Tumor Hypoxia: Definitions and Current Clinical, Biologic, and Molecular Aspects

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

Wang, G. L., Jiang, B. H., Rue, E. A., & Semenza, G. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.12.5510 · Cited by 6,212

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

Maxwell, P. H., Wiesener, M. S., Chang, G.-W., Clifford, S. C., Vaux, E. C., Cockman, M. E., Wykoff, C. C., Pugh, C. W., Maher, E. R., & Ratcliffe, P. J. (1999) · Nature · doi:10.1038/20459 · Cited by 5,180

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

Shweiki, D., Itin, A., Soffer, D., & Keshet, E. (1992) · Nature · doi:10.1038/359843a0 · Cited by 4,617

Radiobiology for the Radiologist.

(1974) · Annals of Internal Medicine · doi:10.7326/0003-4819-80-3-438_1 · Cited by 3,498

Untitled work

(1989) · PubMed · Cited by 3,343

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

Graeber, T. G., Osmanian, C., Jacks, T., Housman, D. E., Koch, C. J., Lowe, S. W., & Giaccia, A. J. (1996) · Nature · doi:10.1038/379088a0 · Cited by 2,300

The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy

Gray, L. H., Conger, A. D., Ebert, M., Hornsey, S., & Scott, O. C. A. (1953) · The British Journal of Radiology · doi:10.1259/0007-1285-26-312-638 · Cited by 2,158

Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression

Holmgren, L., O’Reilly, M. S., & Folkman, J. (1995) · Nature Medicine · doi:10.1038/nm0295-149 · Cited by 1,891

HIF-1: mediator of physiological and pathophysiological responses to hypoxia

Semenza, G. L. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.88.4.1474 · Cited by 1,822

Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix.

Höckel, M., Schlenger, K., Aral, B., Mitze, M., Schäffer, U., & Vaupel, P. W. (1996) · PubMed · Cited by 1,727

PAI‐1, CAIX, and VEGFA expressions as prognosis markers in oral squamous cell carcinoma

Peterle, G. T., Maia, L. L., Trivilin, L. O., de Oliveira, M. M., dos Santos, J. G., Mendes, S. O., Stur, E., Agostini, L. P., Rocha, L. A., Moysés, R. A., et al. (2018) · Journal of Oral Pathology and Medicine · doi:10.1111/jop.12721 · Cited by 47

Perfluorocarbon nanodroplets can reoxygenate hypoxic tumors in vivo without carbogen breathing

Xiang, Y., Bernards, N., Hoang, B., Zheng, J., & Matsuura, N. (2019) · Nanotheranostics · doi:10.7150/ntno.29908 · Cited by 46

Real-time measurement of tumour hypoxia using an implantable microfabricated oxygen sensor

Marland, J. R. K., Gray, M., Dunare, C. C., Blair, E. O., Tsiamis, A., Sullivan, P. J., González‐Fernández, E., Greenhalgh, S. N., Gregson, R., Clutton, R. E., et al. (2020) · Sensing and Bio-Sensing Research · doi:10.1016/j.sbsr.2020.100375 · Cited by 46

Hybrid TiO2–Ruthenium Nano‐photosensitizer Synergistically Produces Reactive Oxygen Species in both Hypoxic and Normoxic Conditions

Gilson, R. C., Black, K. C. L., Lane, D. D., & Achilefu, S. A. (2017) · Angewandte Chemie · doi:10.1002/ange.201704458 · Cited by 46

Temporal Heterogeneity in Blood Supply in Human Tumor Xenografts

Brurberg, K. G., Gaustad, J., Mollatt, C., & Rofstad, E. K. (2008) · Neoplasia · doi:10.1593/neo.08388 · Cited by 46

Involvement of nuclear receptor RZR/RORγ in melatonin-induced HIF-1α inactivation in SGC-7901 human gastric cancer cells

Wang, R.-X., Liu, H., XU, L., Zhang, H., & Zhou, R. (2015) · Oncology Reports · doi:10.3892/or.2015.4238 · Cited by 46

Gene Expression Profile of B16(F10) Murine Melanoma Cells Exposed to Hypoxic Conditions In Vitro

Olbryt, M., Jarząb, M., Jazowiecka-Rakus, J., Simek, K., Szala, S., & Sochanik, A. (2006) · Gene Expression · doi:10.3727/000000006783991818 · Cited by 45

Epigenetics in radiotherapy: Where are we heading?

