The DOI matches its Crossref record; 304 of the 306 references it cites were found in a registry or an index.
Dietary Polyphenols and the Prevention of Diseases
Abstract
Polyphenols are the most abundant antioxidants in the diet and are widespread constituents of fruits, vegetables, cereals, dry legumes, chocolate, and beverages, such as tea, coffee, or wine. Experimental studies on animals or cultured human cell lines support a role of polyphenols in the prevention of cardiovascular diseases, cancers, neurodegenerative diseases, diabetes, or osteoporosis. However, it is very difficult to predict from these results the effects of polyphenol intake on disease prevention in humans. One of the reasons is that these studies have often been conducted at doses or concentrations far beyond those documented in humans. The few clinical studies on biomarkers of oxidative stress, cardiovascular disease risk factors, and tumor or bone resorption biomarkers have often led to contradictory results. Epidemiological studies have repeatedly shown an inverse association between the risk of myocardial infarction and the consumption of tea and wine or the intake level of some particular flavonoids, but no clear associations have been found between cancer risk and polyphenol consumption. More human studies are needed to provide clear evidence of their health protective effects and to better evaluate the risks possibly resulting from too high a polyphenol consumption.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The Folin assay, commonly used to estimate total polyphenols in foods (46), has also been applied to urine samples to compare polyphenol intake (47), but such use may be inappropriate because of the presence of interfering reducing metabolites in such complex biological matrices (46).”
From The food metabolome: a window over dietary exposure (2014) · cites this paper as [46]
Citations
Cites
The Ferric Reducing Ability of Plasma (FRAP) as a Measure of “Antioxidant Power”: The FRAP Assay
Benzie, I. F. F., & Strain, J. (1996) · Analytical Biochemistry · doi:10.1006/abio.1996.0292 · Cited by 23,027
Structure-antioxidant activity relationships of flavonoids and phenolic acids
Rice-Evans, C. A., Miller, N. J., & Paganga, G. (1996) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(95)02227-9 · Cited by 9,085
Polyphenols: Food sources and bioavailability
Manach, C., Scalbert, A., Morand, C., Rémésy, C., & Jiménez, L. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.5.727 · Cited by 8,175
Cancer chemopreventive activity of resveratrol, a natural product derived from grapes
Jang, M., Cai, L., Udeani, G. O., Slowing, K. V., Thomas, C. F., Beecher, C. W. W., Fong, H. H. S., Farnsworth, N. R., Kinghorn, A. D., Mehta, R. G., et al. (1997) · Science · doi:10.1126/science.275.5297.218 · Cited by 4,935 · cited 1×
“[145] Jang, M.”
Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis
Celermajer, D. S., Sorensen, K. E., Gooch, V. M., Spiegelhalter, D. J., Miller, O. I., Sullivan, I. D., Lloyd, J. K., & Deanfield, J. E. (1992) · The Lancet · doi:10.1016/0140-6736(92)93147-f · Cited by 4,742
Interaction of Estrogenic Chemicals and Phytoestrogens with Estrogen Receptor β
Kuiper, G. G. J. M., Lemmen, J. G., Carlsson, B., Corton, J. C., Safe, S. H., van der Saag, P. T., van der Burg, B., & Gustafsson, J.-Å. (1998) · Endocrinology · doi:10.1210/endo.139.10.6216 · Cited by 4,203
Antioxidant Activity and Total Phenolics in Selected Fruits, Vegetables, and Grain Products
Velioğlu, Y. S., Mazza, G., Gao, L., & Oomah, B. D. (1998) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf9801973 · Cited by 3,893
Dietary Intake and Bioavailability of Polyphenols
Scalbert, A., & Williamson, G. (2000) · The Journal of Nutrition · doi:10.1093/jn/130.8.2073s · Cited by 3,658
Self-citationSchächinger, V., Britten, M. B., & Zeiher, A. M. (2000) · Circulation · doi:10.1161/01.cir.101.16.1899 · Cited by 2,589
The Relative Antioxidant Activities of Plant-Derived Polyphenolic Flavonoids
Rice-Evans, C. A., Miller, N. J., Bolwell, P., Bramley, P. M., & Pridham, J. B. (1995) · Free Radical Research · doi:10.3109/10715769509145649 · Cited by 2,160
Research works printed but not linked: 36
- Manach C., 2004, Am. J. Clin. Nutr.
