Assessment of Growth Parameters and Life Span of GHR/BP Gene-Disrupted Mice 1

Coschigano, Karen T.; Clemmons, David; Bellush, Linda L.; Kopchick, John J.

doi:10.1210/endo.141.7.7586

Cited by 611Growth Hormone and Insulin-like Growth FactorsGenetics, Aging, and Longevity in Model OrganismsHypothalamic control of reproductive hormones

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

Assessment of Growth Parameters and Life Span of GHR/BP Gene-Disrupted Mice 1

Coschigano, Karen T., Clemmons, David, Bellush, Linda L., Kopchick, John J.·2000·Endocrinology

DOI 10.1210/endo.141.7.7586

Open this paper in CoChat — free account

Abstract

GH has many biological roles, including promotion of growth. Most, if not all, of its roles are achieved through interaction with its receptor. We chose to study the effects of loss of GH signaling on growth and aging in a mouse model for Laron Syndrome (LS) in which the GHR/BP gene has been disrupted. We observed that mice homozygous for the disruption (-/-) were significantly smaller than normal wild-type (+/+) mice as well as mice heterozygous for the disruption, even at 1.5 yr of age. IGF-I levels were also significantly lower in the -/- mice and remained low as the mice aged. IGFBP-3 levels were severely reduced in the -/- mice, whereas IGFBP-1, -2, and -4 levels remained unchanged. Finally, the -/- mice lived significantly longer than +/+ and +/- mice. The latter result contradicts the anti-aging GH data and suggests the need for further analysis of GH and aging.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1210/endo.141.7.7586

Cites

35 of 35 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Mutations that decrease IGF1 levels or activity cause reduced growth and longer life in mice by up to 65%.
“Mutations that decrease IGF1 levels or activity cause reduced growth and longer life in mice by up to 65% (Coschigano et al., 2000; Holzenberger et al., 2003).”
From The Search for Antiaging Interventions: From Elixirs to Fasting Regimens (2014) · cites this paper as Coschigano et al., 2000

