Suppression of Diacylglycerol Acyltransferase-2 (DGAT2), but Not DGAT1, with Antisense Oligonucleotides Reverses Diet-induced Hepatic Steatosis and Insulin Resistance

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

Bligh, E. G., & Dyer, W. J. (1959) · Canadian Journal of Biochemistry and Physiology · doi:10.1139/o59-099 · Cited by 54,751

Prevalence of Hepatic Steatosis in An Urban Population in the United States: Impact of Ethnicity

Browning, J. D., Szczepaniak, L. S., Dobbins, R., Nuremberg, P., Horton, J. D., Cohen, J. C., Grundy, S. M., & Hobbs, H. H. (2004) · Hepatology · doi:10.1002/hep.20466 · Cited by 3,664

Mechanism of activation of protein kinase B by insulin and IGF‐1.

Alessi, D. R., Andjelković, M., Caudwell, B., Cron, P. D., MORRICE, N. A., Cohen, P., & Hemmings, B. A. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb01045.x · Cited by 3,014

Cellular mechanisms of insulin resistance

Shulman, G. I. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10583 · Cited by 2,714

Molecular mediators of hepatic steatosis and liver injury

Browning, J. D., & Horton, J. D. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200422422 · Cited by 1,772

Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle

Yu, C., Chen, Y., Cline, G. W., Zhang, D., Zong, H., Wang, Y., Bergeron, R., Kim, J. K., Cushman, S. W., Cooney, G. J., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200958200 · Cited by 1,561

Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease

Samuel, V. T., Liu, Z.-X., Qu, X., Elder, B. D., Bilz, S., Befroy, D., Romanelli, A. J., & Shulman, G. I. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313478200 · Cited by 1,322

Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis

Cases, S., Smith, S. J., Zheng, Y.-W., Myers, H. M., Lear, S. R., Sande, E., Novak, S., Collins, C. C., Welch, C. L., Lusis, A. J., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13018 · Cited by 1,138

Enzymes of triacylglycerol synthesis and their regulation

Coleman, R. (2003) · Progress in Lipid Research · doi:10.1016/s0163-7827(03)00051-1 · Cited by 985

Reversal of Nonalcoholic Hepatic Steatosis, Hepatic Insulin Resistance, and Hyperglycemia by Moderate Weight Reduction in Patients With Type 2 Diabetes

Petersen, K. F., Dufour, S., Befroy, D., Lehrke, M., Hendler, R. E., & Shulman, G. I. (2005) · Diabetes · doi:10.2337/diabetes.54.3.603 · Cited by 911

Mechanisms of Insulin Action and Insulin Resistance

Petersen, M. C., & Shulman, G. I. (2018) · Physiological Reviews · doi:10.1152/physrev.00063.2017 · Cited by 3,028

Type 2 diabetes mellitus

DeFronzo, R. A., Ferrannini, E., Groop, L., Henry, R. R., Herman, W. H., Holst, J. J., Hu, F. B., Kahn, C. R., Raz, I., Shulman, G. I., et al. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.19 · Cited by 2,611

Mechanisms for Insulin Resistance: Common Threads and Missing Links

Samuel, V. T., & Shulman, G. I. (2012) · Cell · doi:10.1016/j.cell.2012.02.017 · Cited by 2,294

AMPK in Health and Disease

Steinberg, G. R., & Kemp, B. E. (2009) · Physiological Reviews · doi:10.1152/physrev.00011.2008 · Cited by 1,672

The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

Perry, R. J., Samuel, V. T., Petersen, K. F., & Shulman, G. I. (2014) · Nature · doi:10.1038/nature13478 · Cited by 1,170

Thematic review series: Glycerolipids. DGAT enzymes and triacylglycerol biosynthesis

Yen, C.-L. E., Stone, S. J., Koliwad, S., Harris, C., & Farese, R. V. (2008) · Journal of Lipid Research · doi:10.1194/jlr.r800018-jlr200 · Cited by 1,105

Insulin Resistance: From Mechanisms to Therapeutic Strategies

Lee, S.-H., Park, S., & Choi, C. S. (2021) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2021.0280 · Cited by 1,248

Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: The central role of nontriglyceride fatty acid metabolites†

Neuschwander‐Tetri, B. A. (2010) · Hepatology · doi:10.1002/hep.23719 · Cited by 1,077

Adipocyte Death, Adipose Tissue Remodeling, and Obesity Complications

Strissel, K. J., Stancheva, Z., Miyoshi, H., Perfield, J. W., DeFuria, J., Jick, Z., Greenberg, A. S., & Obin, M. S. (2007) · Diabetes · doi:10.2337/db07-0767 · Cited by 1,007

Overproduction of very low-density lipoproteins is the hallmark of the dyslipidemia in the metabolic syndrome

Adiels, M., Olofsson, S.-O., Taskinen, M.-R., & Borén, J. (2008) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.107.160192 · Cited by 820

Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine

Kim, K. H., Jeong, Y. T., Oh, H., Kim, S. H., Cho, J. M., Kim, Y.-N., Kim, S. S., Kim, D. H., Hur, K. Y., Kim, H. K., et al. (2013) · Nature Medicine · doi:10.1038/nm.3014 · Cited by 774

Insulin resistance drives hepatic de novo lipogenesis in nonalcoholic fatty liver disease

Smith, G. I., Shankaran, M., Yoshino, M., Schweitzer, G. G., Chondronikola, M., Beals, J. W., Okunade, A. L., Patterson, B. W., Nyangau, E., Field, T., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci134165 · Cited by 771

Nonalcoholic fatty liver disease as a nexus of metabolic and hepatic diseases

Samuel, V. T., & Shulman, G. I. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2017.08.002 · Cited by 745

Pathogenesis of non-alcoholic fatty liver disease

Dowman, J. K., Tomlinson, J., & Newsome, P. N. (2009) · QJM · doi:10.1093/qjmed/hcp158 · Cited by 765

Nonalcoholic Fatty Liver Disease, Hepatic Insulin Resistance, and Type 2 Diabetes

Birkenfeld, A. L., & Shulman, G. I. (2013) · Hepatology · doi:10.1002/hep.26672 · Cited by 752

Role of Dietary Fructose and Hepatic De Novo Lipogenesis in Fatty Liver Disease

Softic, S., Cohen, D. E., & Kahn, C. R. (2016) · Digestive Diseases and Sciences · doi:10.1007/s10620-016-4054-0 · Cited by 709

Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD)

Musso, G., Gambino, R. J., & Cassader, M. (2008) · Progress in Lipid Research · doi:10.1016/j.plipres.2008.08.001 · Cited by 691

Metabolites as regulators of insulin sensitivity and metabolism

Yang, Q., Vijayakumar, A., & Kahn, B. B. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0044-8 · Cited by 698

Hepatokines: Linking nonalcoholic fatty liver disease and insulin resistance

Meex, R. C. R., & Watt, M. J. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.56 · Cited by 631

Non-alcoholic fatty liver disease and obesity: Biochemical, metabolic and clinical presentations

Milić, S. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i28.9330 · Cited by 619

Causes and Metabolic Consequences of Fatty Liver

Stefan, N., Kantartzis, K., & Häring, H. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0009 · Cited by 536

Diacylglycerol-mediated insulin resistance

Erion, D. M., & Shulman, G. I. (2010) · Nature Medicine · doi:10.1038/nm0410-400 · Cited by 502

Mechanisms of Disease Progression in Nonalcoholic Fatty Liver Disease

Jou, J. H., Choi, S. S., & Diehl, A. M. (2008) · Seminars in Liver Disease · doi:10.1055/s-0028-1091981 · Cited by 494

Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding

Turner, N., Kowalski, G. M., Leslie, S. J., Risis, S., Yang, C., Lee-Young, R. S., Babb, J. R., Meikle, P. J., Lancaster, G. I., Henstridge, D. C., et al. (2013) · Diabetologia · doi:10.1007/s00125-013-2913-1 · Cited by 430

Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease

Petersen, K. F., Dufour, S., Hariri, A., Nelson-Williams, C., Foo, J. N., Zhang, X.-M., Dziura, J., Lifton, R. P., & Shulman, G. I. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0907295 · Cited by 428

Non-alcoholic steatohepatitis: emerging molecular targets and therapeutic strategies

Musso, G., Cassader, M., & Gambino, R. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2015.3 · Cited by 424

Molecular Mechanisms and Therapeutic Targets in Steatosis and Steatohepatitis

Anderson, N., & Borlak, J. T. (2008) · Pharmacological Reviews · doi:10.1124/pr.108.00001 · Cited by 395

Oxidative stress and calcium dysregulation by palmitate in type 2 diabetes

Ly, L. D., Xu, S., Choi, S.-K., Ha, C.-M., Thoudam, T., Cha, S.-K., Wiederkehr, A., Wollheim, C. B., Lee, I.-K., & Park, K.-S. (2017) · Experimental & Molecular Medicine · doi:10.1038/emm.2016.157 · Cited by 378

Acyl-CoA:diacylglycerol acyltransferase: Molecular biology, biochemistry and biotechnology

Liu, Q., Siloto, R. M. P., Lehner, R. S., Stone, S. J., & Weselake, R. J. (2012) · Progress in Lipid Research · doi:10.1016/j.plipres.2012.06.001 · Cited by 375

Roles of diacylglycerols and ceramides in hepatic insulin resistance

Petersen, M. C., & Shulman, G. I. (2017) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2017.04.004 · Cited by 373

Inflammation as a potential link between nonalcoholic fatty liver disease and insulin resistance

Asrih, M., & Jornayvaz, F. R. (2013) · Journal of Endocrinology · doi:10.1530/joe-13-0201 · Cited by 292

Hepatic triglyceride synthesis and nonalcoholic fatty liver disease

Choi, S. S., & Diehl, A. M. (2008) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3282ff5e55 · Cited by 261

Non-Alcoholic Fatty Liver Disease

Engin, A. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-48382-5_19 · Cited by 253

Hepatic Stearoyl-CoA Desaturase (SCD)-1 Activity and Diacylglycerol but Not Ceramide Concentrations Are Increased in the Nonalcoholic Human Fatty Liver

Kotronen, A., Seppänen‐Laakso, T., Westerbacka, J., Kiviluoto, T. A., Arola, J. T., Ruskeepää, A., Orešič, M., & Yki‐Järvinen, H. (2008) · Diabetes · doi:10.2337/db08-1074 · Cited by 253

Beyond triglyceride synthesis: the dynamic functional roles of MGAT and DGAT enzymes in energy metabolism

Shi, Y., & Cheng, D. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90949.2008 · Cited by 228

Nonalcoholic Fatty Liver Disease: Focus on Lipoprotein and Lipid Deregulation

Tacer, K. F., & Rozman, D. (2011) · Journal of Lipids · doi:10.1155/2011/783976 · Cited by 242

Hepatic lipid droplets: A balancing act between energy storage and metabolic dysfunction in NAFLD

Mashek, D. G. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101115 · Cited by 247

Cellular Mechanisms by Which FGF21 Improves Insulin Sensitivity in Male Mice

Camporez, J. P., Jornayvaz, F. R., Petersen, M. C., Pesta, D. H., Guigni, B. A., Serr, J., Zhang, D., Kahn, M., Samuel, V. T., Jurczak, M. J., et al. (2013) · Endocrinology · doi:10.1210/en.2013-1191 · Cited by 232

Intrahepatic Diacylglycerol Content Is Associated With Hepatic Insulin Resistance in Obese Subjects

Magkos, F., Su, X., Bradley, D. P., Fabbrini, E., Conte, C., Eagon, J. C., Varela, J. E., Brunt, E. M., Patterson, B. W., & Klein, S. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.03.003 · Cited by 223

ACC inhibitor alone or co-administered with a DGAT2 inhibitor in patients with non-alcoholic fatty liver disease: two parallel, placebo-controlled, randomized phase 2a trials

