Microstimulation of primary afferent neurons in the L7 dorsal root ganglia using multielectrode arrays in anesthetized cats: thresholds and recruitment properties
Open accessAbstract
Current research in motor neural prosthetics has focused primarily on issues related to the extraction of motor command signals from the brain (e.g. brain-machine interfaces) to direct the motion of prosthetic limbs. Patients using these types of systems could benefit from a somatosensory neural interface that conveys natural tactile and kinesthetic sensations for the prosthesis. Electrical microstimulation within the dorsal root ganglia (DRG) has been proposed as one method to accomplish this, yet little is known about the recruitment properties of electrical microstimulation in activating nerve fibers in this structure. Current-controlled microstimulation pulses in the range of 1-15 microA (200 micros, leading cathodic pulse) were delivered to the L7 DRG in four anesthetized cats using penetrating microelectrode arrays. Evoked responses and their corresponding conduction velocities (CVs) were measured in the sciatic nerve with a 5-pole nerve cuff electrode arranged as two adjacent tripoles. It was found that in 76% of the 69 electrodes tested, the stimulus threshold was less than or equal to 3 microA, with the lowest recorded threshold being 1.1 microA. The CVs of afferents recruited at threshold had a bimodal distribution with peaks at 70 m s(-1) and 85 m s(-1). In 53% of cases, the CV of the response at threshold was slower (i.e. smaller diameter fiber) than the CVs of responses observed at increasing stimulation amplitudes. In summary, we found that microstimulation applied through penetrating microelectrodes in the DRG provides selective recruitment of afferent fibers from a range of sensory modalities (as identified by CVs) at very low stimulation intensities. We conclude that the DRG may serve as an attractive location from which to introduce surrogate somatosensory feedback into the nervous system.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Electrode arrays can be implanted in the dorsal root ganglia, located close to the spinal cord.
“Rather than targeting the nerve at a location along the residual limb, electrode arrays can also be implanted in the dorsal root ganglia (DRG), located close to the spinal cord (Gaunt et al., 2009).”
From Biomimetic approaches to bionic touch through a peripheral nerve interface (2015) · cites this paper as Gaunt et al., 2009
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Neuronal ensemble control of prosthetic devices by a human with tetraplegia
Hochberg, L. R., Serruya, M. D., Friehs, G. M., Mukand, J. A., Saleh, M., Caplan, A. H., Branner, A., Chen, D., Penn, R. D., & Donoghue, J. P. (2006) · Nature · doi:10.1038/nature04970 · Cited by 3,295 · see citing works
Cortical control of a prosthetic arm for self-feeding
Velliste, M., Perel, S., Spalding, M. C., Whitford, A. S., & Schwartz, A. B. (2008) · Nature · doi:10.1038/nature06996 · Cited by 1,591 · see citing works
(1984) · PubMed · Cited by 908 · see citing works
Brain-Controlled Interfaces: Movement Restoration with Neural Prosthetics
Schwartz, A. B., Cui, X. T., Weber, D. J., & Moran, D. W. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.019 · Cited by 792 · see citing works
Self-citationOperant Conditioning of Cortical Unit Activity
Fetz, E. E. (1969) · Science · doi:10.1126/science.163.3870.955 · Cited by 631 · see citing works
Direct control of paralysed muscles by cortical neurons
Moritz, C. T., Perlmutter, S. I., & Fetz, E. E. (2008) · Nature · doi:10.1038/nature07418 · Cited by 599 · see citing works
Loss of proprioception produces deficits in interjoint coordination.
