The DOI matches its Crossref record; 158 of the 159 references it cites were found in a registry or an index.
Tumor Hypoxia: Definitions and Current Clinical, Biologic, and Molecular Aspects
Abstract
Tissue hypoxia results from an inadequate supply of oxygen (O(2)) that compromises biologic functions. Evidence from experimental and clinical studies increasingly points to a fundamental role for hypoxia in solid tumors. Hypoxia in tumors is primarily a pathophysiologic consequence of structurally and functionally disturbed microcirculation and the deterioration of diffusion conditions. Tumor hypoxia appears to be strongly associated with tumor propagation, malignant progression, and resistance to therapy, and it has thus become a central issue in tumor physiology and cancer treatment. Biochemists and clinicians (as well as physiologists) define hypoxia differently; biochemists define it as O(2)-limited electron transport, and physiologists and clinicians define it as a state of reduced O(2) availability or decreased O(2) partial pressure that restricts or even abolishes functions of organs, tissues, or cells. Because malignant tumors no longer execute functions necessary for homeostasis (such as the production of adequate amounts of adenosine triphosphate), the physiology-based definitions of the term "hypoxia" are not necessarily valid for malignant tumors. Instead, alternative definitions based on clinical, biologic, and molecular effects that are observed at O(2) partial pressures below a critical level have to be applied.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Wang, G. L., Jiang, B. H., Rue, E. A., & Semenza, G. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.12.5510 · Cited by 6,212
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
Maxwell, P. H., Wiesener, M. S., Chang, G.-W., Clifford, S. C., Vaux, E. C., Cockman, M. E., Wykoff, C. C., Pugh, C. W., Maher, E. R., & Ratcliffe, P. J. (1999) · Nature · doi:10.1038/20459 · Cited by 5,180
Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
Shweiki, D., Itin, A., Soffer, D., & Keshet, E. (1992) · Nature · doi:10.1038/359843a0 · Cited by 4,617
Radiobiology for the Radiologist.
(1974) · Annals of Internal Medicine · doi:10.7326/0003-4819-80-3-438_1 · Cited by 3,498
(1989) · PubMed · Cited by 3,343
Self-citationHypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
Graeber, T. G., Osmanian, C., Jacks, T., Housman, D. E., Koch, C. J., Lowe, S. W., & Giaccia, A. J. (1996) · Nature · doi:10.1038/379088a0 · Cited by 2,300
Gray, L. H., Conger, A. D., Ebert, M., Hornsey, S., & Scott, O. C. A. (1953) · The British Journal of Radiology · doi:10.1259/0007-1285-26-312-638 · Cited by 2,158
Holmgren, L., O’Reilly, M. S., & Folkman, J. (1995) · Nature Medicine · doi:10.1038/nm0295-149 · Cited by 1,891
HIF-1: mediator of physiological and pathophysiological responses to hypoxia
Semenza, G. L. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.88.4.1474 · Cited by 1,822
Höckel, M., Schlenger, K., Aral, B., Mitze, M., Schäffer, U., & Vaupel, P. W. (1996) · PubMed · Cited by 1,727
Self-citation
Research works printed but not linked: 35
- Brown, 1998, Cancer Research, 58, 1408
- Hockel, 1996, Cancer Research, 56, 4509
- Brizel, 1996, Cancer Research, 56, 941
- Walenta, 2000, Cancer Research, 60, 916
- Hockel, 1999, Cancer Research, 59, 4525
- Kim, 1997, Cancer Research, 57, 4200
- Anthoney, 1996, Cancer Research, 56, 1374
