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Inhibition of Glycosphingolipid Biosynthesis Reduces Secretion of the β-Amyloid Precursor Protein and Amyloid β-Peptide*[boxs]
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Cell viability was not significantly affected during stable expression of GGA1 variants.
“Cell viability was assessed by MTT [3-(4,5-dimethyl thiazol-2-yl)-2,5-diphenyl tetrazolium bromide] assay as described previously (Tamboli et al., 2005), and was not significantly affected during stable expression of GGA1 variants (data not shown).”
From GGA1 Is Expressed in the Human Brain and Affects the Generation of Amyloid β-Peptide (2006) · cites this paper as Tamboli et al., 2005
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Amyloid β-peptide is produced by cultured cells during normal metabolism
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Elimination of GD3 synthase improves memory and reduces amyloid-β plaque load in transgenic mice
Bernardo, A., Harrison, F. E., McCord, M., Zhao, J., Bruchey, A., Davies, S. S., Jackson Roberts, L., Mathews, P. M., Matsuoka, Y., Ariga, T., et al. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.12.022 · Cited by 127
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GGA1 Is Expressed in the Human Brain and Affects the Generation of Amyloid β-Peptide
Wahle, T., Thal, D. R., Sastre, M., Rentmeister, A., Bogdanovic, N., Famulok, M., Heneka, M. T., & Walter, J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1982-06.2006 · Cited by 88
Self-citation
Metadata
- Authors
- Tamboli, I. Y., Prager, K., Barth, E., Heneka, M., Sandhoff, K., & Walter, J.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2005-07
- Volume
- 280
- Issue
- 30
- Pages
- 28110-28117
- ISSN
- 0021-9258
- Cited by
- 110
- References
- 1
- Language
- en
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