Sainburg, R., Poizner, H., & Ghez, C. (1993) · Journal of Neurophysiology · doi:10.1152/jn.1993.70.5.2136 · Cited by 578 · see citing works
Direct neural sensory feedback and control of a prosthetic arm
Dhillon, G. S., & Horch, K. W. (2005) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2005.856072 · Cited by 573 · see citing works
Mendell, L. M., & Henneman, E. (1971) · Journal of Neurophysiology · doi:10.1152/jn.1971.34.1.171 · Cited by 560 · see citing works
Somatosensory discrimination based on cortical microstimulation
Romo, R., Hernández, A., Zainos, A., & Salinas, E. (1998) · Nature · doi:10.1038/32891 · Cited by 500 · see citing works
Ochoa, J., & Torebjörk, E. (1983) · The Journal of Physiology · doi:10.1113/jphysiol.1983.sp014873 · Cited by 467 · cited 2× · see citing works
“More specifically, a study of intraneural microstimulation of afferent axons to examine electrically evoked sensations reported stimulus thresholds in the similarly low range of 1–2μA (Ochoa and Torebjork, 1983).”
BackgroundSuner, S., Fellows, M. R., Vargas-Irwin, C., Nakata, G. K., & Donoghue, J. P. (2005) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2005.857687 · Cited by 415 · cited 1× · see citing works
“5 years (Suner et al., 2005), but in the DRG, stable recordings have persisted for at most several weeks (Weber et al.”
BackgroundRegulation of Arm and Leg Movement during Human Locomotion
Zehr, E. P., & Duysens, J. (2004) · The Neuroscientist · doi:10.1177/1073858404264680 · Cited by 410 · see citing works
Jankowska, E., & Roberts, W. J. (1972) · The Journal of Physiology · doi:10.1113/jphysiol.1972.sp009817 · Cited by 330 · see citing works
Composition of Peripheral Nerves
Mitchell, G. A. G. (1969) · Postgraduate Medical Journal · doi:10.1136/pgmj.45.525.459-a · Cited by 322 · see citing works
The Society for Neuroscience 1995 annual meeting.
Hu, R. J. (1996) · PubMed · Cited by 313 · see citing works
Discharges of single hindlimb afferents in the freely moving cat
Procházka, A., Westerman, R. A., & Ziccone, S. (1976) · Journal of Neurophysiology · doi:10.1152/jn.1976.39.5.1090 · Cited by 298 · see citing works
Macefield, V. G., Gandevia, S. C., & Burke, D. J. (1990) · The Journal of Physiology · doi:10.1113/jphysiol.1990.sp018247 · Cited by 274 · see citing works
CORD CELLS RESPONDING TO TOUCH, DAMAGE, AND TEMPERATURE OF SKIN
Wall, P. D. (1960) · Journal of Neurophysiology · doi:10.1152/jn.1960.23.2.197 · Cited by 265 · see citing works
Beebe, X., & Rose, T. L. (1988) · IEEE Transactions on Biomedical Engineering · doi:10.1109/10.2122 · Cited by 220 · see citing works
Boyd, I. A., & Kalu, K. U. (1979) · The Journal of Physiology · doi:10.1113/jphysiol.1979.sp012737 · Cited by 197 · see citing works
A Role for the Cerebellum in Learning Movement Coordination
Thach, W. T. (1998) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1998.3846 · Cited by 184 · see citing works
Composition of Peripheral Nerves
CARPENTER, M. B. (1969) · Neurology · doi:10.1212/wnl.19.11.1141-a · Cited by 180 · see citing works
Volatile Anesthetics Depress Spinal Motor Neurons
Rampil, I. J., & King, B. S. (1996) · Anesthesiology · doi:10.1097/00000542-199607000-00018 · Cited by 173 · see citing works
Cogan, S. F., Troyk, P. R., Ehrlich, J., & Plante, T. D. (2005) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2005.851503 · Cited by 162 · see citing works
Spinal Cord Microstimulation Generates Functional Limb Movements in Chronically Implanted Cats
Mushahwar, V. K. (2000) · Experimental Neurology · doi:10.1006/exnr.2000.7381 · Cited by 160 · see citing works
AFFERENT FIBERS IN MUSCLE NERVES
Lloyd, D. P. C., & Chang, H. T. (1948) · Journal of Neurophysiology · doi:10.1152/jn.1948.11.3.199 · Cited by 129 · see citing works
Vallbo, Å. B. (1981) · Brain Research · doi:10.1016/0006-8993(81)90517-5 · Cited by 128 · see citing works
Long-Term Unit Recording from Somatosensory Neurons in the Spinal Ganglia of the Freely Walking Cat
Loeb, G. E., Bak, M. J., & Duysens, J. (1977) · Science · doi:10.1126/science.897663 · Cited by 126 · see citing works
Electrical Stimulation of the Proprioceptive Cortex (Area 3a) Used to Instruct a Behaving Monkey
London, B. M., Jordan, L. R., Jackson, C. R., & Miller, L. E. (2008) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2007.907544 · Cited by 124 · see citing works
McCreery, D. B., Agnew, W. F., Yuen, T. G. H., & Bullara, L. A. (1992) · Medical & Biological Engineering & Computing · doi:10.1007/bf02446202 · Cited by 97 · see citing works
Motor deficits in patients with large-fiber sensory neuropathy.