- Kehrer J. P., 1994, Natural antioxidants, 25
- Bachur N. R., 1978, Cancer Res., 38, 1745
- Serafini M., 1996, Eur. J. Clin. Nutr., 50, 28
- Sharpe P. C., 1995, Q. J. Med., 88, 101
- Sakagami H., 1995, Anticanc. Res., 15, 2121
- Leighton F., 1999, Drugs Exp. Clin. Res., 25, 133
- Montforte M. T., 1995, Il. Farmaco., 50, 595
- Russo P., 2001, Nutr. Metab. Cardiovasc. Dis., 11, 25
- Rotondo S., 2001, Ital. Heart J., 2, 1
- 10.1001/archinte.155.4.381 · DOI · Paper page
- Suschetet M., 1997, Polyphénols 96, 165
- Dong Z., 1997, Cancer Res., 57, 4414
- Gupta S., 1999, Cancer Res., 59, 2115
- 10.1210/en.139.10.4252 · DOI · Paper page
- Naasani I., 2003, Cancer. Res., 63, 824
- Ferry D. R., 1996, Clin. Cancer Res., 2, 659
- Hsieh C. Y., 1998, Cancer Res., 58, 3833
- Shimoi K., 2001, Drug Metab. Dispos., 29, 1521
- Fujimoto N., 2002, Int. J. Oncol, 20, 1233
- Lu L. J., 2000, Cancer Res., 60, 4112
- Suganuma M., 1999, Cancer Res., 59, 44
- Sadzuka Y., 1998, Clin Cancer Res., 4, 153
- Goldbohm R. A., 1997, COST 916 Bioactive plant cell wall components in nutrition and health, 159
- den Tonkelaar I., 2001, Cancer Epidemiol. Biomarkers Prev., 10, 223
- Matsuoka Y., 1995, J. Pharmacol. Exp. Ther., 274, 602
- Levites Y., 2002, J. Biol. Chem., 63, 21
- Orgogozo J.-M., 1997, Rev. Neurol. (Paris), 153, 185
- Geetha B. S., 1994, Indian J. Physiol. Pharmacol, 38, 220
- Shenoy C., 2000, Indian J. Exp. Biol., 38, 278
- Bonina F. P., 2002, Diabetes Nutr. Metab., 15, 14
- Manuel y, 1999, Diabetes Nutr. Metab., 12, 256
- Tamir S., 2000, Cancer Res., 60, 5704
- Petrakis N. L., 1996, Cancer Epidemiol. Biomarkers. Prev., 5, 785
- Whitten P. L., 1995, Journal of Nutrition, 125, 771S
- Brune M., 1989, Eur. J. Clin. Nutr., 43, 547
Cited by
Sorted by citations
Plant Polyphenols as Dietary Antioxidants in Human Health and Disease
Pandey, K. B., & Rizvi, S. I. (2009) · Oxidative Medicine and Cellular Longevity · doi:10.4161/oxim.2.5.9498 · Cited by 3,942
Plant Phenolics: Extraction, Analysis and Their Antioxidant and Anticancer Properties
Dai, J., & Mumper, R. J. (2010) · Molecules · doi:10.3390/molecules15107313 · Cited by 4,872
Plant Polyphenols: Chemical Properties, Biological Activities, and Synthesis
Quideau, S., Deffieux, D., Douat, C., & Pouységu, L. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201000044 · Cited by 2,874
The Immunomodulatory and Anti-Inflammatory Role of Polyphenols
Yahfoufi, N., Alsadi, N., Jambi, M., & Matar, C. (2018) · Nutrients · doi:10.3390/nu10111618 · Cited by 1,737
Phenolic acids: Natural versatile molecules with promising therapeutic applications
Kumar, N., & Goel, N. (2019) · Biotechnology Reports · doi:10.1016/j.btre.2019.e00370 · Cited by 1,755
Metadata
- Authors
- Scalbert, A., Manach, C., Morand, C., Rémésy, C., & Jiménez, L.
- Affiliations
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Institut National de la Recherche Agronomique (FR)
- Danone (France) (FR)
- Venue
- Critical Reviews in Food Science and Nutrition
- Publisher
- Informa UK Limited
- Published
- 2005-06
- Volume
- 45
- Issue
- 4
- Pages
- 287-306
- ISSN
- 1040-8398 (ISSN-L)
- 1549-7852
- OpenAlex
- W2152252699
- Cited by
- 2,999
- References
- 306
- Citations by year
- 2026: 74 · 2025: 103 · 2024: 125 · 2023: 148 · 2022: 157 · 2021: 192 · 2020: 212 · 2019: 178 · 2018: 187 · 2017: 174 · 2016: 184 · 2015: 155 · 2014: 185 · 2013: 200 · 2012: 164
- FWCI
- 40.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Critical Reviews in Food Science and Nutrition (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- dietary polyphenols, antioxidants, disease prevention, cardiovascular disease, cancer, neurodegenerative diseases, diabetes mellitus, osteoporosis, flavonoids, tea, wine, oxidative stress biomarkers, myocardial infarction, dose-response extrapolation
- MeSH terms
- Animals, Antioxidants, Cardiovascular Diseases, Diabetes Mellitus, Diet, Female, Flavonoids, Humans, Neoplasms, Phenols, Primary Prevention, Osteoporosis, Postmenopausal, Neurodegenerative Diseases, Polyphenols
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
