Tumor Hypoxia: Definitions and Current Clinical, Biologic, and Molecular Aspects

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

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Functional imaging of intratumoral hypoxia

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Acidosis induces multi‐drug resistance in rat prostate cancer cells (AT1) in vitro and in vivo by increasing the activity of the p‐glycoprotein via activation of p38

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The Different Routes to Metastasis via Hypoxia-Regulated Programs

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Low-field paramagnetic resonance imaging of tumor oxygenation and glycolytic activity in mice

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Neuroblastoma as an experimental model for neuronal differentiation and hypoxia-induced tumor cell dedifferentiation

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A novel family of fluorescent hypoxia sensors reveal strong heterogeneity in tumor hypoxia at the cellular level

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Ribonucleotide Reductase Requires Subunit Switching in Hypoxia to Maintain DNA Replication

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Measuring Changes in Tumor Oxygenation

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Inactivation of the CYLD Deubiquitinase by HPV E6 Mediates Hypoxia-Induced NF-κB Activation

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Hypoxia Helps Glioma to Fight Therapy

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Hypoxia Induces Proteasome-Dependent Degradation of Estrogen Receptor α in ZR-75 Breast Cancer Cells

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Tumortropic monocyte-mediated delivery of echogenic polymer bubbles and therapeutic vesicles for chemotherapy of tumor hypoxia

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A biomimetic theranostic O2-meter for cancer targeted photodynamic therapy and phosphorescence imaging

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Polarized CD163+ tumor-associated macrophages are associated with increased angiogenesis and CXCL12 expression in gastric cancer

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Hypoxia-mediated autophagic flux inhibits silver nanoparticle-triggered apoptosis in human lung cancer cells

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Metabolic classification of human rectal adenocarcinomas: a novel guideline for clinical oncologists?

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Hypoxia-inducible factor-1 confers resistance to the glycolytic inhibitor 2-deoxy- d -glucose

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NDRG2 is a new HIF-1 Target Gene Necessary for Hypoxia-Induced Apoptosis in A549 Cells

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Tumor-specific gene expression using the survivin promoter is further increased by hypoxia

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Increase in the photoreactivity of uracil derivatives by doubling thionation

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The HIF-1α/CXCR4 pathway supports hypoxia-induced metastasis of human osteosarcoma cells

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The role of hypoxia on the acquisition of epithelial-mesenchymal transition and cancer stemness: a possible link to epigenetic regulation

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Sensitization of Hypoxic Tumors to Radiation Therapy Using Ultrasound-Sensitive Oxygen Microbubbles

Eisenbrey, J. R., Shraim, R., Liu, J., Li, J., Stanczak, M., Oeffinger, B. E., Leeper, D. B., Keith, S. W., Delaney, L. J., Forsberg, F., et al. (2018) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2018.01.042 · Cited by 107

Monocarboxylate transporter 1 and 4 inhibitors as potential therapeutics for treating solid tumours: A review with structure-activity relationship insights

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What is the malignant nature of human ductal carcinoma in situ?

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Overexpression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4 in the human breast and colon malignant tumors

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Critical Role for Mitochondrial Oxidative Phosphorylation in the Activation of Tumor Suppressors Bax and Bak

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The Role of Hypoxia and Cancer Stem Cells in Renal Cell Carcinoma Pathogenesis

Myszczyszyn, A., Czarnecka, A. M., Matak, D., Szymański, Ł., Lian, F., Kornakiewicz, A., Bartnik, E., Kukwa, W., Kiéda, C., & Szczylik, C. A. (2015) · Stem Cell Reviews and Reports · doi:10.1007/s12015-015-9611-y · Cited by 109

PET of Hypoxia with89Zr-Labeled cG250-F(ab′)2in Head and Neck Tumors

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Macrophages-Mediated Delivery of Small Gold Nanorods for Tumor Hypoxia Photoacoustic Imaging and Enhanced Photothermal Therapy

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Therapeutic Strategies Targeting Cancer Stem Cells and Their Microenvironment

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Aptamer-Targeted Photodynamic Platforms for Tumor Therapy

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Carbonic Anhydrase IX Expression in Clear Cell Renal Cell Carcinoma