Smits, K. M., Melotte, V., Niessen, H. E. C., Dubois, L. J., Oberije, C., Troost, E. G. C., Starmans, M. H. W., Boutros, P. C., Vooijs, M., van Engeland, M., et al. (2014) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2014.05.001 · Cited by 46

Angiogenin is up‐regulated in the nucleus and cytoplasm in human primary breast carcinoma and is associated with markers of hypoxia but not survival

Campo, L., Turley, H., Han, C., Pezzella, F., Gatter, K. C., Harris, A. L., & Fox, S. B. (2005) · The Journal of Pathology · doi:10.1002/path.1740 · Cited by 46

Hypoxia-induced dedifferentiation in neuroblastoma cells

Jögi, A., Øra, I., Nilsson, H., Poellinger, L., Axelson, H., & Påhlman, S. (2003) · Cancer Letters · doi:10.1016/s0304-3835(03)00095-8 · Cited by 46

Targeted Knockdown of SEPT9_v1 Inhibits Tumor Growth and Angiogenesis of Human Prostate Cancer Cells Concomitant with Disruption of Hypoxia-Inducible Factor-1 Pathway

Amir, S., Golan, M., & Mabjeesh, N. J. (2010) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-09-0497 · Cited by 47

Autonomous glucose metabolic reprogramming of tumour cells under hypoxia: opportunities for targeted therapy

Huang, M., Yang, L., Peng, X., Wei, S., Fan, Q., Yang, S., Li, X., Li, B., Jin, H., Wu, B., et al. (2020) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-01698-5 · Cited by 54

Hypoxic condition and prognosis in oral squamous cell carcinoma.

de Lima, P. O., Jorge, C. C., Oliveira, D. T., & Pereira, M. C. (2014) · PubMed · Cited by 44

Predictive Modeling of In Vivo Response to Gemcitabine in Pancreatic Cancer

Lee, J. J., Huang, J. S., England, C. G., McNally, L. R., & Frieboes, H. B. (2013) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1003231 · Cited by 44

Aberrant methylation and associated transcriptional mobilization of Alu elements contributes to genomic instability in hypoxia

Pal, A., Srivastava, T., Sharma, M. K., Mehndiratta, M., Das, P., Sinha, S., & Chattopadhyay, P. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00792.x · Cited by 45

Non-receptor protein-tyrosine kinases as molecular targets for antiangiogenic therapy (Review)

Kanda, S., Miyata, Y., Kanetake, H., & Smithgall, T. E. (2007) · International Journal of Molecular Medicine · doi:10.3892/ijmm.20.1.113 · Cited by 46

Expression of hypoxia‐associated proteins in sporadic medullary thyroid cancer is associated with desmoplastic stroma reaction and lymph node metastasis and may indicate somatic mutations in the VHL gene

Koperek, O., Bergner, O., Pichlhöfer, B., Oberndorfer, F., Hainfellner, J. A., Kaserer, K., Horvat, R., Harris, A. L., Niederle, B., & Birner, P. (2011) · The Journal of Pathology · doi:10.1002/path.2926 · Cited by 45

Anti-Proliferation and Anti-Invasion Effects of Diosgenin on Gastric Cancer BGC-823 Cells with HIF-1α shRNAs

Mao, Z.-J., Tang, Q., Zhang, C., Qin, Z., Pang, B., Wei, P.-K., Liu, B., & Chou, Y.-N. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms13056521 · Cited by 45

Tumor Hypoxia Regulates Forkhead Box C1 to Promote Lung Cancer Progression

Lin, Y., Shyu, W., Chang, C., Wang, C.-C., Wu, C., Lee, H., Chen, L., & Hsieh, C. (2017) · Theranostics · doi:10.7150/thno.17895 · Cited by 45

