Cited by 177Nutrition and Health in AgingMuscle Physiology and DisordersBody Composition Measurement Techniques

Physical Activity and Sarcopenic Obesity: Definition, Assessment, Prevalence and Mechanism

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Lee, Duck-chul, Shook, Robin P, Drenowatz, Clemens, Blair, Steven N·2016·Future Science OA

Abstract

Sarcopenic obesity is the coexistance of sarcopenia and obesity. Modern sarcopenia definition includes low muscle mass, weak muscle strength (handgrip strength) and poor physical function (slow walking), although the clinical definition of each varies worldwide. The cut-points for low muscle mass for men and women using appendicular lean mass divided by height (kg/m2) are ≤7.0 and ≤5.4 in Asians, and ≤7.23 and ≤5.67 in Caucasians, respectively. The cut-points for weak handgrip strength (kg) for men and women are <26 and <18 in Asians, and <30 and <20 in Caucasians, respectively. The cut-point for slow walking is ≤0.8 m/s in men and women. Current data suggest the potential benefits of physical activity and fitness on sarcopenic obesity in older adults.

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  • Recent evidence suggests the importance of leptin signalling, fibro-adipogenic precursor (FAP) cells, and mitochondrial dysfunction in increased myosteatosis or skeletal muscle fat infiltration.

    “While the biological mechanisms underlying increased myosteatosis or skeletal muscle fat infiltration are currently unclear, recent evidence suggest the importance of leptin signalling,[ 40 ] fibro‐adipogenic precursor (FAP) cells,[ 18 ] and mitochondrial dysfunction.[ 14 ]”

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Authors
Lee, D.-C., Shook, R. P., Drenowatz, C., & Blair, S. N.
Affiliations
  • University of South Carolina (US)
  • Iowa State University (US)
Corresponding author
Lee, Duck-chul
Venue
Future Science OA
Published
2016-07-14
Volume
2
Issue
3
Pages
FSO127-FSO127
ISSN
2056-5623 (ISSN-L)
OpenAlex
W2465023136
Cited by
177
References
93
Citations by year
2026: 9 · 2025: 17 · 2024: 21 · 2023: 23 · 2022: 23 · 2021: 20 · 2020: 18 · 2019: 18 · 2018: 22 · 2017: 6
FWCI
1.80
Type
journal article
Language
en
Open access
Locations
  • Future Science OA (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Iowa State University Digital Repository (Iowa State University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Health Sciences › Medicine › Physiology › Body Composition Measurement Techniques
Keywords
sarcopenic obesity, sarcopenia, obesity, physical activity, muscle mass, grip strength, walking speed, appendicular lean mass, older adults, prevalence

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