Intrafascicular stimulation of monkey arm nerves evokes coordinated grasp and sensory responses
Open accessAbstract
High-count microelectrode arrays implanted in peripheral nerves could restore motor function after spinal cord injury or sensory function after limb loss. In this study, we implanted Utah Slanted Electrode Arrays (USEAs) intrafascicularly at the elbow or shoulder in arm nerves of rhesus monkeys (n = 4) under isoflurane anesthesia. Input-output curves indicated that pulse-width-modulated single-electrode stimulation in each arm nerve could recruit single muscles with little or no recruitment of other muscles. Stimulus trains evoked specific, natural, hand movements, which could be combined via multielectrode stimulation to elicit coordinated power or pinch grasp. Stimulation also elicited short-latency evoked potentials (EPs) in primary somatosensory cortex, which might be used to provide sensory feedback from a prosthetic limb. These results demonstrate a high-resolution, high-channel-count interface to the peripheral nervous system for restoring hand function after neural injury or disruption or for examining nerve structure.
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Ledbetter et al. achieved 5 to 10 different muscle contractions in a monkey arm using stimulation via the USEA.
“Ledbetter et al. achieved 5 to 10 different muscle contractions in a monkey arm using stimulation via the USEA (Ledbetter et al., 2013).”
From Update on Peripheral Nerve Electrodes for Closed-Loop Neuroprosthetics (2018) · cites this paper as Ledbetter et al., 2013
In a study with four monkeys, USEA implantation at elbow and shoulder levels promoted precise muscle activation; extrinsic muscles of the hand were activated selectively, whereas intrinsic muscles grouped for similar functions were often activated together.
“In a study done with four monkeys, the USEA implantation on elbow level and shoulder level promoted precise muscle activation. In particular, the extrinsic muscles of the hand were activated selectively, whereas the intrinsic muscles grouped for similar functions were often activated together [112].”
From Interfaces with the peripheral nervous system for the control of a neuroprosthetic limb: a review (2020) · cites this paper as [112]
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- Authors
- Ledbetter, N. M., Ethier, C., Oby, E. R., Hiatt, S. D., Wilder, A. M., Ko, J. H., Agnew, S. P., Miller, L. E., & Clark, G. A.
- Affiliations
- University of Utah (US)
- Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois;
- Northwestern University (US)
- Corresponding author
- Clark, Gregory A.
- ORCID
- Venue
- Journal of Neurophysiology
- Publisher
- American Physiological Society
- Published
- 2013-01-15
- Volume
- 109
- Issue
- 2
- Pages
- 580-590
- ISSN
- 0022-3077 (ISSN-L)
- 1522-1598
- PMC
- PMC3545468
- OpenAlex
- W2007905118
- Cited by
- 69
- References
- 46
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 5 · 2023: 5 · 2022: 3 · 2021: 5 · 2020: 5 · 2019: 7 · 2018: 8 · 2017: 7 · 2016: 6 · 2015: 6 · 2014: 4 · 2013: 3 · 2012: 1
- FWCI
- 1.85
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Neurophysiology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (01-NS-053603, R01NS053603)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Engineering › Biomedical Engineering › Muscle activation and electromyography studies
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Keywords
- peripheral nerve stimulation, rhesus monkeys, hand grasp, muscle recruitment, input-output curves, short-latency evoked potentials, primary somatosensory cortex, sensory feedback, artificial limbs, spinal cord injury, nerve regeneration, neural interfaces
- MeSH terms
- Animals, Haplorhini, Arm, Electric Stimulation, Evoked Potentials, Somatosensory, Fascia, Peripheral Nerves, Somatosensory Cortex, Muscle, Skeletal, Hand Strength, Evoked Potentials, Motor, Feedback, Sensory
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