Pulsed Electron Paramagnetic Resonance Imaging: Applications in the Studies of Tumor Physiology

Kishimoto, S., Matsumoto, K., Saito, K., Enomoto, A., Matsumoto, S., Mitchell, J. B., Devasahayam, N., & Krishna, M. C. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7391 · Cited by 45

Hypoxia-Inducible Factor-1α (HIF-1α) Promotes Hypoxia-Induced Invasion and Metastasis in Ovarian Cancer by Targeting Matrix Metallopeptidase 13 (MMP13)

Zhang, H., Yang, Q., Lian, X., Jiang, P., & Cui, J. (2019) · Medical Science Monitor · doi:10.12659/msm.916886 · Cited by 45

Oxygen: viral friend or foe?

Gan, E. S., & Ooi, E. E. (2020) · Virology Journal · doi:10.1186/s12985-020-01374-2 · Cited by 46

Cobalt chloride-induced hypoxia modulates the invasive potential and matrix metalloproteinases of primary and metastatic breast cancer cells.

Ou‐Yang, F., Hou, M., Yang, S., Huang, S.-C., & Lee, W. (2009) · PubMed · Cited by 45

Inhibitors of angiogenesis and cancer-related receptor tyrosine kinases

Mazitschek, R., & Giannis, A. (2004) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2004.06.009 · Cited by 44

Differential oxygen dynamics in two diverse Dunning prostate R3327 rat tumor sublines (MAT-Lu and HI) with respect to growth and respiratory challenge

Zhao, D., Constantinescu, A., Hahn, E. W., et al. (2002) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(02)02822-5 · Cited by 45

ATF4-induced warburg metabolism drives over-proliferation in Drosophila

Sorge, S., Theelke, J., Yildirim, K., Hertenstein, H., McMullen, E., Müller, S., Altbürger, C., Schirmeier, S., & Lohmann, I. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107659 · Cited by 44

Radiocurability Is Associated with Interstitial Fluid Pressure in Human Tumor Xenografts

Rofstad, E. K., Gaustad, J., Brurberg, K. G., Mathiesen, B. S., Galappathi, K., & Simonsen, T. G. (2009) · Neoplasia · doi:10.1593/neo.91152 · Cited by 44

Novel Model for Basaloid Triple-negative Breast Cancer: Behavior In Vivo and Response to Therapy

Volk-Draper, L. D., Rajput, S., Hall, K. L., Wilber, A. C., & Rana, S. (2012) · Neoplasia · doi:10.1593/neo.12956 · Cited by 44

Hypoxia imaging using Positron Emission Tomography in non-small cell lung cancer: Implications for radiotherapy

Bollineni, V. R., Wiegman, E. M., Pruim, J., Groen, H. J. M., & Langendijk, J. A. (2012) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2012.04.003 · Cited by 44

Snail1 Mediates Hypoxia-Induced Melanoma Progression

Liu, S., Kumar, S. M., Martin, J. S., Yang, R., & Xu, X. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.08.038 · Cited by 44

Molecular Imaging of Hypoxia: Strategies for Probe Design and Application

Apte, S., Chin, F. T., & Graves, E. E. (2011) · Current Organic Synthesis · doi:10.2174/157017911796117179 · Cited by 44

Increased HIF-1α Expression Correlates With Cell Proliferation and Vascular Markers CD31 and VEGF-A in Uveal Melanoma

Mouriaux, F., Sanschagrin, F., Diorio, C., Landreville, S., Comoz, F., Petit, E., Bernaudin, M., Rousseau, A. P., Bergeron, D., & Morcos, M. (2014) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.13-13345 · Cited by 48

Tumour, Oxidative Stress and Host T Cell Response: Cementing the Dominance

Bhattacharyya, S., & Saha, J. (2015) · Scandinavian Journal of Immunology · doi:10.1111/sji.12350 · Cited by 44

Rapid uptake of glucose and lactate, and not hypoxia, induces apoptosis in three-dimensional tumor tissue culture

Kasinskas, R. W., Venkatasubramanian, R., & Forbes, N. S. (2014) · Integrative Biology · doi:10.1039/c4ib00001c · Cited by 44

