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Cited by 122

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Evidence for Down-Regulation of Phosphoinositide 3-Kinase/Akt/Mammalian Target of Rapamycin (PI3K/Akt/mTOR)-Dependent Translation Regulatory Signaling Pathways in Ames Dwarf Mice

Sharp, Z. D., Bartke, A.·2005·The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
DOI 10.1093/gerona/60.3.293
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Abstract

How growth hormone (GH) stimulates protein synthesis is unknown. Phosphoinositide 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathways balance anabolic and catabolic activities in response to nutrients and growth factor signaling. As a test of GH signaling, immunoassays of two downstream translation regulatory proteins were compared in ad libitum-fed 2-month-old normal and Ames (Prop1df) dwarf mice. Phosphorylation of the p70 and p85 isoforms of S6 kinase 1 in liver and the p70 isoform in gastrocnemius muscle were significantly decreased in dwarfs. Messenger RNA (mRNA) Cap-binding demonstrated significantly higher levels of translation repressor 4E-BP1/eukaryotic initiation factor 4E (eIF4E) (coprecipitates) from dwarf livers, but not muscle. Consistent with these binding data, significantly less phosphorylation of 4E-BP1 was documented in dwarf liver. These data suggest a link between GH signaling and translation control in a model of extended longevity.

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  • Beneficial effects of diet restriction and dwarf mutations may to some degree result from repression of the mTORC1 pathway.

    “Beneficial effects of diet restriction (DR)21 and dwarf mutations, both of which extend lifespan in rodents, may to some degree result from repression of the mTOR complex 1 (mTORC1) pathway22,23.”

    From Rapamycin fed late in life extends lifespan in genetically heterogeneous mice (2009) · cites this paper as [22]

  • mTORC1 signaling is lower in long-lived Ames dwarf mice than in wild-type controls.

    “mTORC1 signaling was also observed to be lower in long-lived Ames dwarf mice than in wild-type controls 12.”

    From Targeting the biology of aging with mTOR inhibitors (2023) · cites this paper as [12]

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Metadata

Authors
Sharp, Z. D., & Bartke, A.
Venue
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
Publisher
Oxford University Press (OUP)
Published
2005-03-01
Volume
60
Issue
3
Pages
293-300
ISSN
  • 1079-5006
  • 1758-535X
DOI
10.1093/gerona/60.3.293
Cited by
122
References
6
Language
en

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