The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Macrophage Phenotype as a Determinant of Biologic Scaffold Remodeling
Abstract
Macrophage phenotype can be characterized as proinflammatory (M1) or immunomodulatory and tissue remodeling (M2). The present study used a rat model to determine the macrophage phenotype at the site of implantation of two biologic scaffolds that were derived from porcine small intestinal submucosa (SIS) and that differed mainly according to their method of processing: the Restore device (SIS) and the CuffPatch device (carbodiimide crosslinked form of porcine-derived SIS (CDI-SIS)). An autologous tissue graft was used as a control implant. Immunohistologic methods were used to identify macrophage surface markers CD68 (pan macrophages), CD80 and CCR7 (M1 profile), and CD163 (M2 profile) during the remodeling process. All graft sites were characterized by the dense population of CD68+ mononuclear cells present during the first 4 weeks. The SIS device elicited a predominantly CD163+ response (M2 profile, p < 0.001) and showed constructive remodeling at 16 weeks. The CDI-SIS device showed a predominately CD80+ and CCR7+ response (M1 profile, p < 0.03), and at 16 weeks was characterized by chronic inflammation. The autologous tissue graft showed a predominately CD163+ response (M2) at 1 week, with a dual M1/M2 population (CD80+, CCR7+, and CD163+) by 2 and 4 weeks and moderately well organized connective tissue by 16 weeks. The processing methods used during the manufacturing of a biologic scaffold can have a profound influence upon the macrophage phenotype profile and downstream remodeling events. Routine histologic examination alone is inadequate to determine the phenotype of mononuclear cells that participate in the host response to the scaffold.
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“promotion of M2-like phenotypes in vitro [40,44,153] and in vivo [152,154,155].”
From Immune Response to Extracellular Matrix Bioscaffolds: A Comprehensive Review (2025) · cites this paper as [40]
In the citing paper
“Macrophages that polarized toward to the M2 phenotype are identified by high expression levels of IL‐10, CD163, and amplification of the Arginase 1 (Arg1) enzyme, hereby switching the focus to releasing signals for constructive tissue remodeling.[ 68 ]”
From Unraveling and Harnessing the Immune Response at the Cell–Biomaterial Interface for Tissue Engineering Purposes (2024) · cites this paper as [68]
In the citing paper
“Briefly, scaffold materials composed of extracellular matrix (ECM) have been shown to promote a switch from a predominantly M1 cell population immediately following implantation to a population enriched in M2 cells by 7–14 days post implantation [154–156].”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [154]
In the citing paper
“However, modification of such scaffold materials with chemical crosslinking agents which delay or prevent macrophage mediated degradation inhibits the formation of the beneficial M2 response and results in downstream scar tissue formation [154].”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [154]
In the citing paper
“This constructive remodeling response has been directly linked to the ability of the material to modulate macrophage phenotype [154–157].”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [154]
In the citing paper
“Here we find that MΦ activation depends on biomaterial architecture in addition to previously implicated biomaterial chemistry and bioactivity (34–36).”
From Proangiogenic scaffolds as functional templates for cardiac tissue engineering (2010) · cites this paper as [35]
Citations
Cites
1 retracted
Only a specific subset of human peripheral-blood monocytes has endothelial-like functional capacity
Elsheikh, E. B., Uzunel, M., He, Z., Holgersson, J., Nowak, G., & Sumitran–Holgersson, S. (2005) · Blood · doi:10.1182/blood-2005-04-1407 · Cited by 114
RetractedThe chemokine system in diverse forms of macrophage activation and polarization
MANTOVANI, A., SICA, A., SOZZANI, S., ALLAVENA, P., VECCHI, A., & LOCATI, M. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.09.015 · Cited by 6,534
MANTOVANI, A., SOZZANI, S., LOCATI, M., ALLAVENA, P., & SICA, A. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02302-5 · Cited by 5,528
Monocyte and macrophage heterogeneity
Gordon, S., & Taylor, P. R. (2005) · Nature Reviews Immunology · doi:10.1038/nri1733 · Cited by 5,190
Foreign body reaction to biomaterials
Anderson, J. M., Rodriguez, A., & Chang, D. T. (2008) · Seminars in Immunology · doi:10.1016/j.smim.2007.11.004 · Cited by 5,138 · cited 1×
“2 However, phenotypic and functional polarization of the mononuclear phagocyte cell population has recently been described, 3–6 which is similar to the Th1/Th2 polarization scheme of lymphocytes.”
