The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Dectin-1 Mediates the Biological Effects of β-Glucans
Open accessAbstract
The ability of fungal-derived β-glucan particles to induce leukocyte activation and the production of inflammatory mediators, such as tumor necrosis factor (TNF)-α, is a well characterized phenomenon. Although efforts have been made to understand how these carbohydrate polymers exert their immunomodulatory effects, the receptors involved in generating these responses are unknown. Here we show that Dectin-1 mediates the production of TNF-α in response to zymosan and live fungal pathogens, an activity that occurs at the cell surface and requires the cytoplasmic tail and immunoreceptor tyrosine activation motif of Dectin-1 as well as Toll-like receptor (TLR)-2 and Myd88. This is the first demonstration that the inflammatory response to pathogens requires recognition by a specific receptor in addition to the TLRs. Furthermore, these studies implicate Dectin-1 in the production of TNF-α in response to fungi, a critical step required for the successful control of these pathogens.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Brown, G. D., & Gordon, S. (2001) · Nature · doi:10.1038/35092620 · Cited by 1,579
Self-citation
Cited by
Nonviral vectors for gene delivery
Mintzer, M. A., & Simanek, E. E. (2009) · Chemical Reviews · doi:10.1021/cr800409e · Cited by 2,366
Romani, L. (2011) · Nature Reviews Immunology · doi:10.1038/nri2939 · Cited by 1,793
Dectin-1: a signalling non-TLR pattern-recognition receptor
Brown, G. D. (2006) · Nature Reviews Immunology · doi:10.1038/nri1745 · Cited by 1,158
Self-citationPathogenesis of Aspergillus fumigatus in Invasive Aspergillosis
Dagenais, T. R. T., & Keller, N. P. (2009) · Clinical Microbiology Reviews · doi:10.1128/cmr.00055-08 · Cited by 993
An integrated model of the recognition of Candida albicans by the innate immune system
Netea, M. G., Brown, G. D., Kullberg, B. J., & Gow, N. A. R. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1815 · Cited by 946
Self-citationCandida albicans morphogenesis and host defence: discriminating invasion from colonization
Gow, N. A. R., van de Veerdonk, F. L., Brown, A. J. P., & Netea, M. G. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2711 · Cited by 888
CD36 is a sensor of diacylglycerides
Hoebe, K., Georgel, P., Rutschmann, S., Du, X., Mudd, S., Crozat, K., Sovath, S., Shamel, L., Hartung, T., Zähringer, U., et al. (2005) · Nature · doi:10.1038/nature03253 · Cited by 873
Martin, B., Hirota, K., Cua, D. J., Stockinger, B., & Veldhoen, M. (2009) · Immunity · doi:10.1016/j.immuni.2009.06.020 · Cited by 822
Human dectin-1 deficiency and mucocutaneous fungal infections
Ferwerda, B., Ferwerda, G., Plantinga, T. S., Willment, J. A., van Spriel, A. B., Venselaar, H., Elbers, C. C., Johnson, M. D., Cambi, A., Huysamen, C., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0901053 · Cited by 752
Self-citationImmune defence against Candida fungal infections
Netea, M. G., Joosten, L. A. B., van der Meer, J. W. M., Kullberg, B.-J., & van de Veerdonk, F. L. (2015) · Nature Reviews Immunology · doi:10.1038/nri3897 · Cited by 642
Information processing during phagocytosis
Underhill, D. M., & Goodridge, H. S. (2012) · Nature Reviews Immunology · doi:10.1038/nri3244 · Cited by 616
Bellocchio, S., Montagnoli, C., Bozza, S., Gaziano, R., Rossi, G., Mambula, S. S., Vecchi, A., Mantovani, A., Levitz, S. M., & Romani, L. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.5.3059 · Cited by 515
The Beta-Glucan Receptor Dectin-1 Recognizes Specific Morphologies of Aspergillus fumigatus
Steele, C., Rapaka, R. R., Metz, A., Pop, S. M., Williams, D. L., Gordon, S., Kolls, J. K., & Brown, G. D. (2005) · PLoS Pathogens · doi:10.1371/journal.ppat.0010042 · Cited by 509
Self-citationSelf- and nonself-recognition by C-type lectins on dendritic cells
Geijtenbeek, T. B. H., van Vliet, S. J., Engering, A., 't Hart, B. A., & van Kooyk, Y. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104558 · Cited by 503
