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Apoptosis in cancer
Abstract
In the last decade, basic cancer research has produced remarkable advances in our understanding of cancer biology and cancer genetics. Among the most important of these advances is the realization that apoptosis and the genes that control it have a profound effect on the malignant phenotype. For example, it is now clear that some oncogenic mutations disrupt apoptosis, leading to tumor initiation, progression or metastasis. Conversely, compelling evidence indicates that other oncogenic changes promote apoptosis, thereby producing selective pressure to override apoptosis during multistage carcinogenesis. Finally, it is now well documented that most cytotoxic anticancer agents induce apoptosis, raising the intriguing possibility that defects in apoptotic programs contribute to treatment failure. Because the same mutations that suppress apoptosis during tumor development also reduce treatment sensitivity, apoptosis provides a conceptual framework to link cancer genetics with cancer therapy. An intense research effort is uncovering the underlying mechanisms of apoptosis such that, in the next decade, one envisions that this information will produce new strategies to exploit apoptosis for therapeutic benefit.
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Citations
Cites
Apoptosis in the Pathogenesis and Treatment of Disease
Thompson, C. B. (1995) · Science · doi:10.1126/science.7878464 · Cited by 6,524
Death Receptors: Signaling and Modulation
Ashkenazi, A., & Dixit, V. M. (1998) · Science · doi:10.1126/science.281.5381.1305 · Cited by 5,866
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell · doi:10.1016/s0092-8674(00)81902-9 · Cited by 5,218
Self-citationGiancotti, F. G., & Ruoslahti, E. (1999) · Science · doi:10.1126/science.285.5430.1028 · Cited by 3,869
p53 is required for radiation-induced apoptosis in mouse thymocytes
Lowe, S. W., Schmitt, E. M., Smith, S. W., Osborne, B. A., & Jacks, T. (1993) · Nature · doi:10.1038/362847a0 · Cited by 2,864
Self-citationHypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
Graeber, T. G., Osmanian, C., Jacks, T., Housman, D. E., Koch, C. J., Lowe, S. W., & Giaccia, A. J. (1996) · Nature · doi:10.1038/379088a0 · Cited by 2,300
Self-citationSunburn and p53 in the onset of skin cancer
Ziegler, A., Jonason, A. S., Leffellt, D. J., Simon, J. A., Sharma, H. W., Kimmelman, J., Remington, L., Jacks, T., & Brash, D. E. (1994) · Nature · doi:10.1038/372773a0 · Cited by 1,497
A Chemical Inhibitor of p53 That Protects Mice from the Side Effects of Cancer Therapy
Komarov, P. G., Komarova, E. A., Kondratov, R. V., Christov-Tselkov, K., Coon, J. S., Chernov, M. V., & Gudkov, A. V. (1999) · Science · doi:10.1126/science.285.5434.1733 · Cited by 1,270
Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization
Zindy, F., Eischen, C. M., Randle, D. H., Kamijo, T., Cleveland, J. L., Sherr, C. J., & Roussel, M. F. (1998) · Genes & Development · doi:10.1101/gad.12.15.2424 · Cited by 1,245
McDonnell, T. J., Deane, N., Platt, F. M., Nunez, G., Jaeger, U., McKearn, J. P., & Korsmeyer, S. J. (1989) · Cell · doi:10.1016/0092-8674(89)90174-8 · Cited by 1,213
Cited by
Vogelstein, B., Lane, D., & Levine, A. J. (2000) · Nature · doi:10.1038/35042675 · Cited by 6,607
PUMA, a Novel Proapoptotic Gene, Is Induced by p53
Nakano, K., & Vousden, K. H. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00214-3 · Cited by 2,315
Johnstone (2002) · doi:10.1016/s0092-8674(02)00625-6 · Cited by 1,876
Fridman, J. S., & Lowe, S. W. (2003) · Oncogene · doi:10.1038/sj.onc.1207116 · Cited by 1,401
Self-citationThe cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer
Li, T., & Chen, Z. J. (2018) · Journal of Experimental Medicine · doi:10.1084/jem.20180139 · Cited by 1,293
DNA damage and the balance between survival and death in cancer biology
Roos, W. P., Thomas, A. D., & Kaina, B. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2015.2 · Cited by 1,189
Glutathione in Cancer Biology and Therapy
Estrela, J. M., Ortega, A., & Obrador, E. (2006) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360500523878 · Cited by 1,041
Origins, structures, and functions of circulating DNA in oncology
Thierry, A. R., El Messaoudi, S., Gahan, P. B., Anker, P., & Stroun, M. (2016) · Cancer and Metastasis Reviews · doi:10.1007/s10555-016-9629-x · Cited by 818
ROS, stress‐activated kinases and stress signaling in cancer
Benhar, M., Engelberg, D., & Levitzki, A. (2002) · The EMBO Reports · doi:10.1093/embo-reports/kvf094 · Cited by 600
Mustafa, M., Ahmad, R., Tantry, I. Q., Ahmad, W., Siddiqui, S., Alam, M., Abbas, K., Moinuddin, Hassan, M. I., Habib, S., et al. (2024) · Cells · doi:10.3390/cells13221838 · Cited by 595
