7147 · Cited by 189
Fu, H., Liu, B., Frost, J. L., Hong, S., Jin, M., Ostaszewski, B., Shankar, G. M., Costantino, I. M., Carroll, M. C., Mayadas, T. N., et al. (2012) · Glia · doi:10.1002/glia.22331 · Cited by 180
Molecular Basis of Pheromone Detection in Insects
Vogt, R. G. (2005) · Elsevier eBooks · doi:10.1016/b0-44-451924-6/00047-8 · Cited by 178
Tsuda, M., Ueno, H., Kataoka, A., Tozaki‐Saitoh, H., & Inoue, K. (2008) · Glia · doi:10.1002/glia.20623 · Cited by 170
Ghosh, A., Li, W., Febbraio, M., Espinola, R. G., McCrae, K. R., Cockrell, E., & Silverstein, R. L. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34904 · Cited by 172
Panicker, N., Saminathan, H., Jin, H., Neal, M., Harischandra, D. S., Gordon, R., Kanthasamy, K. A., Lawana, V., Sarkar, S., Luo, J. D., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0302-15.2015 · Cited by 166
Molecular Mechanisms of Neuroinflammation in Aging and Alzheimer’s Disease Progression
Andronie-Cioară, F. L., Ardelean, A. I., Nistor-Cseppento, C. D., Jurcău, A., Jurcău, M. C., Pașcalău, N., & Marcu, F. M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24031869 · Cited by 170
Mannose-binding lectin enhances Toll-like receptors 2 and 6 signaling from the phagosome
Ip, W., Takahashi, K., Moore, K. J., Stuart, L. M., & Ezekowitz, R. A. B. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20071164 · Cited by 168
Self-citationMicroglia Demonstrate Age-Dependent Interaction with Amyloid-β Fibrils
Floden, A. M., & Combs, C. K. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-101014 · Cited by 166
Alzheimer’s Disease Pathogenesis: Role of Autophagy and Mitophagy Focusing in Microglia
Eshraghi, M., Adlimoghaddam, A., Mahmoodzadeh, A., Sharifzad, F., Yasavoli-Sharahi, H., Lorzadeh, S., Albensi, B. C., & Ghavami, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073330 · Cited by 158
Fat taste and lipid metabolism in humans
Mattes, R. D. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.08.058 · Cited by 158
Macrophages: An elusive yet emerging therapeutic target of atherosclerosis
Tiwari, R. L., Singh, V., & Barthwal, M. K. (2007) · Medicinal Research Reviews · doi:10.1002/med.20118 · Cited by 155
Miller, Y. I., Choi, S.-H., Fang, L., & Tsimikas, S. (2010) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-90-481-8622-8_8 · Cited by 155
The Important Interface Between Apolipoprotein E and Neuroinflammation in Alzheimer’s Disease
Kloske, C. M., & Wilcock, D. M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00754 · Cited by 152
Casadevall, A., & Pirofski, L. (2006) · Advances in immunology · doi:10.1016/s0065-2776(06)91001-3 · Cited by 146
Jurcău, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111847 · Cited by 152
The impact of nanoparticle ligand density on dendritic-cell targeted vaccines
Bandyopadhyay, A., Fine, R. L., Demento, S., Bockenstedt, L. K., & Fahmy, T. M. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2010.12.054 · Cited by 141
The Neurovascular Unit Dysfunction in Alzheimer’s Disease
Soto-Rojas, L. O., Pacheco‐Herrero, M., Martínez-Gómez, P. A., Campa-Córdoba, B. B., Apátiga-Pérez, R., Villegas-Rojas, M. M., Harrington, C. R., de la Cruz, F., Garcés‐Ramírez, L., & Luna‐Muñoz, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22042022 · Cited by 146
Fibrillar Amyloid Protein Present in Atheroma Activates CD36 Signal Transduction
Medeiros, L. A., Khan, T., Khoury, J. B. E., Pham, C. L. L., Hatters, D. M., Howlett, G. J., Lopez, R., O’Brien, K. D., & Moore, K. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311735200 · Cited by 140