Calle, R. A., Amin, N. B., Carvajal-Gonzalez, S., Ross, T. T., Bergman, A., Aggarwal, S., Crowley, C., Rinaldi, A., Mancuso, J., Aggarwal, N., et al. (2021) · Nature Medicine · doi:10.1038/s41591-021-01489-1 · Cited by 219

An Overview of Sugar‐Modified Oligonucleotides for Antisense Therapeutics

Prakash, T. P. (2011) · Chemistry & Biodiversity · doi:10.1002/cbdv.201100081 · Cited by 220

A high-fat, ketogenic diet causes hepatic insulin resistance in mice, despite increasing energy expenditure and preventing weight gain

Jornayvaz, F. R., Jurczak, M. J., Lee, H., Birkenfeld, A. L., Frederick, D. W., Zhang, D., Zhang, X., Samuel, V. T., & Shulman, G. I. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00361.2010 · Cited by 213

The triglyceride synthesis enzymes DGAT1 and DGAT2 have distinct and overlapping functions in adipocytes

Chitraju, C., Walther, T. C., & Farese, R. V. (2019) · Journal of Lipid Research · doi:10.1194/jlr.m093112 · Cited by 206

Role of DGAT enzymes in triacylglycerol metabolism

Bhatt-Wessel, B., Jordan, T. W., Miller, J. H., & Peng, L. (2018) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2018.08.001 · Cited by 208

The Role of Peroxisome Proliferator-Activated Receptor γ Coactivator-1 β in the Pathogenesis of Fructose-Induced Insulin Resistance

Nagai, Y., Yonemitsu, S., Erion, D. M., Iwasaki, T., Stark, R., Weismann, D., Dong, J., Zhang, D., Jurczak, M. J., Löffler, M. G., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.01.011 · Cited by 203

Therapeutic Landscape for NAFLD in 2020

Neuschwander‐Tetri, B. A. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.01.051 · Cited by 184

SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats

Erion, D. M., Yonemitsu, S., Nie, Y., Nagai, Y., Gillum, M. P., Hsiao, J. J., Iwasaki, T., Stark, R., Weismann, D., Yu, X. X., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812931106 · Cited by 180

Rutin Attenuates Metabolic Changes, Nonalcoholic Steatohepatitis, and Cardiovascular Remodeling in High-Carbohydrate, High-Fat Diet-Fed Rats

Panchal, S. K., Poudyal, H., Arumugam, T. V., & Brown, L. (2011) · Journal of Nutrition · doi:10.3945/jn.111.137877 · Cited by 180

Specific role for acyl CoA

Villanueva, C. J., Monetti, M., Shih, M., Zhou, P., Watkins, S. M., Bhanot, S., & Farese, R. V. (2009) · Hepatology · doi:10.1002/hep.22980 · Cited by 180

A Membrane-Bound Diacylglycerol Species Induces PKCϵ-Mediated Hepatic Insulin Resistance

Lyu, K., Zhang, Y., Zhang, D., Kahn, M., ter Horst, K. W., Rodrigues, M. R. D. S., Gaspar, R. C., Hirabara, S. M., Luukkonen, P. K., Lee, S., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.08.001 · Cited by 173

Non-alcoholic steatohepatitis: a microbiota-driven disease

Moschen, A. R., Kaser, S., & Tilg, H. (2013) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2013.05.009 · Cited by 176

Inhibition of Stearoyl-Coenzyme A Desaturase 1 Dissociates Insulin Resistance and Obesity From Atherosclerosis

Brown, J. M., Chung, S., Sawyer, J. K., Degirolamo, C., Alger, H. M., Nguyen, T., Zhu, X., Duong, M., Wibley, A. L., Shah, R., et al. (2008) · Circulation · doi:10.1161/circulationaha.108.793182 · Cited by 169

Non-alcoholic fatty liver disease: A sign of systemic disease

Reccia, I., Jayant, K., Akladios, C. Y., Virdis, F., Pai, M., Habib, N., & Spalding, D. R. C. (2017) · Metabolism · doi:10.1016/j.metabol.2017.04.011 · Cited by 171

