Cited by 324Coffee research and impactsPhytochemicals and Antioxidant ActivitiesGenomics, phytochemicals, and oxidative stress

The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.

Chlorogenic Acid Compounds from Coffee Are Differentially Absorbed and Metabolized in Humans ,

Open access

Monteiro, Mariana, Farah, Adriana, Perrone, Daniel, Trugo, Luiz C., Donangelo, Carmen·2007·The Journal of Nutrition

DOI 10.1093/jn/137.10.2196

Open this paper in CoChat — free account Open PDF

Abstract

Chlorogenic acids (CGA) are abundant phenolic compounds in coffee, with caffeoylquinic (CQA), feruloylquinic (FQA), and dicaffeoylquinic (diCQA) acids being the major subclasses. Despite the potential biopharmacological properties attributed to these compounds, little is known about their bioavailability in humans. In this study, we evaluated the distribution profile of the major CGA isomers and metabolites in plasma and urine of 6 healthy adults for 4 h after brewed coffee consumption. Three CQA isomers and 3 diCQA isomers were identified in the plasma of all subjects after coffee consumption, whereas 2 FQA were identified in only 1 subject. Two plasma concentration peaks were observed, the first at 0.5-1.0 h and the second at 1.5-4.0 h after coffee consumption. The molar ratio CQA:diCQA was 12.2 in the brewed coffee, whereas in plasma it ranged from 0.6-2.9. The molar ratios 5-CQA:3-CQA and 5-CQA:4-CQA were consistently higher in plasma than in the brew. The main CGA metabolites identified in urine after coffee consumption were: dihydrocaffeic, gallic, isoferulic, ferulic, vanillic, caffeic, 5-CQA, sinapic, rho-hydroxybenzoic, and rho-coumaric acids (gallic and dihydrocaffeic acids being the major ones). This study indicates that the major CGA compounds present in coffee are differentially absorbed and/or metabolized in humans, with a large inter-individual variation. Moreover, urine does not appear to be a major excretion pathway of intact CGA compounds in humans.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1093/jn/137.10.2196

Cites

43 of 43 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Polyphenols: Food sources and bioavailability
Manach, C., Scalbert, A., Morand, C., Rémésy, C., & Jiménez, L. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.5.727 · Cited by 8,175
Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies
Manach, C., Williamson, G., Morand, C., Scalbert, A., & Rémésy, C. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.230s · Cited by 4,219 · cited 1×
“(24), who observed that besides b-glucuronidase and sulfatase activities, this type of extract contains other esterases able to degrade CGA into caffeic acid.”
Background
Total Antioxidant Capacity of Plant Foods, Beverages and Oils Consumed in Italy Assessed by Three Different In Vitro Assays
Pellegrini, N., Colombi, B., Rio, D. D., Salvatore, S., Bianchi, M. A., Brighenti, F., & Serafini, M. (2003) · Journal of Nutrition · doi:10.1093/jn/133.9.2812 · Cited by 1,488
Hierarchical Scheme for LC-MSn Identification of Chlorogenic Acids
Clifford, M. N., Johnston, K. L., Knight, S., & Kuhnert, N. (2003) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf026187q · Cited by 1,264
Risk Factors for Alzheimer's Disease: A Prospective Analysis from the Canadian Study of Health and Aging
Lindsay, J. (2002) · American Journal of Epidemiology · doi:10.1093/aje/kwf074 · Cited by 1,261
Phenolic compounds in coffee
Farah, A., & Donangelo, C. M. (2006) · Brazilian Journal of Plant Physiology · doi:10.1590/s1677-04202006000100003 · Cited by 874
Self-citation
Effect of Roasting on the Formation of Chlorogenic Acid Lactones in Coffee
Farah, A., de Paulis, T., Trugo, L. C., & Martin, P. R. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf048701t · Cited by 540
Self-citation
Chlorogenic Acid Bioavailability Largely Depends on Its Metabolism by the Gut Microflora in Rats
Gonthier, M., Verny, M., Besson, C., Rémésy, C., & Scalbert, A. (2003) · Journal of Nutrition · doi:10.1093/jn/133.6.1853 · Cited by 526
Colonic metabolism of dietary polyphenols: influence of structure on microbial fermentation products
Rechner, A. R., Smith, M. A., Kuhnle, G., Gibson, G. R., Debnam, E. S., Srai, S. K., Moore, K. P., & Rice-Evans, C. A. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2003.09.022 · Cited by 512
The Physiology and Pathophysiology of Gastric Emptying in Humans
Minami, H., & McCallum, R. W. (1984) · Gastroenterology · doi:10.1016/s0016-5085(84)80178-x · Cited by 511