Biomaterials Science: An Introduction to Materials in Medicine
Ratner, B. D., Hoffman, A. S., Schöen, F. J., & Lemons, J. E. (1996) · doi:10.1016/c2009-0-02433-7 · Cited by 5,125
M-1/M-2 Macrophages and the Th1/Th2 Paradigm
Mills, C. D., Kincaid, K., Alt, J. M., Heilman, M. J., & Hill, A. M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.12.6166 · Cited by 3,287
The many faces of macrophage activation
Mosser, D. M. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0602325 · Cited by 1,902
Biological Responses to Materials
Anderson, J. M. (2001) · Annual Review of Materials Research · doi:10.1146/annurev.matsci.31.1.81 · Cited by 1,465
Macrophage Polarization Comes of Age
Mantovani, Sica, & Locati, M. (2005) · Immunity · doi:10.1016/j.immuni.2005.10.001 · Cited by 1,259
Research works printed but not linked: 1
- 16. Burke, B., and Lewis, C.E., eds. The Macrophage. Oxford: Oxford University Press, 2002.
Cited by
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Items 101–200 of 728
Patil, P., Russo, K. A., McCune, J. T., Pollins, A. C., Cottam, M. A., Dollinger, B. R., DeJulius, C. R., Gupta, M. K., d’Arcy, R., Colazo, J. M., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abm6586 · Cited by 144
Sicari, B. M., Johnson, S. A., Siu, B. F., Crapo, P. M., Daly, K. A., Jiang, H., Medberry, C. J., Tottey, S., Turner, N. J., & Badylak, S. F. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.04.017 · Cited by 140
Self-citationCollagen Membrane and Immune Response in Guided Bone Regeneration: Recent Progress and Perspectives
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The effect of source animal age upon extracellular matrix scaffold properties
Tottey, S., Johnson, S. A., Crapo, P. M., Reing, J. E., Zhang, L., Jiang, H., Medberry, C. J., Reines, B., & Badylak, S. F. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2010.09.006 · Cited by 138
Self-citationCorona, B. T., Ward, C. L., Baker, H. B., Walters, J., & Christ, G. J. (2013) · Tissue Engineering Part A · doi:10.1089/ten.tea.2012.0761 · Cited by 137
Lim, J. E., Chung, E., & Son, Y. (2017) · Scientific Reports · doi:10.1038/s41598-017-09639-7 · Cited by 136
Femtosecond laser ablation enhances cell infiltration into three-dimensional electrospun scaffolds
Lee, B. L.-P., Jeon, H., Wang, A., Yan, Z., Yu, J., Grigoropoulos, C. P., & Li, S. (2012) · Acta Biomaterialia · doi:10.1016/j.actbio.2012.04.023 · Cited by 140
The role of skin substitutes in the management of chronic cutaneous wounds
Greaves, N. S., Iqbal, S. A., Baguneid, M. S., & Bayat, A. (2013) · Wound Repair and Regeneration · doi:10.1111/wrr.12029 · Cited by 135
Biocompatibility Evolves: Phenomenology to Toxicology to Regeneration
Crawford, L., Wyatt, M., Bryers, J. D., & Ratner, B. D. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202002153 · Cited by 141
Costa, A., Naranjo, J. D., Londono, R., & Badylak, S. F. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a025676 · Cited by 135
Self-citationShared signaling systems in myeloid cell-mediated muscle regeneration
Tidball, J. G., Dorshkind, K. A., & Wehling‐Henricks, M. (2014) · Development · doi:10.1242/dev.098285 · Cited by 151
Inducing healing-like human primary macrophage phenotypes by 3D hydrogel coated nanofibres
Bartneck, M., Heffels, K., Pan, Y., Bovi, M., Zwadlo‐Klarwasser, G., & Gröll, J. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.02.050 · Cited by 133
