Cited by 2,999Phytochemicals and Antioxidant ActivitiesNutritional Studies and DietAntioxidant Activity and Oxidative Stress

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Dietary Polyphenols and the Prevention of Diseases

Scalbert, Augustin, Manach, Claudine, Morand, Christine, Rémésy, Christian, Jiménez, Liliana·2005·Critical Reviews in Food Science and Nutrition

DOI 10.1080/1040869059096

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Abstract

Polyphenols are the most abundant antioxidants in the diet and are widespread constituents of fruits, vegetables, cereals, dry legumes, chocolate, and beverages, such as tea, coffee, or wine. Experimental studies on animals or cultured human cell lines support a role of polyphenols in the prevention of cardiovascular diseases, cancers, neurodegenerative diseases, diabetes, or osteoporosis. However, it is very difficult to predict from these results the effects of polyphenol intake on disease prevention in humans. One of the reasons is that these studies have often been conducted at doses or concentrations far beyond those documented in humans. The few clinical studies on biomarkers of oxidative stress, cardiovascular disease risk factors, and tumor or bone resorption biomarkers have often led to contradictory results. Epidemiological studies have repeatedly shown an inverse association between the risk of myocardial infarction and the consumption of tea and wine or the intake level of some particular flavonoids, but no clear associations have been found between cancer risk and polyphenol consumption. More human studies are needed to provide clear evidence of their health protective effects and to better evaluate the risks possibly resulting from too high a polyphenol consumption.

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Authors: Scalbert, A., Manach, C., Morand, C., Rémésy, C., & Jiménez, L.
Affiliations: Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
Institut National de la Recherche Agronomique (FR)
Danone (France) (FR)
ORCID: Scalbert, Augustin
Manach, Claudine
Morand, Christine
Jiménez, Liliana
Venue: Critical Reviews in Food Science and Nutrition
Publisher: Informa UK Limited
Published: 2005-06
Volume: 45
Issue: 4
Pages: 287-306
ISSN: 1040-8398 (ISSN-L)
1549-7852
DOI: 10.1080/1040869059096
OpenAlex: W2152252699
Cited by: 2,999
References: 306
Citations by year: 2026: 74 · 2025: 103 · 2024: 125 · 2023: 148 · 2022: 157 · 2021: 192 · 2020: 212 · 2019: 178 · 2018: 187 · 2017: 174 · 2016: 184 · 2015: 155 · 2014: 185 · 2013: 200 · 2012: 164
FWCI: 40.09
Type: journal article
Language: en
Open access: closed
Locations: Critical Reviews in Food Science and Nutrition (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords: dietary polyphenols, antioxidants, disease prevention, cardiovascular disease, cancer, neurodegenerative diseases, diabetes mellitus, osteoporosis, flavonoids, tea, wine, oxidative stress biomarkers, myocardial infarction, dose-response extrapolation
MeSH terms: Animals, Antioxidants, Cardiovascular Diseases, Diabetes Mellitus, Diet, Female, Flavonoids, Humans, Neoplasms, Phenols, Primary Prevention, Osteoporosis, Postmenopausal, Neurodegenerative Diseases, Polyphenols

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