Lipid oversupply, selective insulin resistance, and lipotoxicity: Molecular mechanisms

Chavez, J. A., & Summers, S. A. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2009.09.015 · Cited by 170

Hydroxytyrosol protects against oxidative damage by simultaneous activation of mitochondrial biogenesis and phase II detoxifying enzyme systems in retinal pigment epithelial cells

Zhu, L., Liu, Z., Feng, Z., Hao, J., Shen, W., Li, X., Sun, L., Sharman, E. H., Wang, Y., Wertz, K., et al. (2010) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2009.09.006 · Cited by 167

Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2

Jornayvaz, F. R., Birkenfeld, A. L., Jurczak, M. J., Kanda, S., Guigni, B. A., Jiang, D. C., Zhang, D., Lee, H., Samuel, V. T., & Shulman, G. I. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1103451108 · Cited by 169

Skin-specific Deletion of Stearoyl-CoA Desaturase-1 Alters Skin Lipid Composition and Protects Mice from High Fat Diet-induced Obesity

Sampath, H., Flowers, M. T., Liu, X., Paton, C. M., Sullivan, R., Chu, K., Zhao, M., & Ntambi, J. M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.014225 · Cited by 165

Insights into the Epidemiology, Pathogenesis, and Therapeutics of Nonalcoholic Fatty Liver Diseases

Yu, Y., Cai, J., She, Z., & Li, H. (2018) · Advanced Science · doi:10.1002/advs.201801585 · Cited by 166

Hepatic Fatty Acid Trafficking: Multiple Forks in the Road

Mashek, D. G. (2013) · Advances in Nutrition · doi:10.3945/an.113.004648 · Cited by 167

Nonalcoholic fatty liver disease: A main driver of insulin resistance or a dangerous liaison?

Gruben, N., Shiri‐Sverdlov, R., Koonen, D. P. Y., & Hofker, M. H. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.08.004 · Cited by 156

Acetyl-CoA carboxylase (ACC) as a therapeutic target for metabolic syndrome and recent developments in ACC1/2 inhibitors

Chen, L., Duan, Y., Wei, H., Ning, H., Bi, C., Zhao, Y., Qin, Y. W., & Li, Y. (2019) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2019.1657825 · Cited by 149

Fatty liver, insulin resistance, and dyslipidemia

Adiels, M., Taskinen, M., & Borén, J. (2008) · Current Diabetes Reports · doi:10.1007/s11892-008-0011-4 · Cited by 147

Metabolic Targets in Nonalcoholic Fatty Liver Disease

Esler, W. P., & Bence, K. K. (2019) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2019.04.007 · Cited by 145

Dissociation of Inositol-requiring Enzyme (IRE1α)-mediated c-Jun N-terminal Kinase Activation from Hepatic Insulin Resistance in Conditional X-box-binding Protein-1 (XBP1) Knock-out Mice

Jurczak, M. J., Lee, A., Jornayvaz, F. R., Lee, H., Birkenfeld, A. L., Guigni, B. A., Kahn, M., Samuel, V. T., Glimcher, L. H., & Shulman, G. I. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.316760 · Cited by 143

Lipidomics in non-alcoholic fatty liver disease

Kartsoli, S., Kostara, C. E., Tsimihodimos, V., Bairaktari, E. T., & Christodoulou, D. K. (2020) · World Journal of Hepatology · doi:10.4254/wjh.v12.i8.436 · Cited by 149

Hepatic long-chain acyl-CoA synthetase 5 mediates fatty acid channeling between anabolic and catabolic pathways

Bu, S. Y., & Mashek, D. G. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m009407 · Cited by 138

Abrogation of growth hormone secretion rescues fatty liver in mice with hepatocyte-specific deletion of JAK2

Sos, B. C., Harris, C. A., Nordstrom, S. M., Tran, J. L., Balázs, M., Caplazi, P., Febbraio, M., Applegate, M. A. B., Wagner, K., & Weiss, E. J. (2011) · Journal of Clinical Investigation · doi:10.1172/jci42894 · Cited by 136

