Dim light at night prior to adolescence increases adult anxiety-like behaviors
Open accessAbstract
Dim light at night (dLAN) disrupts circadian organization and influences adult behavior. We examined early dLAN exposure on adult affective responses. Beginning 3 (juvenile) or 5 weeks (adolescent) of age, mice were maintained in standard light-dark cycles or exposed to nightly dLAN (5 lx) for 5 weeks, then anxiety-like and fear responses were assessed. Hypothalami were collected around the clock to assess core clock genes. Exposure to dLAN at either age increased anxiety-like responses in adults. Clock and Rev-ERB expression were altered by exposure to dLAN. In contrast to adults, dLAN exposure during early life increases anxiety and fear behavior.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The effects of light as a circadian disruptor are inconsistent across species and may depend on the developmental window during which circadian disruption occurs, as well as the type of light and its intensity.
“However, the effects of light as a circadian disruptor are inconsistent across species104–108, and may depend on the developmental window during which circadian disruption occurs, as well as the type of light (i.e. halogen, compact fluorescent, or light emitting diode) and its intensity108,109.”
From Circadian rhythm disruption and mental health (2020) · cites this paper as [109]
The Discussion (page unavailable) suggests that developmental vulnerability to dim light at night may explain different behavioral outcomes after early-life versus adult exposure. The paper studies mice under one dim-light condition; it does not establish differences across species or compare halogen, fluorescent, and LED light or multiple intensities. (LLM, conf=0.86)
Experimental — accuracy not yet measuredExposure to dim light at night during early development in mice increases adult anxiety-like responses, whereas exposure of adult mice to light at night reduces anxiety-like responses.
“For example, exposure to dim light at night during early development in mice increases adult anxiety-like responses108,109, whereas exposure of adult mice to light at night reduces anxiety-like responses106.”
From Circadian rhythm disruption and mental health (2020) · cites this paper as [109]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The adolescent brain and age-related behavioral manifestations
Spear, L. P. (2000) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(00)00014-2 · Cited by 5,433 · see citing works
Effect of In Utero and Early-Life Conditions on Adult Health and Disease
Gluckman, P. D., Hanson, M. A., Cooper, C., & Thornburg, K. L. (2008) · New England Journal of Medicine · doi:10.1056/nejmra0708473 · Cited by 3,898 · see citing works
Chambers, R. A., Taylor, J. R., & Potenza, M. N. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.6.1041 · Cited by 1,719 · see citing works
Adolescent cortical development: A critical period of vulnerability for addiction
Crews, F., He, J., & Hodge, C. (2007) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.12.001 · Cited by 1,091 · see citing works
Light at night increases body mass by shifting the time of food intake
Fonken, L. K., Workman, J. L., Walton, J. C., Weil, Z. M., Morris, J. S., Haim, A., & Nelson, R. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1008734107 · Cited by 796 · see citing works
Self-citationCircadian genes, rhythms and the biology of mood disorders
McClung, C. A. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.02.003 · Cited by 666 · see citing works
The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption
Spanagel, R., Pendyala, G., Abarca, C., Zghoul, T., Sanchis-Segura, C., Magnone, M. C., Lascorz, J., Depner, M., Holzberg, D., Soyka, M., et al. (2005) · Nature Medicine · doi:10.1038/nm1163 · Cited by 594 · see citing works
Aberrant light directly impairs mood and learning through melanopsin-expressing neurons
LeGates, T. A., Altimus, C. M., Wang, H., Lee, H.-K., Yang, S., Zhao, H., Kirkwood, A., Weber, E. T., & Hattar, S. (2012) · Nature · doi:10.1038/nature11673 · Cited by 577 · see citing works