Show all 43 references

Sorted by citations

Bioavailability of the polyphenols: Status and controversies
D’Archivio, M., Filesi, C., Varì, R., Scazzocchio, B., & Masella, R. (2010) · International Journal of Molecular Sciences · doi:10.3390/ijms11041321 · Cited by 950
The potential effects of chlorogenic acid, the main phenolic components in coffee, on health: a comprehensive review of the literature
Tajik, N., Tajik, M., Mack, I., & Enck, P. (2017) · European Journal of Nutrition · doi:10.1007/s00394-017-1379-1 · Cited by 730
Chlorogenic Acids from Green Coffee Extract Are Highly Bioavailable in Humans
Farah, A., Monteiro, M., Donangelo, C. M., & Lafay, S. (2008) · The Journal of Nutrition · doi:10.3945/jn.108.095554 · Cited by 578
Self-citation
Bioavailability of dietary flavonoids and phenolic compounds
Crozier, A., Rio, D. D., & Clifford, M. N. (2010) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2010.09.007 · Cited by 568
Chlorogenic acid: A comprehensive review of the dietary sources, processing effects, bioavailability, beneficial properties, mechanisms of action, and future directions
Lu, H., Tian, Z., Cui, Y., Liu, Z., & Ma, X. (2020) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12620 · Cited by 476
The Interactions between Polyphenols and Microorganisms, Especially Gut Microbiota
Makarewicz, M., Drożdż, I., Tarko, T., & Duda‐Chodak, A. (2021) · Antioxidants · doi:10.3390/antiox10020188 · Cited by 444
Chlorogenic acids and the acyl-quinic acids: discovery, biosynthesis, bioavailability and bioactivity
Clifford, M. N., Jaganath, I. B., Ludwig, I. A., & Crozier, A. (2017) · Natural Product Reports · doi:10.1039/c7np00030h · Cited by 418
Metabolite Profiling of Hydroxycinnamate Derivatives in Plasma and Urine after the Ingestion of Coffee by Humans: Identification of Biomarkers of Coffee Consumption
Stalmach, A., Mullen, W., Barron, D., Uchida, K., Yokota, T., Cavin, C., Steiling, H., Williamson, G., & Crozier, A. (2009) · Drug Metabolism and Disposition · doi:10.1124/dmd.109.028019 · Cited by 401
Bioavailability of phenolic acids
Lafay, S., & Gil‐Izquierdo, Á. (2007) · Phytochemistry Reviews · doi:10.1007/s11101-007-9077-x · Cited by 309
Centella asiatica: Phytochemistry and mechanisms of neuroprotection and cognitive enhancement
Gray, N. E., Alcazar Magana, A., Lak, P., Wright, K. M., Quinn, J., Stevens, J. F., Maier, C. S., & Soumyanath, A. (2018) · Phytochemistry Reviews · doi:10.1007/s11101-017-9528-y · Cited by 299
Antihypertensive effects and mechanisms of chlorogenic acids
Zhao, Y., Wang, J., Ballèvre, O. P., Luo, H., & Zhang, W. (2011) · Hypertension Research · doi:10.1038/hr.2011.195 · Cited by 306
Bioavailability of chlorogenic acids following acute ingestion of coffee by humans with an ileostomy
Stalmach, A., Steiling, H., Williamson, G., & Crozier, A. (2010) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2010.03.005 · Cited by 284
Polyphenol metabolites from colonic microbiota exert anti‐inflammatory activity on different inflammation models
Larrosa, M., Luceri, C., Vivoli, E., Pagliuca, C., Lodovici, M., Moneti, G., & Dolara, P. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200800446 · Cited by 260
The Use of Green Coffee Extract as a Weight Loss Supplement: A Systematic Review and Meta-Analysis of Randomised Clinical Trials
Onakpoya, I., Terry, R. H., & Ernst, E. (2010) · Gastroenterology Research and Practice · doi:10.1155/2011/382852 · Cited by 238
Coffee polyphenols suppress diet-induced body fat accumulation by downregulating SREBP-1c and related molecules in C57BL/6J mice
Murase, T., Misawa, K., Minegishi, Y., Aoki, M., Ominami, H., Suzuki, Y., Shibuya, Y., & Hase, T. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00441.2010 · Cited by 228
Inhibiting toxic aggregation of amyloidogenic proteins: A therapeutic strategy for protein misfolding diseases
Cheng, B., Gong, H., Xiao, H., Petersen, R. B., Zheng, L., & Huang, K. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.06.029 · Cited by 223
In vitro transformation of chlorogenic acid by human gut microbiota
Tomás-Barberán, F. A., Garcı́a-Villalba, R., Quartieri, A., Raimondi, S., Amaretti, A., Leonardi, A., & Rossi, M. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300441 · Cited by 202
The influence of beverage composition on delivery of phenolic compounds from coffee and tea
Ferruzzi, M. G. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.01.035 · Cited by 198
