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Cited by 104Sleep and Work-Related FatigueCircadian rhythm and melatoninWorkplace Health and Well-being

Shiftwork and impaired glucose metabolism: a 14-year cohort study on 7104 male workers

Suwazono, Yasushi, Dochi, Mirei, Oishi, Mitsuhiro, Tanaka, Kumihiko, Kobayashi, Etsuko, Sakata, Kouichi·2009·Chronobiology International
DOI 10.1080/07420520903044422
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Abstract

The aim of this study was to assess the effect of shiftwork on hemoglobin A1c (HbA1c) level, as an index of glucose metabolism. A 14 yr prospective cohort study was conducted on day (n = 4219) and alternating shiftworkers (n = 2885) who received annual health checkups between 1991 and 2005 at a Japanese steel company. The endpoints were either a 10%, 15%, 20%, 25%, or 30% increase in HbA1c during the period of observation, compared to HbA1c at entry to the study. The association between the type of job schedule and increase in HbA1c was investigated after adjusting for age, body mass index, mean arterial pressure, total serum cholesterol, creatinine, alanine aminotransferase, gamma-glutamyl transpeptidase, uric acid, drinking habit, smoking habit, and habitual exercise using multivariate pooled logistic regression analyses. Shiftwork was significantly associated with the various HbA1c endpoints (> or =10% HbA1c increase, odds ratio 1.35 [95% confidence interval 1.26-1.44]; > or =15% HbA1c increase, odds ratio 1.29 [95% confidence interval, 1.19-1.40]; > or =20% HbA1c increase, odds ratio 1.23 [95% confidence interval 1.11-1.37]; and > or =25% HbA1c increase, odds ratio 1.19 [95% confidence interval 1.03-1.36]). Age, body mass index, alanine aminotransferase, and gamma-glutamyl transpeptidase were associated positively with all five HbA1c endpoints. Uric acid was associated negatively with all five HbA1c endpoints. Our study on male Japanese workers revealed alternating shiftwork (in addition to other established factors, such as age and body mass index) was a consistent risk factor for impaired glucose metabolism.

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Crossref · 10.1080/07420520903044422

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  • Different forms of shift work induce multiple forms of circadian misalignment, which are believed to underlie raised postprandial glucose and insulin concentrations in shift workers, increased risk of impaired glucose tolerance, and type 2 diabetes.

    “Different forms of shift work are reported to induce multiple forms of circadian misalignment, which are believed to underlie the observed raised postprandial glucose (120) and insulin concentrations in shift workers (121), as well as the increased risk of impaired glucose tolerance (122) and type 2 diabetes observed in epidemiologic studies (81).”

    From Chronotype: Implications for Epidemiologic Studies on Chrono-Nutrition and Cardiometabolic Health (2019) · cites this paper as [122]

  • Epidemiological studies consistently show an increased risk for type 2 diabetes in shift workers.

    “the strongest evidence linking circadian disruption and type 2 diabetes, comes from epidemiological studies consistently showing an increased risk for type 2 diabetes in shift workers [138–140].”

    From Circadian control of glucose metabolism (2014) · cites this paper as [139]

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Authors
Suwazono, Y., Dochi, M., Oishi, M., Tanaka, K., Kobayashi, E., & Sakata, K.
Affiliations
Chiba University (JP)
Corresponding author
Suwazono, Yasushi
ORCID
Venue
Chronobiology International
Publisher
Informa UK Limited
Published
2009-01
Volume
26
Issue
5
Pages
926-941
ISSN
  • 0742-0528 (ISSN-L)
  • 1525-6073
DOI
10.1080/07420520903044422
OpenAlex
W2124194978
Cited by
104
References
44
Citations by year
2025: 5 · 2024: 7 · 2023: 4 · 2022: 4 · 2021: 1 · 2020: 7 · 2019: 3 · 2018: 10 · 2017: 7 · 2016: 11 · 2015: 13 · 2014: 4 · 2013: 2 · 2012: 8
FWCI
11.02
Type
journal article
Language
en
Open access
closed
Locations
  • Chronobiology International (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Fondation pour la Recherche Médicale
  • Japan Diabetes Society
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Health Sciences › Health Professions › General Health Professions › Workplace Health and Well-being
Keywords
shift work, impaired glucose metabolism, HbA1c, diabetes risk, male workers, steelworkers, uric acid, alanine aminotransferase, gamma-glutamyl transferase, body mass index, occupational health
MeSH terms
Adult, Diabetes Mellitus, Glucose, Glycated Hemoglobin, Humans, Male, Prospective Studies, Regression Analysis, Risk, Risk Factors, Time Factors, Work Schedule Tolerance, Models, Statistical, Cohort Studies, Odds Ratio

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