CoChat
Sign Up
Cited by 9

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Analysis of Expression of Genes Involved in Apolipoprotein E-Based Lipoprotein Metabolism in Pregnant Mice Deficient in the Receptor-Associated Protein, the Low Density Lipoprotein Receptor, or Apolipoprotein E1

Umans, Lieve, Overbergh, Lut, Serneels, Lutgarde, Tesseur, Ina, Van Leuven, Fred·1999·Biology of Reproduction
DOI 10.1095/biolreprod61.5.1216
Open this paper in CoChat — free account

Abstract

Mice deficient in receptor-associated protein (RAP) were phenotypically normal, but in contrast to results previously reported in RAP(-/-) mice, nearly 50% of the offspring died at or shortly after birth. To attempt to determine the reason for this, we analyzed the regulation of expression of genes involved in apolipoprotein E (apoE)-based mechanisms in RAP-deficient mice and compared this to results in mice deficient in low density lipoprotein receptor (LDLR) or apoE. The major finding concerned a large increase in hepatic lipoprotein receptor-related protein (LRP) mRNA and LDLR mRNA levels in pregnant RAP knockout mice. This is in contrast to the down-regulation of LRP mRNA and LDLR mRNA, which is normally seen in wild-type mice. Also in LDLR knockout mice, a significant up-regulation in expression of LRP mRNA was demonstrated. In apoE knockout mice, hepatic LRP mRNA did not change significantly, while hepatic LDLR mRNA expression was increased. In placenta and uterus, the deficiency of RAP did not markedly affect the expression of LRP and LDLR. Lipoprotein lipase mRNA and apoE mRNA increased during pregnancy in all mice, independent of their genetic status. The current study does not directly explain the increased mortality of RAP(-/-) pups. The data demonstrate, however, important relative changes in expression of the genes analyzed, an indication that LRP and LDLR play an important role in lipid metabolism during pregnancy.

Overview

Integrity signals

Registry

Crossref · 10.1095/biolreprod61.5.1216

Cites

2 of 2 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Show all 2 references