Bioavailability and metabolism of chlorogenic acids (acyl‐quinic acids) in humans
Clifford, M. N., Kerimi, A., & Williamson, G. (2020) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12518 · Cited by 201
Influence of Coffee Roasting on the Incorporation of Phenolic Compounds into Melanoidins and Their Relationship with Antioxidant Activity of the Brew
Perrone, D., Farah, A., & Donangelo, C. M. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf205388x · Cited by 187
Self-citation
Consumption of Chlorogenic Acids through Coffee and Health Implications
Farah, A., & Lima, J. D. P. (2019) · Beverages · doi:10.3390/beverages5010011 · Cited by 177
Self-citation
Improving the oral bioavailability of beneficial polyphenols through designed synergies
Scheepens, A., Tan, K. W., & Paxton, J. W. (2009) · Genes & Nutrition · doi:10.1007/s12263-009-0148-z · Cited by 173
In vitro colonic metabolism of coffee and chlorogenic acid results in selective changes in human faecal microbiota growth
Mills, C. E., Tzounis, X., Oruña-Concha, M. J., Mottram, D. S., Gibson, G. R., & Spencer, J. P. E. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114514003948 · Cited by 182
Coffee consumption, obesity and type 2 diabetes: a mini-review
Santos, R. M. M., & Lima, D. R. A. (2016) · European Journal of Nutrition · doi:10.1007/s00394-016-1206-0 · Cited by 176
Chlorogenic acid attenuates high-carbohydrate, high-fat diet–induced cardiovascular, liver, and metabolic changes in rats
Bhandarkar, N. S., Brown, L., & Panchal, S. K. (2018) · Nutrition Research · doi:10.1016/j.nutres.2018.11.002 · Cited by 166
Coffee Chlorogenic Acids Incorporation for Bioactivity Enhancement of Foods: A Review
Rojas-González, A., Figueroa-Hernández, C. Y., González-Ríos, Ó., Suárez-Quiroz, M. L., González‐Amaro, R. M., Hernández‐Estrada, Z. J., & Rayas‐Duarte, P. (2022) · Molecules · doi:10.3390/molecules27113400 · Cited by 172
Chlorogenic Acid and Mental Diseases: From Chemistry to Medicine
Nabavi, S. F., Tejada, S., Setzer, W. N., Gortzi, O., Sureda, A., Braidy, N., Daglia, M., Manayi, A., & Nabavi, S. M. (2017) · Current Neuropharmacology · doi:10.2174/1570159x14666160325120625 · Cited by 152
Plant phenolics as functional food ingredients
Santos‐Buelga, C., Gonzaléz‐Paramás, A. M., Taofiq, O., Ayuda‐Durán, B., & González‐Manzano, S. (2019) · Advances in food and nutrition research · doi:10.1016/bs.afnr.2019.02.012 · Cited by 165
Effects of coffee on type 2 diabetes mellitus
Akash, M. S. H., Rehman, K., & Chen, S. (2013) · Nutrition · doi:10.1016/j.nut.2013.11.020 · Cited by 156
Anticancer Properties of Hydroxycinnamic Acids -A Review
Rocha, L. D., Monteiro, M. C., & Teodoro, A. J. (2012) · Cancer and Clinical Oncology · doi:10.5539/cco.v1n2p109 · Cited by 148
Self-citation
The effect of chlorogenic acid on blood pressure: a systematic review and meta-analysis of randomized clinical trials
Onakpoya, I., Spencer, E. A., Thompson, M., & Heneghan, C. J. (2014) · Journal of Human Hypertension · doi:10.1038/jhh.2014.46 · Cited by 148
Protective effects of mate tea (Ilex paraguariensis) on H2O2-induced DNA damage and DNA repair in mice
Miranda, D. D. C., Arçari, D. P., Pedrazzoli, J., Carvalho, P. D. O., Cerutti, S. M., Bastos, D. H. M., & Ribeiro, M. L. (2008) · Mutagenesis · doi:10.1093/mutage/gen011 · Cited by 144
Measurement of caffeic and ferulic acid equivalents in plasma after coffee consumption: Small intestine and colon are key sites for coffee metabolism
Renouf, M., Guy, P. A., Marmet, C., Fraering, A.-L., Longet, K., Moulin, J., Enslen, M., Barron, D., Dionisi, F., Cavin, C., et al. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200900056 · Cited by 137
Coffee, caffeine, chlorogenic acid, and the purinergic system
Stefanello, N., Spanevello, R. M., Passamonti, S., Porciúncula, L. O., Bonan, C. D., Olabiyi, A. A., da Rocha, J. B. T., Assmann, C. E., Morsch, V. M., & Schetinger, M. R. C. (2018) · Food and Chemical Toxicology · doi:10.1016/j.fct.2018.10.005 · Cited by 145
Caffeinated coffee, decaffeinated coffee, and the phenolic phytochemical chlorogenic acid up-regulate NQO1 expression and prevent H2O2-induced apoptosis in primary cortical neurons
Kim, J., Lee, S., Shim, J., Kim, H. W., Kim, J., Jang, Y. J., Yang, H. S., Park, J., Choi, S. H., Yoon, J. H., et al. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2012.02.004 · Cited by 133
Flavanols from green tea and phenolic acids from coffee: Critical quantitative evaluation of the pharmacokinetic data in humans after consumption of single doses of beverages