- Vaupel, 1989, Cancer Research, 49, 6449
- Vaupel, 1987, Cancer Research, 47, 3496
- Kallinowski, 1989, Cancer Research, 49, 3759
- 1973, Advances in experimental medicine and biology, 37, 277
- Vaupel, 1991, Cancer Research, 51, 3316
- Hockel, 1991, Cancer Research, 51, 6098
- Wilson, 1992, Cancer Research, 52, 3988
- 1996, BRITISH JOURNAL OF CANCER, 74, S226
- Valk, 1992, Journal of Nuclear Medicine, 33, 2133
- Groshar, 1993, Journal of Nuclear Medicine, 34, 885
- Lord, 1993, Cancer Research, 53, 5721
- Evans, 1996, Cancer Research, 56, 405
- Riva, 1998, Anticancer Research, 18, 4729
- Prehn, 1991, Cancer Research, 51, 2
- Ausserer, 1994, Molecular and Cellular Biology, 14, 5032, 10.1128/mcb.14.8.5032 · DOI
- Hartmann, 1999, Cancer Research, 59, 1578
- Koong, 1994, Cancer Research, 54, 1425
- Henderson, 1987, Cancer Research, 47, 3110
- Mitchell, 1985, Cancer Research, 45, 2008
- Reynolds, 1996, Cancer Research, 56, 5754
- Stoler, 1992, Cancer Research, 52, 4372
- Russo, 1995, Cancer Research, 55, 1122
- Teicher, 1990, Cancer Research, 50, 3339
- Teicher, 1981, Cancer Research, 41, 73
- Moan, 1985, Cancer Research, 45, 1608
- 1981, Bibliotheca anatomica, 20, 628
- 1996, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 46, S107
- 1998, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 48, S162
Cited by
Sorted by citations
Items 101–200 of 1,008
The urokinase plasminogen activator system: a target for anti-cancer therapy
Ulisse, S., Baldini, E., Sorrenti, S., & D'Armiento, M. (2009) · Current Cancer Drug Targets · doi:10.2174/156800909787314002 · Cited by 312
Redox mechanisms switch on hypoxia-dependent epithelial–mesenchymal transition in cancer cells
Cannito, S., Novo, E., Compagnone, A., di Bonzo, L. V., Busletta, C., Zamara, E., Paternostro, C., Povero, D., Bandino, A., Bozzo, F., et al. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn216 · Cited by 319
Investigating hypoxic tumor physiology through gene expression patterns
Denko, N. C., Fontana, L., Hudson, K. M., Sutphin, P. D., Raychaudhuri, S., Altman, R. B., & Giaccia, A. J. (2003) · Oncogene · doi:10.1038/sj.onc.1206703 · Cited by 313
Cancer Stem Cells and Radioresistance: DNA Repair and Beyond
Schulz, A., Meyer, F., Dubrovska, A., & Borgmann, K. (2019) · Cancers · doi:10.3390/cancers11060862 · Cited by 317
Tumor hypoxia and cancer progression
Zhou, J., Schmid, T., Schnitzer, S. E., & Brüne, B. (2005) · Cancer Letters · doi:10.1016/j.canlet.2005.05.028 · Cited by 306
Masson, N., & Ratcliffe, P. J. (2014) · Cancer & Metabolism · doi:10.1186/2049-3002-2-3 · Cited by 305
Why develop photoactivated chemotherapy?
Bonnet, S. A. (2018) · Dalton Transactions · doi:10.1039/c8dt01585f · Cited by 300
Song, X., Xu, J., Liang, C., Chao, Y., Jin, Q., Wang, C., Chen, M., & Liu, Z. (2018) · Nano Letters · doi:10.1021/acs.nanolett.8b02720 · Cited by 299
Recent advances in luminescent heavy metal complexes for sensing
Ma, D., Ma, V. P., Chan, D. S., Leung, K., He, H., & Leung, C. (2012) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2012.07.005 · Cited by 299
Immunometabolism in early and late stages of rheumatoid arthritis
Weyand, C. M., & Goronzy, J. J. (2017) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2017.49 · Cited by 296
The utility and limitations of glycosylated human CD133 epitopes in defining cancer stem cells
Bidlingmaier, S. M., Zhu, X., & Liu, B. (2008) · Journal of Molecular Medicine · doi:10.1007/s00109-008-0357-8 · Cited by 287