Research works printed but not linked: 57

  1. 1986, A receptor-mediated pathway for cholesterol homeostasis., Science, 232, 34, 10.1126/science.3513311 · DOI · Paper page
  2. 1988, Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor., EMBO J, 7, 4119, 10.1002/j.1460-2075.1988.tb03306.x · DOI
  3. 1990, Sequence identity between the α2-macroglobulin receptor and low density lipoprotein receptor-related protein suggests that this molecule is a multifunctional receptor., J Biol Chem, 265, 17401, 10.1016/S0021-9258(18)38172-9 · DOI · Paper page
  4. 1990, Evidence that the newly cloned low-density-lipoprotein receptor related protein (LRP) is the α2-macroglobulin receptor., FEBS Lett, 276, 151, 10.1016/0014-5793(90)80530-V · DOI
  5. 1980, Primary amines inhibit recycling of A2M receptors in fibroblasts., Cell, 20, 37, 10.1016/0092-8674(80)90232-9 · DOI
  6. 1994, Cloning of a complementary deoxyribonucleic acid encoding the murine homolog of the very low density lipoprotein/apolipoprotein-E receptor: expression pattern and assignment of the gene to mouse chromosome 19., Endocrinology, 135, 387, 10.1210/endo.135.1.8013374 · DOI
  7. 1996, Human apolipoprotein E receptor 2. A novel lipoprotein receptor of the low density lipoprotein receptor family predominantly expressed in brain., J Biol Chem, 271, 8373, 10.1074/jbc.271.14.8373 · DOI · Paper page
  8. 1996, A very new low density lipoprotein receptor homologue with 8 ligand binding repeats in brain of chicken and mouse., J Biol Chem, 271, 11732, 10.1074/jbc.271.20.11732 · DOI · Paper page
  9. 1996, Molecular characterization of a novel hybrid receptor that binds the α2-macroglobulin receptor associated protein., J Biol Chem, 271, 31379, 10.1074/jbc.271.49.31379 · DOI · Paper page
  10. 1996, Elements of neural adhesion molecules and a yeast vacuolar protein sorting receptor are present in a novel mammalian low density lipoprotein receptor family member., J Biol Chem, 271, 24761, 10.1074/jbc.271.40.24761 · DOI
  11. 1998, cDNA cloning of a new low density lipoprotein receptor related protein and mapping of its gene (LRP3) to chromosome bands 19q12-q13.2., Genomics, 51, 132, 10.1006/geno.1998.5339 · DOI
  12. 1998, A novel low-density lipoprotein receptor related protein with type II membrane protein-like structure is abundant in heart., J Biochem, 124, 784, 10.1093/oxfordjournals.jbchem.a022180 · DOI
  13. 1998, Cloning of a novel member of the low density lipoprotein receptor family., Gene, 216, 103, 10.1016/S0378-1119(98)00311-4 · DOI
  14. 1998, Isolation and characterization of LRP6, a novel member of the low density lipoprotein receptor gene family., Biochem Biophys Res Commun, 248, 879, 10.1006/bbrc.1998.9061 · DOI · Paper page
  15. 1990, Cholesterol Metabolism, LDL, and the LDL Receptor.
  16. 1993, Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery., J Clin Invest, 92, 883, 10.1172/JCI116663 · DOI · Paper page
  17. 1994, Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice., J Clin Invest, 93, 1885, 10.1172/JCI117179 · DOI
  18. 1994, The two-receptor model of lipoprotein clearance: tests of the hypothesis in “knockout” mice lacking the low density lipoprotein receptor, apolipoprotein E, or both receptors., Proc Natl Acad Sci USA, 91, 4431, 10.1073/pnas.91.10.4431 · DOI · Paper page
  19. 1992, Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E., Science, 258, 468, 10.1126/science.1411543 · DOI · Paper page
  20. 1995, Apolipoprotein E and the apolipoprotein E-deficient mouse., Annu Rev Nutr, 15, 495, 10.1146/annurev.nu.15.070195.002431 · DOI
  21. 1994, Diet-induced hypercholesterolemia and atherosclerosis in heterozygous apolipoprotein E-deficient mice., Atherosclerosis, 111, 25, 10.1016/0021-9150(94)90188-0 · DOI
  22. 1991, The 39 kDa protein modulates binding of ligands to low density lipoprotein receptor-related protein/alpha-2-macroglobulin receptor., J Biol Chem, 266, 21232, 10.1016/S0021-9258(18)54845-6 · DOI · Paper page
  23. 1992, A novel mechanism for controlling the activity of α2-macroglobulin receptor/low density lipoprotein receptor-related protein., J Biol Chem, 267, 9035, 10.1016/S0021-9258(19)50384-2 · DOI · Paper page
  24. 1992, Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plasminogen activator-inhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearance., J Biol Chem, 267, 26172, 10.1016/S0021-9258(18)35732-6 · DOI
  25. 1992, gp330 Associates with 44-kDa protein in the rat kidney to form the heymann nephritis antigenic complex., Proc Natl Acad Sci USA, 89, 6698, 10.1073/pnas.89.15.6698 · DOI
  26. 1992, The 39 kD receptor associated protein interacts with two members of the low density lipoprotein family, alpha-2-macroglobulin receptor and glycoprotein 330., J Biol Chem, 267, 21162, 10.1016/S0021-9258(19)36811-5 · DOI · Paper page
  27. 1994, The 39-kDa receptor-associated protein regulates ligand binding by the very low density lipoprotein receptor., J Biol Chem, 269, 23268, 10.1016/S0021-9258(17)31648-4 · DOI · Paper page
  28. 1994, Very low density lipoprotein receptor from mammary gland and mammary epithelial cell lines binds and mediates endocytosis of Mr 40,000 receptor associated protein., FEBS Lett, 354, 279, 10.1016/0014-5793(94)01138-9 · DOI
  29. 1994, Effect of 39-kDa receptor-associated protein on the hepatic uptake and endocytosis of chylomicron remnants and low density lipoproteins in the rat., J Biol Chem, 269, 13238, 10.1016/S0021-9258(17)36824-2 · DOI
  30. 1994, Distribution of mRNA coding for alpha-2-macroglobulin, the murinoglobulins, the alpha-2-macroglobulin receptor and the alpha-2-macroglobulin receptor associated protein during mouse embryogenesis and in adult tissues., Differentiation, 55, 213, 10.1046/j.1432-0436.1994.5530213.x · DOI
  31. 1995, Expression in mouse embryos and in adult brain of three members of the amyloid precursor protein family, of the alpha-2-macroglobulin receptor/LDL receptor related protein and of its ligands apolipoprotein E, LPL, alpha-2-macroglobulin and the 40-kDa receptor associated protein., Neuroscience, 65, 1009, 10.1016/0306-4522(94)00555-J · DOI
  32. 1994, The α2-macroglobulin receptor and epithelial glycoprotein-330: two giant receptors mediating endocytosis of multiple ligands., Biochim Biophys Acta, 1197, 197, 10.1016/0304-4157(94)90005-1 · DOI
  33. 1995, Lipoprotein and receptor interactions in vivo., Curr Opin Lipid, 6, 97, 10.1097/00041433-199504000-00007 · DOI · Paper page
  34. 1994, Structures and functions of multiligand lipoprotein receptors: macrophage scavenger receptors and LDL receptor related protein (LRP)., Annu Rev Biochem, 63, 601, 10.1146/annurev.bi.63.070194.003125 · DOI
  35. 1994, LDL receptor-related protein (LRP): a multiligand receptor., Fibrinolysis, 8, 204
  36. 1992, LDL receptor-related protein internalizes and degrades uPA-PAI-1 complexes and is essential for embryo implantation., Cell, 71, 411, 10.1016/0092-8674(92)90511-A · DOI · Paper page
  37. 1992, Rabbit low density lipoprotein receptor: a low density lipoprotein receptor-like protein with distinct ligand specificity., Proc Natl Acad Sci USA, 89, 9252, 10.1073/pnas.89.19.9252 · DOI
  38. 1995, The VLDL receptor: wayward brother of the LDL receptor., Curr Opin Lipid, 6, 104, 10.1097/00041433-199504000-00008 · DOI
  39. 1995, Normal plasma lipoproteins and fertility in gene-targeted mice homozygous for a disruption in the gene encoding very low density lipoprotein receptor., Proc Natl Acad Sci USA, 92, 8453, 10.1073/pnas.92.18.8453 · DOI · Paper page
  40. 1995, Expression of mouse alpha-macroglobulins, lipoprotein receptor-related protein, LDL receptor, apolipoprotein E, and lipoprotein lipase in pregnancy., J Lipid Res, 36, 1774, 10.1016/S0022-2275(20)41496-8 · DOI
  41. 1995, Functional expression of low density lipoprotein receptor-related protein is controlled by receptor-associated protein in vivo., Proc Natl Acad Sci USA, 92, 4537, 10.1073/pnas.92.10.4537 · DOI · Paper page
  42. 1995, Cloning, characterization, and chromosomal localization to 4p16 of the human gene (LRPAP1) coding for the α2-macroglobulin receptor-associated protein and structural comparison with the murine gene coding for the 44-kDa heparin-binding protein., Genomics, 25, 492, 10.1016/0888-7543(95)80050-V · DOI
  43. 1990, Consecutive inactivation of both alleles of the pim-1 protooncogene by homologous recombination in embryonic stem cells., Nature, 348, 649, 10.1038/348649a0 · DOI
  44. 1995, Targeted inactivation of the mouse alpha-2-macroglobulin gene., J Biol Chem, 270, 19778, 10.1074/jbc.270.34.19778 · DOI
  45. 1987, HPRT-deficient (Lesch-Nyhan) mouse embryos derived from germline colonization by cultured cells., Nature, 326, 292, 10.1038/326292a0 · DOI
  46. 1994, Molecular cloning of mouse gene coding for alpha-2-macroglobulin., Genomics, 22, 530
  47. 1989, Structure and expression of mouse apolipoprotein E gene., J Biochem, 106, 98, 10.1093/oxfordjournals.jbchem.a122828 · DOI
  48. 1993, Molecular cloning and sequencing of the murine alpha-2-macroglobulin receptor cDNA., Biochim Biophys Acta, 1173, 71, 10.1016/0167-4781(93)90244-8 · DOI
  49. 1990, A heparin binding protein whose expression increases during differentiation of embryonal carcinoma cells to parietal endoderm cells: cDNA cloning and sequence analysis., J Biochem, 108, 297, 10.1093/oxfordjournals.jbchem.a123197 · DOI
  50. 1982, A new glycoprotein antigen common to teratocarcinoma, visceral endoderm, and renal tubular brush border., Dev Biol, 91, 351, 10.1016/0012-1606(82)90041-0 · DOI
  51. 1999, Alpha-2-macroglobulin and murinoglobulin-1 deficient mice: a mouse model for acute pancreatitis., Am J Pathol
  52. 1995, 39 kDa receptor-associated protein is an ER resident protein and molecular chaperon for LDL receptor-related protein., EMBO J, 14, 2269, 10.1002/j.1460-2075.1995.tb07221.x · DOI · Paper page
  53. 1999, LRP in brain and in cultured neurons of mice deficient in RAP and transgenic for apolipoprotein E4 or amyloid precursor protein., Neuroscience
  54. 1991, Lipoprotein lipase enhances the binding of chylomicrons to low density lipoprotein receptor-related protein., Proc Natl Acad Sci USA, 88, 8342, 10.1073/pnas.88.19.8342 · DOI · Paper page
  55. 1993, Lipoprotein lipase induces catabolism of normal triglyceride-rich lipoproteins via the low density lipoprotein receptor related protein/alpha-2-macroglobulin receptor in vitro. A process mediated by cell-surface proteoglycans., J Biol Chem, 268, 14168, 10.1016/S0021-9258(19)85223-7 · DOI
  56. 1999, A novel role for receptor associated protein in somatostatin modulation: implications for Alzheimer's disease., Neuroscience, 88, 687, 10.1016/S0306-4522(98)00272-3 · DOI
  57. 1997, Regulation of growth hormone (GH) gene expression and secretion during pregnancy and lactation in the rat: role of insulin-like growth factor-I, somatostatin, and GH-releasing hormone., Endocrinology, 138, 3435, 10.1210/endo.138.8.5342 · DOI

Cited by

Sorted by citations

See all 9

Metadata

Authors
Umans, L., Overbergh, L., Serneels, L., Tesseur, I., & Van Leuven, F.
Venue
Biology of Reproduction
Publisher
Oxford University Press (OUP)
Published
1999-11-01
Volume
61
Issue
5
Pages
1216-1225
ISSN
  • 0006-3363
  • 1529-7268
DOI
10.1095/biolreprod61.5.1216
Cited by
9
References
2
Language
en

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review