Williamson, G., Dionisi, F., & Renouf, M. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201000631 · Cited by 131
Use of mass spectrometry fingerprinting to identify urinary metabolites after consumption of specific foods
Lloyd, A. J., Favé, G., Beckmann, M., Lin, W., Tailliart, K., Xie, L., Mathers, J. C., & Draper, J. (2011) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.017921 · Cited by 130
Intestinal transit and systemic metabolism of apple polyphenols
Kahle, K., Kempf, M. A., Schreier, P. H., Scheppach, W. M., Schrenk, D., Kautenburger, T., Hecker, D. C., Hümmer, W., Ackermann, M., & Richling, E. (2010) · European Journal of Nutrition · doi:10.1007/s00394-010-0157-0 · Cited by 133
Coffee Components Inhibit Amyloid Formation of Human Islet Amyloid Polypeptide in Vitro: Possible Link between Coffee Consumption and Diabetes Mellitus
Cheng, B., Liu, X., Gong, H., Huang, L., Chen, H., Zhang, X., Li, C., Yang, M., Ma, B., Jiao, L., et al. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf201702h · Cited by 127
New Biomarkers of Coffee Consumption Identified by the Non-Targeted Metabolomic Profiling of Cohort Study Subjects
Rothwell, J. A., Fillâtre, Y., Martin, J., Lyan, B., Pujos‐Guillot, E., Fezeu, L., Herçberg, S., Comte, B., Galan, P., Touvier, M., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093474 · Cited by 126
Chlorogenic Acids in Cardiovascular Disease: A Review of Dietary Consumption, Pharmacology, and Pharmacokinetics
Li, L., Su, C., Chen, X., Wang, Q., Jiao, W., Luo, H., Tang, J., Wang, W., Li, S., & Guo, S. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c01554 · Cited by 129
Bioavailability of Coffee Chlorogenic Acids and Green Tea Flavan-3-ols
Rio, D. D., Stalmach, A., Calani, L., & Crozier, A. (2010) · Nutrients · doi:10.3390/nu2080820 · Cited by 122
Impact of dose on the bioavailability of coffee chlorogenic acids in humans
Stalmach, A., Williamson, G., & Crozier, A. (2014) · Food Funct. · doi:10.1039/c4fo00316k · Cited by 118
Chlorogenic Acid: A Dietary Phenolic Acid with Promising Pharmacotherapeutic Potential
Singh, A. K., Singla, R. K., & Pandey, A. K. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220816154634 · Cited by 118
Effect of Simultaneous Consumption of Milk and Coffee on Chlorogenic Acids’ Bioavailability in Humans
Duarte, G. S., & Farah, A. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf201906p · Cited by 116
Self-citation
Coffee Consumption Increases the Antioxidant Capacity of Plasma and Has No Effect on the Lipid Profile or Vascular Function in Healthy Adults in a Randomized Controlled Trial.
Agudelo-Ochoa, G. M., Pulgarín-Zapata, I. C., Velásquez-Rodriguez, C. M., Duque-Ramı́rez, M., Naranjo-Cano, M., Quintero-Ortiz, M. M., Lara-Guzmán, Ó., & Muñoz-Durango, K. (2016) · Journal of NutriLife · doi:10.3945/jn.115.224774 · Cited by 105
The Effect of Different Cooking Methods on Phenolics and Vitamin C in Developmentally Young Potato Tubers
Navarre, D. A., Shakya, R., Holden, J. M., & Kumar, S. (2010) · American Journal of Potato Research · doi:10.1007/s12230-010-9141-8 · Cited by 107
Chlorogenic Acid Inhibits Liver Fibrosis by Blocking the miR-21-Regulated TGF-β1/Smad7 Signaling Pathway in Vitro and in Vivo
Yang, F., Luo, L., Zhu, Z., Zhou, X., Wang, Y., Xue, J., Zhang, J., Cai, X., Chen, Z.-L., Ma, Q., et al. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00929 · Cited by 107
Chlorogenic Acid Protects against Atherosclerosis in ApoE−/− Mice and Promotes Cholesterol Efflux from RAW264.7 Macrophages
Wu, C., Luan, H., Zhang, X., Wang, S., Zhang, X., Sun, X., & Guo, P. (2014) · PLoS ONE · doi:10.1371/journal.pone.0095452 · Cited by 107
Molecular Bases Underlying the Hepatoprotective Effects of Coffee
Salomone, F., Galvano, F., & Volti, G. L. (2017) · Nutrients · doi:10.3390/nu9010085 · Cited by 106
Impact of roasting on the phenolic and volatile compounds in coffee beans
Wu, H., Lu, P., Liu, Z., Sharifi‐Rad, J., & Suleria, H. A. R. (2022) · Food Science & Nutrition · doi:10.1002/fsn3.2849 · Cited by 117
Attenuation of oxidative neuronal cell death by coffee phenolic phytochemicals
Cho, E. S., Jang, Y. J., Hwang, M. K., Kang, N. J., Lee, K. W., & Lee, H. J. (2008) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2008.10.021 · Cited by 97
Chemistry of Coffee
Oestreich-Janzen, S. (2010) · Elsevier eBooks · doi:10.1016/b978-008045382-8.00708-5 · Cited by 96