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Lack of Hypoxic Response in Uterine Leiomyomas despite Severe Tissue Hypoxia

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The role of proton dynamics in the development and maintenance of multidrug resistance in cancer

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Hyperpolarized 13C-pyruvate MRI detects real-time metabolic flux in prostate cancer metastases to bone and liver: a clinical feasibility study

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Self-propelled nanomotor reconstructs tumor microenvironment through synergistic hypoxia alleviation and glycolysis inhibition for promoted anti-metastasis

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The Hypoxic Environment in Tumor-Stromal Cells Accelerates Pancreatic Cancer Progression via the Activation of Paracrine Hepatocyte Growth Factor/c-Met Signaling

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Downregulation of c-MYC Protein Levels Contributes to Cancer Cell Survival under Dual Deficiency of Oxygen and Glucose

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High pretreatment serum lactate dehydrogenase level correlates with disease relapse and predicts an inferior outcome in locally advanced nasopharyngeal carcinoma

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Engineering Nanoparticles for Optimized Photodynamic Therapy

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Lack of Correlation between Expression of HIF-1α Protein and Oxygenation Status in Identical Tissue Areas of Squamous Cell Carcinomas of the Uterine Cervix

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Optical Imaging of Tumor Hypoxia and Evaluation of Efficacy of a Hypoxia-Targeting Drug in Living Animals

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PI3 kinase/Akt signaling mediates epithelial–mesenchymal transition in hypoxic hepatocellular carcinoma cells

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Arrest-defective-1 Protein, an Acetyltransferase, Does Not Alter Stability of Hypoxia-inducible Factor (HIF)-1α and Is Not Induced by Hypoxia or HIF

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Oxygenation gain factor: a novel parameter characterizing the association between hemoglobin level and the oxygenation status of breast cancers.

Vaupel, P. W., Mayer, A., Briest, S., & Höckel, M. (2003) · PubMed · Cited by 100

Hypoxia-induced and stress-specific changes in chromatin structure and function

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Predicting Control of Primary Tumor and Survival by DCE MRI During Early Therapy in Cervical Cancer

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HIF1α-associated circDENND4C Promotes Proliferation of Breast Cancer Cells in Hypoxic Environment

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Fructose Metabolism in Cancer

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Hypoxia skews dendritic cells to a T helper type 2‐stimulating phenotype and promotes tumour cell migration by dendritic cell‐derived osteopontin

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Anticancer nanoparticulate polymer‐drug conjugate

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pH/NIR-responsive and self-healing coatings with bacteria killing, osteogenesis, and angiogenesis performances on magnesium alloy

Zhao, Y., He, P., Yao, J., Li, M., Wang, B., Han, L., Huang, Z., Guo, C., Bai, J., Xue, F., et al. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122237 · Cited by 101

Near-infrared uncaging or photosensitizing dictated by oxygen tension

Anderson, E. D., Gorka, A. P., & Schnermann, M. J. (2016) · Nature Communications · doi:10.1038/ncomms13378 · Cited by 99

Tumor microenvironment in head and neck squamous cell carcinomas: Predictive value and clinical relevance of hypoxic markers. A review

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A hypoxia-dependent upregulation of hypoxia-inducible factor-1 by nuclear factor-κB promotes gastric tumour growth and angiogenesis

Nam, S.-Y., Ko, Y. S., Jung, J. H., Yoon, J., Kim, Y. H., Choi, Y. J., Park, J.-W., Chang, M. S., Kim, W. H., & Lee, B. L. (2010) · British Journal of Cancer · doi:10.1038/sj.bjc.6606020 · Cited by 97

Imaging tumor hypoxia by magnetic resonance methods

Pacheco‐Torres, J., López‐Larrubia, P., Ballesteros, P., & Cerdán, S. (2010) · NMR in Biomedicine · doi:10.1002/nbm.1558 · Cited by 99

Hypoxia enhances CXCR4 expression by activating HIF-1 in oral squamous cell carcinoma

Nakashiro, K. (2009) · Oncology Reports · doi:10.3892/or_00000275 · Cited by 99

Synchronous delivery of oxygen and photosensitizer for alleviation of hypoxia tumor microenvironment and dramatically enhanced photodynamic therapy