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans
Kimura, K. D., Tissenbaum, H. A., Liu, Y., & Ruvkun, G. (1997) · Science · doi:10.1126/science.277.5328.942 · Cited by 2,250
Insulin-Like Growth Factors I and II. Peptide, Messenger Ribonucleic Acid and Gene Structures, Serum, and Tissue Concentrations*
Daughaday, W. H., & Rotwein, P. S. (1989) · Endocrine Reviews · doi:10.1210/edrv-10-1-68 · Cited by 1,718
The p66shc adaptor protein controls oxidative stress response and life span in mammals
Migliaccio, E., Giorgio, M., Mele, S., Pelicci, G., Reboldi, P., Pandolfi, P. P., Lanfrancone, L., & Pelicci, P. G. (1999) · Nature · doi:10.1038/46311 · Cited by 1,712
Analysis of serum insulin-like growth factor binding proteins using Western blotting: Use of the method for titration of the binding proteins and competitive binding studies
Hossenlopp, P., Seurin, D., Segovia, B., Hardouin, S., & Binoux, M. (1986) · Analytical Biochemistry · doi:10.1016/0003-2697(86)90507-5 · Cited by 1,143
Dimerization of the Extracellular Domain of the Human Growth Hormone Receptor by a Single Hormone Molecule
Cunningham, B. C., Ultsch, M. H., de Vos, A. M., Mulkerrin, M. G., Clauser, K. R., & Wells, J. A. (1991) · Science · doi:10.1126/science.1948064 · Cited by 873
A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse)
Zhou, Y., Xu, B. C., Maheshwari, H., He, L., Reed, M. A., Lozykowski, M. G., Okada, S., Cataldo, L. R., Coschigamo, K., Wagner, T. E., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.24.13215 · Cited by 802
Self-citation
Characterization of the human growth hormone receptor gene and demonstration of a partial gene deletion in two patients with Laron-type dwarfism.
Godowski, P. J., Leung, D. W., Meacham, L. R., GALGANI, J. P., Hellmiss, R., Keret, R., Rotwein, P. S., Parks, J. S., Laron, Z., & Wood, W. I. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.20.8083 · Cited by 604
Mechanism of the Stimulatory Effect of Growth Hormone on Longitudinal Bone Growth*
Isaksson, O. G. P., Lindahl, A. H., NILSSON, A., & Isgaard, J. (1987) · Endocrine Reviews · doi:10.1210/edrv-8-4-426 · Cited by 579
The growth hormone-binding protein in rat serum is an alternatively spliced form of the rat growth hormone receptor.Preprint
Baumbach, W. R., Horner, D. L., & Logan, J. S. (1989) · Genes & Development · doi:10.1101/gad.3.8.1199 · Cited by 399
Human Growth Hormone
Thomas, M. J., & Thomas, J. A. (1988) · Springer eBooks · doi:10.1007/978-1-4684-5499-4_13 · Cited by 298
Mechanism of signaling by growth hormone receptor
Argetsinger, L. S., & Carter‐Su, C. (1996) · Physiological Reviews · doi:10.1152/physrev.1996.76.4.1089 · Cited by 271
The Growth Hormone/Prolactin Receptor Family
Kelly, P. A., Ali, S., Rozakis, M., Goujon, L., Nagano, M. C., Pellegrini, I., GOULD, D., Djiane, J., Edery, M., Finidori, J., et al. (1993) · Elsevier eBooks · doi:10.1016/b978-0-12-571148-7.50009-9 · Cited by 222
Expression of a mutated bovine growth hormone gene suppresses growth of transgenic mice.
Chen, W. Y., Wight, D. C., Wagner, T. E., & Kopchick, J. J. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.13.5061 · Cited by 198
Self-citation
Growth hormone deficiency in 'little' mice results in aberrant body composition, reduced insulin-like growth factor-I and insulin-like growth factor-binding protein-3 (IGFBP-3), but does not affect IGFBP-2, -1 or -4
Donahue, L. R., & Beamer, W. G. (1993) · Journal of Endocrinology · doi:10.1677/joe.0.1360091 · Cited by 169
Glycine 119 of Bovine Growth Hormone is Critical for Growth-Promoting Activity
Chen, W. Y., Wight, D. C., Mehta, B. V., Wagner, T. E., & Kopchick, J. J. (1991) · Molecular Endocrinology · doi:10.1210/mend-5-12-1845 · Cited by 165
Self-citation
Pituitary and Testicular Function in Growth Hormone Receptor Gene Knockout Mice
Chandrashekar, V., Bartke, A., Coschigano, K. T., & Kopchick, J. J. (1999) · Endocrinology · doi:10.1210/endo.140.3.6557 · Cited by 163
Self-citation
Functional Antagonism between Endogenous Mouse Growth Hormone (GH) and a GH Analog Results in Dwarf Transgenic Mice*