Wartenberg, M., Ling, F. C., Müschen, M., Klein, F., Acker, H., Gassmann, M., Petrat, K., Pütz, V., Hescheler, J., & Sauer, H. (2003) · The FASEB Journal · doi:10.1096/fj.02-0358fje · Cited by 287
Regulation of reactive oxygen species in stem cells and cancer stem cells
Kobayashi, C. I., & Suda, T. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22764 · Cited by 298
Negative and positive regulation of HIF-1: A complex network
Bárdos, J. I., & Ashcroft, M. A. (2005) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2005.05.001 · Cited by 287
Translational Activation of HIF1α by YB-1 Promotes Sarcoma Metastasis
El-Naggar, A. M., Veinotte, C. J., Cheng, H., Grünewald, T. G. P., Negri, G. L., Somasekharan, S. P., Corkery, D., Tirode, F., Mathers, J. A., Khan, D., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.04.003 · Cited by 288
Hypoxia Positron Emission Tomography Imaging With 18F-Fluoromisonidazole
Lee, S. T., & Scott, A. M. (2007) · Seminars in Nuclear Medicine · doi:10.1053/j.semnuclmed.2007.07.001 · Cited by 283
Up-down regulation of HIF-1α in cancer progression
Rashid, M., Zadeh, L. R., Baradaran, B., Molavi, O., Ghesmati, Z., Sabzichi, M., & Ramezani, F. (2021) · Gene · doi:10.1016/j.gene.2021.145796 · Cited by 302
Vergis, R., Corbishley, C. M., Norman, A. R., Bartlett, J., Jhavar, S., Borre, M., Heeboll, S., Horwich, A., Huddart, R., Khoo, V., et al. (2008) · The Lancet Oncology · doi:10.1016/s1470-2045(08)70076-7 · Cited by 282
Grassian, A. R., Parker, S. J., Davidson, S. M., Divakaruni, A. S., Green, C. R., Zhang, X., Slocum, K. L., Pu, M., Lin, F., Vickers, C., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-0772-t · Cited by 280
“The metabolic deficiencies of IDH1-mutant cells occur at oxygen tensions that are likely to occur in solid tumors and some normal tissues (44).”
Bakker, W. J., Harris, I. S., & Mak, T. W. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.10.035 · Cited by 277
Bussink, J., Kaanders, J. H. A. M., & van der Kogel, A. J. (2003) · Radiotherapy and Oncology · doi:10.1016/s0167-8140(03)00011-2 · Cited by 280
Spence, A. M., Muzi, M., Swanson, K. R., O’Sullivan, F., Rockhill, J. K., Rajendran, J. G., Adamsen, T. C. H., Link, J. M., Swanson, P. E., Yagle, K. J., et al. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-4995 · Cited by 282
Overgaard, J., Eriksen, J. G., Nordsmark, M., Alsner, J., & Horsman, M. R. (2005) · The Lancet Oncology · doi:10.1016/s1470-2045(05)70292-8 · Cited by 274
Regulation of Angiogenesis by Hypoxia and Hypoxia‐Inducible Factors
Hickey, M. M., & Simon, M. C. (2006) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(06)76007-0 · Cited by 273
The mechanisms by which polyamines accelerate tumor spread
Soda, K. (2011) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/1756-9966-30-95 · Cited by 276
Zi, Y., Yang, K., He, J., Wu, Z., Liu, J., & Zhang, W. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114449 · Cited by 268
Gao, S., Wang, G., Qin, Z., Wang, X., Zhao, G., Ma, Q., & Zhu, L. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.10.030 · Cited by 260
Hypoxia induces a novel signature of chromatin modifications and global repression of transcription
Johnson, A. B., Denko, N., & Barton, M. C. (2008) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2008.01.001 · Cited by 250
“Within normal cells, hypoxic stress generally leads to cell cycle arrest, apoptosis, and/or necrosis [1].”