Characterization of sub-nuclear changes in Caenorhabditis elegans embryos exposed to brief, intermediate and long-term anoxia to analyze anoxia-induced cell cycle arrest

Hajeri, V. A., Trejo, J., & Padilla, P. A. (2005) · BMC Cell Biology · doi:10.1186/1471-2121-6-47 · Cited by 44

Insights into the Regulatory Role of Non-coding RNAs in Cancer Metabolism

Beltrán‐Anaya, F. O., Cedro‐Tanda, A., Hidalgo‐Miranda, A., & Romero-Cordoba, S. L. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00342 · Cited by 44

An 808 nm Light-Sensitized Upconversion Nanoplatform for Multimodal Imaging and Efficient Cancer Therapy

Gulzar, A., Wang, Z., He, F., et al. (2020) · Inorganic Chemistry · doi:10.1021/acs.inorgchem.0c00170 · Cited by 44

Impact of hypoxia on cervical cancer outcomes

Datta, A., West, C., O’Connor, J. P. B., Choudhury, A., & Hoskin, P. (2021) · International Journal of Gynecological Cancer · doi:10.1136/ijgc-2021-002806 · Cited by 44

Natural compounds and the hypoxia-inducible factor (HIF) signalling pathway

Manolescu, B. N., Oprea, E., Buşu, C., & Cercasov, C. (2009) · Biochimie · doi:10.1016/j.biochi.2009.08.005 · Cited by 46

Comparison of tumor blood perfusion assessed by dynamic contrast‐enhanced MRI with tumor blood supply assessed by invasive imaging

Graff, B. A., Benjaminsen, I. C., Brurberg, K. G., et al. (2005) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.20265 · Cited by 44

The immunohistochemical assessment of hypoxia, vascularity and proliferation in bladder carcinoma

Hoskin, P., Sibtain, A., Daley, F. M., et al. (2004) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2004.03.017 · Cited by 44

Where are we with imaging oxygenation in human tumours?

Padhani, A. R. (2005) · Cancer Imaging · doi:10.1102/1470-7330.2005.0103 · Cited by 44

Structure–Activity Relationships of Benzenesulfonamide‐Based Inhibitors towards Carbonic Anhydrase Isoform Specificity

Bhatt, A., Mahon, B. P., Cruzeiro, V. W. D., et al. (2016) · ChemBioChem · doi:10.1002/cbic.201600513 · Cited by 43

Overview of Nanoparticle-Based Approaches for the Combination of Photodynamic Therapy (PDT) and Chemotherapy at the Preclinical Stage

Menilli, L., Milani, C., Reddi, E., & Moret, F. (2022) · Cancers · doi:10.3390/cancers14184462 · Cited by 45

An Efficacy and Mechanism Driven Study on the Impact of Hypoxia on Lipid Nanoparticle Mediated mRNA Delivery

Ma, Y., & Fenton, O. S. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.3c02584 · Cited by 44

Fluorescence microscopy imaging of mitochondrial metabolism in cancer cells

Gooz, M. B., & Maldonado, E. N. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1152553 · Cited by 44

Single-cell RNA sequencing identifies critical transcription factors of tumor cell invasion induced by hypoxia microenvironment in glioblastoma

Zhang, Y., Zhang, B., Lv, C., Zhang, N., Xing, K., Wang, Z., Lv, R., Yu, M., Xu, C., & Wang, Y. (2023) · Theranostics · doi:10.7150/thno.81407 · Cited by 45

Transcriptional regulation of the plasminogen activator inhibitor type 1 – with an emphasis on negative regulation

Nagamine, Y. (2008) · Thrombosis and Haemostasis · doi:10.1160/th08-05-0294 · Cited by 43

Synthesis and Evaluation of Stable Bidentate Transition Metal Complexes of 1-(Chloromethyl)-5-hydroxy-3-(5,6,7-trimethoxyindol-2-ylcarbonyl)-2,3-dihydro-1H-pyrrolo[3,2-f]quinoline (seco-6-azaCBI-TMI) as Hypoxia Selective Cytotoxins

Milbank, J. B. J., Stevenson, R. J., Ware, D. C., et al. (2009) · Journal of Medicinal Chemistry · doi:10.1021/jm9008746 · Cited by 43

Can biomarkers play a role in the decision about treatment of the clinically negative neck in patients with head and neck cancer?

