Tumor Hypoxia: Definitions and Current Clinical, Biologic, and Molecular Aspects

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Hypoxia Responsive, Tumor Penetrating Lipid Nanoparticles for Delivery of Chemotherapeutics to Pancreatic Cancer Cell Spheroids

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Carboxymethyl dextran-based hypoxia-responsive nanoparticles for doxorubicin delivery

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Transcriptional Regulation of Urokinase-type Plasminogen Activator Receptor by Hypoxia-Inducible Factor 1 Is Crucial for Invasion of Pancreatic and Liver Cancer

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Ascorbate depletion mediates up‐regulation of hypoxia‐associated proteins by cell density and nickel

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In vitro models of tumor vessels and matrix: Engineering approaches to investigate transport limitations and drug delivery in cancer

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Normal to cancer microbiome transformation and its implication in cancer diagnosis

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Metabolic Modulation Induced by Chronic Hypoxia in Rats Using a Comparative Proteomic Analysis of Skeletal Muscle Tissue

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Intrinsic Susceptibility MR Imaging of Chemically Induced Rat Mammary Tumors: Relationship to Histologic Assessment of Hypoxia and Fibrosis

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Synergistic up-regulation of Hexokinase-2, glucose transporters and angiogenic factors in pancreatic cancer cells by glucose deprivation and hypoxia

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Autophagy contributes to the chemo-resistance of non-small cell lung cancer in hypoxic conditions

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Colocalization of Carbonic Anhydrase 9 Expression and Cell Proliferation in Human Head and Neck Squamous Cell Carcinoma

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Imaging hypoxia in gliomas

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In Vitro and In Vivo Evaluation of Bifunctional Bisthiosemicarbazone 64Cu-Complexes for the Positron Emission Tomography Imaging of Hypoxia

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Blood pressure control and diabetic retinopathy

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Metabolic microenvironment of tumor cells: a key factor in malignant progression.

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Capsaicin inhibits benzo(a)pyrene-induced lung carcinogenesis in an in vivo mouse model

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Green tea and black tea consumption in relation to colorectal cancer risk: the Singapore Chinese Health Study

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Tumor Microenvironment-Responsive Nanoparticle Delivery of Chemotherapy for Enhanced Selective Cellular Uptake and Transportation within Tumor

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Hypoxic Microenvironment and Metastatic Bone Disease

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Differential involvement of vascular endothelial growth factor in the survival of hypoxic colon cancer cells

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Role of hydrogen sulphide in physiological and pathological angiogenesis

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Regulation of G1 Arrest and Apoptosis in Hypoxia by PERK and GCN2-Mediated eIF2α Phosphorylation

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Combining Tumor Microenvironment Modulating Nanoparticles with Doxorubicin to Enhance Chemotherapeutic Efficacy and Boost Antitumor Immunity

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Smart Unimolecular Micelle-Based Polyprodrug with Dual-Redox Stimuli Response for Tumor Microenvironment: Enhanced in Vivo Delivery Efficiency and Tumor Penetration

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HIF-transcribed p53 chaperones HIF-1α

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Metabolic targeting of HIF-1α potentiates the therapeutic efficacy of oxaliplatin in colorectal cancer

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Metastasis and stem cell pathways

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Carbonic Anhydrase Inhibitors: Inhibition of Transmembrane, Tumor-Associated Isozyme IX, and Cytosolic Isozymes I and II with Aliphatic Sulfamates

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Advances in the targeting of HIF-1α and future therapeutic strategies for glioblastoma multiforme

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Structure activity study of carbonic anhydrase IX: Selective inhibition with ureido-substituted benzenesulfonamides

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Ascorbate Depletion: A Critical Step in Nickel Carcinogenesis?

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Heading off with the herd: how cancer cells might maneuver supernumerary centrosomes for directional migration

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Dynamics of tumor hypoxia assessed by 18F-FAZA PET/CT in head and neck and lung cancer patients during chemoradiation: Possible implications for radiotherapy treatment planning strategies

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LncRNA-LINC00152 down-regulated by miR-376c-3p restricts viability and promotes apoptosis of colorectal cancer cells.

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A microsystem for sensing and patterning oxidative microgradients during cell culture

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The impact of tumor microenvironment on cancer treatment and its modulation by direct and indirect antivascular strategies

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Hypoxia-inducible transcription factor–1 alpha determines sensitivity of endothelial cells to the proteosome inhibitor bortezomib

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Imaging hypoxia after oxygenation-modification: Comparing [18F]FMISO autoradiography with pimonidazole immunohistochemistry in human xenograft tumors

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Hypoxia Suppression of Bim and Bmf Blocks Anoikis and Luminal Clearing during Mammary Morphogenesis

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Induction of dormancy in hypoxic human papillomavirus-positive cancer cells

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The long noncoding RNA HIF1A‐AS2 facilitates cisplatin resistance in bladder cancer

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Comparative studies of oxaliplatin-based platinum( iv ) complexes in different in vitro and in vivo tumor models