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Increased growth factor production in a human prostatic stromal cell culture model caused by hypoxia

Berger, A. P., Kofler, K., Bektić, J., Rogatsch, H., Steiner, H., Bartsch, G. H., & Klocker, H. (2003) · The Prostate · doi:10.1002/pros.10279 · Cited by 97

Oxygen-Controlled Three-Dimensional Cultures to Analyze Tumor Angiogenesis

Verbridge, S. S., Choi, N., Zheng, Y. Y., Brooks, D. J., Stroock, A. D., & Fischbach, C. (2010) · Tissue Engineering Part A · doi:10.1089/ten.tea.2009.0670 · Cited by 99

Hypoxic regulation of telomerase gene expression by transcriptional and post-transcriptional mechanisms

Anderson, C. J., Hoare, S. F., Ashcroft, M. A., Bilsland, A. E., & Keith, W. N. (2005) · Oncogene · doi:10.1038/sj.onc.1209011 · Cited by 96

Microfluidic oxygen imaging using integrated optical sensor layers and a color camera

Ungerböck, B., Charwat, V., Ertl, P., & Mayr, T. (2013) · Lab on a Chip · doi:10.1039/c3lc41315b · Cited by 96

Assessment of tumor blood perfusion by high‐resolution dynamic contrast‐enhanced MRI: A preclinical study of human melanoma xenografts

Benjaminsen, I. C., Graff, B. A., Brurberg, K. G., et al. (2004) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20149 · Cited by 96

Nanomedicine Strategies in Conquering and Utilizing the Cancer Hypoxia Environment

Pan, Y., Liu, L., Mou, X., & Cai, Y. (2023) · ACS Nano · doi:10.1021/acsnano.3c07763 · Cited by 98

The prognostic value of endogenous hypoxia-related markers for head and neck squamous cell carcinomas treated with ARCON

Jonathan, R. A., Wijffels, K. I. E. M., Peeters, W. J. M., de Wilde, P. C. M., Marres, H. A. M., Merkx, M. A. W., Oosterwijk, E., van der Kogel, A. J., & Kaanders, J. H. A. M. (2006) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2006.04.008 · Cited by 95

Erythropoietin and Erythropoietin Receptor Expression in Head and Neck Cancer: Relationship to Tumor Hypoxia

Arcasoy, M. O., Amin, K., Chou, S.-C., Haroon, Z. A., Varia, M. A., & Raleigh, J. A. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.20.11.1 · Cited by 95

Mechanisms of regulation of PFKFB expression in pancreatic and gastric cancer cells

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Activated Schwann cells in pancreatic cancer are linked to analgesia via suppression of spinal astroglia and microglia

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Imaging Tumor Hypoxia to Advance Radiation Oncology

Lee, C.-T., Boss, M., & Dewhirst, M. W. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5759 · Cited by 98

Hypoxic regulation of PFKFB-3 and PFKFB-4 gene expression in gastric and pancreatic cancer cell lines and expression of PFKFB genes in gastric cancers.

Bobarykina, A. Y., Minchenko, D. O., Opentanova, I. L., Moenner, M., Caro, J., Esumi, H., & Minchenko, О. H. (2006) · Acta Biochimica Polonica · doi:10.18388/abp.2006_3308 · Cited by 96

Prevention of Anastomotic Leakage after Total Gastrectomy with Perioperative Supplemental Oxygen Administration: A Prospective Randomized, Double-blind, Controlled, Single-center Trial

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Thionated organic compounds as emerging heavy-atom-free photodynamic therapy agents

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Hypoxia-Activated PEGylated Paclitaxel Prodrug Nanoparticles for Potentiated Chemotherapy

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A Dialogue between the Hypoxia-Inducible Factor and the Tumor Microenvironment

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Theoretical analysis of the dose dependence of the oxygen enhancement ratio and its relevance for clinical applications

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Hypoxia-inducible miR-182 enhances HIF1α signaling via targeting PHD2 and FIH1 in prostate cancer

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Lysyl oxidase is associated with the epithelial–mesenchymal transition of gastric cancer cells in hypoxia

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In vivo evaluation of [18F]fluoroetanidazole as a new marker for imaging tumour hypoxia with positron emission tomography

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