Effects of Maté Tea (Ilex paraguariensis) Ingestion on mRNA Expression of Antioxidant Enzymes, Lipid Peroxidation, and Total Antioxidant Status in Healthy Young Women
Matsumoto, R. L. T., Bastos, D. H. M., Mendonça, S., Nunes, V. S., Bartchewsky, W., Ribeiro, M. L., & Carvalho, P. D. O. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf803096g · Cited by 92
Polyphenols: Bioavailability, Microbiome Interactions and Cellular Effects on Health in Humans and Animals
Scott, M. B., Styring, A., & McCullagh, J. (2022) · Pathogens · doi:10.3390/pathogens11070770 · Cited by 98
Selective and simultaneous determination of total chlorogenic acids, vanillin and caffeine in foods and beverages by adsorptive stripping voltammetry using a cathodically pretreated boron-doped diamond electrode
Alpar, N., Yardım, Y., & Şentürk, Z. (2017) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2017.10.100 · Cited by 91
Urinary N‐methylpyridinium and trigonelline as candidate dietary biomarkers of coffee consumption
Lang, R., Wahl, A., Stark, T., & Hofmann, T. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201000656 · Cited by 90
The Impact of Coffee and Its Selected Bioactive Compounds on the Development and Progression of Colorectal Cancer In Vivo and In Vitro
Bułdak, R. J., Hejmo, T., Osowski, M., Bułdak, Ł., Kukla, M., Polaniak, R., & Birkner, E. (2018) · Molecules · doi:10.3390/molecules23123309 · Cited by 89
“Some researchers have reported high amounts of intact 3-, 4-, and 5-CQA [129,147], while others have reported their absence [130,148].”
Background
Effects of Caffeic and 5-Caffeoylquinic Acids on Cell Viability and Cellular Uptake in Human Colon Adenocarcinoma Cells
Murad, L. D., Soares, N. D. C. P., Brand, C., Monteiro, M. C., & Teodoro, A. J. (2015) · Nutrition and Cancer · doi:10.1080/01635581.2015.1004736 · Cited by 89
Self-citation
Roasted Coffees High in Lipophilic Antioxidants and Chlorogenic Acid Lactones Are More Neuroprotective than Green Coffees
Chu, Y.-F., Brown, P. H., Lyle, B. J., Chen, Y., Black, R. M., Williams, C. E., Lin, Y.-C., Hsu, C.-W., & Cheng, I. H. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf902095z · Cited by 89
Interaction of chlorogenic acids and quinides from coffee with human serum albumin
Sinisi, V., Forzato, C., Cefarin, N., Navarini, L., & Berti, F. (2014) · Food Chemistry · doi:10.1016/j.foodchem.2014.07.080 · Cited by 89
Polyphenolic and Hydroxycinnamate Contents of Whole Coffee Fruits from China, India, and Mexico
Mullen, W., Nemzer, B. V., Stalmach, A., Ali, S., & Combet, E. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf4003126 · Cited by 93
The phenolic compounds and the antioxidant potential of infusion of herbs from the Brazilian Amazonian region
Ports, P. D. S., Chisté, R. C., Godoy, H. T., & Prado, M. A. (2013) · Food Research International · doi:10.1016/j.foodres.2013.02.010 · Cited by 87
Nutritional Value of Potatoes
Navarre, D. A., Goyer, A., & Shakya, R. (2009) · Elsevier eBooks · doi:10.1016/b978-0-12-374349-7.00014-3 · Cited by 87
Quinic acid: a potential antibiofilm agent against clinical resistant Pseudomonas aeruginosa
Lu, L., Zhao, Y., Yi, G., Li, M., Liao, L., Yang, C., Cho, C. H., Zhang, B., Zhu, J., Zou, K., et al. (2021) · Chinese Medicine · doi:10.1186/s13020-021-00481-8 · Cited by 87
Characterization of Wild Blueberry Polyphenols Bioavailability and Kinetic Profile in Plasma over 24‐h Period in Human Subjects
Zhong, S., Sandhu, A. K., Edirisinghe, I., & Burton‐Freeman, B. M. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700405 · Cited by 86
The Type and Concentration of Milk Increase the in Vitro Bioaccessibility of Coffee Chlorogenic Acids
Tagliazucchi, D., Helal, A., Verzelloni, E., & Conte, A. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf302694a · Cited by 84
Application of Attenuated Total Reflectance–Fourier Transformed Infrared (ATR-FTIR) Spectroscopy To Determine the Chlorogenic Acid Isomer Profile and Antioxidant Capacity of Coffee Beans
Liang, N., Lu, X., Hu, Y., & Kitts, D. D. (2016) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5b05682 · Cited by 85
Parallel reductions in phenolic constituents resulting from the domestication of eggplant
Meyer, R. S., Whitaker, B. D., Little, D. P., Wu, S., Kennelly, E. J., Long, C., & Litt, A. (2015) · Phytochemistry · doi:10.1016/j.phytochem.2015.02.006 · Cited by 78
The Coffee Constituent Chlorogenic Acid Induces Cellular DNA Damage and Formation of Topoisomerase I– and II–DNA Complexes in Cells
