The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Defining BMP functions in the hair follicle by conditional ablation of BMP receptor IA
Open accessAbstract
Using conditional gene targeting in mice, we show that BMP receptor IA is essential for the differentiation of progenitor cells of the inner root sheath and hair shaft. Without BMPRIA activation, GATA-3 is down-regulated and its regulated control of IRS differentiation is compromised. In contrast, Lef1 is up-regulated, but its regulated control of hair differentiation is still blocked, and BMPRIA-null follicles fail to activate Lef1/β-catenin–regulated genes, including keratin genes. Wnt-mediated transcriptional activation can be restored by transfecting BMPRIA-null keratinocytes with a constitutively activated β-catenin. This places the block downstream from Lef1 expression but upstream from β-catenin stabilization. Because mice lacking the BMP inhibitor Noggin fail to express Lef1, our findings support a model, whereby a sequential inhibition and then activation of BMPRIA is necessary to define a band of hair progenitor cells, which possess enough Lef1 and stabilized β-catenin to activate the hair specific keratin genes and generate the hair shaft.
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Cites
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Molecular Mechanisms Regulating Hair Follicle Development
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A common human skin tumour is caused by activating mutations in β-catenin
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Self-citationWNT and DKK determine hair follicle spacing through a reaction-diffusion mechanism
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Rezza, A., Wang, Z., Sennett, R., Qiao, W., Wang, D., Heitman, N., Mok, K. W., Clavel, C., Yi, R., Zandstra, P., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.02.078 · Cited by 197
Tinkle, C. L., Lechler, T., Pasolli, H. A., & Fuchs, E. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307437100 · Cited by 193
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BMP-FGF Signaling Axis Mediates Wnt-Induced Epidermal Stratification in Developing Mammalian Skin
Zhu, X.-J., Liu, Y., Dai, Z.-M., Zhang, X., Yang, X., Li, Y., Qiu, M., Fu, J., Hsu, W., Chen, Y., et al. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004687 · Cited by 89
Bone Morphogenetic Protein Signaling Regulates Postnatal Hair Follicle Differentiation and Cycling
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Back to the Future: From Appendage Development Toward Future Human Hair Follicle Neogenesis
de Groot, S. C., Ulrich, M. M. W., Gho, C. G., & Huisman, M. A. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.661787 · Cited by 33
State-dependent signaling by Cav1.2 regulates hair follicle stem cell function
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Loss of Mpzl3 Function Causes Various Skin Abnormalities and Greatly Reduced Adipose Depots
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Metadata
- Authors
- Kobielak, K., Pasolli, H. A., Alonso, L., Polak, L., & Fuchs, E.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2003-11-10
- Volume
- 163
- Issue
- 3
- Pages
- 609-623
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2107353510
- Cited by
- 260
- References
- 5
- FWCI
- 16.66
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
