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Paradoxical effects from stimulus density manipulation provide new insight into the impact of sleep deprivation on PVT performance

Honn, Kimberly A, Van Dongen, Hans P A·2023·SLEEP Advances

Abstract

Study Objectives: The psychomotor vigilance test (PVT), a 10-min one-choice reaction time task with random response-stimulus intervals (RSIs) between 2 and 10 s, is highly sensitive to behavioral alertness deficits due to sleep loss. To investigate what drives the performance deficits, we conducted an in-laboratory total sleep deprivation (TSD) study and compared performance on the PVT to performance on a 10-min high-density PVT (HD-PVT) with increased stimulus density and truncated RSI range between 2 and 5 s. We hypothesized that the HD-PVT would show greater impairments from TSD than the standard PVT. Methods: n = 86 healthy adults were randomized (2:1 ratio) to 38 h of TSD (n = 56) or corresponding well-rested control (n = 30). The HD-PVT was administered when subjects had been awake for 34 h (TSD group) or 10 h (control group). Performance on the HD-PVT was compared to performance on the standard PVTs administered 1 h earlier and 1 h later. Results: The HD-PVT yielded approximately 60% more trials than the standard PVT. The HD-PVT had faster mean response times (RTs) and equivalent lapses (RTs > 500 ms) compared to the standard PVT, with no differences between the TSD effects on mean RT and lapses between tasks. Further, the HD-PVT had a dampened time-on-task effect in both the TSD and control conditions. Conclusions: Contrary to expectation, the HD-PVT did not show greater performance impairment during TSD, indicating that stimulus density and RSI range are not primary drivers of the PVT’s responsiveness to sleep loss.

