The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Activation of the Human Orbitofrontal Cortex to a Liquid Food Stimulus is Correlated with its Subjective Pleasantness
Abstract
Single-neuron recording studies in non-human primates indicate that orbitofrontal cortex neurons represent the reward value of the sight, smell and taste of food, and even changes in the relative reward value, but provide no direct evidence on brain activity that is correlated with subjective reports of the pleasantness of food. In this fMRI investigation we report a significant correlation between the activation of a region of the human orbitofrontal cortex and the decrease in subjective pleasantness when a liquid food is eaten to satiety. Moreover, a cluster of voxels in the orbitofrontal cortex showed a decrease in its activation that was specific to the particular liquid food consumed in a meal, providing a neural correlate of sensory-specific satiety to a liquid whole food in humans. This sensory-specific reduction in activation of the orbitofrontal cortex correlating with subjective pleasantness is consistent with an important role for the orbitofrontal cortex in human emotion and motivation, and associated subjective states.
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“Watson and colleagues [334] outlined a framework delineating linkages between AN and reward-processing deficits. Their model stressed the highly social nature of eating, the overlapping reward circuitry of gustatory and social stimuli [335,336], and the tendency of individuals with AN to deprive themselves of pleasure.”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [335]
In the citing paper
“Similarly, subjective pleasantness in humans was coded by neural activity in the medial orbitofrontal cortex as measured by functional MRI (fMRI) and was subject to sensory-specific satiety, a form of reinforcer devaluation”
From Food reward, hyperphagia, and obesity (2011) · cites this paper as [100]
In the citing paper
“Diminished activity in the OFC has been found after a specific food item has been eaten to satiety, thereby decreasing its hedonic value and subjective pleasantness [25,26].”
From Social “wanting” dysfunction in autism: neurobiological underpinnings and treatment implications (2012) · cites this paper as [25]
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Metadata
- Authors
- Kringelbach, M. L.
- Affiliations
- University of Oxford (GB)
- Corresponding author
- Kringelbach, M.L.
- ORCID
- Kringelbach, M.L.
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-10-01
- Volume
- 13
- Issue
- 10
- Pages
- 1064-1071
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- OpenAlex
- W1998712051
- Cited by
- 824
- References
- 46
- Citations by year
- 2026: 9 · 2025: 14 · 2024: 20 · 2023: 33 · 2022: 25 · 2021: 33 · 2020: 26 · 2019: 35 · 2018: 27 · 2017: 36 · 2016: 46 · 2015: 51 · 2014: 44 · 2013: 46 · 2012: 57
- FWCI
- 12.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cerebral Cortex (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- orbitofrontal cortex, sensory-specific satiety, food pleasantness, liquid foods, satiety, reward value, emotion and motivation
- MeSH terms
- Adult, Analysis of Variance, Brain Mapping, Feeding Behavior, Frontal Lobe, Humans, Male, Satiation, Smell, Taste, Visual Cortex
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