Horizontal transfer of oncogenes by uptake of apoptotic bodies
Bergsmedh, A., Szeles, A., Henriksson, M., Bratt, A., Folkman, M. J., Spetz, A.-L., & Holmgren, L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.101129998 · Cited by 550
Inhibition of Autophagy by 3-MA Enhances the Effect of 5-FU-Induced Apoptosis in Colon Cancer Cells
Li, J., Hou, N., Faried, A., Tsutsumi, S., Takeuchi, T., & Kuwano, H. (2009) · Annals of Surgical Oncology · doi:10.1245/s10434-008-0260-0 · Cited by 291
VDAC1, mitochondrial dysfunction, and Alzheimer’s disease
Shoshan-Barmatz, V., Nahon-Crystal, E., Shteinfer-Kuzmine, A., & Gupta, R. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.03.010 · Cited by 286
Distinct Microbial Signatures Associated With Different Breast Cancer Types
Banerjee, S., Tian, T., Wei, Z., Shih, N., Feldman, M. D., Peck, K. N., DeMichele, A. M., Alwine, J. C., & Robertson, E. S. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00951 · Cited by 281
Intact p53-Dependent Responses in miR-34–Deficient Mice
Concepcion, C. P., Han, Y.-C., Mu, P., Bonetti, C., Yao, E., D'Andrea, A., Vidigal, J. A., Maughan, W. P., Ogrodowski, P., & Ventura, A. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002797 · Cited by 197
Lin, M.-T., Chang, C.-C., Chen, S.-T., Chang, H.-L., Su, J.-L., Chau, Y.-P., & Kuo, M.-L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402305200 · Cited by 194
Tang, R., Kim, C. S., Solfiell, D. J., Rana, S., Mout, R., Velázquez-Delgado, E. M., Chompoosor, A., Jeong, Y., Yan, B., Zhu, Z.-J., et al. (2013) · ACS Nano · doi:10.1021/nn402753y · Cited by 188
The interaction of flavonoids with mitochondria: effects on energetic processes
Dorta, D. J., Pigoso, A. A., Mingatto, F. E., Rodrigues, T., Prado, I. M. R., Helena, A. F. C., Uyemura, S. A., Santos, A. C., & Curti, C. (2005) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2005.02.004 · Cited by 165
Su, F., Overholtzer, M., Besser, D., & Levine, A. J. (2002) · Genes & Development · doi:10.1101/gad.942902 · Cited by 153
The role of mitochondria in ageing and carcinogenesis
Birch-Machin, M. A. (2006) · Clinical and Experimental Dermatology · doi:10.1111/j.1365-2230.2006.02161.x · Cited by 130
The beneficial effects of spirulina focusing on its immunomodulatory and antioxidant properties
Maddaly, R. (2010) · Nutrition and Dietary Supplements · doi:10.2147/nds.s9838 · Cited by 127
AbouAitah, K., Hassan, H. A., Swiderska-Sroda, A., Gohar, L., Shaker, O. G., Wojnarowicz, J., Opalinska, A., Smalc-Koziorowska, J., Gierlotka, S., & Lojkowski, W. (2020) · Cancers · doi:10.3390/cancers12010144 · Cited by 105
Li, X., Peterson, Y. K., Inks, E. S., Himes, R. A., Li, J., Zhang, Y., Kong, X., & Chou, C. J. (2018) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.8b00136 · Cited by 93
Shan, F., Shao, Z., Jiang, S., & Cheng, Z. (2016) · Cancer Medicine · doi:10.1002/cam4.881 · Cited by 88
Small molecule modulators of protein-protein interactions: selected case studies
Aeluri, M., Chamakuri, S., Dasari, B., Guduru, S. K. R., Jimmidi, R., Jogula, S., & Arya, P. (2014) · Chemical Reviews · doi:10.1021/cr4004049 · Cited by 79
Najar, B., Shortrede, J. E., Pistelli, L., & Buhagiar, J. (2020) · Chemistry & Biodiversity · doi:10.1002/cbdv.201900478 · Cited by 76
Panagopoulos, D., Karabarbounis, A., Yakymenko, I., & Chrousos, G. (2021) · International Journal of Oncology · doi:10.3892/ijo.2021.5272 · Cited by 73
Comparing Pearson, Spearman and Hoeffding’s D measure for gene expression association analysis
FUJITA, A., SATO, J. R., DEMASI, M. A. A., SOGAYAR, M. C., FERREIRA, C. E., & MIYANO, S. (2009) · Journal of Bioinformatics and Computational Biology · doi:10.1142/s0219720009004230 · Cited by 64
Hot water extract of Chlorella vulgaris induced DNA damage and apoptosis
Yusof, Y. A. M., Md. Saad, S., Makpol, S., Shamaan, N. A., & Ngah, W. Z. W. (2010) · Clinics · doi:10.1590/s1807-59322010001200023 · Cited by 62
Zimmerman, M. A., Huang, Q., Li, F., Liu, X., & Li, C.-Y. (2013) · Seminars in Radiation Oncology · doi:10.1016/j.semradonc.2013.05.003 · Cited by 59
Omoruyi, S. I., Ekpo, O. E., Semenya, D. M., Jardine, A., & Prince, S. (2020) · Apoptosis · doi:10.1007/s10495-020-01594-5 · Cited by 53
Liu, Z., Liu, H., Yuan, X., Wang, Y., Li, L., Wang, G., Song, J., Shao, Z., & Fu, R. (2018) · Oncology Letters · doi:10.3892/ol.2018.7865 · Cited by 19
Metadata
- Authors
- Lowe, S. W., & Lin, A. W.
- Venue
- Carcinogenesis
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-03
- Volume
- 21
- Issue
- 3
- Pages
- 485-495
- ISSN
- 0143-3334 (ISSN-L)
- 1460-2180
- OpenAlex
- W2170507464
- Cited by
- 1,876
- References
- 16
- FWCI
- 20.16
- Type
- journal article
- Language
- en
- Open access
- closed
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