Zhang, Z., Zhang, Z., & Schluesener, H. J. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901088 · Cited by 129
Wolf, M. T., Ganguly, S., Wang, T. L., Anderson, C. W., Sadtler, K., Narain, R., Cherry, C., Parrillo, A. J., Park, B. V., Wang, G., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aat7973 · Cited by 131
Engineered human vascularized constructs accelerate diabetic wound healing
Shen, Y.-I., Cho, H., Papa, A. E., Burke, J. A., Chan, X. Y., Duh, E. J., & Gerecht, S. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.06.009 · Cited by 126
Ulrich, D., Edwards, S. L., Su, K. C., Tan, K. S., White, J., Ramshaw, J. A. M., Lo, C. Y.-W., Rosamilia, A., Werkmeister, J. A., & Gargett, C. E. (2013) · Tissue Engineering Part A · doi:10.1089/ten.tea.2013.0170 · Cited by 124
Advanced Strategies for Modulation of the Material–Macrophage Interface
Huyer, L. D., Pascual‐Gil, S., Wang, Y., Mandla, S., Yee, B., & Radisic, M. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201909331 · Cited by 123
Katagiri, W., Osugi, M., Kawai, T., & Hibi, H. (2016) · Head & Face Medicine · doi:10.1186/s13005-016-0101-5 · Cited by 126
Matrix-bound nanovesicles recapitulate extracellular matrix effects on macrophage phenotype
Huleihel, L., Bartolacci, J. G., Dziki, J. L., Vorobyov, T., Arnold, B., Scarritt, M. E., Pineda Molina, C., LoPresti, S. T., Brown, B. N., Naranjo, J. D., et al. (2017) · Tissue Engineering Part A · doi:10.1089/ten.tea.2017.0102 · Cited by 116
Self-citationA Perspective on Immunomodulation and Tissue Repair
Mokarram, N., & Bellamkonda, R. V. (2013) · Annals of Biomedical Engineering · doi:10.1007/s10439-013-0941-0 · Cited by 115
Humbert, P., Brennan, M. Á., Davison, N., Rosset, P., Trichet, V., Blanchard, F., & Layrolle, P. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00663 · Cited by 119
Small Intestinal Submucosa Segments as Matrix for Tissue Engineering: Review
Andrée, B., Bär, A., Haverich, A., & Hilfiker, A. (2012) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2012.0583 · Cited by 114
Qiu, X., Lee, B. L.-P., Ning, X., Murthy, N., Dong, N., & Li, S. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.01.012 · Cited by 113
Rane, A. A., Chuang, J., Shah, A., Hu, D. P., Dalton, N. D., Gu, Y., Peterson, K. L., Omens, J. H., & Christman, K. L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021571 · Cited by 111
The Effect of Biomaterials Used for Tissue Regeneration Purposes on Polarization of Macrophages
Boersema, G. S. A., Grotenhuis, N., Bayon, Y., Lange, J. F., & Bastiaansen-Jenniskens, Y. M. (2016) · BioResearch open access · doi:10.1089/biores.2015.0041 · Cited by 113
Bioelectric modulation of macrophage polarization
Li, C., Levin, M. G., & Kaplan, D. L. (2016) · Scientific Reports · doi:10.1038/srep21044 · Cited by 108
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Fearing, B. V., & Dyke, M. E. V. (2014) · Acta Biomaterialia · doi:10.1016/j.actbio.2014.04.003 · Cited by 111
Faulk, D. M., Wildemann, J. D., & Badylak, S. F. (2015) · Journal of Clinical and Experimental Hepatology · doi:10.1016/j.jceh.2014.03.043 · Cited by 108
Self-citationTian, G., Jiang, S., Li, J.-Q., Wei, F., Li, X., Ding, Y., Yang, Z., Sun, Z., Zha, K.-K., Wang, F., et al. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.03.054 · Cited by 96
