The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Changes in indicators of inflammation after eccentric exercise of the elbow flexors
Abstract
This study examined muscle swelling and changes in inflammatory markers in the blood following eccentric exercise-induced muscle damage. Subjects (N = 14) who had not been involved in a resistance training program performed 24 maximal eccentric actions of the elbow flexors. Muscle swelling was assessed by measures of the upper arm circumference (CIR), ultrasonography (USG), and magnetic resonance imaging (MRI). Plasma concentrations of interleukin-1 alpha, interleukin-1 beta, interleukin-2, interleukin-6, tumor necrosis factor-alpha, and plasma levels of C-reactive protein, cortisol, and zinc were analyzed. Established indicators of muscle damage (maximal isometric force, range of motion, muscle soreness, and plasma creatine kinase, aspartate aminotransferase, and lactate dehydrogenase activities) were also measured. All measures, including CIR and USG, except for MRI, were assessed immediately before and after and for 5 d post-exercise. MRI was taken at pre- and 1, 3, 6, 10, 23, 31, and 58 d post-exercise. All muscle damage indicators changed significantly after exercise. A large increase in CIR (> 20 mm) was found 4-5 d after exercise, and this coincided with USG, showing an increase in muscle thickness. The echointensity of USG increased with the enlargement of the elbow flexors. MRI displayed enlargement of the biceps brachii and brachialis cross-sectional area that started at 1 d, and lasted until 23 d, post-exercise. The most profound increase in the enlargement and signal intensity of the MRI was found 3 or 6 d after exercise. However, none of the plasma levels of inflammatory makers showed significant muscle swelling, which is indicative of muscle edema, but the inflammatory responses after exercise appear to be different from those accompanying infection or tissue injury.
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Cites
Myofibrillar damage following intense eccentric exercise in man
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Muscle function after exercise-induced muscle damage and rapid adaptation
CLARKSON, P. M., NOSAKA, K., & BRAUN, B. (1992) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-199205000-00004 · Cited by 970
Self-citationMuscle stiffness, strength loss, swelling and soreness following exercise-induced injury in humans
Howell, J. N., Chleboun, G., & Conatser, R. (1993) · The Journal of Physiology · doi:10.1113/jphysiol.1993.sp019629 · Cited by 337
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Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6
Pedersen, B. K., & Febbraio, M. A. (2008) · Physiological Reviews · doi:10.1152/physrev.90100.2007 · Cited by 2,388
Delayed Onset Muscle Soreness: Treatment Strategies and Performance Factors
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The Effects of Physical Activity on Serum C-Reactive Protein and Inflammatory Markers
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Anti-inflammatory effects of exercise: role in diabetes and cardiovascular disease
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Time-course of changes in inflammatory and performance responses following a soccer game
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Stimuli and sensors that initiate skeletal muscle hypertrophy following resistance exercise
Wackerhage, H., Schoenfeld, B. J., Hamilton, D. L., Lehti, M., & Hulmi, J. J. (2019) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00685.2018 · Cited by 357
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Damas, F., Phillips, S. M., Lixandrão, M. E., Vechin, F. C., Libardi, C. A., Roschel, H., Tricoli, V., & Ugrinowitsch, C. (2016) · European Journal of Applied Physiology · doi:10.1007/s00421-015-3243-4 · Cited by 202
Time course of changes in performance and inflammatory responses after acute plyometric exercise
Chatzinikolaou, A., Fatouros, I. G., Gourgoulis, V., Avloniti, A., Jamurtas, A. Z., Nikolaidis, M. G., Douroudos, I., Michailidis, Y., Beneka, A., Malliou, P., et al. (2010) · Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e3181d1d318 · Cited by 177
MR properties of excised neural tissue following experimentally induced inflammation
Stanisz, G. J., Webb, S., Munro, C. A., Pun, T., & Midha, R. (2004) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20008 · Cited by 138
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Effects of taurine supplementation following eccentric exercise in young adults
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Pelland, J. C., Remmert, J. F., Robinson, Z. P., Hinson, S. R., & Zourdos, M. C. (2026) · Sports Medicine · doi:10.1007/s40279-025-02344-w · Cited by 18
Metadata
- Authors
- NOSAKA, K., & CLARKSON, P. M.
- Venue
- Medicine & Science in Sports & Exercise
- Published
- 1996-08
- Volume
- 28
- Issue
- 8
- Pages
- 953-961
- ISSN
- 0195-9131 (ISSN-L)
- OpenAlex
- W2054546767
- Cited by
- 365
- References
- 3
- FWCI
- 5.25
- Type
- journal article
- Language
- en
- Open access
- closed
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