Sanes, J. N., Mauritz, K.-H., Evarts, E. V., Dalakas, M. C., & Chu, A. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.3.979 · Cited by 95 · see citing works
A modeling study of nerve fascicle stimulation
Veltink, P. H., van Veen, B. K., Struijk, J. J., Holsheimer, J., & Boom, H. B. K. (1989) · IEEE Transactions on Biomedical Engineering · doi:10.1109/10.32100 · Cited by 95 · see citing works
Spinal Cord Motoneuron Excitability during Isoflurane and Nitrous Oxide Anesthesia
Zhou, H. H., Mehta, M. P., & Leis, A. A. (1997) · Anesthesiology · doi:10.1097/00000542-199702000-00005 · Cited by 87 · see citing works
Limb-state feedback from ensembles of simultaneously recorded dorsal root ganglion neurons
Weber, D. J., Stein, R. B., Everaert, D. G., & Procházka, A. (2007) · Journal of Neural Engineering · doi:10.1088/1741-2560/4/3/s04 · Cited by 87 · see citing works
Self-citationSingle unit conduction velocities from averaged nerve cuff electrode records in freely moving cats
Hoffer, J. A., Loeb, G. E., & Pratt, C. A. (1981) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(81)90033-9 · Cited by 73 · see citing works
Simulation of intrafascicular and extraneural nerve stimulation
Veltink, P. H., van Alste, J. A., & Boom, H. B. K. (1988) · IEEE Transactions on Biomedical Engineering · doi:10.1109/10.1338 · Cited by 71 · see citing works
Yoshida, K., & Horch, K. (1993) · Annals of Biomedical Engineering · doi:10.1007/bf02368649 · Cited by 69 · see citing works
Aoyagi, Y., Stein, R. B., Branner, A., Pearson, K. G., & Normann, R. A. (2003) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(03)00143-2 · Cited by 68 · see citing works
Multielectrode intrafascicular and extraneural stimulation
Veltink, P. H., van Alsté, J. A., & Boom, H. B. K. (1989) · Medical and Biological Engineering and Computing · doi:10.1007/bf02442165 · Cited by 62 · see citing works
Ohara, S., Weiss, N., & Lenz, F. A. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00648.2003 · Cited by 59 · see citing works
Jurkevich, A., Barth, S. W., Kuenzel, W. J., K�HLER, A., & Großmann, R. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19990524)408:1 · Cited by 59 · see citing works
Weber, D. J., Stein, R. B., Everaert, D. G., & Procházka, A. (2006) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2006.875575 · Cited by 54 · see citing works
Self-citationThe organization of the seventh lumbar spinal ganglion of the cat
Burton, H., & McFarlane, J. J. (1973) · The Journal of Comparative Neurology · doi:10.1002/cne.901490207 · Cited by 43 · see citing works
Isoflurane Depresses Motoneuron Excitability by a Direct Spinal Action
Antognini, J. F., Carstens, E., & Buzin, V. (1999) · Anesthesia & Analgesia · doi:10.1097/00000539-199903000-00040 · Cited by 43 · see citing works
Cat hindlimb tactile dermatomes determined with single-unit recordings
Brown, P. B., & Koerber, H. R. (1978) · Journal of Neurophysiology · doi:10.1152/jn.1978.41.2.260 · Cited by 43 · see citing works
Wessels, W. J. T., Feirabend, H. K. P., & Marani, E. (1990) · Developmental Brain Research · doi:10.1016/0165-3806(90)90150-w · Cited by 32 · see citing works
THE RELATION OF THE SHAPE OF THE ACTION POTENTIAL OF NERVE TO CONDUCTION VELOCITY
Gasser, H. S. (1928) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1928.84.3.699 · Cited by 24 · see citing works
Neural interfacing with the peripheral nervous system
Durand, D. M., Yoo, P. B., & Lertmanorat, Z. (2004) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/iembs.2004.1404488 · Cited by 14 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Biomimetic approaches to bionic touch through a peripheral nerve interface
Saal, H. P., & Bensmaia, S. J. (2015) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2015.06.010 · Cited by 179 · see citing works
“Rather than targeting the nerve at a location along the residual limb, electrode arrays can also be implanted in the dorsal root ganglia (DRG), located close to the spinal cord (Gaunt et al., 2009).”