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Mucin 1 Oncoprotein Blocks Hypoxia-inducible Factor 1α Activation in a Survival Response to Hypoxia

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Hypoxia-inducible factor 1α expression and its clinical significance in pancreatic cancer: A meta-analysis

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Fabrication of indocyanine green encapsulated biodegradable microbubbles for structural and functional imaging of cancer

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Microenvironments and Cellular Characteristics in the Micro Tumor Cords of Malignant Solid Tumors

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Metallothionein is up-regulated under hypoxia and promotes the survival of human prostate cancer cells

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Astragalus saponins downregulate vascular endothelial growth factor under cobalt chloride-stimulated hypoxia in colon cancer cells

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Cycling hypoxia induces chemoresistance through the activation of reactive oxygen species-mediated B-cell lymphoma extra-long pathway in glioblastoma multiforme

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Selective silencing of the hypoxia-inducible factor 1 target gene BNIP3 by histone deacetylation and methylation in colorectal cancer

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Bcl-2/Adenovirus E1B 19 kDa Interacting Protein-3 Knockdown Enables Growth of Breast Cancer Metastases in the Lung, Liver, and Bone

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Impaired mitophagy activates mtROS/HIF-1α interplay and increases cancer aggressiveness in gastric cancer cells under hypoxia

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Targeting Hypoxia-Driven Metabolic Reprogramming to Constrain Tumor Progression and Metastasis

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Oxygenation Status of Malignant Tumors vs. Normal Tissues: Critical Evaluation and Updated Data Source Based on Direct Measurements with pO2 Microsensors

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Changes in tumor hypoxia induced by mild temperature hyperthermia as assessed by dual-tracer immunohistochemistry

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Dichloroacetate attenuates hypoxia-induced resistance to 5-fluorouracil in gastric cancer through the regulation of glucose metabolism

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Breast tumor and stromal cell responses to TGF-β and hypoxia in matrix deposition

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Tumor physiologic response to combretastatin A4 phosphate assessed by MRI

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Carbonic Anhydrase IX Expression and Tumor Oxygenation Status Do Not Correlate at the Microregional Level in Locally Advanced Cancers of the Uterine Cervix

Mayer, A., Höckel, M., & Vaupel, P. W. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-0869 · Cited by 71

Understanding the hypoxic niche of multiple myeloma: therapeutic implications and contributions of mouse models

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Recent Progress in the Design of Hypoxia‐Specific Nano Drug Delivery Systems for Cancer Therapy

Sahu, A., Choi, W. I., & Tae, G. (2018) · Advanced Therapeutics · doi:10.1002/adtp.201800026 · Cited by 71

Mechanisms and significance of bifunctional NK4 in cancer treatment

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Metabolism of Selenium, Selenocysteine, and Selenoproteins in Ferroptosis in Solid Tumor Cancers

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Targeting the lactic acid metabolic pathway for antitumor therapy

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Hypoxia modulates early events in T cell receptor‐mediated activation in human T lymphocytes via Kv1.3 channels

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Nutrient sensing, signal transduction and immune responses

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Low-Dose Metronomic Daily Cyclophosphamide and Weekly Tirapazamine: A Well-Tolerated Combination Regimen with Enhanced Efficacy That Exploits Tumor Hypoxia

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Cell-Based Drug Delivery Systems with Innate Homing Capability as a Novel Nanocarrier Platform

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Tumor hypoxia unveiled: insights into microenvironment, detection tools and emerging therapies

Ciepła, J., & Smolarczyk, R. (2024) · Clinical and Experimental Medicine · doi:10.1007/s10238-024-01501-1 · Cited by 81

Challenges of PK/PD measurements in modern drug development

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Hypoxia-inducible factor-1α correlates with MET and metastasis in node-negative breast cancer

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Enamine N -Oxides: Synthesis and Application to Hypoxia-Responsive Prodrugs and Imaging Agents

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In vitro degradation, photo-dynamic and thermal antibacterial activities of Cu-bearing chlorophyllin-induced Ca–P coating on magnesium alloy AZ31

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Dual Inhibition of Met Kinase and Angiogenesis to Overcome HGF-Induced EGFR-TKI Resistance in EGFR Mutant Lung Cancer

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Dynamic contrast‐enhanced‐MRI of tumor hypoxia

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RhoB: Team Oncogene or Team Tumor Suppressor?

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The Role of Oxygen in Avascular Tumor Growth

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Twente Photoacoustic Mammoscope 2: system overview and three-dimensional vascular network images in healthy breasts

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Biomedical application of manganese dioxide nanomaterials

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Ratiometric Nanoparticle Probe Based on FRET‐Amplified Phosphorescence for Oxygen Sensing with Minimal Phototoxicity

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Monocytic delivery of therapeutic oxygen bubbles for dual-modality treatment of tumor hypoxia

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MiR-199a suppresses the hypoxia-induced proliferation of non-small cell lung cancer cells through targeting HIF1α

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Improving the Radiosensitivity of Radioresistant and Hypoxic Glioblastoma

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