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Jung, J. P., Bhuiyan, D. B., & Ogle, B. M. (2016) · Biomaterials Research · doi:10.1186/s40824-016-0074-2 · Cited by 106
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Pouliot, R. A., Young, B. M., Link, P. A., Park, H. E., Kahn, A. R., Shankar, K., Schneck, M. B., Weiss, D. J., & Heise, R. L. (2020) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2020.0042 · Cited by 108
Sadtler, K., Sommerfeld, S. D., Wolf, M. T., Wang, X., Majumdar, S., Chung, L., Kelkar, D. S., Pandey, A., & Elisseeff, J. H. (2017) · Seminars in Immunology · doi:10.1016/j.smim.2017.05.002 · Cited by 108
Dental implant surface chemistry and energy alter macrophage activation in vitro
Hotchkiss, K. M., Ayad, N. B., Hyzy, S. L., Boyan, B. D., & Olivares‐Navarrete, R. (2016) · Clinical Oral Implants Research · doi:10.1111/clr.12814 · Cited by 106
Li, Y., Meng, H., Liu, Y., Narkar, A. R., & Lee, B. P. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b01364 · Cited by 103
Lad, E. M., Cousins, S. W., Arnam, J. S. V., & Proia, A. D. (2015) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-015-3094-z · Cited by 102
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Wang, Y., Bao, J., Wu, X., Wu, Q., Li, Y., Zhou, Y., Li, L., & Bu, H. (2016) · Scientific Reports · doi:10.1038/srep24779 · Cited by 101
Cao, G., Huang, Y., Li, K., Fan, Y., Xie, H., & Li, X. (2019) · Journal of Materials Chemistry B · doi:10.1039/c9tb00530g · Cited by 101
Targeting Macrophage Subsets for Infarct Repair
Ben-Mordechai, T., Palevski, D., Glucksam, Y., Elron-Gross, I., Margalit, R., & Leor, J. (2014) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248414534916 · Cited by 100
Clinical Translation of Tissue Engineered Trachea Grafts
Chiang, T., Pepper, V. K., Best, C. A., Onwuka, E. A., & Breuer, C. K. (2016) · Annals of Otology Rhinology & Laryngology · doi:10.1177/0003489416656646 · Cited by 100
Keane, T. J., Dziki, J. L., Sobieski, E., Smoulder, A. L., Castleton, A. A., Turner, N. J., White, L. J., & Badylak, S. F. (2016) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjw149 · Cited by 103
Self-citationA functional extracellular matrix biomaterial derived from ovine forestomach
Lun, S., Irvine, S. M., Johnson, K. D., Fisher, N. J., Floden, E. W., Negron, L., Dempsey, S. G., McLaughlin, R. J., Vasudevamurthy, M. K., Ward, B. R., et al. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.02.025 · Cited by 99
Keratin films for ocular surface reconstruction: Evaluation of biocompatibility in an in-vivo model
Borrelli, M., Joepen, N., Reichl, S., Finis, D., Schoppe, M., Geerling, G., & Schrader, S. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.11.038 · Cited by 100
Xu, K., Cantu, D. A., Fu, Y., Kim, J., Zheng, X., Hematti, P., & Kao, W. J. (2013) · Acta Biomaterialia · doi:10.1016/j.actbio.2013.06.021 · Cited by 99
Immunoengineering nerve repair
Mokarram, N., Dymanus, K., Srinivasan, A., Lyon, J. G., Tipton, J., Chu, J. K., ENGLISH, A. W., & Bellamkonda, R. V. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1705757114 · Cited by 97
Linard, C., Busson, É., Holler, V., Strup-Perrot, C., Lacavé-Lapalun, J.-V., L’Homme, B., Prat, M., Devauchelle, P., Sabourin, J., Simon, J.-M., et al. (2013) · Stem Cells Translational Medicine · doi:10.5966/sctm.2013-0030 · Cited by 95