Chen, W. Y., White, M. E., Wagner, T. E., et al. (1991) · Endocrinology · doi:10.1210/endo-129-3-1402 · Cited by 156
Deficits in Female Reproductive Function in GH-R-KO Mice; Role of IGF-I
Danilovich, N., Wernsing, D. R., Coschigano, K. T., Kopchick, J. J., & Bartke, A. (1999) · Endocrinology · doi:10.1210/endo.140.6.6992 · Cited by 156
Self-citation
In vitro and in vivo studies of antagonistic effects of human growth hormone analogs.
Chen, W. Y., Chen, N. Y., Yun, J., et al. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)40764-2 · Cited by 147
Evidence for generation of the growth hormone-binding protein through proteolysis of the growth hormone membrane receptor.
Sotiropoulos, A., Goujon, L., Simonin, G., et al. (1993) · Endocrinology · doi:10.1210/endo.132.4.8462483 · Cited by 145
Does growth hormone prevent or accelerate aging?
Bartke, A., Brown‐Borg, H. M., Bode, A. M., Carlson, J. C., Hunter, W. S., & Bronson, R. T. (1998) · Experimental Gerontology · doi:10.1016/s0531-5565(98)00032-1 · Cited by 119
TRANSGENIC MODELS OF GROWTH HORMONE ACTION
Kopchick, J. J., Bellush, L. L., & Coschigano, K. T. (1999) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.19.1.437 · Cited by 117
Self-citation
The "Little People" of the Island of Krk - Revisited. Etiology of Hypopituitarism Revealed
Kržišnik, C., Kolacio, Z., Battelino, T., Brown, M., Parks, J. S., & Laron, Z. (1999) · International Journal on Disability and Human Development · doi:10.1515/ijdhd.1999.1.1.9 · Cited by 116
Effects of streptozotocin treatment in growth hormone (GH) and GH antagonist transgenic mice
Chen, N. Y., Chen, W. Y., Bellush, L. L., Yang, C., Striker, L. J., Striker, G. E., & Kopchick, J. J. (1995) · Endocrinology · doi:10.1210/endo.136.2.7835300 · Cited by 102
Self-citation
Cellular mechanisms in the processing of growth hormone and its receptor
Roupas, P., & Herington, A. C. (1989) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(89)90184-6 · Cited by 98
Protection against Diabetes-Induced Nephropathy in Growth Hormone Receptor/Binding Protein Gene-Disrupted Mice1
Bellush, L. L., Doublier, S., Holland, A. N., et al. (2000) · Endocrinology · doi:10.1210/endo.141.1.7284 · Cited by 84
Self-citation
Regulation of Insulin-Like Growth Factor (IGF) Binding Proteins in Transgenic Mice with Altered Expression of Growth Hormone and IGF-I
Camacho‐Hübner, C., Clemmons, D. R., & D’Ercole, A. J. (1991) · Endocrinology · doi:10.1210/endo-129-3-1201 · Cited by 80
Self-citation
Growth Hormone Stimulates the Tyrosine Kinase Activity of JAK2 and Induces Tyrosine Phosphorylation of Insulin Receptor Substrates and Shc in Rat Tissues**This work was supported by Fundacao de Amparo a Pesquisa do Estado de Sao Paulo and Conselho Nacional de Pesquisa (PRONEX).
Thirone, A. C. P., Carvalho, C. R. D. O., & Saad, M. J. A. (1999) · Endocrinology · doi:10.1210/endo.140.1.6417 · Cited by 63
Growth Hormone Binding Proteins and Various Forms of Growth Hormone: Implications for Measurements
BAUMANN, G. (1990) · Acta Paediatrica · doi:10.1111/j.1651-2227.1990.tb11677.x · Cited by 52
Growth Hormone Receptors ‐ their Structure, Location and Role
Waters, M. J., Barnard, R. T., Lobie, P., et al. (1990) · Acta Paediatrica · doi:10.1111/j.1651-2227.1990.tb11600.x · Cited by 48
Mouse growth hormone-binding protein and growth hormone receptor transcripts are produced from a single gene by alternative splicing.
Edens, A., Southard, J. N., & Talamantes, F. J. (1994) · Endocrinology · doi:10.1210/endo.135.6.7988474 · Cited by 43
Insulin Exposure and Aging Theory
Parr, T. B. (2009) · Gerontology · doi:10.1159/000213848 · Cited by 40
The GH Receptor and Signal Transduction
Kelly, P. A., Goujon, L., Sotiropoulos, A., et al. (2008) · Hormone Research · doi:10.1159/000184185 · Cited by 39
Does the serum binding protein for growth hormone have a functional role?
Herington, A. C., Ymer, S. I., & Tiong, T. S. (1991) · PubMed · Cited by 20
The Growth Hormone Receptor and Growth Hormone-Binding Protein: Structure, Functions, and Regulation
Cramer, S. D., & Talamantes, F. J. (1993) · Elsevier eBooks · doi:10.1016/b978-0-12-629055-4.50009-x · Cited by 8