Burgos‐Morón, E., Calderón‐Montaño, J. M., Orta, M. L., Pastor, N., Pérez‐Guerrero, C., Austin, C. A., Mateos, S., & López‐Lázaro, M. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf300999e · Cited by 78
Absorption and Metabolism of Chlorogenic Acids in Cultured Gastric Epithelial Monolayers
Farrell, T. L., Dew, T. P., Poquet, L., Hanson, P. J., & Williamson, G. (2011) · Drug Metabolism and Disposition · doi:10.1124/dmd.111.040147 · Cited by 78
Dose‐dependent absorption of chlorogenic acids in the small intestine assessed by coffee consumption in ileostomists
Erk, T., Williamson, G., Renouf, M., Marmet, C., Steiling, H., Dionisi, F., Barron, D., Melcher, R., & Richling, E. (2012) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201200222 · Cited by 74
Bioavailability of hydroxycinnamates in an instant green/roasted coffee blend in humans. Identification of novel colonic metabolites
Gómez‐Juaristi, M., Martínez‐López, S., Sarriá, B., Bravo, L., & Mateos, R. (2017) · Food & Function · doi:10.1039/c7fo01553d · Cited by 77
Pharmacokinetics of caffeine and its metabolites in plasma and urine after consuming a soluble green/roasted coffee blend by healthy subjects
Martínez-López, S., Sarriá, B., Baeza, G., Mateos, R., & Bravo, L. (2014) · Food Research International · doi:10.1016/j.foodres.2014.05.043 · Cited by 72
Impact of paper filtered coffee on oxidative DNA-damage: Results of a clinical trial
Mišík, M., Hoelzl, C., Wagner, K., Cavin, C., Moser, B., Kundi, M., Simic, T., Elbling, L., Kager, N., Ferk, F., et al. (2010) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2010.08.003 · Cited by 73
In vitro and in vivo conjugation of dietary hydroxycinnamic acids by UDP-glucuronosyltransferases and sulfotransferases in humans
Wong, C. C., Meinl, W., Glatt, H. R., Barron, D., Stalmach, A., Steiling, H., Crozier, A., & Williamson, G. (2009) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2009.09.001 · Cited by 71
Identification of novel circulating coffee metabolites in human plasma by liquid chromatography–mass spectrometry
Redeuil, K. M., Menozzi, C., Guy, P. A., Rezzi, S., Dionisi, F., Williamson, G., Nagy, K., & Renouf, M. (2011) · Journal of Chromatography A · doi:10.1016/j.chroma.2011.05.050 · Cited by 72
Identification of chicoric acid as a hypoglycemic agent from Ocimum gratissimum leaf extract in a biomonitoring in vivo study
Casanova, L. M., Silva, D., Sola‐Penna, M., Camargo, L. M. D. M., Celestrini, D. D. M., Tinoco, L. W., & Costa, S. S. (2014) · Fitoterapia · doi:10.1016/j.fitote.2013.12.024 · Cited by 72
Nondairy Creamer, but Not Milk, Delays the Appearance of Coffee Phenolic Acid Equivalents in Human Plasma
Renouf, M., Marmet, C., Guy, P. A., Fraering, A.-L., Longet, K., Moulin, J., Enslen, M., Barron, D., Cavin, C., Dionisi, F., et al. (2009) · Journal of Nutrition · doi:10.3945/jn.109.113027 · Cited by 70
Dose–response plasma appearance of coffee chlorogenic and phenolic acids in adults
Renouf, M., Marmet, C., Giuffrida, F., Lepage, M., Barron, D., Beaumont, M., Williamson, G., & Dionisi, F. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300349 · Cited by 69
Mediation of coffee-induced improvements in human vascular function by chlorogenic acids and its metabolites: Two randomized, controlled, crossover intervention trials
Mills, C. E., Flury, A., Marmet, C., Poquet, L., Rimoldi, S. F., Sartori, C. S., Rexhaj, E., Brenner, R., Allemann, Y., Zimmermann, D., et al. (2016) · Clinical Nutrition · doi:10.1016/j.clnu.2016.11.013 · Cited by 69
Chlorogenic acid protects paraoxonase 1 activity in high density lipoprotein from inactivation caused by physiological concentrations of hypochlorite
Gugliucci, A., & Bastos, D. H. M. (2009) · Fitoterapia · doi:10.1016/j.fitote.2009.01.001 · Cited by 68
Chlorogenic acid and caffeine in combination inhibit fat accumulation by regulating hepatic lipid metabolism-related enzymes in mice
Zheng, G., Qiu, Y., Zhang, Q., & Li, D. (2014) · British Journal Of Nutrition · doi:10.1017/s0007114514001652 · Cited by 68
Yerba Maté (Ilex paraguariensis) Aqueous Extract Decreases Intestinal SGLT1 Gene Expression but Does Not Affect Other Biochemical Parameters in Alloxan-Diabetic Wistar Rats
de Oliveira, D. M., Freitas, H. S., de Souza, M. F. F., Arçari, D. P., Ribeiro, M. L., Carvalho, P. D. O., & Bastos, D. H. M. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf8021404 · Cited by 66