Periadolescence: age-dependent behavior and psychopharmacological responsivity in rats
Spear, L. P., & Brake, S. C. (1983) · Developmental Psychobiology · doi:10.1002/dev.420160203 · Cited by 539 · see citing works
Enduring consequences of maternal obesity for brain inflammation and behavior of offspring
Bilbo, S. D., & Tsang, V. (2010) · The FASEB Journal · doi:10.1096/fj.09-144014 · Cited by 489 · see citing works
Cunningham, M. G., Bhattacharyya, S., & Benes, F. M. (2002) · Journal of Comparative Neurology · doi:10.1002/cne.10376 · Cited by 474 · see citing works
Wigger, A., & Neumann, I. D. (1999) · Physiology & Behavior · doi:10.1016/s0031-9384(98)00300-x · Cited by 443 · see citing works
Television-viewing Habits and Sleep Disturbance in School Children
Owens, J., Maxim, R. A., McGuinn, M., Hart, C. N., Msall, M. E., & Alario, A. J. (1999) · PEDIATRICS · doi:10.1542/peds.104.3.e27 · Cited by 427 · see citing works
Sex differences in anxiety and emotional behavior
Donner, N. C., & Lowry, C. A. (2013) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-013-1271-7 · Cited by 379 · see citing works
McCormick, C. M., & Zovkic, I. B. (2006) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.07.012 · Cited by 373 · see citing works
Light-at-night, circadian disruption and breast cancer: assessment of existing evidence
Stevens, R. G. (2009) · International Journal of Epidemiology · doi:10.1093/ije/dyp178 · Cited by 345 · see citing works
Isgor, C., Kabbaj, M., Akil, H., & Watson, S. J. (2004) · Hippocampus · doi:10.1002/hipo.10207 · Cited by 341 · see citing works
Nader, N., Chrousos, G. P., & Kino, T. (2009) · The FASEB Journal · doi:10.1096/fj.08-117697 · Cited by 341 · see citing works
Dim Light at Night Disrupts Molecular Circadian Rhythms and Increases Body Weight
Fonken, L. K., Aubrecht, T. G., Meléndez‐Fernández, O. H., Weil, Z. M., & Nelson, R. J. (2013) · Journal of Biological Rhythms · doi:10.1177/0748730413493862 · Cited by 325 · see citing works
Self-citationSullivan, E. L., Grayson, B. E., Takahashi, D. L., Robertson, N. D., Maier, A., Bethea, C. L., Smith, M. S., Coleman, K., & Grove, K. L. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5560-09.2010 · Cited by 324 · see citing works
The comorbidity of bipolar and anxiety disorders: prevalence, psychobiology, and treatment issues
Freeman, M. P., Freeman, S. A., & McElroy, S. L. (2002) · Journal of Affective Disorders · doi:10.1016/s0165-0327(00)00299-8 · Cited by 303 · see citing works
Impact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopamine Production and Mood Regulation
Chung, S., Lee, E. J., Yun, S., Choe, H. K., Park, S., Son, H. J., Kim, K., Dluzen, D. E., Lee, I., Hwang, O., et al. (2014) · Cell · doi:10.1016/j.cell.2014.03.039 · Cited by 298 · see citing works
Romeo, R. D., Mueller, A., Sisti, H. M., Ogawa, S., McEwen, B. S., & Brake, W. G. (2003) · Hormones and Behavior · doi:10.1016/s0018-506x(03)00063-1 · Cited by 285 · see citing works
McCormick, C. M., Smith, C. L., & Mathews, I. Z. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.09.005 · Cited by 278 · see citing works
Castañeda, T. R., de Prado, B. M., Prieto, D., & Mora, F. (2004) · Journal of Pineal Research · doi:10.1046/j.1600-079x.2003.00114.x · Cited by 276 · see citing works
Circadian polymorphisms associated with affective disorders
Kripke, D. F., Nievergelt, C. M., Joo, E., Shekhtman, T., & Kelsoe, J. R. (2009) · Journal of Circadian Rhythms · doi:10.1186/1740-3391-7-2 · Cited by 225 · see citing works
Meaney, M. J., Sapolsky, R. M., & McEwen, B. S. (1985) · Developmental Brain Research · doi:10.1016/0165-3806(85)90259-7 · Cited by 219 · see citing works
Television viewing, bedroom television, and sleep duration from infancy to mid-childhood
Cespedes, E. M., Gillman, M. W., Kleinman, K., Rifas-Shiman, S. L., Redline, S., & Taveras, E. M. (2014) · Pediatrics · doi:10.1542/peds.2013-3998 · Cited by 219 · see citing works
McFadden, E. C., Jones, M. E., Schoemaker, M. J., Ashworth, A., & Swerdlow, A. J. (2014) · American Journal of Epidemiology · doi:10.1093/aje/kwu117 · Cited by 211 · see citing works
