Selectivity of direct and network-mediated stimulation of the retinal ganglion cells with epi-, sub- and intraretinal electrodes
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OBJECTIVE: Intra-retinal placement of stimulating electrodes can provide close and stable proximity to target neurons. We assessed improvement in stimulation thresholds and selectivity of the direct and network-mediated retinal stimulation with intraretinal electrodes, compared to epiretinal and subretinal placements. APPROACH: Stimulation thresholds of the retinal ganglion cells (RGCs) in wild-type rat retina were measured using the patch-clamp technique. Direct and network-mediated responses were discriminated using various synaptic blockers. MAIN RESULTS: Three types of RGC responses were identified: short latency (SL, τ < 5 ms) originating in RGCs, medium latency (ML, 3 < τ < 70 ms) originating in the inner nuclear layer and long latency (LL, τ > 40 ms) originating in photoreceptors. Cathodic epiretinal stimulation exhibited the lowest threshold for direct RGC response and the highest direct selectivity (network/direct thresholds ratio), exceeding a factor of 3 with pulse durations below 0.5 ms. For network-mediated stimulation, the lowest threshold was obtained with anodic pulses in OPL position, and its network selectivity (direct/network thresholds ratio) increased with pulse duration, exceeding a factor of 4 at 10 ms. Latency of all three types of responses decreased with increasing strength of the stimulus. SIGNIFICANCE: These results define the optimal range of pulse durations, pulse polarities and electrode placement for the retinal prostheses aiming at direct or network-mediated stimulation of RGCs.
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The device position and the characteristics of the electrical pulses determine which cell population is predominantly activated.
“The device position (epiretinal, subretinal or suprachoroidal) and the characteristics of the electrical pulses (such as duration and waveform) determine which cell population is predominantly activated [28,29].”
From Advances in visual prostheses: engineering and biological challenges (2022) · cites this paper as [28]
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- Authors
- Boinagrov, D., Pangratz-Fuehrer, S., Goetz, G., & Palanker, D.
- Affiliations
- Stanford University (US)
- Corresponding author
- Boinagrov, David
- Venue
- Journal of Neural Engineering
- Publisher
- IOP Publishing
- Published
- 2014-03-10
- Volume
- 11
- Issue
- 2
- Pages
- 026008
- ISSN
- 1741-2552 (ISSN-L)
- 1741-2560
- PMC
- PMC4082997
- OpenAlex
- W2058723867
- Cited by
- 146
- References
- 56
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 7 · 2023: 9 · 2022: 10 · 2021: 13 · 2020: 18 · 2019: 15 · 2018: 15 · 2017: 14 · 2016: 14 · 2015: 13 · 2014: 3 · 2013: 1
- FWCI
- 6.70
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Neural Engineering (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Chongqing University
- National Institutes of Health
- National Eye Institute (R01EY018608)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- retinal ganglion cells, retinal prosthesis, epiretinal stimulation, subretinal stimulation, stimulation selectivity, stimulation threshold, pulse duration, pulse polarity, inner plexiform layer, photoreceptors, rat retina
- MeSH terms
- Action Potentials, Animals, Electric Stimulation, Electrodes, Implanted, Male, Microelectrodes, Nerve Net, Retinal Ganglion Cells, Rats, Long-Evans, Rats
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