Coordinated, multi-joint, fatigue-resistant feline stance produced with intrafascicular hind limb nerve stimulation
Open accessAbstract
The production of graceful skeletal movements requires coordinated activation of multiple muscles that produce torques around multiple joints. The work described herein is focused on one such movement, stance, that requires coordinated activation of extensor muscles acting around the hip, knee and ankle joints. The forces evoked in these muscles by external stimulation all have a complex dependence on muscle length and shortening velocities, and some of these muscles are biarticular. In order to recreate sit-to-stand maneuvers in the anesthetized feline, we excited the hind limb musculature using intrafascicular multielectrode stimulation (IFMS) of the muscular branch of the sciatic nerve, the femoral nerve and the main branch of the sciatic nerve. Stimulation was achieved with either acutely or chronically implanted Utah Slanted Electrode Arrays (USEAs) via subsets of electrodes (1) that activated motor units in the extensor muscles of the hip, knee and ankle joints, (2) that were able to evoke large extension forces and (3) that manifested minimal coactivation of the targeted motor units. Three hind limb force-generation strategies were investigated, including sequential activation of independent motor units to increase force, and interleaved or simultaneous IFMS of three sets of six or more USEA electrodes that excited the hip, knee and ankle extensors. All force-generation strategies evoked stance, but the interleaved IFMS strategy also reduced muscle fatigue produced by repeated sit-to-stand maneuvers compared with fatigue produced by simultaneous activation of different motor neuron pools. These results demonstrate the use of interleaved IFMS as a means to recreate coordinated, fatigue-resistant multi-joint muscle forces in the unilateral hind limb. This muscle activation paradigm could provide a promising neuroprosthetic approach for the restoration of sit-to-stand transitions in individuals who are paralyzed by spinal cord injury, stroke or disease.
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Recent penetrating neural interface applications require a greater number of electrodes (>60) to achieve complex neuromodulation or neurophysiological goals.
“Recent penetrating neural interface applications are requiring a greater number of electrodes (>60) to achieve complex neuromodulation [9,10,16] or neurophysiological [8] goals.”
From A new high-density (25 electrodes/mm<sup>2</sup>) penetrating microelectrode array for recording and stimulating sub-millimeter neuroanatomical structures (2013) · cites this paper as [16]
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- Authors
- Normann, R. A., Dowden, B. R., Frankel, M. A., Wilder, A. M., Hiatt, S. D., Ledbetter, N. M., Warren, D. A., & Clark, G. A.
- Affiliations
- University of Utah (US)
- Corresponding author
- Normann, R A
- Venue
- Journal of Neural Engineering
- Publisher
- IOP Publishing
- Published
- 2012-03-14
- Volume
- 9
- Issue
- 2
- Pages
- 026019
- ISSN
- 1741-2552 (ISSN-L)
- 1741-2560
- PMC
- PMC3377012
- OpenAlex
- W2001566012
- Cited by
- 37
- References
- 54
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 4 · 2015: 3 · 2014: 7 · 2013: 4 · 2012: 4
- FWCI
- 2.37
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neural Engineering (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Research Institute, Georgia Institute of Technology
- Georgia Institute of Technology
- Fundación Ramón Areces
- National Institutes of Health (5r01ns064318-02)
- Defense Advanced Research Projects Agency (N66001, N66001-06-C-8005)
- National Institute of Neurological Disorders and Stroke (R01-NS064318, R01NS039677, R01-NS064318-01A1)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Engineering › Biomedical Engineering › Muscle activation and electromyography studies
- Health Sciences › Medicine › Pathology and Forensic Medicine › Spinal Cord Injury Research
- Keywords
- sit-to-stand, sciatic nerve, femoral nerve, muscle fatigue, neuroprosthetics, spinal cord injury, stroke
- MeSH terms
- Algorithms, Anesthesia, Animals, Biomechanical Phenomena, Cats, Computer Simulation, Electric Stimulation, Electrodes, Electrodes, Implanted, Femoral Nerve, Hindlimb, Joints, Motor Neurons, Muscle Contraction, Recruitment, Neurophysiological, Sciatic Nerve, Walking, Muscle, Skeletal, Muscle Fatigue, Neural Prostheses
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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