Interplays between ATM/Tel1 and ATR/Mec1 in sensing and signaling DNA double-strand breaks

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Human CtIP promotes DNA end resection

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ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

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53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

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ATR and ATRIP: Partners in Checkpoint Signaling

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The 3′ to 5′ Exonuclease Activity of Mre11 Facilitates Repair of DNA Double-Strand Breaks

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A Cell Cycle-Dependent Regulatory Circuit Composed of 53BP1-RIF1 and BRCA1-CtIP Controls DNA Repair Pathway Choice

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Choreography of the DNA Damage Response

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A splicing mutation affecting expression of ataxia–telangiectasia and Rad3–related protein (ATR) results in Seckel syndrome

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TopBP1 Activates the ATR-ATRIP Complex

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DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1

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Regulation of <i>RAD53</i> by the <i>ATM</i> -Like Kinases <i>MEC1</i> and <i>TEL1</i> in Yeast Cell Cycle Checkpoint Pathways

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The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species

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Human CtIP Mediates Cell Cycle Control of DNA End Resection and Double Strand Break Repair

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Comparison of ARM and HEAT protein repeats

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Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair

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A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation.Preprint

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CDK targets Sae2 to control DNA-end resection and homologous recombination

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The Rad9–Hus1–Rad1 (9–1–1) clamp activates checkpoint signaling via TopBP1Preprint

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ATM Activation and Its Recruitment to Damaged DNA Require Binding to the C Terminus of Nbs1

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Cell Cycle-dependent Complex Formation of BRCA1·CtIP·MRN Is Important for DNA Double-strand Break Repair

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The Mre11 Complex Is Required for Repair of Hairpin-Capped Double-Strand Breaks and Prevention of Chromosome Rearrangements

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Rif1 Prevents Resection of DNA Breaks and Promotes Immunoglobulin Class Switching

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The CDK regulates repair of double‐strand breaks by homologous recombination during the cell cycle

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A DNA Damage Response Pathway Controlled by Tel1 and the Mre11 Complex

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TopBP1 activates ATR through ATRIP and a PIKK regulatory domainPreprint

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Ku prevents Exo1 and Sgs1‐dependent resection of DNA ends in the absence of a functional MRX complex or Sae2

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Ctp1 Is a Cell-Cycle-Regulated Protein that Functions with Mre11 Complex to Control Double-Strand Break Repair by Homologous Recombination

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Budding yeast Rad9 is an ATP-dependent Rad53 activating machine

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ATM-related Tel1 associates with double-strand breaks through an Xrs2-dependent mechanismPreprint

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The yeast Fun30 and human SMARCAD1 chromatin remodellers promote DNA end resection

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RPA Coordinates DNA End Resection and Prevents Formation of DNA Hairpins

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Loss of protein phosphatase 6 in mouse keratinocytes increases susceptibility to ultraviolet-B-induced carcinogenesis

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ATM and ATR Influence Meiotic Crossover Formation Through Antagonistic and Overlapping Functions in Caenorhabditis elegans

Li, W., & Yanowitz, J. L. (2019) · Genetics · doi:10.1534/genetics.119.302193 · Cited by 22 · see citing works

Genome instability: Linking ageing and brain degeneration

Barzilai, A., Schumacher, B., & Shiloh, Y. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.03.011 · Cited by 20 · see citing works

A diRNA–protein scaffold module mediates SMC5/6 recruitment in plant DNA repair

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A cell cycle-independent mode of the Rad9-Dpb11 interaction is induced by DNA damage

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How do cells sense DNA lesions?

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Mutation Spectra of the MRN (MRE11, RAD50, NBS1/NBN) Break Sensor in Cancer Cells

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Pch2 Prevents Mec1/Tel1-Mediated Hop1 Phosphorylation Occurring Independently of Red1 in Budding Yeast Meiosis

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Identification of Putative Mek1 Substrates during Meiosis in Saccharomyces cerevisiae Using Quantitative Phosphoproteomics

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Radiation Therapy for Glioma Stem Cells

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Nuclear DNA replication and repair in parasites of the genusLeishmania: Exploiting differences to develop innovative therapeutic approaches

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Recruitment of Scc2/4 to double-strand breaks depends on γH2A and DNA end resection

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CDK-mediated Yku80 Phosphorylation Regulates the Balance Between Non-homologous End Joining (NHEJ) and Homologous Directed Recombination (HDR)

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Unexpected Function of the Glucanosyltransferase Gas1 in the DNA Damage Response Linked to Histone H3 Acetyltransferases in Saccharomyces cerevisiae