Niacin inhibits fat accumulation, oxidative stress, and inflammatory cytokine IL-8 in cultured hepatocytes: Impact on non-alcoholic fatty liver disease

Ganji, S. H., Kashyap, M. L., & Kamanna, V. S. (2015) · Metabolism · doi:10.1016/j.metabol.2015.05.002 · Cited by 132

Adipose triacylglycerol lipase is a major regulator of hepatic lipid metabolism but not insulin sensitivity in mice

Turpin-Nolan, S. M., Hoy, A. J., Brown, R. D., Rudaz, C. G., Honeyman, J. E., Matzaris, M., & Watt, M. J. (2010) · Diabetologia · doi:10.1007/s00125-010-1895-5 · Cited by 130

Cardiac diacylglycerol accumulation in high fat-fed mice is associated with impaired insulin-stimulated glucose oxidation

Zhang, L., Ussher, J. R., Oka, T., Cadete, V. J. J., Wagg, C. S., & Lopaschuk, G. D. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq266 · Cited by 130

CTRP3 attenuates diet-induced hepatic steatosis by regulating triglyceride metabolism

Peterson, J. M., Seldin, M. M., Wei, Z., Aja, S. M., & Wong, G. W. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00102.2013 · Cited by 123

The Race to Bash NASH: Emerging Targets and Drug Development in a Complex Liver Disease

Romero, F. A., Jones, C. T., Xu, Y., Fenaux, M., & Halcomb, R. L. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b01701 · Cited by 126

Hepatocyte Deletion of Triglyceride‐Synthesis Enzyme Acyl CoA: Diacylglycerol Acyltransferase 2 Reduces Steatosis Without Increasing Inflammation or Fibrosis in Mice

Gluchowski, N. L., Gabriel, K. R., Chitraju, C., Bronson, R. T., Mejhert, N., Boland, S., Wang, K., Lai, Z. W., Farese, R. V., & Walther, T. C. (2019) · Hepatology · doi:10.1002/hep.30765 · Cited by 128

Pck1 Gene Silencing in the Liver Improves Glycemia Control, Insulin Sensitivity, and Dyslipidemia in db/db Mice

Gómez-Valadés, A. G., Méndez‐Lucas, A., Vidal‐Alabró, A., Blasco, F. X., Chillón, M., Bartrons, R., Bermúdez, J., & Perales, J. C. (2008) · Diabetes · doi:10.2337/db07-1087 · Cited by 123

MASH: the nexus of metabolism, inflammation, and fibrosis

Steinberg, G. R., Carpentier, A. C., & Wang, D. (2025) · Journal of Clinical Investigation · doi:10.1172/jci186420 · Cited by 135

Diacylglycerol acyltransferase 2 acts upstream of diacylglycerol acyltransferase 1 and utilizes nascent diglycerides and de novo synthesized fatty acids in HepG2 cells

Wurie, H. R., Buckett, L. K., & Zammit, V. A. (2012) · FEBS Journal · doi:10.1111/j.1742-4658.2012.08684.x · Cited by 121

Pathophysiology of type 2 diabetes and the impact of altered metabolic interorgan crosstalk

Sanches, J. M., Zhao, L. N., Salehi, A. A., Wollheim, C. B., & Kaldis, P. (2021) · FEBS Journal · doi:10.1111/febs.16306 · Cited by 136

Novel antisense inhibition of diacylglycerol O-acyltransferase 2 for treatment of non-alcoholic fatty liver disease: a multicentre, double-blind, randomised, placebo-controlled phase 2 trial

Loomba, R. S., Morgan, E. S., Watts, L. M., Xia, S., Hannan, L. A., Geary, R. S., Baker, B. F., & Bhanot, S. (2020) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(20)30186-2 · Cited by 113

The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2

Qi, J., Lang, W., Geisler, J. G., WANG, P. H., Petrounia, I. P., Mai, S., Smith, C., Askari, H. B., Struble, G. T., Williams, R., et al. (2012) · Journal of Lipid Research · doi:10.1194/jlr.m020156 · Cited by 115