Self-citationInsulin-like actions of glucagon-like peptide-1: a dual receptor hypothesis
Tomás, E., & Habener, J. F. (2009) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2009.11.007 · Cited by 135
Woo, M., Yang, J., Beltran, C., & Cho, S. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.750018 · Cited by 136
The Lipoxygenases: Their Regulation and Implication in Alzheimer’s Disease
Czapski, G. A., Czubowicz, K., Strosznajder, J. B., & Strosznajder, R. P. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1776-x · Cited by 137
Endothelial Cell Receptors in Tissue Lipid Uptake and Metabolism
Abumrad, N. A., Cabodevilla, A. G., Samovski, D., Pietka, T., Basu, D., & Goldberg, I. J. (2021) · Circulation Research · doi:10.1161/circresaha.120.318003 · Cited by 127
Chylomicron remnants are increased in the postprandial state in CD36 deficiency
Masuda, D., Hirano, K., Oku, H., Sandoval, J. C., Kawase, R., Yuasa‐Kawase, M., Yamashita, Y., Takada, M., Tsubakio‐Yamamoto, K., Tochino, Y., et al. (2008) · Journal of Lipid Research · doi:10.1194/jlr.p700032-jlr200 · Cited by 124
Phosphocholine as a pattern recognition ligand for CD36
Boullier, A., Friedman, P., Harkewicz, R., Hartvigsen, K., Green, S. R., Almazan, F., Dennis, E. A., Steinberg, D. H., Witztum, J. L., & Quehenberger, O. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m400496-jlr200 · Cited by 123
CD36 and TLR Interactions in Inflammation and Phagocytosis: Implications for Malaria
Erdman, L. K., Cosı́o, G., Helmers, A. J., Gowda, D. C., Grinstein, S., & Kain, K. C. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901374 · Cited by 124
Manocha, G. D., & Combs, C. K. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-117 · Cited by 122
Chuang, P., Lin, Y.-J., Wu, M., Wing, L.-Y. C., Shoji, Y., & Tsai, S. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090551 · Cited by 118
CD36 Signals to the Actin Cytoskeleton and Regulates Microglial Migration via a p130Cas Complex
Stuart, L. M., Bell, S. A., Stewart, C. R., Silver, J. M., Richard, J., Goss, J. L., Tseng, A. A., Zhang, A., Khoury, J. B. E., & Moore, K. J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702887200 · Cited by 112
Self-citationThrombospondin-1 CD47 Signalling: From Mechanisms to Medicine
Kale, A., Rogers, N. M., & Ghimire, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084062 · Cited by 113
Tau and src family tyrosine kinases
Lee, G. S. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.09.002 · Cited by 111
Microbial Phagocytic Receptors and Their Potential Involvement in Cytokine Induction in Macrophages
Fu, Y., & Harrison, R. E. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.662063 · Cited by 118
BACE1: More than just a β‐secretase
Taylor, H. A., Przemylska, L., Clavane, E. M., & Meakin, P. J. (2022) · Obesity Reviews · doi:10.1111/obr.13430 · Cited by 107
Baranova, I. N., Bocharov, A. V., Vishnyakova, T. G., Kurlander, R. J., Chen, Z., Fu, D., Arias, I. M., Csákó, G., Patterson, A. P., & Eggerman, T. L. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.007526 · Cited by 110
Du, X., Jiang, S., Zeng, X., Zhang, J., Pan, K., Zhou, J., Xie, Y., Kan, H., Song, W., Sun, Q., et al. (2018) · Toxicology Letters · doi:10.1016/j.toxlet.2018.03.022 · Cited by 102
Reed-Geaghan, E. G., Reed, Q. W., Cramer, P. E., & Landreth, G. E. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2637-10.2010 · Cited by 106