C-type lectin receptors orchestrate antifungal immunity
Hardison, S. E., & Brown, G. D. (2012) · Nature Immunology · doi:10.1038/ni.2369 · Cited by 460
Self-citationAspergillus fumigatus Triggers Inflammatory Responses by Stage-Specific β-Glucan Display
Hohl, T. M., Van Epps, H. L., Rivera, A., Morgan, L. A., Chen, P. L., Feldmesser, M., & Pamer, E. G. (2005) · PLoS Pathogens · doi:10.1371/journal.ppat.0010030 · Cited by 428
Histoplasma capsulatum α-(1,3)-glucan blocks innate immune recognition by the β-glucan receptor
Rappleye, C. A., Eissenberg, L. G., & Goldman, W. E. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609848104 · Cited by 419
Liu‐Bryan, R., Scott, P., Sydlaske, A., Rose, D. M., & Terkeltaub, R. (2005) · Arthritis & Rheumatism · doi:10.1002/art.21238 · Cited by 414
Gersuk, G. M., Underhill, D. M., Zhu, L., & Marr, K. A. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.6.3717 · Cited by 334
Immune Recognition of Candida albicans β‐glucan by Dectin‐1
Gow, N. A. R., Netea, M. G., Munro, C. A., Ferwerda, G., Bates, S., Mora‐Montes, H. M., Walker, L., Jansen, T., Jacobs, L., Tsoni, V., et al. (2007) · The Journal of Infectious Diseases · doi:10.1086/523110 · Cited by 314
Self-citationLigand recognition by antigen-presenting cell C-type lectin receptors
McGreal, E. P., Miller, J. L., & Gordon, S. (2005) · Current Opinion in Immunology · doi:10.1016/j.coi.2004.12.001 · Cited by 310
Self-citationDynamic, Morphotype-Specific Candida albicans β-Glucan Exposure during Infection and Drug Treatment
Wheeler, R. T., Kombe, D., Agarwala, S. D., & Fink, G. R. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.1000227 · Cited by 309
Current Perspectives on Echinocandin Class Drugs
Perlin, D. S. (2011) · Future Microbiology · doi:10.2217/fmb.11.19 · Cited by 274
Plantinga, T. S., van der Velden, W. J. F. M., Ferwerda, B., van Spriel, A. B., Adema, G., Feuth, T., Donnelly, J. P., Brown, G. D., Kullberg, B., Blijlevens, N. M. A., et al. (2009) · Clinical Infectious Diseases · doi:10.1086/604714 · Cited by 247
Self-citationDuffy, D., Rouilly, V., Libri, V., Hasan, M., Beitz, B., David, M., Urrutia, A., Bisiaux, A., LaBrie, S. T., Dubois, A., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.03.002 · Cited by 242
Botschuijver, S., Roeselers, G., Levin, E., Jonkers, D. M., Welting, O., Heinsbroek, S. E. M., de Weerd, H. H., Boekhout, T., Fornai, M., Masclee, A. A., et al. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.06.004 · Cited by 202
Host–microbe interactions: innate pattern recognition of fungal pathogens
van de Veerdonk, F. L., Kullberg, B. J., van der Meer, J. W., Gow, N. A., & Netea, M. G. (2008) · Current Opinion in Microbiology · doi:10.1016/j.mib.2008.06.002 · Cited by 169
Xu, S., Huo, J., Lee, K.-G., Kurosaki, T., & Lam, K.-P. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m806650200 · Cited by 166
Bertuzzi, M., Schrettl, M., Alcazar-Fuoli, L., Cairns, T. C., Muñoz, A., Walker, L. A., Herbst, S., Safari, M., Cheverton, A. M., Chen, D., et al. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004413 · Cited by 158
Fungal antioxidant pathways promote survival against neutrophils during infection
Leal, S. M., Vareechon, C., Cowden, S., Cobb, B. A., Latgé, J.-P., Momany, M., & Pearlman, E. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63239 · Cited by 146
Wang, H., Wang, M., Chen, J., Tang, Y., Dou, J., Yu, J., Xi, T., & Zhou, C. (2011) · International Immunopharmacology · doi:10.1016/j.intimp.2011.06.006 · Cited by 146
Kyrmizi, I., Gresnigt, M. S., Akoumianaki, T., Samonis, G., Sidiropoulos, P., Boumpas, D., Netea, M. G., van de Veerdonk, F. L., Kontoyiannis, D. P., & Chamilos, G. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300132 · Cited by 142
Bi, L., Gojestani, S., Wu, W., Hsu, Y.-M. S., Zhu, J., Ariizumi, K., & Lin, X. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.131300 · Cited by 126
Disconnection of man and the soil: Reason for the asthma and atopy epidemic?