A review for the peripheral nerve interface designer
Larson, C. E., & Meng, E. (2020) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2019.108523 · Cited by 133 · see citing works
Kolarcik, C. L., Catt, K., Rost, E., Albrecht, I. N., Bourbeau, D., Du, Z., Kozai, T. D. Y., Luo, X., Weber, D. J., & Tracy Cui, X. (2015) · Journal of Neural Engineering · doi:10.1088/1741-2560/12/1/016008 · Cited by 126 · see citing works
Self-citationWeber, D. J., London, B. M., Hokanson, J., Ayers, C. A., Gaunt, R. A., Torres, R. R., Zaaimi, B., & Miller, L. E. (2011) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2011.2163145 · Cited by 101 · see citing works
Self-citationInterfacing the Somatosensory System to Restore Touch and Proprioception: Essential Considerations
Weber, D. J., Friesen, R., & Miller, L. E. (2012) · Journal of Motor Behavior · doi:10.1080/00222895.2012.735283 · Cited by 98 · see citing works
Self-citationThe development of neural stimulators: a review of preclinical safety and efficacy studies
Shepherd, R. K., Villalobos, J., Burns, O., & Nayagam, D. A. X. (2018) · Journal of Neural Engineering · doi:10.1088/1741-2552/aac43c · Cited by 81 · see citing works
Intrafascicular peripheral nerve stimulation produces fine functional hand movements in primates
Badi, M., Wurth, S. M., Scarpato, I., Roussinova, E., Losanno, E., Bogaard, A. R., Delacombaz, M., Borgognon, S., Čvančara, P., Fallegger, F., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abg6463 · Cited by 62 · see citing works
Ultracompliant Hydrogel‐Based Neural Interfaces Fabricated by Aqueous‐Phase Microtransfer Printing
Huang, W., Ong, X. C., Kwon, I. S., Gopinath, C., Fisher, L. E., Wu, H., Fedder, G. K., Gaunt, R. A., & Bettinger, C. J. (2018) · Advanced Functional Materials · doi:10.1002/adfm.201801059 · Cited by 61 · see citing works
Self-citationKolarcik, C. L., Bourbeau, D., Azemi, E., Rost, E., Zhang, L., Lagenaur, C. F., Weber, D. J., & Cui, X. T. (2012) · Acta Biomaterialia · doi:10.1016/j.actbio.2012.06.034 · Cited by 59 · see citing works
Self-citationWang, Q., Millard, D. C., Zheng, H. J. V., & Stanley, G. B. (2012) · Journal of Neural Engineering · doi:10.1088/1741-2560/9/2/026008 · Cited by 50 · see citing works
Material considerations for peripheral nerve interfacing
Kim, Y.-T., & Romero-Ortega, M. I. (2012) · MRS Bulletin · doi:10.1557/mrs.2012.99 · Cited by 47 · see citing works
Dorsal Root Ganglion Stimulation for Chronic Pain: Hypothesized Mechanisms of Action
Graham, R. D., Sankarasubramanian, V., & Lempka, S. F. (2021) · Journal of Pain · doi:10.1016/j.jpain.2021.07.008 · Cited by 44 · see citing works
Modality-Specific Axonal Regeneration: Toward Selective Regenerative Neural Interfaces
Lotfi, P., Garde, K., Chouhan, A. K., Bengali, E., & Romero-Ortega, M. I. (2011) · Frontiers in Neuroengineering · doi:10.3389/fneng.2011.00011 · Cited by 42 · see citing works
Eliciting naturalistic cortical responses with a sensory prosthesis via optimized microstimulation
Choi, J. S., Brockmeier, A. J., McNiel, D., von Kraus, L. M., Príncipe, J. C., & Francis, J. T. (2016) · Journal of Neural Engineering · doi:10.1088/1741-2560/13/5/056007 · Cited by 35 · see citing works
