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Cited by 98Neuroscience and Neural EngineeringMuscle activation and electromyography studiesVagus Nerve Stimulation Research

Interleaved, multisite electrical stimulation of cat sciatic nerve produces fatigue-resistant, ripple-free motor responses

McDonnall, D., Clark, G.A., Normann, R.A.·2004·IEEE Transactions on Neural Systems and Rehabilitation Engineering
DOI 10.1109/tnsre.2004.828425
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Abstract

We studied the use of physiologically based, multisite, intrafascicular electrical stimulation of the sciatic nerve to achieve ripple-free contractions and sustained, fatigue-resistant forces over a physiological range of forces in cat gastrocnemius muscle. Electrode arrays containing 100, 0.5-1.5-mm-long penetrating microelectrodes were inserted into the sciatic nerves of cats, and forces generated by gastrocnemius muscles in response to stimulation of the nerves were monitored via a force transducer attached to the tendons. In single-electrode stimulation, responses evoked by low-frequency [15 pulses/second, (p/s)] stimulation exhibited greater fatigue resistance than did responses evoked by higher frequency stimulation (30 and 60 p/s), but showed far more ripple within each response. We compared interleaved 15 p/s stimulation of four electrodes (100 micros biphasic pulses, 750-ms pulse trains) that produced a net stimulation frequency of 60 p/s with multielectrode 60 p/s quasi-simultaneous stimulation protocols. Across a broad range of forces (10% to 80% of maximum), responses evoked by multielectrode 15 p/s interleaved stimulation exhibited substantially less fatigue than did responses evoked by 60 p/s quasi-simultaneous stimulation, and less ripple than responses evoked by single-electrode 15 p/s stimulation. The effectiveness of this physiologically based stimulation paradigm encourages its application in the field of motor neuroprosthetics.

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  • Control of multiple functions with a single electrode could reduce the number of implantation sites required to produce a variety of functional joint moments for FNS systems.

    “Control of multiple functions with a single electrode could reduce the number of implantation sites required to produce a variety of functional joint moments for FNS systems [5].”

    From Optimization of selective stimulation parameters for multi-contact electrodes (2013) · cites this paper as [5]

  • In similar experiments with a spiral nerve cuff electrode placed around the femoral nerve trunk, stimulation resulted in selective recruitment of no more than three muscles and only the sartorius could be consistently recruited in all subjects.

    “In similar experiments conducted with a spiral nerve cuff electrode placed around the femoral nerve trunk, stimulation resulted in selective recruitment of no more than three muscles and only the sartorius could be consistently recruited in all subjects [24].”

    From Selective stimulation of the human femoral nerve with a flat interface nerve electrode (2010) · cites this paper as [24]

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Authors
McDonnall, D., Clark, G. A., & Normann, R. A.
Affiliations
University of Utah (US)
ORCID
Clark, G.A.
Venue
IEEE Transactions on Neural Systems and Rehabilitation Engineering
Publisher
Institute of Electrical and Electronics Engineers (IEEE)
Published
2004-06
Volume
12
Issue
2
Pages
208-215
ISSN
  • 1534-4320 (ISSN-L)
  • 1558-0210
DOI
10.1109/tnsre.2004.828425
OpenAlex
W2171464914
Semantic Scholar
2d842b7d3130493a776739c0efe2ba2a5365ea82
Cited by
98
References
18
Citations by year
2026: 3 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 5 · 2018: 5 · 2017: 3 · 2016: 6 · 2015: 3 · 2014: 7 · 2013: 4 · 2012: 5
FWCI
1.88
Type
journal article
Language
en
Open access
closed
Licence
ieeexplore.ieee.org/Xplorehelp/downloads/license-information/IEEE.html (vor)
Locations
  • IEEE Transactions on Neural Systems and Rehabilitation Engineering (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Princeton University
  • Directorate for Biological Sciences
  • National Institute of Neurological Disorders and Stroke (1-R01-NS-39677, R01NS039677)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
  • Physical Sciences › Engineering › Biomedical Engineering › Muscle activation and electromyography studies
  • Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
Keywords
sciatic nerve, gastrocnemius, muscle fatigue resistance, microelectrode arrays, stimulation frequency, biphasic pulses, cats
MeSH terms
Animals, Cats, Electric Stimulation, Electrodes, Implanted, Equipment Design, Microelectrodes, Muscle Contraction, Sciatic Nerve, Stress, Mechanical, Muscle, Skeletal, Muscle Fatigue, Equipment Failure Analysis

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