Takes, R. P., Rinaldo, A., Rodrigo, J. P., et al. (2008) · Head & Neck · doi:10.1002/hed.20759 · Cited by 43

A miR-297/hypoxia/DGK-α axis regulating glioblastoma survival

Kefas, B. A., Floyd, D. H., Comeau, L., et al. (2013) · Neuro-Oncology · doi:10.1093/neuonc/not118 · Cited by 43

Tumor cell response to bevacizumab single agent therapy in vitro

Hein, M., & Graver, S. (2013) · Cancer Cell International · doi:10.1186/1475-2867-13-94 · Cited by 42

Assessment of tumor oxygenation and its impact on treatment response in bevacizumab-treated recurrent glioblastoma

Bonekamp, D., Mouridsen, K., Radbruch, A., et al. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16630322 · Cited by 43

One‐Pot Synthesis of Dual Stimulus‐Responsive Degradable Hollow Hybrid Nanoparticles for Image‐Guided Trimodal Therapy

Hayashi, K., Maruhashi, T., Nakamura, M., Sakamoto, W., & Yogo, T. (2016) · Advanced Functional Materials · doi:10.1002/adfm.201603394 · Cited by 43

Eukaryotic elongation factor 2 is a prognostic marker and its kinase a potential therapeutic target in HCC

Pott, L. L., Hagemann, S., Reis, H., Lorenz, K., Bracht, T., Herold, T., Skryabin, B. V., Megger, D. A., Kälsch, J., Weber, F., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.14447 · Cited by 43

Emerging role of RUNX3 in the regulation of tumor microenvironment

Manandhar, S., & Lee, Y. M. (2018) · BMB Reports · doi:10.5483/bmbrep.2018.51.4.033 · Cited by 43

Novel fluorinated carbonic anhydrase IX inhibitors reduce hypoxia-induced acidification and clonogenic survival of cancer cells

Kazokaitė, J., Niemans, R., Dudutienė, V., Becker, H. M., Leitāns, J., Zubrienė, A., Baranauskienė, L., Gondi, G., Zeidler, R., Matulienė, J., et al. (2018) · Oncotarget · doi:10.18632/oncotarget.25508 · Cited by 44

A novel fluorescent turn-on probe for highly selective detection of nitroreductase in tumor cells

Zhu, K., Qin, T., Zhao, C., et al. (2018) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2018.08.134 · Cited by 43

Dual P-Glycoprotein and CA XII Inhibitors: A New Strategy to Reverse the P-gp Mediated Multidrug Resistance (MDR) in Cancer Cells

Teodori, E., Braconi, L., Bua, S., Lapucci, A., Bartolucci, G., Manetti, D., Romanelli, M. N., Dei, S., Supuran, C. T., & Coronnello, M. (2020) · Molecules · doi:10.3390/molecules25071748 · Cited by 44

Hypoxia, hypoxia-inducible gene 2 (HIG2)/HILPDA, and intracellular lipolysis in cancer

Povero, D., Johnson, S. M., & Liu, J. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.06.013 · Cited by 46

The expression level of luciferase within tumour cells can alter tumour growth upon in vivo bioluminescence imaging

Brutkiewicz, S. A., Mendonca, M. S., Stantz, K. M., Comerford, K., Bigsby, R. M., Hutchins, G. D., Goebl, M. G., & Harrington, M. A. (2007) · Luminescence · doi:10.1002/bio.953 · Cited by 45

A prospective pilot clinical trial evaluating the utility of a dynamic near-infrared imaging device for characterizing suspicious breast lesions

Xu, R. X., Young, D. C., Mao, J. J. M., & Povoski, S. P. (2007) · Breast Cancer Research · doi:10.1186/bcr1837 · Cited by 43

Role of Prolactin and Vasoinhibins in the Regulation of Vascular Function in Mammary Gland