Flagged first, then by citations

Sorted by citations

IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
Holzenberger, M., Dupont, J., Ducos, B., Leneuve, P., Géloën, A., Even, P. C., Cervera, P., & Le Bouc, Y. (2003) · Nature · doi:10.1038/nature01298 · Cited by 2,109
Ink4a/Arf expression is a biomarker of aging
Krishnamurthy, J., Torrice, C., Ramsey, M. R., Kovalev, G. I., Al-Regaiey, K., Su, L., & Sharpless, N. E. (2004) · Journal of Clinical Investigation · doi:10.1172/jci22475 · Cited by 1,486
Extension of Chronological Life Span in Yeast by Decreased TOR Pathway Signaling
Powers, R. W., Kaeberlein, M., Caldwell, S. D., Kennedy, B. K., & Fields, S. (2006) · Genes & Development · doi:10.1101/gad.1381406 · Cited by 982
Body size, energy metabolism and lifespan
Speakman, J. R. (2005) · Journal of Experimental Biology · doi:10.1242/jeb.01556 · Cited by 914
Molecular mechanisms of dietary restriction promoting health and longevity
Green, C. L., Lamming, D. W., & Fontana, L. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00411-4 · Cited by 714
Evolutionary medicine: from dwarf model systems to healthy centenarians?
Longo, V. D., & Finch, C. E. (2003) · Science · doi:10.1126/science.1077991 · Cited by 575
The GH/IGF-1 axis in ageing and longevity
Junnila, R. K., List, E. O., Berryman, D. E., Murrey, J. W., & Kopchick, J. J. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.67 · Cited by 574
Self-citation
Evidence for lifespan extension and delayed age–related biomarkers in insulin receptor substrate 1 null mice
Selman, C., Lingard, S., Choudhury, A. I., Batterham, R. L., Claret, M., Clements, M., Ramadani, F., Okkenhaug, K., Schuster, E., Blanc, E., et al. (2008) · The FASEB Journal · doi:10.1096/fj.07-9261com · Cited by 532
Deletion, But Not Antagonism, of the Mouse Growth Hormone Receptor Results in Severely Decreased Body Weights, Insulin, and Insulin-Like Growth Factor I Levels and Increased Life Span
Coschigano, K. T., Holland, A. N., Riders, M. E., List, E. O., Flyvbjerg, A., & Kopchick, J. J. (2003) · Endocrinology · doi:10.1210/en.2003-0374 · Cited by 510
Self-citation
Insulin/IGF-I-signaling pathway: an evolutionarily conserved mechanism of longevity from yeast to humans
Barbieri, M., Bonafè, M., Franceschi, C., & Paolisso, G. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00296.2003 · Cited by 456
The Genetics of Aging
Finch, C. E., & Ruvkun, G. (2001) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.2.1.435 · Cited by 446
Extending the Lifespan of Long-Lived Mice
Bartke, A., Wright, J. C., Mattison, J. A., Ingram, D. K., Miller, R. A., & Roth, G. S. (2001) · Nature · doi:10.1038/35106646 · Cited by 422
The starvation hormone, fibroblast growth factor-21, extends lifespan in mice
Zhang, Y., Xie, Y., Berglund, E. D., Coate, K. C., He, T. T., Katafuchi, T., Xiao, G., Potthoff, M. J., Wei, W., Wan, Y., et al. (2012) · eLife · doi:10.7554/elife.00065 · Cited by 420
Calorie restriction and cancer prevention: metabolic and molecular mechanisms
Longo, V. D., & Fontana, L. (2010) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2009.11.004 · Cited by 378
DNA damage and ageing: new-age ideas for an age-old problem
Garinis, G. A., van der Horst, G. T. J., Vijg, J., & H.J. Hoeijmakers, J. (2008) · Nature Cell Biology · doi:10.1038/ncb1108-1241 · Cited by 366
Endocrine regulation of ageing
Russell, S. J., & Kahn, C. R. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2234 · Cited by 356
The Search for Antiaging Interventions: From Elixirs to Fasting Regimens
de Cabo, R., Carmona-Gutierrez, D., Bernier, M., Hall, M. N., & Madeo, F. (2014) · Cell · doi:10.1016/j.cell.2014.05.031 · Cited by 345
Mechanisms of disease: metabolic effects of growth hormone and insulin-like growth factor 1
LeRoith, D., & Yakar, S. (2007) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0427 · Cited by 344
The Growth Hormone Receptor: Mechanism of Receptor Activation, Cell Signaling, and Physiological Aspects
Dehkhoda, F., Lee, C. M. M., Medina, J., & Brooks, A. J. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00035 · Cited by 304
Calorie restriction and prevention of age‐associated chronic disease
Omodei, D., & Fontana, L. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.03.015 · Cited by 293
Insulin/IGF-like signalling, the central nervous system and aging