BackgroundExploiting nanotechnology to overcome tumor drug resistance: Challenges and opportunities
Kirtane, A. R., Kalscheuer, S., & Panyam, J. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.09.001 · Cited by 264
Wei, H., Liu, L., & Chen, Q. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.03.013 · Cited by 266
ARCON: a novel biology-based approach in radiotherapy
Kaanders, J. H., Bussink, J., & van der Kogel, A. J. (2002) · The Lancet Oncology · doi:10.1016/s1470-2045(02)00929-4 · Cited by 257
Nanoparticles for modulating tumor microenvironment to improve drug delivery and tumor therapy
Yang, S., & Gao, H. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.05.004 · Cited by 256
Generali, D., Berruti, A., Brizzi, M. P., Campo, L., Bonardi, S., Wigfield, S., Bersiga, A., Allevi, G., Milani, M., Aguggini, S., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-2690 · Cited by 253
Exosomes: Key mediators of metastasis and pre-metastatic niche formation
Lobb, R. J., Lima, L. G., & Möller, A. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.01.004 · Cited by 252
The biology of extracellular microvesicles
Sedgwick, A., & D’Souza‐Schorey, C. (2018) · Traffic · doi:10.1111/tra.12558 · Cited by 257
Wang, Y., Jin, Y., Chen, W., Wang, J., Chen, H., Sun, L. N., Li, X., Ji, J., Yu, Q., Shen, L., et al. (2018) · Chemical Engineering Journal · doi:10.1016/j.cej.2018.10.002 · Cited by 245
Carbon dots: a booming material for biomedical applications
Su, W., Wu, H., Xu, H., Zhang, Y., Li, Y., Li, X., & Fan, L. (2019) · Materials Chemistry Frontiers · doi:10.1039/c9qm00658c · Cited by 244
Microenvironmental and cellular consequences of altered blood flow in tumours
Raghunand, N., Gatenby, R. A., & Gillies, R. J. (2003) · British Journal of Radiology · doi:10.1259/bjr/12913493 · Cited by 240
Silencing of the Hypoxia-Inducible Cell Death Protein BNIP3 in Pancreatic Cancer
Okami, J., Simeone, D. M., & Logsdon, C. D. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0089 · Cited by 237
Targeting the hypoxic fraction of tumours using hypoxia-activated prodrugs
Phillips, R. M. (2016) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-015-2920-7 · Cited by 248
Cycling hypoxia: A key feature of the tumor microenvironment
Michiels, C., Tellier, C., & Féron, O. (2016) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2016.06.004 · Cited by 244
Hewitson, K. S., Liénard, B. M. R., McDonough, M. A., Clifton, I. J., Butler, D., Soares, A. S., Oldham, N. J., McNeill, L. A., & Schofield, C. J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m608337200 · Cited by 235
Antiangiogenic therapy and tumor progression
Blagosklonny, M. V. (2004) · Cancer Cell · doi:10.1016/s1535-6108(03)00336-2 · Cited by 238
The Coppery Age: Copper (Cu)‐Involved Nanotheranostics
Dong, C., Feng, W., Xu, W., Yu, L., Xiang, H., Chen, Y., & Zhou, J. (2020) · Advanced Science · doi:10.1002/advs.202001549 · Cited by 236
Kanapathipillai, M., Brock, A., & Ingber, D. E. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.05.005 · Cited by 234
Silver Nanoplate Contrast Agents for in Vivo Molecular Photoacoustic Imaging
Homan, K. A., Souza, M., Truby, R. L., Luke, G. P., Green, C., Vreeland, E. C., & Emelianov, S. (2011) · ACS Nano · doi:10.1021/nn204100n · Cited by 233
Carbonic Anhydrase Inhibition and the Management of Hypoxic Tumors
Supuran, C. T. (2017) · Metabolites · doi:10.3390/metabo7030048 · Cited by 234
Photoacoustic Imaging for Cancer Detection and Staging
Mehrmohammadi, M., Yoon, S. J., Yeager, D., & Emelianov, S. (2013) · Current molecular imaging · doi:10.2174/2211555211302010010 · Cited by 232
Ketogenic Diets Enhance Oxidative Stress and Radio-Chemo-Therapy Responses in Lung Cancer Xenografts
Allen, B. G., Bhatia, S. K., Buatti, J. M., Brandt, K. E., Lindholm, K. E., Button, A. M., Szweda, L. I., Smith, B. J., Spitz, D. R., & Fath, M. A. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-0287 · Cited by 232
Three-dimensional multispecies nonlinear tumor growth—II: Tumor invasion and angiogenesis
Frieboes, H. B., Jin, F., Chuang, Y.-L., Wise, S. M., Lowengrub, J. S., & Vittorio Cristini, C. (2010) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2010.02.036 · Cited by 236
Hepatocyte growth factor and the Met system as a mediator of tumor–stromal interactions