Cell-material interactions in tendon tissue engineering
Lin, J., Zhou, W., Han, S., Bunpetch, V., Zhao, K., Liu, C., Yin, Z., & Ouyang, H. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.01.012 · Cited by 96
Barnett‐Vanes, A., Sharrock, A. E., Birrell, M. A., & Rankin, S. M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0142520 · Cited by 100
Mori, K., Hiroi, M., Shimada, J., & Ohmori, Y. (2011) · Cancers · doi:10.3390/cancers3043726 · Cited by 95
Biomaterials-Mediated Regulation of Macrophage Cell Fate
Liu, Y., & Segura, T. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.609297 · Cited by 92
Wang, R. M., Johnson, T. D., He, J., Rong, Z., Wong, M., Nigam, V., Behfar, A., Xu, Y., & Christman, K. L. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.03.016 · Cited by 90
Koržinskas, T., Jung, O., Smeets, R., Stojanović, S., Najman, S. J., Glenske, K., Hahn, M. P., Wenisch, S., Schnettler, R., & Barbeck, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19102952 · Cited by 91
Guillory, R. J., Bowen, P. K., Hopkins, S. P., Shearier, E. R., Earley, E. J., Gillette, A. A., Aghion, E., Bocks, M. L., Drelich, J. W., & Goldman, J. (2016) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.6b00591 · Cited by 91
Daly, K. A., Liu, S., Agrawal, V., Brown, B. N., Johnson, S. A., Medberry, C. J., & Badylak, S. F. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.09.040 · Cited by 91
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Robb, K. P., Shridhar, A., & Flynn, L. E. (2017) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.7b00619 · Cited by 90
Dong, Z., Peng, Z., Chang, Q., & Lu, F. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080364 · Cited by 90
The Biocompatibility of Implant Materials
Ratner, B. D. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800196-7.00003-7 · Cited by 88
Sicari, B. M., Dearth, C. L., & Badylak, S. F. (2013) · The Anatomical Record · doi:10.1002/ar.22794 · Cited by 88
Self-citationInduction of specific macrophage subtypes by defined micro-patterned structures
Bartneck, M., Schulte, V. A., Paul, N. E., Diez, M., Lensen, M. C., & Zwadlo-Klarwasser, G. (2010) · Acta Biomaterialia · doi:10.1016/j.actbio.2010.04.025 · Cited by 87
Bessa‐Gonçalves, M., Ribeiro-Machado, C., Costa, M. M., Ribeiro, C. N. M., Barbosa, J., Barbosa, M. A., & Santos, S. G. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.10.046 · Cited by 87
Feng, B., Ji, T.-J., Wang, X., Fu, W. E., Ye, L., Zhang, H., & Li, F. (2020) · Materials & Design · doi:10.1016/j.matdes.2020.108773 · Cited by 85
Human monocyte activation by biologic and biodegradable meshes in vitro
Orenstein, S. B., Qiao, Y., Kaur, M., Klueh, U., Kreutzer, D. L., & Novitsky, Y. W. (2009) · Surgical Endoscopy · doi:10.1007/s00464-009-0664-3 · Cited by 86
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Taraballi, F., Corradetti, B., Minardi, S., Powell, S. T., Cabrera, F. J., Eps, J. L. V., Weiner, B. K., & Tasciotti, E. (2016) · Journal of Tissue Engineering · doi:10.1177/2041731415624667 · Cited by 86
Sadtler, K., Allen, B. W., Estrellas, K. M., Housseau, F., Pardoll, D. M., & Elisseeff, J. H. (2016) · Tissue Engineering Part A · doi:10.1089/ten.tea.2016.0304 · Cited by 89
Yeon, B., Park, M. H., Moon, H. J., Kim, S.-J., Cheon, Y. W., & Jeong, B. (2013) · Biomacromolecules · doi:10.1021/bm400868j · Cited by 85
