Adolescent Depressive Symptoms as Predictors of Adult Depression: Moodiness or Mood Disorder?
Abstract
OBJECTIVE: The authors' goal was to examine the relationship between subclinical depressive symptoms in adolescence and major depressive episodes in adulthood. METHOD: An epidemiologic sample of 776 young people received psychiatric assessments in 1983, 1985, and 1992. Among adolescents not meeting criteria for major depression, the authors estimated the magnitude of the association between subclinical adolescent depressive symptoms and adult major depression. RESULTS: Symptoms of major depression in adolescence strongly predicted an adult episode of major depression: having depressive symptoms more than two-standard-deviations above the mean in number predicted a two-fold to three-fold greater risk for an adult major depressive episode. CONCLUSIONS: Symptoms of depression in adolescence strongly predict an episode of major depression in adulthood, even among adolescents without major depression.
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Experiences of depressive and anxiety symptoms in childhood and adolescence are associated with an elevated risk of poor mental health in adulthood.
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Cites
Continuity of psychopathology in a community sample of adolescents
ORVASCHEL, H., LEWINSOHN, P. M., & SEELEY, J. R. (1995) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199511000-00020 · Cited by 169 · see citing works
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Mood disorders in children and adolescents: an epidemiologic perspective
Kessler, R. C., Avenevoli, S., & Ries Merikangas, K. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01129-5 · Cited by 1,181 · see citing works
Rueger, S. Y., Malecki, C. K., Pyun, Y., Aycock, C., & Coyle, S. (2016) · Psychological Bulletin · doi:10.1037/bul0000058 · Cited by 946 · see citing works
The prevention of depressive symptoms in children and adolescents: a meta-analytic review
Horowitz, J. L., & Garber, J. (2006) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.74.3.401 · Cited by 803 · see citing works
Subthreshold Depression in Adolescence and Mental Health Outcomes in Adulthood
Fergusson, D. M., Horwood, L. J., Ridder, E. M., & Beautrais, A. L. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.1.66 · Cited by 792 · see citing works
Adult Outcomes of Youth Irritability: A 20-Year Prospective Community-Based Study
Stringaris, A., Cohen, P., Pine, D. S., & Leibenluft, E. (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.08121849 · Cited by 486 · see citing works
Self-citationDevelopment and natural history of mood disorders
Costello, E. J., Pine, D. S., Hammen, C., March, J. S., Plotsky, P. M., Weissman, M. M., Biederman, J., Goldsmith, H. H., Kaufman, J., Lewinsohn, P. M., et al. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01372-0 · Cited by 430 · see citing works
Self-citationSubthreshold depression in adolescence: a systematic review
Bertha, E. A., & Balázs, J. (2013) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-013-0411-0 · Cited by 398 · see citing works
Evaluation of the PHQ-2 as a Brief Screen for Detecting Major Depression Among Adolescents
Richardson, L. P., Rockhill, C., Russo, J. E., Grossman, D. C., Richards, J., McCarty, C., McCauley, E., & Katon, W. (2010) · Pediatrics · doi:10.1542/peds.2009-2712 · Cited by 377 · see citing works
Oswald, T. K., Rumbold, A. R., Kedzior, S. G. E., & Moore, V. M. (2020) · PLoS ONE · doi:10.1371/journal.pone.0237725 · Cited by 367 · see citing works
Research review: altered reward function in adolescent depression: what, when and how?
Forbes, E. E., & Dahl, R. E. (2012) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2011.02477.x · Cited by 350 · see citing works
Nabkasorn, C., Miyai, N., Sootmongkol, A., Junprasert, S., Yamamoto, H., Arita, M., & Miyashita, K. (2006) · European Journal of Public Health · doi:10.1093/eurpub/cki159 · Cited by 353 · see citing works
Stringaris, A., Vidal-Ribas Belil, P., Artiges, E., Lemaitre, H., Gollier-Briant, F., Wolke, S., Vulser, H., Miranda, R., Penttilä, J., Struve, M., et al. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2015.14101298 · Cited by 322 · see citing works
Developmental Trajectories of Anxiety and Depression in Early Adolescence
McLaughlin, K. A., & King, K. (2015) · Journal of Abnormal Child Psychology · doi:10.1007/s10802-014-9898-1 · Cited by 327 · see citing works
Hanson, J. L., Hariri, A. R., & Williamson, D. E. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.05.010 · Cited by 338 · see citing works
Blunted neural response to rewards prospectively predicts depression in adolescent girls
Bress, J. N., Foti, D., Kotov, R., Klein, D. N., & Hajcak, G. (2013) · Psychophysiology · doi:10.1111/j.1469-8986.2012.01485.x · Cited by 317 · see citing works
Developmental trajectories of adolescents' depressive symptoms: predictors of change
Garber, J., Keiley, M. K., & Martin, N. C. (2002) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.70.1.79 · Cited by 326 · see citing works
Developmental trajectories of adolescents' depressive symptoms: Predictors of change.