Eiland, L. R., Ramroop, J. R., Hill, M. N., Manley, J., & McEwen, B. S. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.04.015 · Cited by 203 · see citing works
Enduring and sex-specific effects of adolescent social isolation in rats on adult stress reactivity
Weintraub, A. Y., Singaravelu, J., & Bhatnagar, S. (2010) · Brain Research · doi:10.1016/j.brainres.2010.04.068 · Cited by 186 · see citing works
Dose-dependent responses of avian daily rhythms to artificial light at night
de Jong, M., Jeninga, L., Ouyang, J. Q., van Oers, K., Spoelstra, K., & Visser, M. E. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.12.012 · Cited by 182 · see citing works
Dominoni, D. M., Carmona‐Wagner, E. O., Hofmann, M. M., Kranstauber, B., & Partecke, J. (2013) · Journal of Animal Ecology · doi:10.1111/1365-2656.12150 · Cited by 175 · see citing works
Outdoor Light at Night (LAN) Is Correlated With Eveningness in Adolescents
Vollmer, C., Michel, U., & Randler, C. (2012) · Chronobiology International · doi:10.3109/07420528.2011.635232 · Cited by 162 · see citing works
Logan, R. W., Edgar, N. M., Gillman, A. G., Hoffman, D., Zhu, X., & McClung, C. A. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.01.011 · Cited by 154 · see citing works
Tsoory, M., & Richter‐Levin, G. (2005) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145705006255 · Cited by 132 · see citing works
Anxiety and increased 5-HT1A receptor response in NCAM null mutant mice
Stork, O., Welzl, H., Wotjak, C. T., Hoyer, D., Delling, M., Cremer, H., & Schachner, M. (1999) · Journal of Neurobiology · doi:10.1002/(sici)1097-4695(19990905)40:3 · Cited by 127 · see citing works
Sleep-Related Problems in Children and Adolescents With Anxiety Disorders
Chase, R. M., & Pincus, D. B. (2011) · Behavioral Sleep Medicine · doi:10.1080/15402002.2011.606768 · Cited by 126 · see citing works
Pohl, J., Olmstead, M. C., Wynne-Edwards, K. E., Harkness, K., & Menard, J. L. (2007) · Behavioral Neuroscience · doi:10.1037/0735-7044.121.3.462 · Cited by 120 · see citing works
Chronic dim light at night provokes reversible depression-like phenotype: possible role for TNF
Bedrosian, T. A., Weil, Z. M., & Nelson, R. J. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.96 · Cited by 112 · see citing works
Self-citationNighttime dim light exposure alters the responses of the circadian system
Shuboni‐Mulligan, D. D., & Yan, L. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.08.009 · Cited by 107 · see citing works
Lin, Y., Lin, S., & Wang, S. Z. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.12.003 · Cited by 105 · see citing works
Feder, A., Coplan, J. D., Goetz, R. R., Mathew, S. J., Pine, D. S., Dahl, R. E., Ryan, N. D., Greenwald†, S., & Weissman, M. M. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.05.005 · Cited by 103 · see citing works
An Association Analysis of Circadian Genes in Anxiety Disorders
Sipilä, T., Kananen, L., Greco, D., Donner, J., Silander, K., Terwilliger, J. D., Auvinen, P., Peltonen, L., Lönnqvist, J. K., Pirkola, S. P., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.12.011 · Cited by 96 · see citing works
Postnatal ontogenesis of the circadian clock within the rat liver
Sládek, M., Jindráková, Z., Bendová, Z., & Sumová, A. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00184.2006 · Cited by 95 · see citing works
Juvenile Obesity Enhances Emotional Memory and Amygdala Plasticity through Glucocorticoids
Boitard, C., Maroun, M., Tantot, F., Cavaroc, A., Sauvant, J., Marchand, A. R., Layé, S., Capuron, L., Darnaudéry, M., Castanon, N., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.3122-14.2015 · Cited by 89 · see citing works
Exposure to dim light at night during early development increases adult anxiety-like responses
Borniger, J. C., McHenry, Z. D., Abi Salloum, B. A., & Nelson, R. J. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.05.012 · Cited by 89 · see citing works
Self-citationSeverino, G., Manchia, M., Contu, P., Squassina, A., Lampus, S. F., Ardau, R., Chillotti, C., & Zompo, M. D. (2009) · Bipolar Disorders · doi:10.1111/j.1399-5618.2009.00667.x · Cited by 70 · see citing works
