Shorter sleep time relates to lower human defensin 5 secretion and compositional disturbance of the intestinal microbiota accompanied by decreased short-chain fatty acid production
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Sleep is essential for our health. Short sleep is known to increase disease risks via imbalance of intestinal microbiota, dysbiosis. However, mechanisms by which short sleep induces dysbiosis remain unknown. Small intestinal Paneth cell regulates the intestinal microbiota by secreting antimicrobial peptides including α-defensin, human defensin 5 (HD5). Disruption of circadian rhythm mediating sleep-wake cycle induces Paneth cell failure. We aim to clarify effects of short sleep on HD5 secretion and the intestinal microbiota. Fecal samples and self-reported sleep time were obtained from 35 healthy middle-aged Japanese (41 to 60-year-old). Shorter sleep time was associated with lower fecal HD5 concentration (r = 0.354, p = 0.037), lower centered log ratio (CLR)-transformed abundance of short-chain fatty acid (SCFA) producers in the intestinal microbiota such as [Ruminococcus] gnavus group (r = 0.504, p = 0.002) and Butyricicoccus (r = 0.484, p = 0.003), and lower fecal SCFA concentration. Furthermore, fecal HD5 positively correlated with the abundance of these genera and SCFA concentration. These findings suggest that short sleep relates to disturbance of the intestinal microbiota via decreased HD5 secretion.
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Self-citationSerum adiponectin and insulin secretion: A direct or inverse association?
Nakamura, A., Miyoshi, H., Ukawa, S., Nakamura, K., Nakagawa, T., Terauchi, Y., Tamakoshi, A., & Atsumi, T. (2018) · Journal of Diabetes Investigation · doi:10.1111/jdi.12821 · Cited by 27 · see citing works
Self-citationNakamura, K., Sakuragi, N., & Ayabe, T. (2013) · Analytical Biochemistry · doi:10.1016/j.ab.2013.08.021 · Cited by 26 · see citing works
Self-citationYokoi, Y., Adachi, T., Sugimoto, R., Kikuchi, M., Ayabe, T., & Nakamura, K. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.01.050 · Cited by 11 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases
Loh, J. S., Mak, W. Q., Tan, L. K. S., Ng, C. X., Chan, H. H., Yeow, S. H., Foo, J. B., Ong, Y. S., How, C. W., & Khaw, K. Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01743-1 · Cited by 1,193 · see citing works
- Authors
- Shimizu, Y., Yamamura, R., Yokoi, Y., Ayabe, T., Ukawa, S., Nakamura, K., Okada, E., Imae, A., Nakagawa, T., Tamakoshi, A., & Nakamura, K.
- Affiliations
- Hokkaido University (JP)
- Osaka Metropolitan University (JP)
- National Institute of Biomedical Innovation, Health and Nutrition (JP)
- Suttu Municipal Clinic, Hokkaido, Japan
- The Hokkaido Centre for Family Medicine (JP)
- Corresponding author
- Nakamura, Kiminori
- ORCID
- Venue
- Gut Microbes
- Publisher
- Informa UK Limited
- Published
- 2023-03-21
- Volume
- 15
- Issue
- 1
- Pages
- 2190306-2190306
- ISSN
- 1949-0976 (ISSN-L)
- 1949-0984
- PMC
- PMC10038026
- OpenAlex
- W4353020753
- Cited by
- 53
- References
- 86
- Citations by year
- 2026: 18 · 2025: 19 · 2024: 13 · 2023: 3
- FWCI
- 4.72
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Gut Microbes (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Japan Society for the Promotion of Science (22K16009)
- Japan Science and Technology Agency (JPMJCE 1301)
- Ministry of Agriculture, Forestry and Fisheries (14538261)
- Japan Foundation for Aging and Health (2015-58-2)
- Mitsubishi Foundation (10492)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Keywords
- short sleep duration, human defensin 5, gut microbiota, dysbiosis, short-chain fatty acids, Paneth cells, antimicrobial peptides, circadian rhythm, Ruminococcus gnavus, Butyricicoccus, fecal microbiota composition
- MeSH terms
- Gastrointestinal Microbiome, Adult, Fatty Acids, Volatile, Humans, Middle Aged, Sleep, Defensins, Dysbiosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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