von Hertzen, L., & Haahtela, T. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.11.013 · Cited by 126
Non-canonical signalling mediates changes in fungal cell wall PAMPs that drive immune evasion
Pradhan, A., Avelar, G. M., Bain, J. M., Childers, D., Pelletier, C., Larcombe, D. E., Shekhova, E., Netea, M. G., Brown, G. D., Erwig, L., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13298-9 · Cited by 119
Self-citationMielke, L. A., Elkins, K. L., Wei, L., Starr, R., Tsichlis, P. N., O'Shea, J. J., & Watford, W. T. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901336 · Cited by 98
Fernandez, P. L., Dutra, F. F., Alves, L., Figueiredo, R. T., Mourão-Sa, D., Fortes, G. B., Bergstrand, S., Lönn, D., Cevallos, R. R., Pereira, R. M. S., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.146076 · Cited by 95
The role of the cell wall in fungal pathogenesis
Arana, D. M., Prieto, D., Román, E., Nombela, C., Alonso‐Monge, R., & Pla, J. (2009) · Microbial Biotechnology · doi:10.1111/j.1751-7915.2008.00070.x · Cited by 92
Mesa-Arango, A. C., Rueda, C., Román, E., Quintin, J., Terrón, M. C., Luque, D., Netea, M. G., Pla, J., & Zaragoza, O. (2016) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02681-15 · Cited by 86
Methods of Controlling Invasive Fungal Infections Using CD8+ T Cells
Kumaresan, P. R., da Silva, T. A., & Kontoyiannis, D. P. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01939 · Cited by 85
Becker, K. L., Gresnigt, M. S., Smeekens, S. P., Jacobs, C. W., Magis‐Escurra, C., Jaeger, M., Wang, X., Lubbers, R., Oosting, M., Joosten, L. A. B., et al. (2015) · Clinical & Experimental Allergy · doi:10.1111/cea.12354 · Cited by 83
Mutation-selective tumor remission with Ras-targeted, whole yeast-based immunotherapy
Lu, Y., Bellgrau, D., Dwyer-Nield, L. D., Malkinson, A. M., Duke, R. C., Rodell, T. C., & Franzusoff, A. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1487 · Cited by 71
Lee, H.-M., Shin, D.-M., Choi, D.-K., Lee, Z.-W., Kim, K.-H., Yuk, J.-M., Kim, C. D., Lee, J.-H., & Jo, E.-K. (2009) · Cellular Microbiology · doi:10.1111/j.1462-5822.2009.01285.x · Cited by 69
Horneck Johnston, C. J. H., Ledwith, A. E., Lundahl, M. L. E., Charles-Messance, H., Hackett, E. E., O’Shaughnessy, S. D., Clegg, J., Prendeville, H., McGrath, J. P., Walsh, A. M., et al. (2024) · iScience · doi:10.1016/j.isci.2024.109030 · Cited by 67
Candida species in cystic fibrosis: A road less travelled
Chotirmall, S. H., Greene, C. M., & McElvaney, N. G. (2010) · Medical Mycology · doi:10.3109/13693786.2010.503320 · Cited by 61
MacCallum, D. M. (2009) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2009.00576.x · Cited by 56
Characterisation of Innate Fungal Recognition in the Lung
Faro-Trindade, I., Willment, J. A., Kerrigan, A. M., Redelinghuys, P., Hadebe, S., Reid, D. M., Srinivasan, N., Wainwright, H., Lang, D. M., Steele, C., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035675 · Cited by 55
Self-citationYamamoto, F. Y., Yin, F., Rossi, W., Hume, M., & Gatlin, D. M. (2018) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2018.04.003 · Cited by 51
Kuhn, D. M., & Vyas, V. K. (2012) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2011.00785.x · Cited by 38
Ferreira-Gomes, M., Wich, M., Böde, S., Hube, B., Jacobsen, I. D., & Jungnickel, B. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.698849 · Cited by 29
Naglik, J. R. (2014) · New Journal of Science · doi:10.1155/2014/390241 · Cited by 29
Inflammatory ER stress responses dictate the immunopathogenic progression of systemic candidiasis
Awasthi, D., Chopra, S., Cho, B. A., Emmanuelli, A., Sandoval, T. A., Hwang, S.-M., Chae, C.-S., Salvagno, C., Tan, C., Vasquez-Urbina, L., et al. (2023) · Journal of Clinical Investigation · doi:10.1172/jci167359 · Cited by 24
Muire, P. J., Hanson, L. A., Wills, R., & Petrie-Hanson, L. (2017) · PLOS ONE · doi:10.1371/journal.pone.0184077 · Cited by 21
Chen, S., Fuller, K. K., Dunlap, J. C., & Loros, J. J. (2018) · Journal of Biological Rhythms · doi:10.1177/0748730417745178 · Cited by 15
“…(PRRs) against fungi may be important for circadian gating; for example, Dectin-1 and TLR2 colocalize during recognition of fungal zymosan (Brown et al., 2003), and Dectin-1 synergizes with TLR4 (which also detects bacterial LPS) for recognition of Candida albicans by the innate immune…”
Metadata
- Authors
- Brown, G. D., Herre, J., Williams, D. L., Willment, J. A., Marshall, A. S. J., & Gordon, S.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2003-04-28
- Volume
- 197
- Issue
- 9
- Pages
- 1119-1124
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2126924404
- Cited by
- 1,205
- References
- 1
- FWCI
- 22.25
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