The Cellular Basis for Volume Changes in the Rat Cortex during Puberty: White and Gray Matter
Juraska, J. M., & Markham, J. A. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1308.058 · Cited by 69 · see citing works
Toki, S., Morinobu, S., Imanaka, A., Yamamoto, S., Yamawaki, S., & Honma, K. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05288.x · Cited by 69 · see citing works
Combined effects of exposure to dim light at night and fine particulate matter on C3H/HeNHsd mice
Hogan, M., Kovalycsik, T., Sun, Q., Rajagopalan, S., & Nelson, R. J. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.07.033 · Cited by 54 · see citing works
Self-citationSetting the biological time in central and peripheral clocks during ontogenesis
Sumová, A., Bendová, Z., Sládek, M., El‐Hennamy, R. E., Laurinová, K., Jindráková, Z., & Illnerová, H. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.03.023 · Cited by 45 · see citing works
Weiner, N., Clement, H.-W., Gemsa, D., & Wesemann, W. (1992) · Neurochemistry International · doi:10.1016/0197-0186(92)90062-v · Cited by 43 · see citing works
When does it start ticking? Ontogenetic development of the mammalian circadian system
Christ, E., Korf, H., & von Gall, C. (2012) · Progress in brain research · doi:10.1016/b978-0-444-59427-3.00006-x · Cited by 33 · see citing works
Tenk, C. M., Kavaliers, M., & Ossenkopp, K. (2012) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2012.12.004 · Cited by 28 · see citing works
Circadian rhythm of serotonin binding in rat brain
Wesemann, W., & Weiner, N. (1990) · Progress in Neurobiology · doi:10.1016/0301-0082(90)90029-g · Cited by 26 · see citing works
Frank, E., Benabou, M., Bentzley, B. S., Bianchi, M. T., Goldstein, T. R., Konopka, G., Maywood, E. S., Pritchett, D., Sheaves, B., & Thomas, J. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12600 · Cited by 20 · see citing works
Increased Anxiety in Offspring Reared by Circadian Clock Mutant Mice
Koizumi, H., Kurabayashi, N., Watanabe, Y., & Sanada, K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066021 · Cited by 14 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Circadian rhythm disruption and mental health
Walker, W. H., Walton, J. C., DeVries, A. C., & Nelson, R. J. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0694-0 · Cited by 1,030 · see citing works
Self-citationSmarr, B. L., Grant, A. D., Perez, L., Zucker, I., & Kriegsfeld, L. J. (2017) · Scientific Reports · doi:10.1038/s41598-017-03406-4 · Cited by 86 · see citing works
- Authors
- Cissé, Y. M., Peng, J., & Nelson, R. J.
- Affiliations
- The Ohio State University Wexner Medical Center (US)
- The Ohio State University (US)
- Corresponding author
- Cissé, Yasmine M.
- Venue
- Chronobiology International
- Publisher
- Informa UK Limited
- Published
- 2016-09-03
- Volume
- 33
- Issue
- 10
- Pages
- 1473-1480
- ISSN
- 0742-0528 (ISSN-L)
- 1525-6073
- PMC
- PMC5568526
- OpenAlex
- W2516520651
- Cited by
- 34
- References
- 58
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 4 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 3 · 2018: 3 · 2017: 5
- FWCI
- 1.70
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Chronobiology International (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Division of Integrative Organismal Systems (IOS 11-18792)
- National Institute of Dental and Craniofacial Research (T32DE014320)
- National Institute of Neurological Disorders and Stroke (P30NS045758)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Physical Sciences › Environmental Science › Global and Planetary Change › Impact of Light on Environment and Health
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- dim light at night, circadian rhythm disruption, anxiety-like behavior, fear response, adolescent exposure, early life exposure, clock genes, REV-ERB, hypothalamus, emotional behavior, mice
- MeSH terms
- Aging, Animals, Anxiety, Behavior, Animal, Circadian Rhythm, Female, Light, Male, Motor Activity, Photoperiod, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