Broughton, S., & Partridge, L. (2009) · Biochemical Journal · doi:10.1042/bj20082102 · Cited by 228
The World Goes Bats: Living Longer and Tolerating Viruses
Gorbunova, V., Seluanov, A., & Kennedy, B. K. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.06.013 · Cited by 162
Identification and Application of Gene Expression Signatures Associated with Lifespan Extension
Tyshkovskiy, A., Bozaykut, P., Borodinova, A. A., Gerashchenko, M. V., Ables, G. P., Garratt, M., Khaitovich, P., Clish, C. B., Miller, R. A., & Gladyshev, V. N. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.06.018 · Cited by 167
ROLE of IGF-1 System in the Modulation of Longevity: Controversies and New Insights From a Centenarians’ Perspective
Vitale, G., Pellegrino, G., Vollery, M., & Hofland, L. J. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00027 · Cited by 166
The retardation of aging by caloric restriction: its significance in the transgenic era
Barger, J. L., Walford, R. L., & Weindruch, R. (2003) · Experimental Gerontology · doi:10.1016/j.exger.2003.10.017 · Cited by 160
Tipping the metabolic scales towards increased longevity in mammals
Riera, C. E., & Dillin, A. (2015) · Nature Cell Biology · doi:10.1038/ncb3107 · Cited by 153
Sex- and age-specific differences in core body temperature of C57Bl/6 mice
Sanchez-Alavez, M., Alboni, S., & Conti, B. (2011) · AGE · doi:10.1007/s11357-010-9164-6 · Cited by 140
Mouse Models to Disentangle the Hallmarks of Human Aging
Folgueras, A. R., Freitas-Rodríguez, S., Velasco, G., & López-Otín, C. (2018) · Circulation Research · doi:10.1161/circresaha.118.312204 · Cited by 113
Lifespan extension in genetically modified mice
Ladiges, W., Van Remmen, H., Strong, R., Ikeno, Y., Treuting, P., Rabinovitch, P., & Richardson, A. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00491.x · Cited by 101
NEUROENDOCRINE AGING IN MEN
Anawalt, B. D., & Merriam, G. R. (2001) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(05)70206-1 · Cited by 93
Cell culture-based profiling across mammals reveals DNA repair and metabolism as determinants of species longevity
Ma, S., Upneja, A., Galecki, A., Tsai, Y.-M., Burant, C. F., Raskind, S., Zhang, Q., Zhang, Z. D., Seluanov, A., Gorbunova, V., et al. (2016) · eLife · doi:10.7554/elife.19130 · Cited by 89
The GH-IGF1 axis and longevity: the paradigm of IGF1 deficiency
Laron, Z. (2008) · HORMONES · doi:10.14310/horm.2002.1111034 · Cited by 80
Growth hormone receptor gene disruption in mature-adult mice improves male insulin sensitivity and extends female lifespan
Duran‐Ortiz, S., List, E. O., Ikeno, Y., Young, J., Basu, R., Bell, S., McHugh, T., Funk, K., Mathes, S., Qian, Y., et al. (2021) · Aging Cell · doi:10.1111/acel.13506 · Cited by 58
Open-minded scepticism: inferring the causal mechanisms of human ageing from genetic perturbations
de Magalhães, J. P. (2005) · Ageing Research Reviews · doi:10.1016/j.arr.2004.05.003 · Cited by 54
Expression of oxidative phosphorylation components in mitochondria of long-living Ames dwarf mice
Brown-Borg, H. M., Johnson, W. T., & Rakoczy, S. G. (2012) · AGE · doi:10.1007/s11357-011-9212-x · Cited by 52
Bring Back the Rat!
Carter, C. S., Richardson, A., Huffman, D. M., & Austad, S. (2020) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glz298 · Cited by 51
GH Does Not Modulate the Early Fasting-Induced Release of Free Fatty Acids in Mice
Steyn, F. J., Leong, J. W., Huang, L., Tan, H. Y., Xie, T. Y., Nelson, C., Waters, M. J., Veldhuis, J. D., Epelbaum, J., & Chen, C. (2012) · Endocrinology · doi:10.1210/en.2011-1681 · Cited by 44
The Influence of Metformin on IGF-1 Levels in Humans: A Systematic Review and Meta-Analysis
Yang, X., Kord-Varkaneh, H., Talaei, S., Clark, C. C. T., Zanghelini, F., Tan, S. C., Zarezadeh, M., Mousavi, S. M., Rahmani, J., & Zhang, Y. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2019.104588 · Cited by 43
The Geroscience Hypothesis: Is It Possible to Change the Rate of Aging?
Austad, S. N. (2016) · Advances in Geroscience · doi:10.1007/978-3-319-23246-1_1 · Cited by 43
Impairment of insulin signalling in peripheral tissue fails to extend murine lifespan
Merry, T. L., Kuhlow, D., Laube, B., Pöhlmann, D., Pfeiffer, A. F. H., Kahn, C. R., Ristow, M., & Zarse, K. (2017) · Aging Cell · doi:10.1111/acel.12610 · Cited by 30

