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Cited by 1,038Metabolism, Diabetes, and CancerColorectal Cancer Screening and DetectionCancer Risks and Factors

The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.

Diabetes Mellitus and Risk of Colorectal Cancer: A Meta-Analysis

Larsson, Susanna C., Orsini, Nicola, Wolk, Alicja·2005·JNCI: Journal of the National Cancer Institute
DOI 10.1093/jnci/dji375
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Abstract

BACKGROUND: Diabetes has been associated with an increased risk of colorectal cancer in most, but not all, studies. Findings have also been inconclusive with regard to sex and subsite in the colorectum. To resolve these inconsistencies, we conducted a meta-analysis of published data on the association between diabetes and the incidence and mortality of colorectal cancer. METHODS: We identified studies by a literature search of Medline from January 1, 1966, through July 31, 2005, and by searching the reference lists of pertinent articles. Summary relative risks (RRs) with 95% confidence intervals (CIs) were calculated with a random-effects model. All statistical tests were two-sided. RESULTS: Analysis of 15 studies (six case-control and nine cohort studies), including 2 593 935 participants, found that diabetes was associated with an increased risk of colorectal cancer, compared with no diabetes (summary RR of colorectal cancer incidence = 1.30, 95% CI = 1.20 to 1.40), without heterogeneity between studies (P(heterogeneity) = .21). These results were consistent between case-control and cohort studies and between studies conducted in the United States and in Europe. The association between diabetes and colorectal cancer incidence did not differ statistically significantly by sex (summary RR among women = 1.33, 95% CI = 1.23 to 1.44; summary RR among men = 1.29, 95% CI = 1.15 to 1.44; P(heterogeneity) = .26) or by cancer subsite (summary RR for colon = 1.43, 95% CI = 1.28 to 1.60; summary RR for rectum = 1.33, 95% CI = 1.14 to 1.54; P(heterogeneity) = .42). Diabetes was positively associated with colorectal cancer mortality (summary RR = 1.26, 95% CI = 1.05 to 1.50), but there was evidence for heterogeneity between studies (P(heterogeneity) = .04). CONCLUSIONS: Our findings strongly support a relationship between diabetes and increased risk of colon and rectal cancer in both women and men.

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Crossref · 10.1093/jnci/dji375

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59 of 59 references verified0 citation errors · 0 not checkable

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  • Patients with type 2 diabetes have increased risks of various types of cancer, particularly liver, pancreas, endometrium, colon, rectum, breast, and bladder cancer.

    “Patients with type 2 diabetes have increased risks of various types of cancer, particularly liver, pancreas, endometrium, colon, rectum, breast, and bladder cancer.”

    From Metformin: An Old But Still the Best Treatment for Type 2 Diabetes (2013) · cites this paper as [134]

  • Cancer mortality is increased in patients with type 2 diabetes.

    “Cancer mortality is also increased [133,134].”

    From Metformin: An Old But Still the Best Treatment for Type 2 Diabetes (2013) · cites this paper as [134]

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Metadata

Authors
Larsson, S. C., Orsini, N., & Wolk, A.
Affiliations
Karolinska Institutet (SE)
Corresponding author
Larsson, Susanna C.
ORCID
Venue
JNCI: Journal of the National Cancer Institute
Publisher
Oxford University Press (OUP)
Published
2005-11-16
Volume
97
Issue
22
Pages
1679-1687
ISSN
  • 0027-8874 (ISSN-L)
  • 1460-2105
DOI
10.1093/jnci/dji375
OpenAlex
W2153388523
Cited by
1,038
References
59
Citations by year
2026: 23 · 2025: 23 · 2024: 30 · 2023: 37 · 2022: 29 · 2021: 51 · 2020: 56 · 2019: 46 · 2018: 55 · 2017: 43 · 2016: 63 · 2015: 70 · 2014: 81 · 2013: 88 · 2012: 82
FWCI
2.00
Type
journal article
Language
en
Open access
closed
Locations
  • JNCI Journal of the National Cancer Institute (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
  • Health Sciences › Medicine › Oncology › Colorectal Cancer Screening and Detection
  • Health Sciences › Medicine › Oncology › Cancer Risks and Factors
Keywords
diabetes mellitus, colorectal cancer, cancer incidence, cancer mortality, colon cancer, rectal cancer, sex differences, cancer subsite, risk factors
MeSH terms
Diabetes Mellitus, Type 2, Europe, Female, Humans, Male, United States, Colorectal Neoplasms, Cohort Studies, Incidence, Confidence Intervals, Case-Control Studies, Risk Assessment, Diabetes Complications

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