Acyl-CoA:diacylglycerol acyltransferase: Properties, physiological roles, metabolic engineering and intentional control

Chen, G., Harwood, J. L., Lemieux, M. J., Stone, S. J., & Weselake, R. J. (2022) · Progress in Lipid Research · doi:10.1016/j.plipres.2022.101181 · Cited by 121

Prevention of Hepatic Steatosis and Hepatic Insulin Resistance by Knockdown of cAMP Response Element-Binding Protein

Erion, D. M., Ignatova, I. D., Yonemitsu, S., Nagai, Y., Chatterjee, P., Weismann, D., Hsiao, J. J., Zhang, D., Iwasaki, T., Stark, R., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.10.007 · Cited by 108

Curcumin limits the fibrogenic evolution of experimental steatohepatitis

Vizzutti, F., Provenzano, A., Galastri, S., Milani, S., Delogu, W., Novo, E., Caligiuri, A., Zamara, E., Arena, U., Laffi, G., et al. (2009) · Laboratory Investigation · doi:10.1038/labinvest.2009.112 · Cited by 106

Functional and Topological Analysis of Yeast Acyl-CoA:Diacylglycerol Acyltransferase 2, an Endoplasmic Reticulum Enzyme Essential for Triacylglycerol Biosynthesis

Liu, Q., Siloto, R. M. P., Snyder, C. L., & Weselake, R. J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.204412 · Cited by 105

Foxa1 Reduces Lipid Accumulation in Human Hepatocytes and Is Down-Regulated in Nonalcoholic Fatty Liver

Moya, M., Benet, M., Guzmán, C., Tolosa, L., García‐Monzón, C., Pareja, E., Castell, J. V., & Jover, R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030014 · Cited by 103

Palmitate induces insulin resistance without significant intracellular triglyceride accumulation in HepG2 cells

Lee, J.-Y., Cho, H.-K., & Kwon, Y. H. (2009) · Metabolism · doi:10.1016/j.metabol.2009.10.012 · Cited by 106

Non-alcoholic fatty liver disease and cardiovascular risk

Brea, Á., & Puzo, J. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.09.085 · Cited by 109

DGAT2 inhibition blocks SREBP-1 cleavage and improves hepatic steatosis by increasing phosphatidylethanolamine in the ER

Rong, S., Xia, M., Vale, G., Wang, S., Kim, C.-W., Li, S., McDonald, J. G., Radhakrishnan, A., & Horton, J. D. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.01.011 · Cited by 102

Diacylglycerol acyltranferase 1 anti-sense oligonucleotides reduce hepatic fibrosis in mice with nonalcoholic steatohepatitis

Yamaguchi, K., Yang, L., McCall, S. J., Huang, J., Yu, X. X., Pandey, S., Bhanot, S., Monia, B. P., Li, Y.-X., & Diehl, A. M. (2007) · Hepatology · doi:10.1002/hep.21988 · Cited by 102

Beneficial effects of mangiferin on hyperlipidemia in high-fat-fed hamsters

Guo, F., Huang, C., Liao, X., Wang, Y., He, Y., Feng, R., Li, Y., & Sun, C. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100392 · Cited by 118

Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling

Zhang, C., Wendel, A. A., Keogh, M. R., Harris, T. E., Chen, J., & Coleman, R. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1110730109 · Cited by 102

The discovery of drugs for obesity, the metabolic effects of leptin and variable receptor pharmacology: perspectives from β3-adrenoceptor agonists

Arch, J. R. S. (2008) · Naunyn-Schmiedeberg's Archives of Pharmacology · doi:10.1007/s00210-008-0271-1 · Cited by 96

Lipoic Acid Improves Mitochondrial Function in Nonalcoholic Steatosis Through the Stimulation of Sirtuin 1 and Sirtuin 3

Valdecantos, M. P., Pérez‐Matute, P., González‐Muniesa, P., Prieto-Hontoria, P. L., Moreno-Aliaga, M. J., & Martínez, J. A. (2012) · Obesity · doi:10.1038/oby.2012.32 · Cited by 94