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Figure 1. Signature effects captured by the PVT. (A) Performance degrades with increasing time on task, which is exacerbated by sleep loss. A 10-min standard PVT was administered every 3 h throughout 38 h of total sleep deprivation (TSD), which lasted from 08:00 until 22:00 the following evening. Mean RT (± SE) from 16 healthy adults is plotted per 1-min interval across the 10-min task duration, showing progressive slowing within each test bout, especially in the later part of the TSD period. Note that placement of the 1-min bins in each test is not to scale on the hours awake axis. Adapted from Fig. 2 in Grant et al. [12]. (B) Performance is worse for shorter response-stimulus intervals (RSIs), which is exacerbated by sleep loss. The percentage of RTs classified as lapses (RT > 500 ms) from 54 healthy adults who completed a 10-min PVT at 10:00 after 3.5 h awake and 24 h later after 27.5 h awake is plotted as a function of RSI sub-groups (with continuous-range RSIs between 2 and 10 s divided into 7 equal intervals on a log scale). Curves redrawn from data provided as part of Fig. 3 in Yang et al. [55]. (C) Extended wakefulness causes a rightward skewing of the RT distribution. The distribution of raw RTs from 9 healthy adults performing the PVT at 01:30 after 16 hours of wakefulness and after 40 hours of wakefulness is plotted. Adapted from Fig. 4.1 in Dinges and Kribbs [2]. (D) Sleep deprivation produces “lapses” evident as the emergence of slow RTs interspersed among fast RTs. Individual RTs for a healthy adult performing a PVT at 20:00 after 12 h awake (top panel) and again after 60 h awake (bottom panel). Gaps indicate false starts, the prevalence of which increases after sleep deprivation as well. Adapted from Fig. 3 in Doran et al. [3].
Figure 1. Signature effects captured by the PVT. (A) Performance degrades with increasing time on task, which is exacerbated by sleep loss. A 10-min standard PVT was administered every 3 h throughout 38 h of total sleep deprivation (TSD), which lasted from 08:00 until 22:00 the following evening. Mean RT (± SE) from 16 healthy adults is plotted per 1-min interval across the 10-min task duration, showing progressive slowing within each test bout, especially in the later part of the TSD period. Note that placement of the 1-min bins in each test is not to scale on the hours awake axis. Adapted from Fig. 2 in Grant et al. [12]. (B) Performance is worse for shorter response-stimulus intervals (RSIs), which is exacerbated by sleep loss. The percentage of RTs classified as lapses (RT > 500 ms) from 54 healthy adults who completed a 10-min PVT at 10:00 after 3.5 h awake and 24 h later after 27.5 h awake is plotted as a function of RSI sub-groups (with continuous-range RSIs between 2 and 10 s divided into 7 equal intervals on a log scale). Curves redrawn from data provided as part of Fig. 3 in Yang et al. [55]. (C) Extended wakefulness causes a rightward skewing of the RT distribution. The distribution of raw RTs from 9 healthy adults performing the PVT at 01:30 after 16 hours of wakefulness and after 40 hours of wakefulness is plotted. Adapted from Fig. 4.1 in Dinges and Kribbs [2]. (D) Sleep deprivation produces “lapses” evident as the emergence of slow RTs interspersed among fast RTs. Individual RTs for a healthy adult performing a PVT at 20:00 after 12 h awake (top panel) and again after 60 h awake (bottom panel). Gaps indicate false starts, the prevalence of which increases after sleep deprivation as well. Adapted from Fig. 3 in Doran et al. [3].CC BY-NC-ND · PubMed Central
Figure 2. Testing timeline, task specifications, and descriptive statistics.
Figure 2. Testing timeline, task specifications, and descriptive statistics.CC BY-NC-ND · PubMed Central
Figure 3. (A) Mean RT, (B) number of lapses, (C) percent of lapses, and (D) false starts. Data shown are mean ± SE on the standard PVT (open circles) and the HD-PVT (closed circles), by condition, as a function of measurement time. Data from control subjects are shown in blue and from TSD subjects in red.
Figure 3. (A) Mean RT, (B) number of lapses, (C) percent of lapses, and (D) false starts. Data shown are mean ± SE on the standard PVT (open circles) and the HD-PVT (closed circles), by condition, as a function of measurement time. Data from control subjects are shown in blue and from TSD subjects in red.CC BY-NC-ND · PubMed Central
Figure 4. Time-on-task effect displayed as mean RT per 1-min bin on the standard PVT and the HD-PVT. Data shown are mean ± SE by condition as a function of measurement time.
Figure 4. Time-on-task effect displayed as mean RT per 1-min bin on the standard PVT and the HD-PVT. Data shown are mean ± SE by condition as a function of measurement time.CC BY-NC-ND · PubMed Central
Figure 5. Response-stimulus interval (RSI) effect displayed as mean RT for each RSI on the standard PVT and the HD-PVT. Data shown are mean ± SE per RSI duration in the TSD condition (left) and the control condition (right) on the standard PVT at 17:00 (open circles), the HD-PVT at 18:00 (filled circles), and the standard PVT at 19:00 (open triangles). Note that although the figure shows all RSIs for each test (i.e. 2–10 s for the standard PVT and 2–5 s for the HD-PVT), the analyses of the RSI effect included only RSIs common between the two task versions, as indicated by the gray rectangles (i.e. 2–5 s).
Figure 5. Response-stimulus interval (RSI) effect displayed as mean RT for each RSI on the standard PVT and the HD-PVT. Data shown are mean ± SE per RSI duration in the TSD condition (left) and the control condition (right) on the standard PVT at 17:00 (open circles), the HD-PVT at 18:00 (filled circles), and the standard PVT at 19:00 (open triangles). Note that although the figure shows all RSIs for each test (i.e. 2–10 s for the standard PVT and 2–5 s for the HD-PVT), the analyses of the RSI effect included only RSIs common between the two task versions, as indicated by the gray rectangles (i.e. 2–5 s).CC BY-NC-ND · PubMed Central
Figure 6. Illustration of the one-choice diffusion decision model for the PVT. After presentation of a stimulus and subsequent stimulus encoding, a decision process takes place during which evidence is accumulated through neuronal processing resembling a random walk with a certain drift rate. When the accumulated evidence reaches an evidence criterion, the decision process stops and a response is made. While performing the PVT, the evidence criterion must be set in advance of the stimulus onset and maintained throughout the RSI, which in the face of sleep deprivation may require sustained effort. Figure adapted from Ratcliff and Van Dongen [75].
Figure 6. Illustration of the one-choice diffusion decision model for the PVT. After presentation of a stimulus and subsequent stimulus encoding, a decision process takes place during which evidence is accumulated through neuronal processing resembling a random walk with a certain drift rate. When the accumulated evidence reaches an evidence criterion, the decision process stops and a response is made. While performing the PVT, the evidence criterion must be set in advance of the stimulus onset and maintained throughout the RSI, which in the face of sleep deprivation may require sustained effort. Figure adapted from Ratcliff and Van Dongen [75].CC BY-NC-ND · PubMed Central

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Metadata

Authors
Honn, K. A., & Van Dongen, H. P. A.
Affiliations
Sleep and Performance Research Center and Department of Translational Medicine and Physiology, Washington State University , Spokane, WA , USA
Venue
SLEEP Advances
Published
2022-12-07
Volume
4
Issue
1
ISSN
2632-5012
Cited by
9
References
7
Language
en
Funders
  • Office of the Assistant Secretary of Defense for Health Affair (W81XWH-16-1-0319)
  • Peer Reviewed Medical Research Program Expansion (W81XWH-20-1-0442)
  • Department of Defense

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