Cited by 190Oral microbiology and periodontitis researchNitric Oxide and Endothelin EffectsBlood Pressure and Hypertension Studies

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Antibacterial Mouthwash Blunts Oral Nitrate Reduction and Increases Blood Pressure in Treated Hypertensive Men and Women

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Bondonno, Catherine P., Liu, Alex H., Croft, Kevin D., Considine, Michael J., Puddey, Ian B., Woodman, Richard J., Hodgson, Jonathan M.·2015·American Journal of Hypertension

DOI 10.1093/ajh/hpu192

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Abstract

BACKGROUND: Endothelial nitric oxide (NO) is fundamental to cardiovascular health. Dietary nitrate and nitrate from endothelial derived NO metabolism provides a significant contribution to the circulating NO pool through the nitrate–nitrite–NO pathway. A critical step in this pathway is the reduction of nitrate to nitrite by the oral microbiota. We aimed to assess the effects of antibacterial mouthwash use on markers of nitrate–nitrite–NO metabolism and blood pressure in treated hypertensive men and women. METHODS: Fifteen treated hypertensive men and women (mean age 65 years) were recruited to a randomized controlled cross-over trial. The effects of 3-day use of antibacterial mouthwash on oral nitrate to nitrite reduction, salivary and plasma nitrate and nitrite, plasma cyclic guanosine monophosphate (cGMP) and systolic and diastolic blood pressure were compared to control (water). RESULTS: Relative to control, 3-day antibacterial mouthwash use resulted in decreased oral nitrate to nitrite reduction (P = 0.02), decreased salivary nitrite (P = 0.01) and increased salivary nitrate (P < 0.001), and there was a trend toward a decrease in plasma nitrite concentration (P = 0.09). Use of antibacterial mouthwash over 3 days also resulted in higher systolic blood pressure (2.3mm Hg; 95% CI: 0.5, 4.0; P = 0.01), but not diastolic blood pressure (P = 0.4) or plasma cGMP (P = 0.7), relative to control. CONCLUSIONS: Interruption of the nitrate–nitrite–NO pathway through the use of antibacterial mouthwash was paralleled by a small elevation of systolic blood pressure in treated hypertensive men and women.

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Authors: Bondonno, C. P., Liu, A. H., Croft, K. D., Considine, M. J., Puddey, I. B., Woodman, R. J., & Hodgson, J. M.
Affiliations: The University of Western Australia (AU)
Flinders University (AU)
ORCID: Bondonno, Catherine P.
Liu, Alex H.
Croft, Kevin D.
Considine, Michael J.
Puddey, Ian B.
Woodman, Richard J.
Hodgson, Jonathan M.
Venue: American Journal of Hypertension
Publisher: Oxford University Press (OUP)
Published: 2014-10-30
Volume: 28
Issue: 5
Pages: 572-575
ISSN: 0895-7061 (ISSN-L)
1941-7225
DOI: 10.1093/ajh/hpu192
OpenAlex: W2129513013
Cited by: 190
References: 20
Citations by year: 2026: 24 · 2025: 21 · 2024: 27 · 2023: 13 · 2022: 15 · 2021: 15 · 2020: 17 · 2019: 24 · 2018: 13 · 2017: 10 · 2016: 6 · 2015: 4
FWCI: 8.90
Type: journal article
Language: en
Open access: green
research-repository.uwa.edu.au
Licence: other-oa
academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: American Journal of Hypertension (publishedVersion)
UWA Profiles and Research Repository (UWA) (publishedVersion, other-oa)
PubMed (publishedVersion)
Topics: Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Keywords: antibacterial mouthwash, nitrate-nitrite-NO pathway, oral microbiota, salivary nitrate, salivary nitrite, plasma nitrite, cyclic GMP, blood pressure, hypertension, endothelial nitric oxide
MeSH terms: Aged, Anti-Bacterial Agents, Blood Pressure, Female, Humans, Hypertension, Male, Middle Aged, Mouthwashes, Nitrates, Saliva, Cross-Over Studies

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Antibacterial Mouthwash Blunts Oral Nitrate Reduction and Increases Blood Pressure in Treated Hypertensive Men and Women

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