Sensory feedback for upper limb prostheses
Hsiao, S. S., Fettiplace, M. R., & Darbandi, B. (2011) · Progress in brain research · doi:10.1016/b978-0-444-53355-5.00005-1 · Cited by 34 · see citing works
Flexible microelectrode array for interfacing with the surface of neural ganglia
Sperry, Z. J., Na, K., Parizi, S. S., Chiel, H. J., Seymour, J. P., Yoon, E., & Bruns, T. M. (2018) · Journal of Neural Engineering · doi:10.1088/1741-2552/aab55f · Cited by 33 · see citing works
Microstimulation of afferents in the sacral dorsal root ganglia can evoke reflex bladder activity
Bruns, T. M., Weber, D. J., & Gaunt, R. A. (2014) · Neurourology and Urodynamics · doi:10.1002/nau.22514 · Cited by 29 · see citing works
Self-citationAyers, C. A., Fisher, L. E., Gaunt, R. A., & Weber, D. J. (2016) · Journal of Neurophysiology · doi:10.1152/jn.00961.2015 · Cited by 28 · see citing works
Self-citationFisher, L. E., Ayers, C. A., Ciollaro, M., Ventura, V., Weber, D. J., & Gaunt, R. A. (2014) · Journal of Neural Engineering · doi:10.1088/1741-2560/11/3/036007 · Cited by 29 · see citing works
Self-citationPeripheral Nervous System Topics
Marani, E., & Lakke, E. A. J. F. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-374236-0.10004-5 · Cited by 24 · see citing works
Bourbeau, D. J., Hokanson, J., Rubin, J. E., & Weber, D. J. (2011) · Journal of Neural Engineering · doi:10.1088/1741-2560/8/5/056009 · Cited by 23 · see citing works
Self-citationThe Effect of Contact Force on the Responses of Tactile Nerve Fibers to Scanned Textures
Saal, H. P., Suresh, A. K., Solorzano, L., Weber, A. I., & Bensmaı̈a, S. J. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.08.024 · Cited by 22 · see citing works
The mechanisms of electrical neuromodulation
Balbinot, G. C., Milosevic, M., Morshead, C. M., Iwasa, S. N., Zariffa, J., Milosevic, L., Valiante, T. A., Hoffer, J. A., & Popović, M. R. (2024) · The Journal of Physiology · doi:10.1113/jp286205 · Cited by 24 · see citing works
Quantitative models of feline lumbosacral dorsal root ganglia neuronal cell density
Ostrowski, A. K., Sperry, Z. J., Kulik, G., & Bruns, T. M. (2017) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2017.07.018 · Cited by 21 · see citing works
Selectivity of afferent microstimulation at the DRG using epineural and penetrating electrode arrays
Nanivadekar, A. C., Ayers, C. A., Gaunt, R. A., Weber, D. J., & Fisher, L. E. (2019) · Journal of Neural Engineering · doi:10.1088/1741-2552/ab4a24 · Cited by 19 · see citing works
Self-citationStimulation of the dorsal root ganglion using an Injectrode ®
Dalrymple, A. N., Ting, J. E., Bose, R., Trevathan, J. K., Nieuwoudt, S., Lempka, S. F., Franke, M., Ludwig, K. A., Shoffstall, A. J., Fisher, L. E., et al. (2021) · Journal of Neural Engineering · doi:10.1088/1741-2552/ac2ffb · Cited by 19 · see citing works
Self-citationDelhaye, B. P., Schluter, E. W., & Bensmaı̈a, S. J. (2016) · IEEE Transactions on Haptics · doi:10.1109/toh.2016.2573298 · Cited by 14 · see citing works
Microneurography as a minimally invasive method to assess target engagement during neuromodulation
Verma, N., Knudsen, B. E., Gholston, A. K., Skubal, A. C., Blanz, S. L., Settell, M. L., Frank, J., Trevathan, J. K., & Ludwig, K. A. (2023) · Journal of Neural Engineering · doi:10.1088/1741-2552/acc35c · Cited by 13 · see citing works