Matsumoto, K., & Nakamura, T. (2006) · International Journal of Cancer · doi:10.1002/ijc.21808 · Cited by 237
Vleugel, M. M., Greijer, A. E., Shvarts, A., van der Groep, P., van Berkel, M., Aarbodem, Y., van Tinteren, H., Harris, A. L., van Diest, P. J., & van der Wall, E. (2005) · Journal of Clinical Pathology · doi:10.1136/jcp.2004.019885 · Cited by 227
The Warburg effect: Evolving interpretations of an established concept
Chen, X., Qian, Y., & Wu, S. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.08.027 · Cited by 234
Tumor Hypoxia: Impact on Radiation Therapy and Molecular Pathways
Sørensen, B. S., & Horsman, M. R. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00562 · Cited by 241
Modeling tumor cell adaptations to hypoxia in multicellular tumor spheroids
Riffle, S., & Hegde, R. S. (2017) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-017-0570-9 · Cited by 231
The A3 adenosine receptor: An enigmatic player in cell biology
Gessi, S., Merighi, S., Varani, K., Leung, E., Lennan, S. M., & Borea, P. A. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.09.002 · Cited by 225
Adenosine receptors and cancer
Gessi, S., Merighi, S., Sacchetto, V., Simioni, C., & Borea, P. A. (2010) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2010.09.020 · Cited by 229
Assessment of tumor oxygenation by electron paramagnetic resonance: principles and applications
Gallez, B., Baudelet, C., & Jordan, B. F. (2004) · NMR in Biomedicine · doi:10.1002/nbm.900 · Cited by 225
Ratiometric Molecular Sensor for Monitoring Oxygen Levels in Living Cells
Yoshihara, T., Yamaguchi, Y., Hosaka, M., et al. (2012) · Angewandte Chemie International Edition · doi:10.1002/anie.201107557 · Cited by 222
Multimodality Brain Tumor Imaging: MR Imaging, PET, and PET/MR Imaging
Fink, J. R., Muzi, M., Peck, M., & Krohn, K. A. (2015) · Journal of Nuclear Medicine · doi:10.2967/jnumed.113.131516 · Cited by 230
Cao, X., Fang, L., Gibbs, S. T., Huang, Y. S., Dai, Z., Wen, P., Zheng, X., Sadée, W., & Sun, D. (2006) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-006-0291-9 · Cited by 222
Airley, R. E., Loncaster, J. A., Raleigh, J. A., Harris, A. L., Davidson, S. E., Hunter, R. D., West, C., & Stratford, I. J. (2003) · International Journal of Cancer · doi:10.1002/ijc.10904 · Cited by 220
Yoon, S.-O., Shin, S., & Mercurio, A. M. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-4122 · Cited by 226
Choi, H., Chun, Y., Kim, S.-W., Kim, M.-S., & Park, J. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.025817 · Cited by 219
Connolly, E. P., Braunstein, S. E., Formenti, S. C., & Schneider, R. J. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.10.3955-3965.2006 · Cited by 227
Attalla, S. S., Taifour, T., Bui, T., & Muller, W. J. (2020) · Oncogene · doi:10.1038/s41388-020-01560-0 · Cited by 215
Improving cancer therapy through the nanomaterials-assisted alleviation of hypoxia
Sahu, A., Kwon, I., & Tae, G. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119578 · Cited by 219
Fluence rate as a modulator of PDT mechanisms
Henderson, B. W., Busch, T. M., & Snyder, J. W. (2006) · Lasers in Surgery and Medicine · doi:10.1002/lsm.20327 · Cited by 217
Saxena, K., & Jolly, M. K. (2019) · Biomolecules · doi:10.3390/biom9080339 · Cited by 223
Diagaradjane, P., Shetty, A., Wang, J. C., Elliott, A. M., Schwartz, J., Shentu, S., Park, H. C., Deorukhkar, A., Stafford, R. J., Cho, S. H., et al. (2008) · Nano Letters · doi:10.1021/nl080496z · Cited by 215
Zhang, X., Tian, G., Yin, W., Wang, L., Zheng, X., Yan, L., Li, J., Su, H., Chen, C., Gu, Z., et al. (2015) · Advanced Functional Materials · doi:10.1002/adfm.201404402 · Cited by 215
Targeting the hypoxia-inducible factor (HIF) pathway in cancer
Poon, E., Harris, A. L., & Ashcroft, M. A. (2009) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399409001173 · Cited by 215
RBE and related modeling in carbon-ion therapy
Karger, C. P., & Peschke, P. (2017) · Physics in Medicine and Biology · doi:10.1088/1361-6560/aa9102 · Cited by 224
Mitochondrial Akt Regulation of Hypoxic Tumor Reprogramming
Chae, Y. C., Vaira, V., Caino, M. C., Tang, H., Seo, J. H., Kossenkov, A. V., Ottobrini, L., Martelli, C., Lucignani, G., Bertolini, I., et al. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.07.004 · Cited by 214
Carbonic anhydrase 9 as an endogenous marker for hypoxic cells in cervical cancer.
