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Cited by 87Suicide and Self-Harm StudiesDeath Anxiety and Social ExclusionNeural and Behavioral Psychology Studies

Adolescent suicide attempts and ideation are linked to brain function during peer interactions

Harms, Madeline B., Casement, Melynda D., Teoh, Jia Yuan, Ruiz, Sarah, Scott, Hannah, Wedan, Riley, Quevedo, Karina·2019·Psychiatry Research: Neuroimaging
DOI 10.1016/j.pscychresns.2019.05.001
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Abstract

Understanding the neural correlates of social interaction among depressed adolescents with suicidal tendencies might help personalize treatment. We tested whether brain function during social interaction is disrupted for depressed adolescents with (1) high suicide ideation and (2) recent attempts. Depressed adolescents with high suicide ideation, including attempters (n = 45;HS) or low suicide ideation (n = 42;LS), and healthy adolescents (n = 39;HC), completed a version of the Cyberball peer interaction task during an fMRI scan. Groups were compared on brain activity during peer exclusion and inclusion versus a non-social condition. During peer exclusion and inclusion, HS youth showed significantly lower activity in precentral and postcentral gyrus, superior temporal gyrus, medial frontal gyrus, insula, and putamen compared to LS youth; and significantly reduced activity in caudate and anterior cingulate cortex compared to HC youth. In a second analysis, suicide attempters (n = 26;SA) were compared to other groups. SA adolescents showed significantly higher activity in ACC and superior and middle frontal gyrus than all other groups. Brain activity was significantly correlated with negative emotionality, social functioning, and cognitive control. Conclusions: Adolescent suicide ideation and attempts were linked to altered neural function during positive and negative peer interactions. We discuss the implications of these findings for suicide prevention efforts.

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  • Adolescents with high suicidal ideation had significantly reduced activity in the pre- and post-central gyrus, superior temporal gyrus, medial frontal gyrus, insula, and putamen compared to those with low suicidal ideation.

    “The authors found that adolescents with high SI had significantly reduced activity in the pre- and post-central gyrus, superior temporal gyrus, medial frontal gyrus, insula, and putamen compared to those with low SI”

    From New methods for assessing rapid changes in suicide risk (2021) · cites this paper as [65]

  • These studies have mostly assessed suicide risk in larger clinical samples of participants diagnosed with mood disorders and other psychiatric conditions with which suicide is a comorbid phenotype, but rarely have they investigated suicide transdiagnostically.

    “Finally, these studies have mostly assessed suicide risk in larger clinical samples of participants diagnosed with mood disorders (64–75) and other psychiatric conditions (76–79) with which suicide is a comorbid phenotype, but rarely have they investigated suicide transdiagnostically.”

    From New methods for assessing rapid changes in suicide risk (2021) · cites this paper as [65]

  • Adolescents with high suicidal ideation had significantly reduced activity in the caudate and anterior cingulate cortex compared to healthy adolescents.

    “and significantly reduced activity in the caudate and anterior cingulate cortex compared to healthy adolescents (65).”

    From New methods for assessing rapid changes in suicide risk (2021) · cites this paper as [65]

  • Blunted striatal activation may characterize youth with STB and NSSI.

    “blunted striatal activation may characterize STB and NSSI youth”

    From Neural correlates associated with suicide and nonsuicidal self-injury in youth (2021) · cites this paper as [82]

  • Compared to low ideators and controls, high ideators including attempters show reduced insula and putamen activation across conditions, but subsequent analyses indicate increased ACC, superior frontal gyrus, and middle frontal gyrus activation among attempters versus ideators.

    “compared to low ideators and controls, high ideators (including attempters) show reduced activation in the insula and putamen across conditions, but subsequent analyses indicate a pattern of increased activation in the ACC, superior frontal gyrus, and middle frontal gyrus among attempters versus ideators (82).”

    From Neural correlates associated with suicide and nonsuicidal self-injury in youth (2021) · cites this paper as [82]

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Authors
Harms, M. B., Casement, M. D., Teoh, J. Y., Ruiz, S., Scott, H., Wedan, R., & Quevedo, K.
Affiliations
  • University of Minnesota (US)
  • University of Oregon (US)
Corresponding author
Quevedo, Karina
ORCID
Venue
Psychiatry Research: Neuroimaging
Publisher
Elsevier BV
Published
2019-07
Volume
289
Pages
1-9
ISSN
0925-4927 (ISSN-L)
DOI
10.1016/j.pscychresns.2019.05.001
OpenAlex
W2943656147
Cited by
87
References
64
Citations by year
2026: 4 · 2025: 13 · 2024: 6 · 2023: 10 · 2022: 15 · 2021: 24 · 2020: 15
FWCI
15.76
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Psychiatry Research Neuroimaging (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • World Health Organization
  • National Institute of Mental Health (K01MH092601, K01MH103511)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
  • Social Sciences › Psychology › Social Psychology › Death Anxiety and Social Exclusion
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
adolescent suicide attempts, suicidal ideation, depression, peer interaction, Cyberball task, social exclusion, social inclusion, anterior cingulate cortex, insula, putamen, caudate nucleus, negative affectivity, social functioning, cognitive control, suicide prevention
MeSH terms
Adolescent, Adolescent Behavior, Cerebral Cortex, Depression, Female, Humans, Interpersonal Relations, Magnetic Resonance Imaging, Male, Peer Group, Psychological Distance, Suicide, Attempted, Neostriatum, Suicidal Ideation

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