Robotics, Stem Cells, and Brain-Computer Interfaces in Rehabilitation and Recovery from Stroke
Boninger, M. L., Wechsler, L. R., & Stein, J. M. (2014) · American Journal of Physical Medicine & Rehabilitation · doi:10.1097/phm.0000000000000128 · Cited by 14 · see citing works
Effects of Synchronous Electrode Pulses on Neural Recruitment During Multichannel Microstimulation
Hokanson, J., Gaunt, R. A., & Weber, D. J. (2018) · Scientific Reports · doi:10.1038/s41598-018-31247-2 · Cited by 13 · see citing works
Self-citationGreen, D. B., Kilgore, J. A., Bender, S. A., Daniels, R. J., Gunzler, D. D., Vrabec, T. L., & Bhadra, N. (2022) · Bioelectronic Medicine · doi:10.1186/s42234-022-00093-z · Cited by 11 · see citing works
Graham, R. D., Bruns, T. M., Duan, B., & Lempka, S. F. (2020) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.13211 · Cited by 12 · see citing works
DRG microstimulation evokes postural responses in awake, standing felines
King, K., Cusack, W. F., Nanivadekar, A. C., Ayers, C. A., Urbin, M. A., Gaunt, R. A., Fisher, L. E., & Weber, D. J. (2019) · Journal of Neural Engineering · doi:10.1088/1741-2552/ab50f4 · Cited by 9 · see citing works
Self-citationDosen, S. S., Prahm, C., Amsuess, S., Vujaklija, I., & Farina, D. (2021) · Springer eBooks · doi:10.1007/978-3-030-60746-3_15 · Cited by 9 · see citing works
London, B. M., Torres, R. R., Slutzky, M. W., & Miller, L. E. (2011) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/iembs.2011.6091854 · Cited by 9 · see citing works
Hokanson, J., Ayers, C. A., Gaunt, R. A., Bruns, T. M., & Weber, D. J. (2011) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/iembs.2011.6091857 · Cited by 8 · see citing works
Self-citationVujaklija, I., & Farina, D. (2022) · Springer eBooks · doi:10.1007/978-3-031-10355-1_41 · Cited by 8 · see citing works
Focalizing electrical neural stimulation with penetrating microelectrode arrays: A modeling study
Joucla, S., Rousseau, L., & Yvert, B. (2012) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2012.05.006 · Cited by 8 · see citing works
Kolarcik, C. L., Castro, C. A., Lesniak, A. J., Demetris, A. J., Fisher, L. E., Gaunt, R. A., Weber, D. J., & Cui, X. T. (2020) · Journal of Neural Engineering · doi:10.1088/1741-2552/ab94d7 · Cited by 7 · see citing works
Self-citationUrbin, M. A., Liu, M. F., Bottorff, E. C., Gaunt, R. A., Fisher, L. E., & Weber, D. J. (2019) · Journal of Neural Engineering · doi:10.1088/1741-2552/ab4c6c · Cited by 5 · see citing works
Self-citationBadi, M., Borgognon, S., O’Doherty, J. E., & Shokur, S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822828-9.00008-3 · Cited by 4 · see citing works
Neuroprostheses for somatosensory function
Fisher, L. E., Hokanson, J., & Weber, D. J. (2015) · Elsevier eBooks · doi:10.1016/b978-1-78242-101-6.00006-9 · Cited by 3 · see citing works
Self-citationRestoring the sense of touch with electrical stimulation of the nerve and brain
Callier, T., & Bensmaı̈a, S. J. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822828-9.00010-1 · Cited by 3 · see citing works