Olive, P. L., Aquino‐Parsons, C., MacPhail, S. H., Liao, S. Y., Raleigh, J. A., Lerman, M. I., & Stanbridge, E. J. (2001) · PubMed · Cited by 206
Cancer cell differentiation heterogeneity and aggressive behavior in solid tumors
Jögi, A., Vaapil, M., Johansson, M., & Påhlman, S. (2012) · Upsala Journal of Medical Sciences · doi:10.3109/03009734.2012.659294 · Cited by 209
Hypoxia‐inducible factor‐1 and oncogenic signalling
Bárdos, J. I., & Ashcroft, M. A. (2004) · BioEssays · doi:10.1002/bies.20002 · Cited by 208
Clinical photoacoustic imaging platforms
Choi, W., Park, E.-Y., Jeon, S., & Kim, C. (2018) · Biomedical Engineering Letters · doi:10.1007/s13534-018-0062-7 · Cited by 204
Molecular and Cellular Pharmacology of the Hypoxia-Activated Prodrug TH-302
Meng, F., Evans, J., Bhupathi, D., Banica, M., Lan, L., Lorente, G., Duan, J.-X., Cai, X., Mowday, A. M., Guise, C. P., et al. (2011) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-11-0634 · Cited by 205
Modulating tumor hypoxia by nanomedicine for effective cancer therapy
Jahanban‐Esfahlan, R., de la Guardia, M., Ahmadi, D., & Yousefi, B. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.25859 · Cited by 201
“It is well documented that hypoxic tolerant tumor cells are resistant to most anti-cancer treatments, especially radiotherapy (RT) (Höckel and Vaupel, 2001; Rofstad et al., 2000), chemotherapy (CT) (Cosse and Michiels, 2008; Shannon et al.”
BackgroundZhang, Q., Tang, X., Lu, Q., Zhang, Z., Brown, J. J., & Le, A. D. (2005) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-05-0198 · Cited by 205
Molecular imaging of hypoxia with radiolabelled agents
Mees, G., Dierckx, R. A. J. O., Vangestel, C., & de Wiele, C. V. (2009) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-009-1195-9 · Cited by 201
Vullo, D., Franchi, M., Gallori, E., Pastorek, J., Scozzafava, A., Pastoreková, S., & Supuran, C. T. (2003) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(03)00091-x · Cited by 201
Hypoxic tumor microenvironment: Opportunities to develop targeted therapies
Patel, A., & Sant, S. (2016) · Biotechnology Advances · doi:10.1016/j.biotechadv.2016.04.005 · Cited by 205
Pugh, C. W., & Ratcliffe, P. J. (2002) · Seminars in Cancer Biology · doi:10.1016/s1044-579x(02)00103-7 · Cited by 205
Redox sensor CtBP mediates hypoxia-induced tumor cell migration
Zhang, Q., Wang, S.-Y., Nottke, A. C., Rocheleau, J. V., Piston, D. W., & Goodman, R. H. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603269103 · Cited by 200
Effects of Acute versus Chronic Hypoxia on DNA Damage Responses and Genomic Instability
Pires, I. M., Bencokova, Z., Milani, M., Folkes, L. K., Li, J., Stratford, M. R., Harris, A. L., & Hammond, E. M. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-2715 · Cited by 209
Prediction of Tumor Recurrence and Therapy Monitoring Using Ultrasound-Guided Photoacoustic Imaging
Mallidi, S., Watanabe, K., Timerman, D., Schoenfeld, D., & Hasan, T. G. (2015) · Theranostics · doi:10.7150/thno.10155 · Cited by 200
Yasuda, H. (2008) · Nitric Oxide · doi:10.1016/j.niox.2008.04.026 · Cited by 199
Targeting amino acid metabolism in cancer growth and anti-tumor immune response
Ananieva, E. A. (2015) · World Journal of Biological Chemistry · doi:10.4331/wjbc.v6.i4.281 · Cited by 203
Kharaishvili, G., Simkova, D., Bouchalova, K., Gachechiladze, M., Narsia, N., & Bouchal, J. (2014) · Cancer Cell International · doi:10.1186/1475-2867-14-41 · Cited by 197
“LOXL2 has been reported to be involved in invasiveness [27] and specifically expressed by fibroblasts in tumor tissue [28].”
