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Cited by 260Nutritional Studies and DietPhytochemicals and Antioxidant ActivitiesCardiovascular Health and Risk Factors

Low intake of fruits, berries and vegetables is associated with excess mortality in men: the Kuopio Ischaemic Heart Disease Risk Factor (KIHD) Study

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Rissanen, Tiina H., Voutilainen, Sari, Virtanen, Jyrki K., Venho, Birgitta, Vanharanta, Meri, Mursu, Jaakko, Salonen, Jukka T.·2003·The Journal of Nutrition
DOI 10.1093/jn/133.1.199
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Abstract

Diets rich in fruits and vegetables have been of interest because of their potential health benefits against chronic diseases such as cardiovascular disease (CVD) and cancer. The aim of this work was to assess the association of the dietary intake of a food group that includes fruits, berries and vegetables with all-cause, CVD-related and non-CVD-related mortality. The subjects were Finnish men aged 42-60 y examined in 1984-1989 in the prospective Kuopio Ischaemic Heart Disease Risk Factor (KIHD) Study. Dietary intakes were assessed by 4-d food intake record during the baseline phase of the KIHD Study. The risk of all-cause and non-CVD-related deaths was studied in 2641 men and the risk of CVD-related death in 1950 men who had no history of CVD at baseline. During a mean follow-up time of 12.8 y, cardiovascular as well as noncardiovascular and all-cause mortality were lower among men with the highest consumption of fruits, berries and vegetables. After adjustment for the major CVD risk factors, the relative risk for men in the highest fifth of fruit, berry and vegetable intake for all-cause death, CVD-related and non-CVD-related death was 0.66 [95% confidence interval (CI) 0.50-0.88], 0.59 (0.33-1.06), and 0.68 (0.46-1.00), respectively, compared with men in the lowest fifth. These data show that a high fruit, berry and vegetable intake is associated with reduced risk of mortality in middle-aged Finnish men. Consequently, the findings of this work indicate that diets that are rich in plant-derived foods can promote longevity.

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  • The Kuopio Ischemic Heart Disease Risk Factor Study showed a significantly lower risk of CVD-related deaths among 1,950 men in the highest quartile of berry intake (>408 g/day) versus men with the lowest intake (<133 g/day) during a mean follow-up of 12.8 years.

    “Data reported from the Kuopio Ischemic Heart Disease Risk Factor Study (KIHD) showed a significantly lower risk of CVD-related deaths among 1,950 men in the highest quartile of berry intake (>408 g/day) versus men with the lowest intake (<133 g/day) during a mean follow-up of 12.8 years.”

    From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [27]

  • In the KIHD study, a model adjusted for major CVD risk factors showed an inverse correlation between intakes of fruits, berries, and vegetables and serum haptoglobin.

    “These findings were based on a model adjusted for major CVD risk factors, which further showed an inverse correlation between intakes of fruits, berries, and vegetables and serum haptoglobin, a marker of inflammation.”

    From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [27]

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Authors
Rissanen, T. H., Voutilainen, S., Virtanen, J. K., Venho, B., Vanharanta, M., Mursu, J., & Salonen, J. T.
Affiliations
University of Eastern Finland (FI)
Corresponding author
Salonen, Jukka T.
ORCID
Venue
The Journal of Nutrition
Publisher
Elsevier BV
Published
2003-01
Volume
133
Issue
1
Pages
199-204
ISSN
0022-3166 (ISSN-L)
DOI
10.1093/jn/133.1.199
OpenAlex
W2154817556
Cited by
260
References
32
Citations by year
2026: 4 · 2024: 3 · 2023: 9 · 2022: 4 · 2021: 6 · 2020: 7 · 2019: 9 · 2018: 11 · 2017: 12 · 2016: 13 · 2015: 9 · 2014: 13 · 2013: 21 · 2012: 14
FWCI
17.59
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Suomen Kulttuurirahasto
  • Institut pour la Recherche en Santé Publique
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
Keywords
fruit and vegetable intake, berries, dietary intake, all-cause mortality, cardiovascular mortality, non-cardiovascular mortality, middle-aged men, plant-based diet, longevity, Kuopio Ischaemic Heart Disease Risk Factor Study
MeSH terms
Adult, Coronary Disease, Diet, Finland, Fruit, Humans, Male, Middle Aged, Prospective Studies, Registries, Risk Factors, Vegetables, Incidence

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