Human psychophysics of direct cortical stimulation of somatosensory cortex
Cronin, J. A. (2018) · ResearchWorks at the University of Washington (University of Washington) · Cited by 3 · see citing works
Somatosensory Neuromodulation with a Focus Towards Clinical Systems
Graczyk, E. L., & Tyler, D. J. (2022) · Handbook of Neuroengineering · doi:10.1007/978-981-15-2848-4_92-1 · Cited by 2 · see citing works
High-fidelity interfacing for bionic rehabilitation
Vujaklija, I. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-23987-8.00003-1 · Cited by 2 · see citing works
VENTRAL ROOT OR DORSAL ROOT GANGLION MICROSTIMULATION TO EVOKE HINDLIMB MOTOR RESPONSES
Bourbeau, D. J. (2011) · D-Scholarship@Pitt (University of Pittsburgh) · Cited by 2 · see citing works
Somatosensory Neuromodulation with a Focus Towards Clinical Systems
Graczyk, E. L., & Tyler, D. J. (2023) · Handbook of Neuroengineering · doi:10.1007/978-981-16-5540-1_92 · Cited by 1 · see citing works
Restore axonal conductance in a locally demyelinated axon with electromagnetic stimulation
Ye, H., Chen, Y., Chen, J., & Hendee, J. (2025) · Journal of Neural Engineering · doi:10.1088/1741-2552/adb213 · Cited by 1 · see citing works
Progress in Peripheral Neural Interfaces
Qiao, S., Mauser, K. A., & Yoshida, K. (2013) · Wiley eBooks · doi:10.1002/9781118628522.ch4 · Cited by 1 · see citing works
Hokanson, J. (2014) · D-Scholarship@Pitt (University of Pittsburgh)
Self-citationSperry, Z. J. (2019) · Deep Blue (University of Michigan)
Ansah, G. J., Brocco, M. D., Bhowmick, S., Duran, M. A., Gopinath, C., Jantz, M., Lempka, S. F., & Fisher, L. E. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.14.732127 · Cited by 1 · see citing works
- Authors
- Gaunt, R. A., Hokanson, J. A., & Weber, D. J.
- Affiliations
- University of Pittsburgh (US)
- Venue
- Journal of Neural Engineering
- Publisher
- IOP Publishing
- Published
- 2009-09-01
- Volume
- 6
- Issue
- 5
- Pages
- 055009
- ISSN
- 1741-2552 (ISSN-L)
- 1741-2560
- PMC
- PMC2894985
- OpenAlex
- W2053762946
- Cited by
- 53
- References
- 49
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 6 · 2020: 2 · 2019: 5 · 2018: 5 · 2017: 2 · 2016: 3 · 2015: 2 · 2014: 5 · 2013: 1 · 2012: 6
- FWCI
- 1.80
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Neural Engineering (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5r01eb007749-04)
- National Institute of Neurological Disorders and Stroke (R21NS056136)
- National Institute of Biomedical Imaging and Bioengineering (1R01EB007749, R01 EB007749)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Physical Sciences › Engineering › Biomedical Engineering › Muscle activation and electromyography studies
- Keywords
- electrical microstimulation, dorsal root ganglia, primary afferent neurons, somatosensory feedback, stimulation threshold, fiber recruitment, conduction velocity, cuff electrodes, sciatic nerve, tactile perception
- MeSH terms
- Action Potentials, Animals, Cats, Differential Threshold, Electric Stimulation, Electrodes, Implanted, Equipment Design, Evoked Potentials, Ganglia, Spinal, Microelectrodes, Neurons, Afferent, Recruitment, Neurophysiological, Equipment Failure Analysis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