Clapp, C., Thébault, S. C., & de la Escalera, G. M. (2008) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-008-9067-7 · Cited by 43

Defining the gene expression signature of rhabdomyosarcoma by meta-analysis

Romualdi, C., Pittà, C. D., Tombolan, L., Bortoluzzi, S., Sartori, F., Rosolen, A., & Lanfranchi, G. (2006) · BMC Genomics · doi:10.1186/1471-2164-7-287 · Cited by 43

Discovery of a highly efficient nitroaryl group for detection of nitroreductase and imaging of hypoxic tumor cells

Wang, S., Wu, X., Zhang, Y., Zhang, D., Xie, B., Pan, Z., Ouyang, K., & Peng, T. (2021) · Organic & Biomolecular Chemistry · doi:10.1039/d1ob00356a · Cited by 44

Down Regulation of Wnt Signaling Mitigates Hypoxia-Induced Chemoresistance in Human Osteosarcoma Cells

Scholten, D. J., Timmer, C. M., Peacock, J. D., Pelle, D. W., Williams, B. O., & Steensma, M. R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111431 · Cited by 43

Pyruvate Induces Transient Tumor Hypoxia by Enhancing Mitochondrial Oxygen Consumption and Potentiates the Anti-Tumor Effect of a Hypoxia-Activated Prodrug TH-302

Takakusagi, Y., Matsumoto, S., Saito, K., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107995 · Cited by 42

Radiotherapy for the management of locally advanced squamous cell carcinoma of the head and neck

Ko, C. J., & Citrin, D. E. (2008) · Oral Diseases · doi:10.1111/j.1601-0825.2008.01495.x · Cited by 42

Molecular Imaging of Tumor Hypoxia with Positron Emission Tomography

Kelada, O. J., & Carlson, D. J. (2014) · Radiation Research · doi:10.1667/rr13590.1 · Cited by 42

The domino effect: Role of hypoxia in malignant transformation of oral submucous fibrosis

Bajaj, S., Chaudhary, M. S., Bohra, S., Swastika, N., & Hande, A. H. (2015) · Journal of Oral and Maxillofacial Pathology · doi:10.4103/0973-029x.164519 · Cited by 42

An MRI Method To Map Tumor Hypoxia Using Red Blood Cells Loaded with a pO 2 -Responsive Gd-Agent

Gregorio, E. D., Ferrauto, G., Gianolio, E., et al. (2015) · ACS Nano · doi:10.1021/acsnano.5b02604 · Cited by 42

MiR200 and miR302: Two Big Families Influencing Stem Cell Behavior

Balzano, F., Cruciani, S., Basoli, V., Santaniello, S., Facchin, F., Ventura, C., & Maioli, M. (2018) · Molecules · doi:10.3390/molecules23020282 · Cited by 41

Construction of a near-infrared responsive upconversion nanoplatform against hypoxic tumors via NO-enhanced photodynamic therapy

Lan, Y., Zhu, X., Tang, M., et al. (2020) · Nanoscale · doi:10.1039/c9nr10453d · Cited by 42

Oxygen-Sufficient Nanoplatform for Chemo-Sonodynamic Therapy of Hypoxic Tumors

Huang, B., Chen, S., Pei, W., Xu, Y., Jiang, Z., Niu, C., & Wang, L. (2020) · Frontiers in Chemistry · doi:10.3389/fchem.2020.00358 · Cited by 42

In-vitro tumor microenvironment models containing physical and biological barriers for modelling multidrug resistance mechanisms and multidrug delivery strategies

Rahmanian, M., Seyfoori, A., Ghasemi, M., Shamsi, M., Kolahchi, A. R., Modarres, H. P., Sanati‐Nezhad, A., & Majidzadeh‐A, K. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.04.024 · Cited by 42

Methoxy poly (ethylene glycol)-block-poly (glutamic acid)-graft-6-(2-nitroimidazole) hexyl amine nanoparticles for potential hypoxia-responsive delivery of doxorubicin