Pathway-selective Insulin Resistance and Metabolic Disease: The Importance of Nutrient Flux

Otero, Y. F., Stafford, J. M., & McGuinness, O. P. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.r114.576355 · Cited by 97

Organophosphorus Flame Retardants Impair Intracellular Lipid Metabolic Function in Human Hepatocellular Cells

Hao, Z., Zhang, Z., Lu, D., Ding, B., Shu, L., Zhang, Q., & Wang, C. (2019) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.9b00058 · Cited by 94

Acid Sphingomyelinase Deficiency Prevents Diet-induced Hepatic Triacylglycerol Accumulation and Hyperglycemia in Mice

Deevska, G. M., Rozenova, K. A., Giltiay, N. V., Chambers, M. A., White, J., Boyanovsky, B. B., Jia, W. P., Daugherty, A., Smart, E. J., Reid, M. B., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m807800200 · Cited by 91

The role of lipids in the pathogenesis and treatment of type 2 diabetes and associated co-morbidities

Erion, D. M., Park, H., & Lee, H. (2016) · BMB Reports · doi:10.5483/bmbrep.2016.49.3.268 · Cited by 89

DGAT2 Inhibition Alters Aspects of Triglyceride Metabolism in Rodents but Not in Non-human Primates

McLaren, D. G., Han, S., Murphy, B. A., Wilsie, L. C., Stout, S. J., Zhou, H., Roddy, T. P., Gorski, J. N., Metzger, D. E., Shin, M. K., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.04.004 · Cited by 89

The Molecular Mechanisms Underlying Mitochondria-Associated Endoplasmic Reticulum Membrane-Induced Insulin Resistance

Cheng, H., Gang, X., He, G., Liu, Y., Wang, Y., Zhao, X. Y., & Wang, G. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.592129 · Cited by 89

Discovery and Optimization of Imidazopyridine-Based Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2)

Futatsugi, K., Kung, D. W., Orr, S. T. M., Cabral, S., Hepworth, D., Aspnes, G., Bader, S., Bian, J., Boehm, M., Carpino, P. A., et al. (2015) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b01006 · Cited by 88

Mitochondrial oxidative injury: a key player in nonalcoholic fatty liver disease

Dornas, W., & Schuppan, D. (2020) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00121.2020 · Cited by 89

Antisense oligonucleotide reduction of DGAT2 expression improves hepatic steatosis and hyperlipidemia in obese mice†

Yu, X. X., Murray, S. F., Pandey, S., Booten, S. L., Bao, D., Song, X., Kelly, S., Chen, S., McKay, R. A., Monia, B. P., et al. (2005) · Hepatology · doi:10.1002/hep.20783 · Cited by 305

Hepatocyte Deletion of Triglyceride‐Synthesis Enzyme Acyl CoA: Diacylglycerol Acyltransferase 2 Reduces Steatosis Without Increasing Inflammation or Fibrosis in Mice

Gluchowski, N. L., Gabriel, K. R., Chitraju, C., Bronson, R. T., Mejhert, N., Boland, S., Wang, K., Lai, Z. W., Farese, R. V., & Walther, T. C. (2019) · Hepatology · doi:10.1002/hep.30765 · Cited by 128

Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis

Yamaguchi, K., Yang, L., McCall, S. J., Huang, J., Yu, X. X., Pandey, S., Bhanot, S., Monia, B. P., Li, Y.-X., & Diehl, A. M. (2007) · Hepatology · doi:10.1002/hep.21655 · Cited by 1,067

266-OR: Plasma Membrane sn-1,2 Diacylglycerol Mediates Lipid-Induced Hepatic Insulin Resistance

Lyu, K., ZHANG, Y., Zhang, D., Kahn, M., Nozaki, Y., Bhanot, S., Bogan, J. S., Cline, G. W., Samuel, V. T., & Shulman, G. I. (2019) · Diabetes · doi:10.2337/db19-266-or

Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2

Savage, D. B. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27300 · Cited by 447