Methionine oxidation induces amyloid fibril formation by full-length apolipoprotein A-I
Wong, Y. Q., Binger, K. J., Howlett, G. J., & Griffin, M. D. W. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910136107 · Cited by 102
Möhle, L., Israël, N., Paarmann, K., Krohn, M., Pietkiewicz, S., Müller, A. J., Lavrik, I. N., Buguliskis, J. S., Schott, B. H., Schlüter, D., et al. (2016) · Acta Neuropathologica Communications · doi:10.1186/s40478-016-0293-8 · Cited by 103
Dual role of lipoproteins in endothelial cell dysfunction in atherosclerosis
Stancu, C. S., Toma, L., & Sima, A. V. (2012) · Cell and Tissue Research · doi:10.1007/s00441-012-1437-1 · Cited by 110
Tsuda, M., Tozaki‐Saitoh, H., Masuda, T., Toyomitsu, E., Tezuka, T., Yamamoto, T. S., & Inoue, K. (2007) · Glia · doi:10.1002/glia.20591 · Cited by 106
Pennathur, S., Pasichnyk, K., Bahrami, N. M., Zeng, L., Febbraio, M., Yamaguchi, I., & Okamura, D. M. (2015) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.04.016 · Cited by 96
Li, Y., Gerbod-Giannone, M.-C., Seitz, H., Cui, D., Thorp, E. B., Tall, A. R., Matsushima, G. K., & Tabas, I. A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m510579200 · Cited by 91
Wilkinson, K., Boyd, J. D., Glicksman, M. A., Moore, K. J., & Khoury, J. B. E. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.232116 · Cited by 90
Self-citationHo, G., Hashimoto, M., Adame, A., Izu, M., Alford, M., Thal, L., Hansen, L., & Masliah, E. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.06.016 · Cited by 98
Simone, R. D., Ajmone‐Cat, M. A., & Minghetti, L. (2004) · Molecular Neurobiology · doi:10.1385/mn:29:2:197 · Cited by 89
Metadata
- Authors
- Moore, K. J., El Khoury, J., Medeiros, L. A., Terada, K., Geula, C., Luster, A. D., & Freeman, M. W.
- Affiliations
- Harvard University (US)
- Beth Israel Deaconess Medical Center (US)
- Corresponding author
- Freeman, Mason W.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2002-12
- Volume
- 277
- Issue
- 49
- Pages
- 47373-47379
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2106020004
- Cited by
- 327
- References
- 32
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 7 · 2023: 10 · 2022: 14 · 2021: 18 · 2020: 17 · 2019: 13 · 2018: 10 · 2017: 10 · 2016: 15 · 2015: 19 · 2014: 8 · 2013: 18 · 2012: 20
- FWCI
- 8.21
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (R01AG020255, R01AG20255-01)
- National Heart, Lung, and Blood Institute (R01 HL45098, R01HL045098)
- National Institute of Diabetes and Digestive and Kidney Diseases (P01-DK50305, P01DK050305)
- National Institute of Neurological Disorders and Stroke (NS41330-02, K08NS041330)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Keywords
- amyloid-beta, CD36, scavenger receptors, microglia, macrophages, Src kinase, Lyn kinase, Fyn, receptor signaling, neuroinflammation, reactive oxygen species, chemokine production, microglial recruitment, Alzheimer's disease, atherosclerosis, amyloid plaques
- MeSH terms
- Alleles, Animals, Brain, Crosses, Genetic, Female, Immunohistochemistry, Inflammation, Leukocytes, Mononuclear, Ligands, Macrophages, Mice, Inbred C57BL, Models, Biological, Phosphorylation, Precipitin Tests, Proto-Oncogene Proteins, Tyrosine, Blotting, Western, Signal Transduction, Amyloid beta-Peptides, Reactive Oxygen Species, Microglia, Mice, Knockout, CD36 Antigens, src-Family Kinases, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinases, Mitogen-Activated Protein Kinase 3, Proto-Oncogene Proteins c-fyn, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