Garber, J., Keiley, M. K., & Martin, N. C. (2002) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.70.1.79 · Cited by 326 · see citing works
Neural systems of positive affect: relevance to understanding child and adolescent depression?
FORBES, E. E., & DAHL, R. E. (2005) · Development and Psychopathology · doi:10.1017/s095457940505039x · Cited by 318 · see citing works
Depression in Children and Adolescents
Garber, J. (2006) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2006.07.007 · Cited by 263 · see citing works
Characteristics, correlates, and outcomes of childhood and adolescent depressive disorders
Rao, U., & Chen, L.-A. (2009) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2009.11.1/urao · Cited by 252 · see citing works
Horowitz, J. L., Garber, J., Ciesla, J. A., Young, J. F., & Mufson, L. (2007) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.75.5.693 · Cited by 236 · see citing works
Wang, P., Wang, X., Wu, Y., Xie, X., Wang, X., Zhao, F., Ouyang, M., & Lei, L. (2018) · Personality and Individual Differences · doi:10.1016/j.paid.2018.02.008 · Cited by 221 · see citing works
Adolescent life events as predictors of adult depression
Pine, D. S., Cohen, P., Johnson, J. G., & Brook, J. S. (2002) · Journal of Affective Disorders · doi:10.1016/s0165-0327(00)00331-1 · Cited by 184 · see citing works
Self-citationDepressive Symptoms and Adolescent Romance: Theory, Research, and Implications
Davila, J. (2008) · Child Development Perspectives · doi:10.1111/j.1750-8606.2008.00037.x · Cited by 180 · see citing works
Alterations in reward-related decision making in boys with recent and future depression
Forbes, E. E., Shaw, D. S., & Dahl, R. E. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.026 · Cited by 173 · see citing works
A School-Based Mindfulness Pilot Study for Ethnically Diverse At-Risk Adolescents
Bluth, K., Campo, R. A., Pruteanu-Malinici, S., Reams, A., Mullarkey, M., & Broderick, P. C. (2016) · Mindfulness · doi:10.1007/s12671-014-0376-1 · Cited by 171 · see citing works
Paperwalla, K. N., Levin, T. T., Weiner, J., & Saravay, S. M. (2004) · Medical Clinics of North America · doi:10.1016/j.mcna.2004.06.007 · Cited by 164 · see citing works
Academic Stress, Physical Activity, Sleep, and Mental Health among Chinese Adolescents
Zhu, X., Haegele, J. A., Liu, H., & Yu, F. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18147257 · Cited by 154 · see citing works
“Of additional concern, the identification of mental health disorders such as anxiety and depression during adolescence is strongly associated with increased risk of experiencing mental health concerns across the lifespan [6].”
