Cited by 230Redox biology and oxidative stressAntioxidant Activity and Oxidative StressAlzheimer's disease research and treatments

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4-Hydroxy-2-Nonenal, a Reactive Product of Lipid Peroxidation, and Neurodegenerative Diseases: A Toxic Combination Illuminated by Redox Proteomics Studies

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Perluigi, Marzia, Coccia, Raffaella, Butterfield, D. Allan·2012·Antioxidants & Redox Signaling

DOI 10.1089/ars.2011.4406PMC PMC3449441

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Abstract

SIGNIFICANCE: Among different forms of oxidative stress, lipid peroxidation comprises the interaction of free radicals with polyunsaturated fatty acids, which in turn leads to the formation of highly reactive electrophilic aldehydes. Among these, the most abundant aldehydes are 4-hydroxy-2-nonenal (HNE) and malondialdehyde, while acrolein is the most reactive. HNE is considered a robust marker of oxidative stress and a toxic compound for several cell types. Proteins are particularly susceptible to modification caused by HNE, and adduct formation plays a critical role in multiple cellular processes. RECENT ADVANCES: With the outstanding progress of proteomics, the identification of putative biomarkers for neurodegenerative disorders has been the main focus of several studies and will continue to be a difficult task. CRITICAL ISSUES: The present review focuses on the role of lipid peroxidation, particularly of HNE-induced protein modification, in neurodegenerative diseases. By comparing results obtained in different neurodegenerative diseases, it may be possible to identify both similarities and specific differences in addition to better characterize selective neurodegenerative phenomena associated with protein dysfunction. Results obtained in our laboratory and others support the common deregulation of energy metabolism and mitochondrial function in neurodegeneration. FUTURE DIRECTIONS: Research towards a better understanding of the molecular mechanisms involved in neurodegeneration together with identification of specific targets of oxidative damage is urgently required. Redox proteomics will contribute to broaden the knowledge in regard to potential biomarkers for disease diagnosis and may also provide insight into damaged metabolic networks and potential targets for modulation of disease progression.

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Understanding the Basis for Down Syndrome Phenotypes
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4-Hydroxynonenal in the Pathomechanisms of Oxidative Stress
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Protein Targets of Oxidative Damage in Human Neurodegenerative Diseases with Abnormal Protein Aggregates
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Current challenges and future applications for protein maps and post‐translational vector maps in proteome projects
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The Oxidative Stress Metabolite 4-Hydroxynonenal Promotes Alzheimer Protofibril Formation
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The Lipid Peroxidation Product 4‐Hydroxynonenal Inhibits Neurite Outgrowth, Disrupts Neuronal Microtubules, and Modifies Cellular Tubulin
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Proteomic Analysis of Protein Expression and Oxidative Modification in R6/2 Transgenic Mice
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α-Synuclein Selectively Binds to Anionic Phospholipids Embedded in Liquid-Disordered Domains
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Multifunctional roles of enolase in Alzheimer’s disease brain: beyond altered glucose metabolism
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Collapsin Response Mediator Protein-2 Is Associated with Neurofibrillary Tangles in Alzheimer's Disease
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Collapsin Response Mediator Protein-2: An Emerging Pathologic Feature and Therapeutic Target for Neurodisease Indications
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Modulation of lipid peroxidation and mitochondrial function improves neuropathology in Huntington’s disease mice
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Activities of key glycolytic enzymes in the brains of patients with Alzheimer's disease
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Regulation of senescence by eukaryotic translation initiation factor 5A: implications for plant growth and development
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Snaring the Function of α-Synuclein
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Conversion of amnestic Mild Cognitive Impairment to dementia of Alzheimer type is independent to memory deterioration
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4-Hydroxynonenal–protein adducts: A reliable biomarker of lipid oxidation in liver diseases
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Alzheimer Disease and the Role of Free Radicals in the Pathogenesis of the Disease
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Oxidatively Modified GST and MRP1 in Alzheimer?s Disease Brain: Implications for Accumulation of Reactive Lipid Peroxidation Products
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Proteomic analysis of 4-hydroxy-2-nonenal-modified proteins in G93A-SOD1 transgenic mice-A model of familial amyotrophic lateral sclerosis
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Oxidation Chemistry of Catecholamines and Neuronal Degeneration: An Update
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Peroxiredoxin-6 protects against mitochondrial dysfunction and liver injury during ischemia-reperfusion in mice
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β-Amyloid Mediated Nitration of Manganese Superoxide Dismutase
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Proteomic identification of proteins oxidized by Aβ(1–42) in synaptosomes: Implications for Alzheimer's disease
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See all 230

Authors: Perluigi, M., Coccia, R., & Butterfield, D. A.
Affiliations: Department of Biochemical Sciences, Faculty of Pharmacy and Medicine, Sapienza University of Rome, Rome, Italy.
Sapienza University of Rome (IT)
University of Kentucky (US)
ORCID: Coccia, Raffaella
Butterfield, D. Allan
Venue: Antioxidants & Redox Signaling
Publisher: SAGE Publications
Published: 2012-12
Volume: 17
Issue: 11
Pages: 1590-1609
ISSN: 1523-0864 (ISSN-L)
1557-7716
DOI: 10.1089/ars.2011.4406
PMC: PMC3449441
OpenAlex: W2073597659
Cited by: 229
References: 221
Citations by year: 2026: 14 · 2025: 19 · 2024: 13 · 2023: 14 · 2022: 14 · 2021: 20 · 2020: 15 · 2019: 16 · 2018: 18 · 2017: 20 · 2016: 12 · 2015: 19 · 2014: 19 · 2013: 13 · 2012: 3
FWCI: 1.02
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Antioxidants and Redox Signaling (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
Funders: National Institutes of Health (AG-05119)
National Institute on Aging (P01AG005119, R01AG029839, AG029839, AG0 5119)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords: 4-hydroxynonenal, lipid peroxidation, neurodegenerative diseases, protein alkylation, protein adducts, oxidative stress, redox proteomics, biomarkers, mitochondrial dysfunction, energy metabolism, malondialdehyde, acrolein
MeSH terms: Aldehydes, Antioxidants, Fatty Acids, Unsaturated, Humans, Malondialdehyde, Oxidation-Reduction, Protein Processing, Post-Translational, Proteins, Lipid Peroxidation, Neurodegenerative Diseases

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4-Hydroxy-2-Nonenal, a Reactive Product of Lipid Peroxidation, and Neurodegenerative Diseases: A Toxic Combination Illuminated by Redox Proteomics Studies

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