In Vitro Comparison of the Charge-Injection Limits of Activated Iridium Oxide (AIROF) and Platinum-Iridium Microelectrodes
Abstract
The charge-injection limits of activated iridium oxide electrodes (AIROF) and PtIr microelectrodes with similar geometric area and shape have been compared in vitro using a stimulation waveform that delivers cathodal current pulses with current-limited control of the electrode bias potential in the interpulse period. Charge-injection limits were compared over a bias range of 0.1-0.7 V (versus Ag/AgCl) and pulse frequencies of 20, 50, and 100 Hz. The AIROF was capable of injecting between 4 and 10 times the charge of the PtIr electrode, with a maximum value of 3.9 mC/cm2 obtained at a 0.7 V bias and 20 Hz frequency.
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- Authors
- Cogan, S. F., Troyk, P. R., Ehrlich, J., & Plante, T. D.
- Affiliations
- EIC Laboratories (US)
- Illinois Institute of Technology (US)
- Venue
- IEEE Transactions on Biomedical Engineering
- Published
- 2005-09
- Volume
- 52
- Issue
- 9
- Pages
- 1612-1614
- ISSN
- 0018-9294 (ISSN-L)
- OpenAlex
- W2159277823
- Cited by
- 162
- References
- 8
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 9 · 2023: 10 · 2022: 6 · 2021: 8 · 2020: 8 · 2019: 11 · 2018: 7 · 2017: 11 · 2016: 7 · 2015: 9 · 2014: 9 · 2013: 10 · 2012: 5
- FWCI
- 1.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- IEEE Transactions on Biomedical Engineering (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r44ns039714-03, 5r01eb002184-04)
- National Institute of Neurological Disorders and Stroke (R44 NS039714-03)
- National Institute of Biomedical Imaging and Bioengineering (R01 EB002184-02)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Chemistry › Electrochemistry › Electrochemical Analysis and Applications
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
- Keywords
- charge injection limit, neurostimulation, stimulation frequency
- MeSH terms
- Electric Stimulation, Equipment Design, Iridium, Microelectrodes, Electric Impedance, Platinum Compounds, Equipment Failure Analysis, Static Electricity
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