BackgroundQuennet, V., Yaromina, A., Zips, D., Rosner, A., Walenta, S., Baumann, M. A., & Mueller‐Klieser, W. (2006) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2006.08.012 · Cited by 197
Borad, M. J., Reddy, S. G., Bahary, N., Uronis, H. E., Sigal, D., Cohn, A. L., Schelman, W. R., Stephenson, J., Chiorean, E. G., Rosen, P. J., et al. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2014.55.7504 · Cited by 197
PET radiopharmaceuticals for imaging of tumor hypoxia: a review of the evidence.
Lopci, E., Grassi, I., Chiti, A., Nanni, C., Cicoria, G., Toschi, L., Fonti, C., Lodi, F., Mattioli, S., & Fanti, S. (2014) · PubMed Central · Cited by 196
Li, Y., Patel, S. P., Roszik, J., & Qin, Y. W. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01591 · Cited by 203
Current and future trends in photoacoustic breast imaging
Manohar, S., & Dantuma, M. (2019) · Photoacoustics · doi:10.1016/j.pacs.2019.04.004 · Cited by 193
Tan, E. Y., Yan, M., Campo, L., Han, C., Takano, E. A., Turley, H., Candiloro, I. L. M., Pezzella, F., Gatter, K. C., Millar, E. K. A., et al. (2009) · British Journal of Cancer · doi:10.1038/sj.bjc.6604844 · Cited by 195
Lee, L. C., Leung, P. K., & Lo, K. K. (2017) · Dalton Transactions · doi:10.1039/c7dt03465b · Cited by 197
Ács, G., Zhang, P. J., McGrath, C. M., Acs, P. I., McBroom, J. W., Mohyeldin, A., Liu, S., Lu, H., & Verma, A. M. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64314-3 · Cited by 194
HIF-1 antagonizes p53-mediated apoptosis through a secreted neuronal tyrosinase
Sendoel, A., Köhler, I., Fellmann, C., Lowe, S. W., & Hengartner, M. O. (2010) · Nature · doi:10.1038/nature09141 · Cited by 191
Metadata
- Authors
- Hockel, M., & Vaupel, P.
- Affiliations
- Johannes Gutenberg University Mainz (DE)
- Corresponding author
- Vaupel, P.
- ORCID
- Vaupel, P.
- Venue
- JNCI Journal of the National Cancer Institute
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-02-21
- Volume
- 93
- Issue
- 4
- Pages
- 266-276
- ISSN
- 0027-8874 (ISSN-L)
- 1460-2105
- OpenAlex
- W2125257427
- Semantic Scholar
- 6c70b98add72efaae8670b5183983be403de59ae
- Cited by
- 2,662
- References
- 159
- Citations by year
- 2026: 46 · 2025: 65 · 2024: 93 · 2023: 134 · 2022: 110 · 2021: 139 · 2020: 149 · 2019: 120 · 2018: 110 · 2017: 148 · 2016: 143 · 2015: 123 · 2014: 114 · 2013: 104 · 2012: 114
- FWCI
- 5.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JNCI Journal of the National Cancer Institute (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- tumor hypoxia, tissue hypoxia, solid tumors, tumor microcirculation, oxygen partial pressure, tumor progression, treatment resistance, tumor physiology, oxygen diffusion
- MeSH terms
- Animals, Humans, Neoplasms, Oxygen, Predictive Value of Tests, Prognosis, Risk Factors, Cell Hypoxia, Disease Progression
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review