Evolutionary genomics of yeast pathogens in the Saccharomycotina
Open accessAbstract
Saccharomycotina comprises a diverse group of yeasts that includes numerous species of industrial or clinical relevance. Opportunistic pathogens within this clade are often assigned to the genus Candida but belong to phylogenetically distant lineages that also comprise non-pathogenic species. This indicates that the ability to infect humans has evolved independently several times among Saccharomycotina. Although the mechanisms of infection of the main groups of Candida pathogens are starting to be unveiled, we still lack sufficient understanding of the evolutionary paths that led to a virulent phenotype in each of the pathogenic lineages. Deciphering what genomic changes underlie the evolutionary emergence of a virulence trait will not only aid the discovery of novel virulence mechanisms but it will also provide valuable information to understand how new pathogens emerge, and what clades may pose a future danger. Here we review recent comparative genomics efforts that have revealed possible evolutionary paths to pathogenesis in different lineages, focusing on the main three agents of candidiasis worldwide: Candida albicans, C. parapsilosis and C. glabrata We will discuss what genomic traits may facilitate the emergence of virulence, and focus on two different genome evolution mechanisms able to generate drastic phenotypic changes and which have been associated to the emergence of virulence: gene family expansion and interspecies hybridization.
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The four most common Candida species can account for more than 80% of candidemia cases, and over 30 Candida species have been identified as candidemia agents.
“although the four most common Candida (C. albicans, C. glabrata, C. parapsilosis, and C. tropicalis) can account for more than 80% of the cases, there is a long list with over 30 Candida that have been identified as candidemia agents [9]”
From Evolutionary Emergence of Drug Resistance in Candida Opportunistic Pathogens (2018) · cites this paper as [9]
Candida opportunistic pathogens belong to distinct lineages that are interspersed with non-pathogenic relatives.
“When highlighted on a phylogenetic tree, Candida opportunistic pathogens belong to distinct lineages, which are interspersed with non-pathogenic relatives [9].”
From Evolutionary Emergence of Drug Resistance in Candida Opportunistic Pathogens (2018) · cites this paper as [9]
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Self-citation
- Authors
- Gabaldón, T., Naranjo-Ortíz, M. A., & Marcet-Houben, M.
- Affiliations
- Institució Catalana de Recerca i Estudis Avançats (ES)
- Universitat Pompeu Fabra (ES)
- Corresponding author
- Gabaldón, Toni
- Venue
- FEMS Yeast Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-08-03
- Volume
- 16
- Issue
- 6
- Pages
- fow064
- ISSN
- 1567-1356 (ISSN-L)
- 1567-1364
- PMC
- PMC5815160
- OpenAlex
- W2488745281
- Cited by
- 105
- References
- 64
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 11 · 2023: 16 · 2022: 4 · 2021: 17 · 2020: 10 · 2019: 13 · 2018: 11 · 2017: 7
- FWCI
- 0.93
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- FEMS Yeast Research (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- RECERCAT (Consorci de Serveis Universitaris de Catalunya) (publishedVersion, other-oa)
- Repositori digital de la UPF (Universitat Pompeu Fabra) (publishedVersion, cc-by-nc)
- HighWire Press Open Archive (submittedVersion)
- Funders
- European Commission (H2020-MSCA-ITN, H2020-MSCA-ITN-2014, 2007–2013, FP7 2007-2013, 642095, FP7-PEOPLE-2013, FP7/2007, FP7‐PEOPLE‐ 2013‐ITN, 606786, H2020-MSCA)
- Ministerio de Economía y Competitividad (642095, SEV‐2012‐0208, BIO2012-37161)
- Horizon 2020 Framework Programme (MSCA-ITN-2014, FP7/2007-2013, H2020MSCA‐ITN‐2014, H2020-MSCA, H2020-MSCA-ITN-2014-642095, 642095, H2020-MSCA-ITN)
- Agència de Gestió d'Ajuts Universitaris i de Recerca (SGR857)
- European Regional Development Fund (H2020-MSCA-ITN-2014, FP7/2007‐2013, 2007 – 2013)
- FP7 People: Marie-Curie Actions (FP7-PEOPLE-2013-ITN-606786, 2007-2013, 2013‐ITN‐606786, FP7-PEOPLE-2013-ITN, FP7/2007‐2013/, FP7-PEOPLE-2013)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Keywords
- Saccharomycotina, pathogenic yeasts, Candida, candidiasis, virulence evolution, Candida albicans, Candida parapsilosis, Candida glabrata, comparative genomics, gene family expansion, interspecific hybridization, genome evolution, opportunistic pathogens
- MeSH terms
- Ascomycota, Evolution, Molecular, Genomics, Virulence Factors
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