Ahmad, Z., Lv, S., Tang, Z., Shah, A., & Chen, X. (2015) · Journal of Biomaterials Science Polymer Edition · doi:10.1080/09205063.2015.1107707 · Cited by 42

Multi-tracer small animal PET imaging of the tumour response to the novel pan-Erb-B inhibitor CI-1033

Dorow, D. S., Cullinane, C. M., Conus, N. M., Roselt, P. D., Binns, D., McCarthy, T. J., McArthur, G. A., & Hicks, R. J. (2006) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-005-0039-5 · Cited by 42

NK4 gene therapy targeting HGF-Met and angiogenesis

Matsumoto, K. (2007) · Frontiers in bioscience · doi:10.2741/2813 · Cited by 42

Assessment of fraction of radiobiologically hypoxic cells in human melanoma xenografts by dynamic contrast‐enhanced MRI

Egeland, T. A. M., Gaustad, J., Vestvik, I. K., et al. (2006) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20852 · Cited by 42

Combined hyperthermia and chlorophyll-based photodynamic therapy: tumour growth and metabolic microenvironment

Kelleher, D. K., Thews, O., Scherz, A. J., et al. (2003) · British Journal of Cancer · doi:10.1038/sj.bjc.6601457 · Cited by 42

Targeting the Vascular Endothelial Growth Factor Pathway in the Treatment of Human Malignancy

Tonra, J. R., & Hicklin, D. J. (2006) · Immunological Investigations · doi:10.1080/08820130600991794 · Cited by 43

Up-regulation of the hypoxia-inducible factor–1 transcriptional pathway in colorectal carcinomas

Furlan, D., Sahnane, N., Carnevali, I. W., Cerutti, R., Bertoni, F., Kwee, I., Uccella, S., Bertolini, V., Chiaravalli, A. M., & Capella, C. (2008) · Human Pathology · doi:10.1016/j.humpath.2008.02.013 · Cited by 42

Radiobiological effects of hypoxia-dependent uptake of 64Cu-ATSM: enhanced DNA damage and cytotoxicity in hypoxic cells

Weeks, A. J., Paul, R. L., Marsden, P. K., et al. (2009) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-009-1305-8 · Cited by 42

Evaluation of the antineoplastic activity of gallic acid in oral squamous cell carcinoma under hypoxic conditions

Guimarães, T. A., Farias, L. C., Fraga, C. A. D. C., Feltenberger, J. D., Melo, G. A., Coletta, R. D., Santos, S. H. S., de Paula, A. M. B., & Guimarães, A. L. S. (2016) · Anti-Cancer Drugs · doi:10.1097/cad.0000000000000342 · Cited by 44

Erythropoietin restores the antitumor effectiveness of photodynamic therapy in mice with chemotherapy-induced anemia.

Gołąb, J., Olszewska, D., Mróz, P., Kozar, K., Kamiński, R., Jalili, A., & Jakóbisiak, M. (2002) · PubMed · Cited by 42

Hyperbaric Oxygen Activates Enzyme‐Driven Cascade Reactions for Cooperative Cancer Therapy and Cancer Stem Cells Elimination

Xiong, Y., Yong, Z., Chen, X., Deng, Q., Wang, Q., Li, S., Wang, C., Zhang, Z., Yang, X., & Li, Z. (2023) · Advanced Science · doi:10.1002/advs.202301278 · Cited by 42

Expression of DDX3 Is Directly Modulated by Hypoxia Inducible Factor-1 Alpha in Breast Epithelial Cells

Botlagunta, M., Krishnamachary, B., Vesuna, F., Winnard, P. T., Bol, G. M., Patel, A. H., & Raman, V. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017563 · Cited by 41

In Vitro Optimization of EtNBS-PDT against Hypoxic Tumor Environments with a Tiered, High-Content, 3D Model Optical Screening Platform

Klein, O. J., Bhayana, B., Park, Y. J., et al. (2012) · Molecular Pharmaceutics · doi:10.1021/mp300262x · Cited by 41

Quantitative Assessment of Heterogeneity in Tumor Metabolism Using FDG-PET

Vriens, D., Disselhorst, J. A., Oyen, W. J. G., et al. (2012) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2011.11.039 · Cited by 41