The colonic metabolites dihydrocaffeic acid and dihydroferulic acid are more effective inhibitors of in vitro platelet activation than their phenolic precursors
Baeza, G., Bachmair, E., Wood, S. G., Mateos, R., Bravo, L., & de Roos, B. (2017) · Food & Function · doi:10.1039/c6fo01404f · Cited by 69
Non-polyphenolic natural inhibitors of amyloid aggregation
Ma, L., Yang, C., Zheng, J., Chen, Y., Xiao, Y., & Huang, K. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112197 · Cited by 66
Bioavailability of Dietary Polyphenols and the Cardiovascular Diseases
Shivashankara, K. S., & Acharya, S. N. (2010) · The Open Nutraceuticals Journal · doi:10.2174/1876396001003010227 · Cited by 67
Plasma appearance and correlation between coffee and green tea metabolites in human subjects
Renouf, M., Guy, P. A., Marmet, C., Longet, K., Fraering, A.-L., Moulin, J., Barron, D., Dionisi, F., Cavin, C., Steiling, H., et al. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114510002709 · Cited by 62
First synthesis, characterization, and evidence for the presence of hydroxycinnamic acid sulfate and glucuronide conjugates in human biological fluids as a result of coffee consumption
Fumeaux, R., Menozzi, C., Stalmach, A., Munari, C., Kraehenbuehl, K., Steiling, H., Crozier, A., Williamson, G., & Barron, D. (2010) · Organic & Biomolecular Chemistry · doi:10.1039/c0ob00137f · Cited by 62
Sweet potato (Ipomoea batatas L.) leaves suppressed oxidation of low density lipoprotein (LDL) in vitro and in human subjects
Nagai, M., Tani, M., Kishimoto, Y., Iizuka, M., Saita, E., Toyozaki, M., Kamiya, T., Ikeguchi, M., & Kondo, K. N. (2011) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.10-84 · Cited by 61
Quantitative analysis of plasma caffeic and ferulic acid equivalents by liquid chromatography tandem mass spectrometry
Guy, P. A., Renouf, M., Barron, D., Cavin, C., Dionisi, F., Kochhar, S., Rezzi, S., Williamson, G., & Steiling, H. (2009) · Journal of Chromatography B · doi:10.1016/j.jchromb.2009.10.006 · Cited by 61
A Comprehensive Overview of the Risks and Benefits of Coffee Consumption
Pourshahidi, L. K., Navarini, L., Petracco, M., & Strain, J. (2016) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12206 · Cited by 64
Antioxidant and antifungal activity of carnauba wax powder extracts
Andrade, L. B. D. S., Julião, M. S. D. S., Cruz, R. C. V., Rodrigues, T. H. S., Fontenelle, R. O. D. S., & da Silva, A. L. C. (2018) · Industrial Crops and Products · doi:10.1016/j.indcrop.2018.09.004 · Cited by 60
Antioxidants in Potatoes: A Functional View on One of the Major Food Crops Worldwide
Hellmann, H. A., Goyer, A., & Navarre, D. A. (2021) · Molecules · doi:10.3390/molecules26092446 · Cited by 59
Antiproliferative and cytotoxic effects of green coffee and yerba mate extracts, their main hydroxycinnamic acids, methylxanthine and metabolites in different human cell lines
Amigo‐Benavent, M., Wang, S., Mateos, R., Sarriá, B., & Bravo, L. (2017) · Food and Chemical Toxicology · doi:10.1016/j.fct.2017.05.019 · Cited by 58
Insights on the Health Benefits of the Bioactive Compounds of Coffee Silverskin Extract
Fernandez-Gomez, B., Lezama, A., Amigo-Benavent, M., Ullate, M., Herrero, M., Martín, M. Á., Mesa, M. D., & del Castillo, M. D. (2016) · Journal of Functional Foods · doi:10.1016/j.jff.2016.06.001 · Cited by 58
Consumption of dietary caffeine and coffee in physically active populations: physiological interactions
Tunnicliffe, J. M., Erdman, K. A., Reimer, R. A., Lun, V. M. Y., & Shearer, J. (2008) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h08-124 · Cited by 61
The effect of green-coffee extract supplementation on obesity: A systematic review and dose-response meta-analysis of randomized controlled trials
Gorji, Z., Kord‐Varkaneh, H., Talaei, S., Nazary-Vannani, A., Clark, C. C. T., Fatahi, S., Rahmani, J., Salamat, S., & Zhang, Y. (2019) · Phytomedicine · doi:10.1016/j.phymed.2019.153018 · Cited by 59
Selective bio‐availability of phenolic acids from Scottish strawberries
Russell, W. R., Scobbie, L., Labat, A., & Duthie, G. G. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200800302 · Cited by 57
Dietary supplementation with decaffeinated green coffee improves diet-induced insulin resistance and brain energy metabolism in mice
Ho, L., Varghese, M., Wang, J., Zhao, W., Chen, F., Knable, L. A., Ferruzzi, M. G., & Pasinetti, G. M. (2012) · Nutritional Neuroscience · doi:10.1179/1476830511y.0000000027 · Cited by 58

