MORPHOMETRIC ANALYSIS OF THE MACULA IN EYES WITH DISCIFORM AGE-RELATED MACULAR DEGENERATION
Abstract
PURPOSE: To evaluate the extent of neural cell death in eyes with disciform age-related macular degeneration. METHODS: Six eyes with disciform degeneration at various stages and five age-matched control eyes were selected for morphometric analysis using digitized light microscopic images. Disciform scars were classified as subneurosensory retinal, subretinal pigment epithelial, or combined lesions. The nuclei of the ganglion cell, inner nuclear, and outer nuclear layers were counted in contiguous 100 microm segments spanning a distance from 1,500 microm nasal to 1,500 microm temporal to the fovea. RESULTS: The outer nuclear layer was most severely attenuated in eyes with disciform scars, demonstrating a 69.4% reduction in cell number relative to control eyes. A loss in retinal ganglion cells (by 7.3%) and an increase in inner nuclear layer cells (by 10%) were observed, but these changes were not significant. Photoreceptor loss was most pronounced when the disciform scar was not covered by the retinal pigment epithelium. CONCLUSION: The nuclei of the outer nuclear layer are significantly attenuated in eyes with disciform age-related macular degeneration, while the ganglion cell and inner nuclear layers are relatively preserved. These findings suggest that replacement of outer nuclear function, by either retinal transplantation or implantation of the intraocular retinal prosthesis, might be a feasible therapeutic option for patients with this condition.
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Although the RPE is the most affected cell layer in AMD, the photoreceptor layer is also severely attenuated.
“Although RPE is the most affected cell layer, the photoreceptor layer is also severely attenuated (87).”
From Unraveling a Multifactorial Late-Onset Disease: From Genetic Susceptibility to Disease Mechanisms for Age-Related Macular Degeneration (2009) · cites this paper as [87]
The outer nuclear layer can be severely attenuated, with an almost 70% reduction of photoreceptor length shown in one study.
“The outer nuclear layer can be severely attenuated, with an almost 70% reduction of photoreceptor length shown in one study.136”
From Age-related macular degeneration (2008) · cites this paper as [136]
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- Authors
- KIM, S. Y., SADDA, S., PEARLMAN, J., HUMAYUN, M. S., de JUAN, E., MELIA, B. M., & GREEN, W. R.
- Affiliations
- Johns Hopkins University (US)
- Venue
- Retina
- Published
- 2002-08
- Volume
- 22
- Issue
- 4
- Pages
- 471-477
- ISSN
- 0275-004X (ISSN-L)
- OpenAlex
- W1992625034
- Cited by
- 158
- References
- 34
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 6 · 2020: 7 · 2019: 11 · 2018: 3 · 2017: 13 · 2016: 6 · 2015: 10 · 2014: 9 · 2013: 8 · 2012: 13
- FWCI
- 6.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Retina (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal and Macular Surgery
- Keywords
- photoreceptor loss, outer nuclear layer, retinal ganglion cells, inner nuclear layer, retinal pigment epithelium, retinal cell death, retinal transplantation
- MeSH terms
- Aged, Cell Count, Cell Nucleus, Female, Humans, Interneurons, Macula Lutea, Macular Degeneration, Male, Retinal Ganglion Cells, Cell Death
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