Fukano, Y., Usui, M. L., Underwood, R. A., Isenhath, S., Marshall, A. J., Hauch, K. D., Ratner, B. D., Olerud, J. E., & Fleckman, P. (2010) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.32798 · Cited by 83
Xu, M., Su, T., Jin, X., Li, Y., Yao, Y., Liu, K., Chen, K., Lu, F., & He, Y. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.08.015 · Cited by 86
Witt, R. G., Raff, G. W., Gundy, J. V., Rodgers-Ohlau, M., & Si, M. (2013) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezs638 · Cited by 83
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Agrawal, V., Kelly, J., Tottey, S., Daly, K. A., Johnson, S. A., Siu, B. F., Reing, J. E., & Badylak, S. F. (2011) · Tissue Engineering Part A · doi:10.1089/ten.tea.2011.0257 · Cited by 82
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Xiang, G., Liu, K., Wang, T., Hu, X., Wang, J., Gao, Z., Lei, W., Feng, Y., & Tao, T. H. (2020) · Advanced Science · doi:10.1002/advs.202002328 · Cited by 76
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Fu, W. E., Liu, S., Chen, M., Tian, G., Zha, K., Yang, Z., Jiang, S., Li, M., Sui, X., Chen, Z., et al. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.664592 · Cited by 78
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Bonito, V., Smits, A. I. P. M., Goor, O. J. G. M., Ippel, B. D., Driessen‐Mol, A., Münker, T. J. A. G., Bosman, A. W., Mes, T., Dankers, P. Y. W., & Bouten, C. V. C. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.02.032 · Cited by 80
Brown, B. N., Chung, W. L., Almarza, A. J., Pavlick, M. D., Reppas, S. N., Ochs, M. W., Russell, A. J., & Badylak, S. F. (2012) · Journal of Oral and Maxillofacial Surgery · doi:10.1016/j.joms.2011.12.030 · Cited by 83
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Petty, A. J., Keate, R. L., Jiang, B., Ameer, G. A., & Rivnay, J. (2020) · Chemistry of Materials · doi:10.1021/acs.chemmater.0c00767 · Cited by 77
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Metadata
- Authors
- Badylak, S. F., Valentin, J. E., Ravindra, A. K., McCabe, G. P., & Stewart-Akers, A. M.
- Affiliations
- University of Pittsburgh (US)
- Purdue University West Lafayette (US)
- McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
- Corresponding author
- Badylak, Stephen F.
- Venue
- Tissue Engineering Part A
- Publisher
- SAGE Publications
- Published
- 2008-11
- Volume
- 14
- Issue
- 11
- Pages
- 1835-1842
- ISSN
- 1937-3341 (ISSN-L)
- 1937-335X
- OpenAlex
- W2042569529
- Cited by
- 729
- References
- 51
- Citations by year
- 2026: 14 · 2025: 20 · 2024: 31 · 2023: 25 · 2022: 28 · 2021: 50 · 2020: 49 · 2019: 46 · 2018: 41 · 2017: 67 · 2016: 62 · 2015: 47 · 2014: 71 · 2013: 63 · 2012: 34
- FWCI
- 28.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Tissue Engineering Part A (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR054940)
- Topics
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Keywords
- macrophage phenotype, M1/M2 macrophages, porcine small intestinal submucosa, carbodiimide crosslinking, chronic inflammation, CD163, CD80, CCR7, CD68, tissue grafts
- MeSH terms
- CD163 Antigen, Animals, Immunohistochemistry, Macrophages, Random Allocation, Receptors, Cell Surface, Swine, Antigens, Differentiation, Myelomonocytic, Antigens, CD, Rats, Sprague-Dawley, B7-1 Antigen, Tissue Engineering, Rats, Receptors, CCR7, Tissue Scaffolds
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