BackgroundByrne, M. L., Whittle, S., Vijayakumar, N., Dennison, M., Simmons, J. G., & Allen, N. B. (2017) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2016.12.004 · Cited by 150 · see citing works
Schwartz, O. S., Dudgeon, P., Sheeber, L. B., Yap, M. B. H., Simmons, J. G., & Allen, N. B. (2012) · Journal of Abnormal Child Psychology · doi:10.1007/s10802-011-9542-2 · Cited by 154 · see citing works
Increased Risks of Developing Anxiety and Depression in Young Patients With Crohn's Disease
Loftus, E. V., Guérin, A., Yu, A. P., Wu, E. Q., Yang, M., Chao, J., & Mulani, P. M. (2011) · American Journal of Gastroenterology · doi:10.1038/ajg.2011.142 · Cited by 142 · see citing works
Rostral Anterior Cingulate Cortex Volume Correlates with Depressed Mood in Normal Healthy Children
Boes, A. D., McCormick, L. M., Coryell, W. H., & Nopoulos, P. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.07.018 · Cited by 139 · see citing works
Sund, A. M., Larsson, B., & Wichstrøm, L. (2011) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-010-0208-0 · Cited by 141 · see citing works
Jin, C., Gao, C., Chen, C., Ma, S., Netra, R., Wang, Y., Zhang, M., & Li, D. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.08.017 · Cited by 136 · see citing works
Examining minor and major depression in adolescents
González‐Tejera, G., Canino, G., Ramírez, R., Chávez, L., Shrout, P., Bird, H., Bravo, M., Martínez‐Taboas, A., Ribera, J., & Bauermeister, J. (2005) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2005.00370.x · Cited by 127 · see citing works
Olino, T. M., Silk, J. S., Osterritter, C., & Forbes, E. E. (2015) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2014.0165 · Cited by 122 · see citing works
Major depressive disorder in adolescence: the role of subthreshold symptoms
GEORGIADES, K., LEWINSOHN, P. M., MONROE, S. M., & SEELEY, J. R. (2006) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000223313.25536.47 · Cited by 118 · see citing works
Emotional reactivity and internalizing symptoms: Moderating role of emotion regulation
Shapero, B. G., Abramson, L. Y., & Alloy, L. B. (2016) · Cognitive Therapy and Research · doi:10.1007/s10608-015-9722-4 · Cited by 114 · see citing works
Kovacs, M., & Lopez‐Duran, N. (2010) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2010.02230.x · Cited by 111 · see citing works
Yap, M. B. H., Schwartz, O. S., Byrne, M. L., Simmons, J. G., & Allen, N. B. (2010) · Journal of Research on Adolescence · doi:10.1111/j.1532-7795.2010.00665.x · Cited by 112 · see citing works
Zhu, X., Haegele, J. A., & Healy, S. (2019) · Mental Health and Physical Activity · doi:10.1016/j.mhpa.2019.04.002 · Cited by 105 · see citing works
Bezold, C. P., Banay, R. F., Coull, B. A., Hart, J. E., James, P., Kubzansky, L. D., Missmer, S. A., & Laden, F. (2018) · Annals of Epidemiology · doi:10.1016/j.annepidem.2018.01.009 · Cited by 98 · see citing works
Are adolescents with frequent pain symptoms more depressed?
Härmä, A.-M., Kaltiala-Heino, R., Rimpelä, M., & Rantanen, P. (2002) · Scandinavian Journal of Primary Health Care · doi:10.1080/pri.20.2.92.96 · Cited by 93 · see citing works
Rasing, S. P. A., Creemers, D. H. M., Janssens, J. M. A. M., & Scholte, R. H. J. (2017) · Frontiers in Psychology · doi:10.3389/fpsyg.2017.01066 · Cited by 88 · see citing works
Pelkonen, M., Marttunen, M., Kaprio, J., Huurre, T., & Aro, H. (2008) · Journal of Affective Disorders · doi:10.1016/j.jad.2007.06.001 · Cited by 77 · see citing works
Specific functional connectivity alterations of the dorsal striatum in young people with depression
Kerestes, R., Harrison, B. J., Dandash, O., Stephanou, K., Whittle, S., Pujol, J., & Davey, C. G. (2015) · NeuroImage: Clinical · doi:10.1016/j.nicl.2014.12.017 · Cited by 75 · see citing works
Kouros, C. D., & Garber, J. (2014) · Developmental Psychology · doi:10.1037/a0038190 · Cited by 69 · see citing works
Wolitzky-Taylor, K., Dour, H., Zinbarg, R., Mineka, S., Vrshek-Schallhorn, S., Epstein, A., Bobova, L., Griffith, J., Waters, A., Nazarian, M., et al. (2014) · Depression and Anxiety · doi:10.1002/da.22250 · Cited by 61 · see citing works
Wante, L., Mezulis, A., Van Beveren, M.-L., & Braet, C. (2017) · Child Neuropsychology · doi:10.1080/09297049.2016.1212986 · Cited by 56 · see citing works
Emotional Reactivity and Risk for Psychopathology Among Adolescents
Pine, D. S., Cohen, P., & Brook, J. S. (2001) · CNS Spectrums · doi:10.1017/s1092852900022860 · Cited by 55 · see citing works
