Phenol-Explorer 2.0: a major update of the Phenol-Explorer database integrating data on polyphenol metabolism and pharmacokinetics in humans and experimental animals
Open accessAbstract
Phenol-Explorer, launched in 2009, is the only comprehensive web-based database on the content in foods of polyphenols, a major class of food bioactives that receive considerable attention due to their role in the prevention of diseases. Polyphenols are rarely absorbed and excreted in their ingested forms, but extensively metabolized in the body, and until now, no database has allowed the recall of identities and concentrations of polyphenol metabolites in biofluids after the consumption of polyphenol-rich sources. Knowledge of these metabolites is essential in the planning of experiments whose aim is to elucidate the effects of polyphenols on health. Release 2.0 is the first major update of the database, allowing the rapid retrieval of data on the biotransformations and pharmacokinetics of dietary polyphenols. Data on 375 polyphenol metabolites identified in urine and plasma were collected from 236 peer-reviewed publications on polyphenol metabolism in humans and experimental animals and added to the database by means of an extended relational design. Pharmacokinetic parameters have been collected and can be retrieved in both tabular and graphical form. The web interface has been enhanced and now allows the filtering of information according to various criteria. Phenol-Explorer 2.0, which will be periodically updated, should prove to be an even more useful and capable resource for polyphenol scientists because bioactivities and health effects of polyphenols are dependent on the nature and concentrations of metabolites reaching the target tissues. The Phenol-Explorer database is publicly available and can be found online at http://www.phenol-explorer.eu. Database URL: http://www.phenol-explorer.eu.
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For polyphenols, more than 230 phase I/II metabolites have been identified and associated with consumption of specific polyphenol-containing foods.
“For polyphenols, .230phase I/II metabolites have been identified and associated with the consumption of specific polyphenol-containing foods (70).”
From The food metabolome: a window over dietary exposure (2014) · cites this paper as [70]
Phenol-Explorer is an exception, providing a comprehensive overview of human and animal metabolites formed from polyphenols.
“One exception is Phenol-Explorer, which gives a comprehensive overview of the human and animal metabolites formed from polyphenols (70).”
From The food metabolome: a window over dietary exposure (2014) · cites this paper as [70]
Databases specific to the food metabolome are still largely missing, except for Phenol-Explorer, a database of all known polyphenol metabolites.
“Databases specific for the food metabolome are still largely missing apart from Phenol-Explorer, a database on all known polyphenol metabolites (70).”
From The food metabolome: a window over dietary exposure (2014) · cites this paper as [70]
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- Authors
- Rothwell, J. A., Urpi-Sarda, M., Boto-Ordonez, M., Knox, C., Llorach, R., Eisner, R., Cruz, J., Neveu, V., Wishart, D., Manach, C., Andres-Lacueva, C., & Scalbert, A.
- Affiliations
- Unité de Nutrition Humaine (FR)
- University of Alberta (CA)
- Corresponding author
- Scalbert, A.
- Venue
- Database
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-08-09
- Volume
- 2012
- Issue
- 0
- Pages
- bas031-bas031
- ISSN
- 1758-0463 (ISSN-L)
- PMC
- PMC3414821
- OpenAlex
- W2105772474
- Cited by
- 188
- References
- 20
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 11 · 2023: 16 · 2022: 14 · 2021: 14 · 2020: 11 · 2019: 22 · 2018: 10 · 2017: 12 · 2016: 10 · 2015: 15 · 2014: 21 · 2013: 16
- FWCI
- 11.67
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- Database (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- HAL (acceptedVersion, cc-by-nc)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (acceptedVersion, cc-by)
- RECERCAT (Consorci de Serveis Universitaris de Catalunya) (acceptedVersion, other-oa)
- Rovira & Virgili repository (submittedVersion, cc-by)
- Funders
- Danone
- University of Alberta
- Ministerio de Ciencia e Innovación (CSD2007-063, AGL-2009-13906- C02)
- Institut National Du Cancer (2011-105, INCa 2011-105)
- Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición
- Instituto de Salud Carlos III
- European Social Fund
- Topics
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Nursing › Nutrition and Dietetics › Pomegranate: compositions and health benefits
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Keywords
- polyphenols, polyphenol metabolism, pharmacokinetics, polyphenol metabolites, dietary polyphenols, dietary bioactive compounds, urine, plasma, biotransformation, relational database design, online databases
- MeSH terms
- Animals, Food Analysis, Humans, Software, Internet, Polyphenols, Databases, Chemical
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