Mitochondria-specific Oxygen Probe Based on Iridium Complexes Bearing Triphenylphosphonium Cation

Murase, T., Yoshihara, T., & Tobita, S. (2012) · Chemistry Letters · doi:10.1246/cl.2012.262 · Cited by 41

Glycolysis inhibitor 2-deoxy-D-glucose suppresses carcinogen-induced rat hepatocarcinogenesis by restricting cancer cell metabolism

WANG, Z., ZHANG, L., ZHANG, D., et al. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.2945 · Cited by 41

Bisecting N-Acetylglucosamine Structures Inhibit Hypoxia-Induced Epithelial-Mesenchymal Transition in Breast Cancer Cells

Tan, Z., Wang, C., Li, X., & Guan, F. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00210 · Cited by 42

Recent Advances in Functional‐Polymer‐Decorated Transition‐Metal Nanomaterials for Bioimaging and Cancer Therapy

Zhao, W., Li, A., Zhang, A., Zheng, Y., & Liu, J. (2018) · ChemMedChem · doi:10.1002/cmdc.201800462 · Cited by 43

Photothermal-Controlled Generation of Alkyl Radical from Organic Nanoparticles for Tumor Treatment

Xia, R., Zheng, X., Hu, X., et al. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b18953 · Cited by 41

MRI Distinguishes Tumor Hypoxia Levels of Different Prognostic and Biological Significance in Cervical Cancer

Hillestad, T., Hompland, T., Fjeldbo, C. S., Skingen, V. E., Salberg, U. B., Aarnes, E., Nilsen, A., Lund, K. V., Evensen, T. S., Kristensen, G. B., et al. (2020) · Cancer Research · doi:10.1158/0008-5472.can-20-0950 · Cited by 41

Local delivery to malignant brain tumors: potential biomaterial-based therapeutic/adjuvant strategies

Alghamdi, M. A., Gumbleton, M., & Newland, B. (2021) · Biomaterials Science · doi:10.1039/d1bm00896j · Cited by 45

Severe hypoxia is a typical characteristic of human hepatocellular carcinoma: Scientific fact or fallacy?

Cramer, T., & Vaupel, P. W. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2021.12.028 · Cited by 41

Elevated Serum Level of IL-23 Correlates with Expression of VEGF in Human Colorectal Carcinoma

Ljujić, B., Radosavljevic, G. D., Jovanović, I., Pavlovic, S. M., Zdravkovic, N. S., Milovanović, M., Aćimović, L., Knežević, M., Banković, D., Zdravkovic, D., et al. (2010) · Archives of Medical Research · doi:10.1016/j.arcmed.2010.02.009 · Cited by 41

Hypoxia-inducible factor 2α: a novel target in gliomas

Renfrow, J. J., Soike, M. H., Debinski, W., Ramkissoon, S. H., Mott, R. T., Frenkel, M. B., Sarkaria, J. N., Lesser, G. J., & Strowd, R. E. (2018) · Future Medicinal Chemistry · doi:10.4155/fmc-2018-0163 · Cited by 40

Characterization of tumor hypoxia by 31P MR spectroscopy.

Steen, R. G. (1991) · American Journal of Roentgenology · doi:10.2214/ajr.157.2.1853799 · Cited by 28

The Clinical Importance of Assessing Tumor Hypoxia: Relationship of Tumor Hypoxia to Prognosis and Therapeutic Opportunities

Walsh, J. C., Lebedev, A. Y., Aten, E., Madsen, K. S., Marciano, L., & Kolb, H. C. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5378 · Cited by 432

Hypoxia-induced tumor biological behavior changes and application of radiotracers for PET imaging of tumor hypoxia

Zhang, M., Jiang, H., & Xu, H. (2017) · doi:10.3760/cma.j.issn.1671-7368.2017.07.021

Determination of the dynamics of tumor hypoxia during radiation therapy using biological imaging on mouse xenograft tumors

Maftei, C. (2013)

Hypoxia PET/CT imaging: implications for radiation oncology.

Arabi, M., & Piert, M. (2010) · PubMed · Cited by 28