Self-citationSocial anhedonia and medial prefrontal response to mutual liking in late adolescents
Healey, K. L., Morgan, J., Musselman, S. C., Olino, T. M., & Forbes, E. E. (2014) · Brain and Cognition · doi:10.1016/j.bandc.2013.12.004 · Cited by 53 · see citing works
Shapero, B. G., Stange, J. P., McArthur, B. A., Abramson, L. Y., & Alloy, L. B. (2019) · Cognition and Emotion · doi:10.1080/02699931.2018.1462148 · Cited by 46 · see citing works
Rantamäki, T., & Kohtala, S. (2020) · Pharmacological Reviews · doi:10.1124/pr.119.018697 · Cited by 45 · see citing works
General psychological distress symptoms and help-avoidance in young Australians
Wilson, C. J. (2010) · Advances in Mental Health · doi:10.5172/jamh.9.1.63 · Cited by 45 · see citing works
Bosch, N. M., Riese, H., Ormel, J., Verhulst, F., & Oldehinkel, A. J. (2009) · Biological Psychology · doi:10.1016/j.biopsycho.2009.01.005 · Cited by 44 · see citing works
Study of proportion and determinants of depression among college students in Mangalore city
Naushad, S., Rani, M., Sharma, S., Farooqui, W., Singh, R., & Verma, S. (2014) · Nigerian Medical Journal · doi:10.4103/0300-1652.129657 · Cited by 45 · see citing works
Schmitt, J. C., Valiente, R. M., García-Escalera, J., Arnáez, S., Espinosa, V., Sandín, B., & Chorot, P. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19095365 · Cited by 45 · see citing works
Saraceno, L., Heron, J., Munafò, M., Craddock, N., & van den Bree, M. B. M. (2012) · Addiction · doi:10.1111/j.1360-0443.2011.03662.x · Cited by 38 · see citing works
Dynamics of Positive Emotion Regulation: Associations with Youth Depressive Symptoms
Fussner, L. M., Luebbe, A. M., & Bell, D. J. (2015) · Journal of Abnormal Child Psychology · doi:10.1007/s10802-014-9916-3 · Cited by 34 · see citing works
Childhood social adversity and risk of depressive symptoms in adolescence in a US national sample
Björkenstam, E., Pebley, A. R., Burström, B., & Kosidou, K. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.01.035 · Cited by 30 · see citing works
Silk, J. S., Price, R. B., Rosen, D., Ryan, N. D., Forbes, E. E., Siegle, G. J., Dahl, R. E., McMakin, D. L., Kendall, P. C., & Ladouceur, C. D. (2019) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2018.10.012 · Cited by 27 · see citing works
Szemenyei, E., Reinhardt, M., Szabó, E., Szabó, K.-G., Urbán, R., Harvey, S. T., Morgan, A., Demetrovics, Z., & Kökönyei, G. (2020) · Assessment · doi:10.1177/1073191118796558 · Cited by 22 · see citing works
Bidirectional association between sedentary behaviour and depressive symptoms in adolescent girls
Raudsepp, L. (2016) · European Journal of Sport Science · doi:10.1080/17461391.2016.1174312 · Cited by 14 · see citing works
Van Assche, E., Moons, T., Van Leeuwen, K., Colpin, H., Verschueren, K., Van Den Noortgate, W., Goossens, L., & Claes, S. (2016) · European Psychiatry · doi:10.1016/j.eurpsy.2016.01.2428 · Cited by 13 · see citing works
Miller, L., & Barton, Y. A. (2015) · Journal of Religion and Health · doi:10.1007/s10943-015-0047-0 · Cited by 9 · see citing works
Ćavar Mišković, F., & Milas, G. (2025) · Medicina · doi:10.3390/medicina61071154 · Cited by 7 · see citing works
- Authors
- Pine, D. S., Cohen, E., Cohen, P., & Brook, J.
- Affiliations
- New York State Psychiatric Institute (US)
- ORCID
- Pine, Daniel S.
- Venue
- American Journal of Psychiatry
- Published
- 1999-01-01
- Volume
- 156
- Issue
- 1
- Pages
- 133-135
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2119664141
- Cited by
- 619
- References
- 1
- Citations by year
- 2026: 3 · 2025: 18 · 2024: 20 · 2023: 23 · 2022: 28 · 2021: 42 · 2020: 21 · 2019: 32 · 2018: 24 · 2017: 23 · 2016: 31 · 2015: 34 · 2014: 43 · 2013: 27 · 2012: 23
- FWCI
- 14.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH-36971, R01MH036971)
- National Institute on Drug Abuse (DA 03188, R01DA003188, DA00244)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Keywords
- adolescent depressive symptoms, subthreshold depression, major depressive episode, adult depression, depression risk prediction, mood disorders, moodiness, longitudinal follow-up
- MeSH terms
- Adolescent, Psychology, Adolescent, Adult, Age Factors, Child, Depression, Depressive Disorder, Female, Humans, Male, New York, Probability, Regression Analysis, Sampling Studies
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