The Research on Avian Growth Hormone Receptor Gene
Chen, Q. (2009) · Journal of Jinling Institute of Technology
A novel phenotype for Laron dwarfism in miniature Bos indicus cattle suggests that the expression of growth hormone receptor 1A in liver is required for normal growth☆
Liu, J., Boyd, C. K., Kobayashi, Y., et al. (1999) · Domestic Animal Endocrinology · doi:10.1016/s0739-7240(99)00051-x · Cited by 29
The Research Progress of Growth Hormone Receptor Gene Expression
Li, Q. (2010) · China Animal Husbandry & Veterinary Medicine
Growth hormone receptor-deficient pigs resemble the pathophysiology of human Laron syndrome and reveal altered activation of signaling cascades in the liver
Hinrichs, A., Kessler, B., Kurome, M., Blutke, A., Kemter, E., Bernau, M., Scholz, A. M., Rathkolb, B., Renner, S., Bultmann, S., et al. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.03.006 · Cited by 96
Expression of two variants of growth hormone receptor messenger ribonucleic acid in porcine liver.
Liu, J., Carroll, J. A., Matteri, R. L., et al. (2000) · Journal of Animal Science · doi:10.2527/2000.782306x · Cited by 9

Authors: Coschigano, K. T., Clemmons, D., Bellush, L. L., & Kopchick, J. J.
Affiliations: Ohio University (US)
University of North Carolina at Chapel Hill (US)
Corresponding author: Kopchick, John J.
ORCID: Coschigano, Karen T.
Clemmons, David
Kopchick, John J.
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 2000-07
Volume: 141
Issue: 7
Pages: 2608-2613
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/endo.141.7.7586
OpenAlex: W2152185756
Cited by: 611
References: 35
Citations by year: 2026: 5 · 2025: 6 · 2024: 15 · 2023: 19 · 2022: 12 · 2021: 12 · 2020: 17 · 2019: 16 · 2018: 14 · 2017: 11 · 2016: 15 · 2015: 24 · 2014: 15 · 2013: 17 · 2012: 26
FWCI: 26.40
Type: journal article
Language: en
Open access: closed
Locations: Endocrinology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (AG02331)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords: growth hormone receptor, Laron syndrome, growth, aging, lifespan, insulin-like growth factor I, IGFBP-3, IGFBP-1, IGFBP-2, IGFBP-4, growth hormone signaling, dwarfism
MeSH terms: Aging, Animals, Carrier Proteins, Female, Heterozygote, Homozygote, Insulin-Like Growth Factor I, Longevity, Male, Mice, Inbred BALB C, Receptors, Somatotropin, Weight Gain, Gene Deletion, Insulin-Like Growth Factor Binding Protein 3, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Assessment of Growth Parameters and Life Span of GHR/BP Gene-Disrupted Mice 1

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks