Declining levels of functionally specialized synaptic proteins in plasma neuronal exosomes with progression of Alzheimer's disease

Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy

Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359

Mild cognitive impairment as a diagnostic entity

Petersen, R. C. (2004) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2004.01388.x · Cited by 7,864

Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease

Sperling, R. A., Aisen, P. S., Beckett, L. A., Bennett, D. A., Craft, S., Fagan, A. M., Iwatsubo, T., Jack, C. R., Kaye, J., Montine, T. J., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.003 · Cited by 7,155

Alzheimer's Disease Is a Synaptic Failure

Selkoe, D. J. (2002) · Science · doi:10.1126/science.1074069 · Cited by 4,420

Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS–ADRDA criteria

Dubois, B., Feldman, H. H., Jacova, C., DeKosky, S. T., Barberger-Gateau, P., Cummings, J., Delacourte, A., Galasko, D., Gauthier, S., Jicha, G., et al. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70178-3 · Cited by 4,411

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

Terry, R. D., Masliah, E., Salmon, D. P., Butters, N., DeTeresa, R., Hill, R., Hansen, L. A., & Katzman, R. (1991) · Annals of Neurology · doi:10.1002/ana.410300410 · Cited by 4,397

Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity

DeKosky, S. T., & Scheff, S. W. (1990) · Annals of Neurology · doi:10.1002/ana.410270502 · Cited by 2,376

Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects

Shaw, L. M., Vanderstichele, H., Knapik‐Czajka, M., Clark, C. M., Aisen, P. S., Petersen, R. C., Blennow, K., Soares, H., Simon, A., Lewczuk, P., et al. (2009) · Annals of Neurology · doi:10.1002/ana.21610 · Cited by 2,065

Neuroligins and neurexins link synaptic function to cognitive disease

Südhof, T. C. (2008) · Nature · doi:10.1038/nature07456 · Cited by 1,849 · cited 1×

Plasma Extracellular Vesicles Enriched for Neuronal Origin: A Potential Window into Brain Pathologic Processes

Mustapic, M., Eitan, E., Werner, J. K., Berkowitz, S. T., Lazaropoulos, M. P., Tran, J., Goetzl, E. J., & Kapogiannis, D. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00278 · Cited by 441

Circulating Extracellular Vesicles in Human Disease

Shah, R. V., Patel, T. C., & Freedman, J. E. (2018) · New England Journal of Medicine · doi:10.1056/nejmra1704286 · Cited by 765

Therapeutically harnessing extracellular vesicles

Cheng, L., & Hill, A. F. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00410-w · Cited by 737

Targeting and Crossing the Blood-Brain Barrier with Extracellular Vesicles

Saint-Pol, J., Gosselet, F., Duban-Deweer, S., Pottiez, G., & Karamanos, Y. (2020) · Cells · doi:10.3390/cells9040851 · Cited by 503

Extracellular Vesicles and Neurodegenerative Diseases

Hill, A. F. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.0147-18.2019 · Cited by 437

High complement levels in astrocyte‐derived exosomes of Alzheimer disease

Goetzl, E. J., Schwartz, J. B., Abner, E. L., Jicha, G. A., & Kapogiannis, D. (2018) · Annals of Neurology · doi:10.1002/ana.25172 · Cited by 373

Extracellular vesicles through the blood–brain barrier: a review

Ramos‐Zaldívar, H. M., Polakovičová, I., Salas‐Huenuleo, E., Corvalán, A. H., Kogan, M. J., Yefi, C. P., & Andía, M. E. (2022) · Fluids and Barriers of the CNS · doi:10.1186/s12987-022-00359-3 · Cited by 320

L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma

Norman, M., Ter‐Ovanesyan, D., Trieu, W., Lazarovits, R., Kowal, E. J. K., Lee, J.-H., Chen‐Plotkin, A. S., Regev, A., Church, G. M., & Walt, D. R. (2021) · Nature Methods · doi:10.1038/s41592-021-01174-8 · Cited by 261

Plasma neuronal exosomes serve as biomarkers of cognitive impairment in HIV infection and Alzheimer’s disease

Pulliam, L., Sun, B., Mustapić, M., Chawla, S., & Kapogiannis, D. (2019) · Journal of NeuroVirology · doi:10.1007/s13365-018-0695-4 · Cited by 246

Association of Extracellular Vesicle Biomarkers With Alzheimer Disease in the Baltimore Longitudinal Study of Aging

Kapogiannis, D., Mustapic, M., Shardell, M. D., Berkowitz, S. T., Diehl, T. C., Spangler, R. D., Tran, J., Lazaropoulos, M. P., Chawla, S., Gulyani, S., et al. (2019) · JAMA Neurology · doi:10.1001/jamaneurol.2019.2462 · Cited by 241

Mesenchymal stem cell-derived exosome: a promising alternative in the therapy of Alzheimer’s disease

Guo, M., Yin, Z., Chen, F., & Lei, P. (2020) · Alzheimer s Research & Therapy · doi:10.1186/s13195-020-00670-x · Cited by 205

Characterization and Biomarker Analyses of Post-COVID-19 Complications and Neurological Manifestations

Sun, B., Tang, N., Peluso, M. J., Iyer, N. S., Torres, L., Donatelli, J. L., Munter, S. E., Nixon, C. C., Rutishauser, R. L., Rodríguez-Barraquer, I., et al. (2021) · Cells · doi:10.3390/cells10020386 · Cited by 190

Detection of Aggregation-Competent Tau in Neuron-Derived Extracellular Vesicles

Guix, F. X., Corbett, G. T., Cha, D., Mustapić, M., Liu, W., Mengel, D., Chen, Z., Aïkawa, E., Young‐Pearse, T. L., Kapogiannis, D., et al. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19030663 · Cited by 186

Fluid Biomarkers for Synaptic Dysfunction and Loss

Camporesi, E., Nilsson, J., Brinkmalm, A., Becker, B., Ashton, N. J., Blennow, K., & Zetterberg, H. (2020) · Biomarker Insights · doi:10.1177/1177271920950319 · Cited by 165

New windows into the brain: Central nervous system-derived extracellular vesicles in blood

Shi, M., Sheng, L., Stewart, T., Zabetian, C. P., & Zhang, J. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.01.005 · Cited by 181

Diagnostic and therapeutic potential of exosomes in Alzheimer’s disease

Martins, T. S., Trindade, D., Vaz, M., Campelo, I., Almeida, M., Trigo, G., Silva, O. A. B. D. C. E., & Henriques, A. G. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15112 · Cited by 177

Exosome Determinants of Physiological Aging and Age-Related Neurodegenerative Diseases

D’Anca, M., Fenoglio, C., Serpente, M., Arosio, B., Cesari, M., Scarpini, E. A., & Galimberti, D. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00232 · Cited by 154

Stem Cell-Derived Exosomes: a New Strategy of Neurodegenerative Disease Treatment

Hosseini, N. F., Sheykhhasan, M., Asl, S. S., & Najafi, R. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02324-x · Cited by 155

The Emerging Role of Neural Cell-Derived Exosomes in Intercellular Communication in Health and Neurodegenerative Diseases

Huo, L., Du, X., Li, X., Liu, S., & Xu, Y. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.738442 · Cited by 149

The emerging role of exosomes in Alzheimer’s disease

Zhang, T., Ma, S., Lv, J., Wang, X., Afewerky, H. K., Li, H. R., & Lu, Y. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101321 · Cited by 141

Role of exosomes in the pathogenesis, diagnosis, and treatment of central nervous system diseases

Fan, Y., Chen, Z., & Zhang, M. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03493-6 · Cited by 134

Propagation of Tau via Extracellular Vesicles

Pérez, M., Avila, J., & Hernández, F. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00698 · Cited by 118

Complement protein levels in plasma astrocyte‐derived exosomes are abnormal in conversion from mild cognitive impairment to Alzheimer's disease dementia

Winston, C. N., Goetzl, E. J., Schwartz, J. B., Elahi, F. M., & Rissman, R. A. (2018) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2018.11.002 · Cited by 120

SARS‐CoV‐2 and Mitochondrial Proteins in Neural‐Derived Exosomes of COVID‐19

Peluso, M. J., Deeks, S. G., Mustapić, M., Kapogiannis, D., Henrich, T. J., Lu, S., Goldberg, S. A., Hoh, R., Chen, J. Y., Martinez, E. O., et al. (2022) · Annals of Neurology · doi:10.1002/ana.26350 · Cited by 116

Neuronal pentraxins as biomarkers of synaptic activity: from physiological functions to pathological changes in neurodegeneration

Gómez de San José, N., Massa, F., Halbgebauer, S., Oeckl, P., Steinacker, P., & Otto, M. (2022) · Journal of Neural Transmission · doi:10.1007/s00702-021-02411-2 · Cited by 112

Assessing Neuronal and Astrocyte Derived Exosomes From Individuals With Mild Traumatic Brain Injury for Markers of Neurodegeneration and Cytotoxic Activity

Winston, C. N., Romero, H. K., Ellisman, M., Nauss, S., Julovich, D. A., Conger, T., Hall, J. R., Campana, W., O’Bryant, S. E., Nievergelt, C. M., et al. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01005 · Cited by 105

Extracellular Vesicles in neural cell interaction and CNS homeostasis

Schnatz, A., Müller, C., Brahmer, A., & Krämer‐Albers, E. (2021) · FASEB BioAdvances · doi:10.1096/fba.2021-00035 · Cited by 112

Neuron-derived extracellular vesicles enriched from plasma show altered size and miRNA cargo as a function of antidepressant drug response

Saeedi, S., Nagy, C., Ibrahim, P., Théroux, J., Wakid, M., Fiori, L. M., Yang, J., Rotzinger, S., Foster, J. A., Mechawar, N., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01255-2 · Cited by 110

Brain Derived Exosomes Are a Double-Edged Sword in Alzheimer’s Disease

Song, Z., Xu, Y., Deng, W., Zhang, L., Zhu, H., Yü, P., Qu, Y., Zhao, W., Han, Y., & Qin, C. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00079 · Cited by 103

Extracellular vesicles in the diagnosis and treatment of central nervous system diseases

Rizvanov, A. A., Shaimardanova, A. A., Solovyeva, V. V., Chulpanova, D. S., James, V. H., & Kitaeva, K. V. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.266908 · Cited by 103

MicroRNA expression profiles of neuron-derived extracellular vesicles in plasma from patients with amyotrophic lateral sclerosis

Katsu, M., Hama, Y., Utsumi, J., Takashina, K., Yasumatsu, H., Mori, F., Wakabayashi, K., Shoji, M., & Sasaki, H. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.03.048 · Cited by 99

Exosome: A novel neurotransmission modulator or non-canonical neurotransmitter?

Xia, X., Wang, Y., Qin, Y., Zhao, S., & Zheng, J. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101558 · Cited by 107

Synaptic proteins in neuron-derived extracellular vesicles as biomarkers for Alzheimer’s disease: novel methodology and clinical proof of concept

Eitan, E., Thornton‐Wells, T. A., Elgart, K., Erden, E., Gershun, E., Levine, A. A., Volpert, O. V., Azadeh, M., Smith, D. G., & Kapogiannis, D. (2023) · Extracellular Vesicles and Circulating Nucleic Acids · doi:10.20517/evcna.2023.13 · Cited by 97

Biomarker potential of brain‐secreted extracellular vesicles in blood in Alzheimer's disease

Badhwar, A., & Haqqani, A. S. (2020) · Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring · doi:10.1002/dad2.12001 · Cited by 87

A new paradigm for diagnosis of neurodegenerative diseases: peripheral exosomes of brain origin

Younas, N., Flores, L. C. F., Hopfner, F., Höglinger, G. U., & Zerr, I. (2022) · Translational Neurodegeneration · doi:10.1186/s40035-022-00301-5 · Cited by 84

Exosomes as cell-derivative carriers in the diagnosis and treatment of central nervous system diseases

Shetgaonkar, G. G., Marques, S. M., DCruz, C. E. M., Vibhavari, R. J. A., Kumar, L., & Shirodkar, R. K. (2021) · Drug Delivery and Translational Research · doi:10.1007/s13346-021-01026-0 · Cited by 400

Biogenesis, Composition and Potential Therapeutic Applications of Mesenchymal Stem Cells Derived Exosomes in Various Diseases

Yuan, Y., Wang, J., Zhang, Y., Li, L., Reza, A. M. M. T., & Gurunathan, S. (2023) · International Journal of Nanomedicine · doi:10.2147/ijn.s407029 · Cited by 85

Blood extracellular vesicles carrying synaptic function‐ and brain‐related proteins as potential biomarkers for Alzheimer's disease

Tian, C., Stewart, T., Hong, Z., Guo, Z., Aro, P., Soltys, D., Pan, C., Peskind, E. R., Zabetian, C. P., Shaw, L. M. J., et al. (2022) · Alzheimer s & Dementia · doi:10.1002/alz.12723 · Cited by 80

Emergence of Extracellular Vesicles as “Liquid Biopsy” for Neurological Disorders: Boom or Bust

Kumar, A., Nader, M. A., & Deep, G. (2024) · Pharmacological Reviews · doi:10.1124/pharmrev.122.000788 · Cited by 79

Extracellular Vesicle Biomarkers Track Cognitive Changes Following Intranasal Insulin in Alzheimer’s Disease

Mustapić, M., Tran, J., Craft, S., & Kapogiannis, D. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-180578 · Cited by 79

Emerging blood exosome-based biomarkers for preclinical and clinical Alzheimer’s disease: a meta-analysis and systematic review

Chen, L., Liu, W., Lin, H., Lin, M., Yu, Y., Liu, H., Dai, Y., Chen, L.-W., Jia, W., He, X., et al. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.335832 · Cited by 76

Neuron-derived extracellular vesicles in blood reveal effects of exercise in Alzheimer’s disease

Delgado‐Peraza, F., Nogueras‐Ortiz, C. J., Simonsen, A. H., Knight, D. D., Yao, P. J., Goetzl, E. J., Jensen, C. S., Høgh, P., Gottrup, H., Vestergaard, K., et al. (2023) · Alzheimer s Research & Therapy · doi:10.1186/s13195-023-01303-9 · Cited by 76

Neuronally derived extracellular vesicles: an emerging tool for understanding Alzheimer’s disease

Watson, L. S., Hamlett, E. D., Stone, T. D., & Sims‐Robinson, C. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0317-5 · Cited by 75

The Basic Characteristics of the Pentraxin Family and Their Functions in Tumor Progression

Wang, Z., Wang, X., Zou, H., Dai, Z., Feng, S., Zhang, M., Xiao, G., Liu, Z., & Cheng, Q. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01757 · Cited by 73

Extracellular Vesicles in Alzheimer’s and Parkinson’s Disease: Small Entities with Large Consequences

Vandendriessche, C., Bruggeman, A., Cauwenberghe, C. V., & Vandenbroucke, R. E. (2020) · Cells · doi:10.3390/cells9112485 · Cited by 75

Emerging evidence implicating a role for neurexins in neurodegenerative and neuropsychiatric disorders

Cuttler, K., Hassan, M., Carr, J. A., Cloete, R. E. A., & Bardien, S. (2021) · Open Biology · doi:10.1098/rsob.210091 · Cited by 69

Brain insulin resistance and altered brain glucose are related to memory impairments in schizophrenia

Wijtenburg, S. A., Kapogiannis, D., Korenic, S. A., Mullins, R. J., Tran, J., Gaston, F. E., Chen, S., Mustapić, M., Hong, L. E., & Rowland, L. M. (2019) · Schizophrenia Research · doi:10.1016/j.schres.2019.01.031 · Cited by 73

Extracellular vesicles, the emerging mirrors of brain physiopathology

Cano, A. C., Ettcheto, M., Bernuz, M., Puerta, R., Antonio, E. E., Sánchez‐López, E., Souto, E. B., Camins, A., Martí, M., Pividori, M. I., et al. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.79063 · Cited by 75

Brain‐derived extracellular vesicles: Potential diagnostic biomarkers for central nervous system diseases

Xu, X., Iqbal, Z., Xu, L., Wen, C., Duan, L., Xia, J., Yang, N., Zhang, Y., & Liang, Y. (2024) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.13610 · Cited by 68

Exosomes: Innocent Bystanders or Critical Culprits in Neurodegenerative Diseases

Beatriz, M., Vilaça, R., & Lopes, C. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.635104 · Cited by 67

Promise of extracellular vesicles for diagnosis and treatment of epilepsy

Upadhya, D., & Shetty, A. K. (2019) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2019.106499 · Cited by 66

Neuron-Derived Plasma Exosome Proteins after Remote Traumatic Brain Injury

Goetzl, E. J., Peltz, C. B., Mustapić, M., Kapogiannis, D., & Yaffe, K. S. (2019) · Journal of Neurotrauma · doi:10.1089/neu.2019.6711 · Cited by 65

Enrichment of extracellular vesicles using Mag-Net for the analysis of the plasma proteome

Wu, C. C., Tsantilas, K. A., Park, J., Plubell, D. L., Sanders, J. A., Naicker, P., Govender, I. S., Buthelezi, S. G., Stoychev, S., Jordaan, J., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-60595-7 · Cited by 121

Role of Extracellular Vesicles in Amyotrophic Lateral Sclerosis

Ferrara, D., Pasetto, L., Bonetto, V., & Basso, M. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00574 · Cited by 65

Diagnostic and Therapeutic Potential of Exosomes in Neurodegenerative Diseases

Gao, P., Li, X., Du, X., Liu, S., & Xu, Y. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.790863 · Cited by 61

Biomarkers in Neurodegenerative Diseases: Proteomics Spotlight on ALS and Parkinson’s Disease

Raghunathan, R., Turajane, K., & Wong, L. C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169299 · Cited by 63

Extracellular vesicles as an emerging tool for the early detection of Alzheimer’s disease

Li, T.-R., Wang, X.-N., Sheng, C., Li, Y.-X., Li, F. Z.-T., Sun, Y., & Han, Y. (2019) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2019.111175 · Cited by 60

Mag-Net: Rapid enrichment of membrane-bound particles enables high coverage quantitative analysis of the plasma proteomePreprint

Wu, C. C., Tsantilas, K. A., Park, J., Plubell, D. L., Sanders, J. A., Naicker, P., Govender, I. S., Buthelezi, S. G., Stoychev, S., Jordaan, J., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.06.10.544439 · Cited by 60

T he roles of extracellular vesicle micro RNA s in the central nervous system

Blandford, S. N., Galloway, D. A., & Moore, C. S. (2018) · Glia · doi:10.1002/glia.23445 · Cited by 62

Extracellular vesicles and Alzheimer’s disease in the novel era of Precision Medicine: implications for disease progression, diagnosis and treatment

Gomes, P., Tzouanou, F., Skolariki, K., Vamvaka-Iakovou, A., Nogueras‐Ortiz, C. J., Tsirtsaki, K., Waites, C. L., Vlamos, P., Sousa, N., Costa‐Silva, B., et al. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114183 · Cited by 60

Extracellular vesicles: biological mechanisms and emerging therapeutic opportunities in neurodegenerative diseases

Wang, L., Zhang, X., Yang, Z., Wang, B., Gong, H., Zhang, K., Lin, Y., & Sun, M. (2024) · Translational Neurodegeneration · doi:10.1186/s40035-024-00453-6 · Cited by 55

Regulation of AMPAR trafficking in synaptic plasticity by BDNF and the impact of neurodegenerative disease

Keifer, J. (2022) · Journal of Neuroscience Research · doi:10.1002/jnr.25022 · Cited by 57

Growth Hormone-Releasing Hormone Modulation of Neuronal Exosome Biomarkers in Mild Cognitive Impairment

Winston, C. N., Goetzl, E. J., Baker, L. D., Vitiello, M. V., & Rissman, R. A. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180302 · Cited by 54

The evolving role of extracellular vesicles (exosomes) as biomarkers in traumatic brain injury: Clinical perspectives and therapeutic implications

Khan, N. A., Asim, M., El-Menyar, A. A., Biswas, K. H., Rizoli, S. B., & Al-Thani, H. A. S. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.933434 · Cited by 52

Extracellular vesicles: translational research and applications in neurology

Manolopoulos, A., Yao, P. J., & Kapogiannis, D. (2025) · Nature Reviews Neurology · doi:10.1038/s41582-025-01080-z · Cited by 60

Extracellular vesicles in neurodegenerative diseases: Insights and new perspectives

Yuan, Q., Li, X., Zhang, S.-M., Wang, H., & Wang, Y. (2019) · Genes & Diseases · doi:10.1016/j.gendis.2019.12.001 · Cited by 60

Future avenues for Alzheimer's disease detection and therapy: liquid biopsy, intracellular signaling modulation, systems pharmacology drug discovery

Hampel, H. J., Vergallo, A., Caraci, F., Cuello, A. C., Lemercier, P., Vellas, B. J., Giudici, K. V., Baldacci, F., Hänisch, B., Haberkamp, M., et al. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108081 · Cited by 52

β-Amyloid in blood neuronal-derived extracellular vesicles is elevated in cognitively normal adults at risk of Alzheimer’s disease and predicts cerebral amyloidosis

Li, T., Yao, Y., Jiang, X., Dong, Q., Yu, X., Wang, T., Cai, Y., & Han, Y. (2022) · Alzheimer s Research & Therapy · doi:10.1186/s13195-022-01010-x · Cited by 52

Deficient neurotrophic factors of CSPG4‐type neural cell exosomes in Alzheimer disease

Goetzl, E. J., Nogueras‐Ortiz, C. J., Mustapić, M., Mullins, R. J., Abner, E. L., Schwartz, J. B., & Kapogiannis, D. (2018) · The FASEB Journal · doi:10.1096/fj.201801001 · Cited by 48

Biomarker-Drug and Liquid Biopsy Co-development for Disease Staging and Targeted Therapy: Cornerstones for Alzheimer’s Precision Medicine and Pharmacology

Hampel, H. J., Goetzl, E. J., Kapogiannis, D., Lista, S., & Vergallo, A. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00310 · Cited by 47

Recent advances in optical label‐free characterization of extracellular vesicles

Imanbekova, M., Suarasan, S., Lu, Y. P., Jurchuk, S., & Wachsmann‐Hogiu, S. (2022) · Nanophotonics · doi:10.1515/nanoph-2022-0057 · Cited by 47

Circulating extracellular vesicles: friends and foes in neurodegeneration

Calvani, R., Picca, A., Guerra, F., Coelho-Júnior, H. J., Bucci, C., & Marzetti, E. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.320972 · Cited by 48

Brain Exosomes: Friend or Foe in Alzheimer’s Disease?

Kaur, S., Verma, H., Dhiman, M., Tell, G., Gigli, G. L., Janes, F., & Mantha, A. K. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02547-y · Cited by 45

Resting-State Functional Connectivity Is Associated With Cerebrospinal Fluid Levels of the Synaptic Protein NPTX2 in Non-demented Older Adults

Soldan, A., Moghekar, A., Walker, K. A., Pettigrew, C. A., Hou, X., Lu, H., Miller, M. I., Alfini, A. J., Albert, M., Xu, D., et al. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00132 · Cited by 45

Neuroligin-1 is altered in the hippocampus of Alzheimer’s disease patients and mouse models, and modulates the toxicity of amyloid-beta oligomers

Dufort‐Gervais, J., Provost, C., Charbonneau, L., Norris, C. M., Calon, F., Mongrain, V., & Brouillette, J. (2020) · Scientific Reports · doi:10.1038/s41598-020-63255-6 · Cited by 48

Astrocytes deliver CK1 to neurons via extracellular vesicles in response to inflammation promoting the translation and amyloidogenic processing of APP

Li, Z., Moniruzzaman, M., Dastgheyb, R. M., Yoo, S., Wang, M., Hao, H., Liu, J., Casaccia, P., Nogueras‐Ortiz, C. J., Kapogiannis, D., et al. (2020) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12035 · Cited by 45

Extracellular Vesicles at CNS barriers: Mode of action

Krämer‐Albers, E. (2022) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2022.102569 · Cited by 47

Biomarker and therapeutic potential of peripheral extracellular vesicles in Alzheimer’s disease

Vandendriessche, C., Kapogiannis, D., & Vandenbroucke, R. E. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114486 · Cited by 44

SERS spectroscopy with machine learning to analyze human plasma derived sEVs for coronary artery disease diagnosis and prognosis

Huang, X., Liu, B., Guo, S., Guo, W., Liao, K., Hu, G., Shi, W., Kuss, M. A., Duryee, M. J., Anderson, D. R., et al. (2022) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10420 · Cited by 43

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Kandimalla, R., Saeed, M., Tyagi, N., Gupta, R. C., & Aqil, F. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104974 · Cited by 45

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Boiten, W., van Steenoven, I., Xiao, M.-F., Worley, P., Noli, B., Cocco, C., Ferri, G.-L., Lemstra, A., & Teunissen, C. (2020) · Cells · doi:10.3390/cells10010038 · Cited by 42

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Puricelli, C., Boggio, E. M., Gigliotti, C. L., Stoppa, I., Sutti, S., Giordano, M., Dianzani, U., & Rolla, R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054565 · Cited by 49

Profile of pathogenic proteins in total circulating extracellular vesicles in mild cognitive impairment and during the progression of Alzheimer's disease

Perrotte, M., Haddad, M., Page, A. Y. L., Frost, E. H., Fülöp, T., & Ramassamy, C. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.10.010 · Cited by 42

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Haddad, M., Perrotte, M., Khedher, M. R. B., Demongin, C., Page, A. Y. L., Fülöp, T., & Ramassamy, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194906 · Cited by 41

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Camporesi, E., Lashley, T., Gobom, J., Lantero‐Rodriguez, J., Hansson, O., Zetterberg, H., Blennow, K., & Becker, B. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01119-4 · Cited by 43

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Lista, S., Santos‐Lozano, A., Emanuele, E., Mercuri, N. B., Gabelle, A., López‐Ortiz, S., Martín-Hernández, J., Maisto, N., Imbimbo, C., Caraci, F., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-023-02376-6 · Cited by 44

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Nielsen, J. E., Pedersen, K. S., Vestergård, K., Maltesen, R. G., Christiansen, G., Lundbye‐Christensen, S., Moos, T., Kristensen, S. R., & Pedersen, S. (2020) · Biomedicines · doi:10.3390/biomedicines8070199 · Cited by 39

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Bodart‐Santos, V., Pinheiro, L. S., da Silva‐Junior, A. J., Frozza, R. L., Ahrens, R., Gonçalves, R. A., Andrade, M. M., Chen, Y., Alcantara, C. D. L., Grinberg, L. T., et al. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.13134 · Cited by 39

Endosomal dysfunction impacts extracellular vesicle release: Central role in Aβ pathology

Arbo, B. D., Cechinel, L. R., Palazzo, R. P., & Siqueira, I. R. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.101006 · Cited by 40

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Gámez‐Valero, A., Beyer, K., & Borràs, F. E. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.10.006 · Cited by 38

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Tarawneh, R. M. (2020) · Biomarker Insights · doi:10.1177/1177271920976367 · Cited by 42

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Gonzales, M. M., Krishnamurthy, S., Garbarino, V. R., Daeihagh, A. S., Gillispie, G. J., Deep, G., Craft, S., & Orr, M. E. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111589 · Cited by 37

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Plasma Extracellular Vesicle Size and Concentration Are Altered in Alzheimer’s Disease, Dementia With Lewy Bodies, and Frontotemporal Dementia

Longobardi, A., Benussi, L., Nicsanu, R., Bellini, S., Ferrari, C., Saraceno, C., Zanardini, R., Catania, M., Fede, G. D., Squitti, R., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.667369 · Cited by 36

Small extracellular vesicles in plasma reveal molecular effects of modified Mediterranean-ketogenic diet in participants with mild cognitive impairment

Kumar, A., Sharma, M., Su, Y., Singh, S., Hsu, F., Neth, B. J., Register, T. C., Blennow, K., Zetterberg, H., Craft, S., et al. (2022) · Brain Communications · doi:10.1093/braincomms/fcac262 · Cited by 37

Recent advances in the clinical application of exosomes for disease diagnosis and therapeutic strategies

Wen, C., Ma, H., Xu, L., Gu, Z., Li, H., Zhang, Y., Liang, Y., & Xu, X. G. (2025) · International Journal of Surgery · doi:10.1097/js9.0000000000002518 · Cited by 37

Brain-Derived Exosomal Proteins as Effective Biomarkers for Alzheimer’s Disease: A Systematic Review and Meta-Analysis

Kim, K. Y., Shin, K. Y., & Chang, K. (2021) · Biomolecules · doi:10.3390/biom11070980 · Cited by 36

Mesenchymal Stem Cell-Derived Exosomes as a Neuroregeneration Treatment for Alzheimer’s Disease

Shah, S., Mansour, H. M., Aguilar, T. M., & Lucke-Wold, B. P. (2024) · Biomedicines · doi:10.3390/biomedicines12092113 · Cited by 37

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Ma, Q., Teng, E., Zuo, X., Jones, M. R., Teter, B., Zhao, E. Y., Zhu, C., Bilousova, T. V., Gylys, K. H., Apostolova, L. G., et al. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.02.014 · Cited by 34

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Olivero, G., Cisani, F., Marimpietri, D., Paolo, D. D., Gagliani, M. C., Podestà, M., Cortese, K., & Pittaluga, A. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.670158 · Cited by 29

Decreased synaptic proteins in neuronal exosomes of frontotemporal dementia and Alzheimer's disease

Goetzl, E. J., Kapogiannis, D., Schwartz, J. B., Lobach, I. V., Goetzl, L., Abner, E. L., Jicha, G. A., Karydas, A. M., Boxer, A., & Miller, B. L. (2016) · The FASEB Journal · doi:10.1096/fj.201600816r · Cited by 398

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Galasko, D. R., Xiao, M., Xu, D., Zhang, J., Craig, M. T., Pelkey, K. A., Resnick, S. M., Troncoso, J. C., Reeves, R. H., McBain, C. J., et al. (2017) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2017.07.429

Pathological (Dis)Similarities in Neuronal Exosome-Derived Synaptic and Organellar Marker Levels Between Alzheimer’s Disease and Frontotemporal Dementia

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Selective regional loss of exocytotic presynaptic vesicle proteins in Alzheimer’s disease brains

Sze, C., Bi, H., Kleinschmidt-DeMasters, B. K., Filley, C. M., & Martin, L. J. (2000) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(00)00285-9 · Cited by 166

Blood neuro‐exosomal synaptic proteins predict Alzheimer's disease at the asymptomatic stage

Jia, L., Zhu, M., Kong, C., Pang, Y., Zhang, H., Qiu, Q., Wei, C., Tang, Y., Wang, Q., Li, Y., et al. (2020) · Alzheimer s & Dementia · doi:10.1002/alz.12166 · Cited by 247