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Nicotinamide Suppresses the DNA Damage Sensitivity of Saccharomyces cerevisiae Independently of Sirtuin Deacetylases

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Uncoupling Sae2 Functions in Downregulation of Tel1 and Rad53 Signaling Activities

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Heterochromatin formation via recruitment of DNA repair proteins

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Polymer perspective of genome mobilization

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PCNA antagonizes cohesin-dependent roles in genomic stability

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MRN- and 9-1-1-Independent Activation of the ATR-Chk1 Pathway during the Induction of the Virulence Program in the Phytopathogen Ustilago maydis

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p53/E2F1/miR-25 axis regulates apoptosis induction in glioblastoma cells: a qualitative model

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Antagonistic relationship of NuA4 with the non-homologous end-joining machinery at DNA damage sites

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Phosphorylation-Dependent Enhancement of Rad53 Kinase Activity through the INO80 Chromatin Remodeling Complex

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Protracted Exposure to a Sub-background Radiation Environment Negatively Impacts the Anhydrobiotic Recovery of Desiccated Yeast Sentinels

Lapointe, M., Laframboise, T., Pirkkanen, J., Tai, T. C., Lees, S. J., Maria, S. R. S., Tharmalingam, S., Boreham, D. R., & Thome, C. (2024) · Health Physics · doi:10.1097/hp.0000000000001804 · Cited by 6 · see citing works

Regulation of Pkc1 Hyper-Phosphorylation by Genotoxic Stress

Liu, L., Veis, J., Reiter, W., Motari, E., Costello, C. E., Samuelson, J. C., Ammerer, G., & Levin, D. E. (2021) · Journal of Fungi · doi:10.3390/jof7100874 · Cited by 4 · see citing works

Moh1 coordinates ROS-dependent apoptosis in genotoxic stress response of Candida albicans

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γH2A/γH2AX Mediates DNA Damage-Specific Control of Checkpoint Signaling in Saccharomyces cerevisiae

Siler, J., Guo, N., Liu, Z., Qin, Y., & Bi, X. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052462 · Cited by 3 · see citing works

DNA Damage-Induced Phosphorylation of Histone H2A at Serine 15 Is Linked to DNA End Resection

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Ataxia-Telangiectasia and Nijmegen Breakage Syndrome

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Mec1-mediated Atg9 phosphorylation regulates the PAS recruitment of Atg9 vesicles upon energy stress

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Profiling Tel1 signaling reveals a non-canonical motif targeting DNA repair and telomere control machineries

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SWI/SNF chromatin remodeling complex regulates a non-chromatin substrate

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Chromatin Regulators and DNA Repair: A Dissertation

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The Influence of Histone Chaperones and Histone Modifying Proteins in Regulating the DNA Damage Checkpoint

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Characterization of Dbf4 structure and function in Saccharomyces cerevisiae DNA replication and checkpoint responses.

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The Role of Nej1-Lif1 in Double Strand Break Repair Pathway Choice and Non-Homologous End-Joining

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Saccharomyces cerevisiae Tel1 & Tel2 role in DNA double-strand break repairs

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The role of Bcl-2 and bax protein expression on individual radiosensitivity

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The Mre11-Rad50-Xrs2 Complex in the DNA Damage Response

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DNA damage-specific effects of Tel1/ATM and γH2A/γH2AX on checkpoint signaling in Saccharomyces cerevisiaePreprint

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A Sterol-PI(4)P Exchanger Controls the Tel1/ATM Axis of the DNA Damage ResponsePreprint

Ovejero, S., Kumanski, S., Soulet, C., Azarli, J., Pardo, B., Santt, O., Constantinou, A., Pasero, P., & Moriel‐Carretero, M. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4104813

Translation control of autophagy genes upon hydroxyurea-induced genotoxic stressPreprint

Mohanan, G., Nag, K., Senger, H. S., & Rajyaguru, P. I. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.09.648074

Sumo-Directed Control of the Resolvase Yen1 in Mitotic Cells

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Régulation spatiale des cassures d’ADN double-brin méiotiques chez Saccharomyces cerevisiae : rôle de la protéine kinase Tel1

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Beyond Lactylation: Interrogating ATR's Role and Model Consistency in DNA Damage Response

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Translation control of autophagy genes modulates cellular response to hydroxyurea-induced genotoxic stress

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Enhanced Tel1ATM Checkpoint Signaling at Protein-Bound Double-Strand Breaks

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Dual role for Saccharomyces cerevisiae Tel1 in the checkpoint response to double‐strand breaks

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ATM regulates ATR chromatin loading in response to DNA double-strand breaks

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