Authors: Monteiro, M., Farah, A., Perrone, D., Trugo, L. C., & Donangelo, C.
Affiliations: Universidade Federal do Rio de Janeiro (BR)
Corresponding author: Farah, Adriana
ORCID: Monteiro, Mariana
Farah, Adriana
Perrone, Daniel
Donangelo, Carmen
Venue: The Journal of Nutrition
Publisher: Elsevier BV
Published: 2007-10
Volume: 137
Issue: 10
Pages: 2196-2201
ISSN: 0022-3166 (ISSN-L)
DOI: 10.1093/jn/137.10.2196
OpenAlex: W2130794819
Cited by: 324
References: 43
Citations by year: 2026: 13 · 2025: 11 · 2024: 14 · 2023: 8 · 2022: 22 · 2021: 24 · 2020: 17 · 2019: 17 · 2018: 18 · 2017: 18 · 2016: 21 · 2015: 14 · 2014: 22 · 2013: 19 · 2012: 19
FWCI: 11.13
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 5610 d)
Locations: Journal of Nutrition (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
Keywords: chlorogenic acid, coffee, caffeoylquinic acids, feruloylquinic acids, dicaffeoylquinic acids, bioavailability, metabolism, plasma distribution, urinary excretion, gallic acid, dihydrocaffeic acid, interindividual variability, phenolic compounds
MeSH terms: Adult, Chlorogenic Acid, Coffee, Female, Humans, Male, Middle Aged, Area Under Curve

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Chlorogenic Acid Compounds from Coffee Are Differentially Absorbed and Metabolized in Humans ,

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks