Characterization of depression in children with autism spectrum disorders
Open accessAbstract
Depressive syndromes represent a disabling comorbidity for many children with autism spectrum disorders (ASD); however, the ascertainment of depression can be complicated by phenotypic overlap between the 2 conditions, by ways in which autistic symptomatology can mask cardinal features of depression and by atypical manifestations of depression in children with ASD. These issues have contributed to wide variation in the estimation of prevalence rates of depression in individuals with ASD and invoke the need for new approaches to the specific detection of depression and other neuropsychiatric comorbidities that aggregate in children affected by ASD. The authors review the scientific literature relevant to the occurrence of depression in ASD and consider important parameters of risk, including psychosocial factors such as insight into affectation status, as well as biological factors such as the aggregation of depressive syndromes in certain families affected by autism, which has suggested possible overlap in genetic influences underlying the 2 conditions. Variability in the manifestations of depression across environmental contexts provides important clues to intervention and underscores the potential importance of involving multiple informants in ascertaining depression in children and adolescents with ASD. A practical strategy for evaluating the presence of depression in youth with ASD is synthesized from the available data and discussed.
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A co-occurring diagnosis may be further complicated by the ways in which the symptoms and features overlap (e.g., social withdrawal) and by the atypical manifestation of depression symptoms in ASD.
“A co-occurring diagnosis may be further complicated by the ways in which the symptoms and features overlap (e.g., social withdrawal) and by the atypical manifestation of depression symptoms in ASD [115].”
From Pharmacological treatment in autism: a proposal for guidelines on common co-occurring psychiatric symptoms (2025) · cites this paper as [115]
Emotion regulation problems may manifest differently in autism spectrum disorder.
“Further, ER problems may manifest differently in ASD.15,38,59”
From Emotion Regulation (2014) · cites this paper as [59]
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Does the autistic child have a “theory of mind” ?
Baron-Cohen, S., Leslie, A. M., & Frith, U. (1985) · Cognition · doi:10.1016/0010-0277(85)90022-8 · Cited by 8,599 · see citing works
Genetic Epidemiology of Major Depression: Review and Meta-Analysis
Sullivan, P. F., Neale, M. C., & Kendler, K. S. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.10.1552 · Cited by 3,431 · see citing works
Simonoff, E., Pickles, A., Charman, T., Chandler, S., Loucas, T., & Baird, G. (2008) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e318179964f · Cited by 3,399 · see citing works
Autism as a strongly genetic disorder: evidence from a British twin study
Bailey, A., Le Couteur, A., Gottesman, I., Bolton, P., Simonoff, E., Yuzda, E., & Rutter, M. (1995) · Psychological Medicine · doi:10.1017/s0033291700028099 · Cited by 2,461 · see citing works
The clinical significance of loneliness: a literature review
Heinrich, L. M., & Gullone, E. (2006) · Clinical Psychology Review · doi:10.1016/j.cpr.2006.04.002 · Cited by 1,986 · see citing works
Comorbid psychiatric disorders in children with autism: interview development and rates of disorders
Leyfer, O. T., Folstein, S. E., Bacalman, S., Davis, N. O., Dinh, E., Morgan, J., Tager-Flusberg, H., & Lainhart, J. E. (2006) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-006-0123-0 · Cited by 1,637 · see citing works
Autistic Traits in the General Population: A Twin Study
Constantino, J. N., & Todd, R. D. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.5.524 · Cited by 1,317 · see citing works
Self-citationBullying, Depression, and Suicidality in Adolescents
Klomek, A. B., Marrocco, F. A., KLEINMAN, M., Schonfeld, I. S., & Gould, M. S. (2006) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000242237.84925.18 · Cited by 990 · see citing works
Prevalence of Parent-Reported Diagnosis of Autism Spectrum Disorder Among Children in the US, 2007
Kogan, M. D., Blumberg, S. J., Schieve, L. A., Boyle, C. A., Perrin, J. M., Ghandour, R. M., Singh, G. K., Strickland, B. B., Trevathan, E., & van Dyck, P. C. (2009) · Pediatrics · doi:10.1542/peds.2009-1522 · Cited by 892 · see citing works
The Prevalence of Anxiety and Mood Problems among Children with Autism and Asperger Syndrome
Kim, J. A., Szatmári, P., Bryson, S. E., Streiner, D. L., & Wilson, F. (2000) · Autism · doi:10.1177/1362361300004002002 · Cited by 885 · see citing works
The genetics of autism spectrum disorders and related neuropsychiatric disorders in childhood
Lichtenstein, P., Carlström, E., Råstam, M., Gillberg, C., & Anckarsäter, H. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.10020223 · Cited by 738 · see citing works
Taylor, J. L., & Seltzer, M. M. (2011) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-010-1070-3 · Cited by 735 · see citing works
Hill, E., Berthoz, S., & Frith, U. (2004) · Journal of Autism and Developmental Disorders · doi:10.1023/b:jadd.0000022613.41399.14 · Cited by 619 · see citing works
Humphrey, N., & Lewis, S. (2008) · Autism · doi:10.1177/1362361307085267 · Cited by 587 · see citing works
Depression in Persons with Autism: Implications for Research and Clinical Care
Ghaziuddin, M., Ghaziuddin, N., & Greden, J. (2002) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1016330802348 · Cited by 579 · see citing works
Comorbid psychopathology with autism spectrum disorder in children: An overview
Matson, J. L., & Nebel-Schwalm, M. S. (2006) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2005.12.004 · Cited by 538 · see citing works
Presentation of depression in autism and Asperger syndrome: A review
Stewart, M. E., Barnard, L., Pearson, J., Hasan, R., & O’Brien, G. (2006) · Autism · doi:10.1177/1362361306062013 · Cited by 515 · see citing works
Atypical behaviors in children with autism and children with a history of language impairment
Dominick, K. C., Davis, N. O., Lainhart, J. E., Tager-Flusberg, H. B., & Folstein, S. E. (2006) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2006.02.003 · Cited by 496 · see citing works
Peer interaction and loneliness in high-functioning children with autism
Bauminger, N., Shulman, C., & Agam, G. (2003) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1025827427901 · Cited by 495 · see citing works
Children with Autism: Quality of Life and Parental Concerns
Lee, L.-C., Harrington, R. A., Louie, B. B., & Newschaffer, C. J. (2007) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-007-0491-0 · Cited by 446 · see citing works
Gurney, J. G., McPheeters, M. L., & Davis, M. M. (2006) · Archives of Pediatrics & Adolescent Medicine · doi:10.1001/archpedi.160.8.825 · Cited by 411 · see citing works
Health Outcomes Related to Early Adolescent Depression
Keenan‐Miller, D., Hammen, C. L., & Brennan, P. A. (2007) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2007.03.015 · Cited by 399 · see citing works
Piven, J., & Palmer, P. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.4.557 · Cited by 364 · see citing works
Solomon, M., Goodlin‐Jones, B. L., & Anders, T. F. (2004) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-004-5286-y · Cited by 328 · see citing works
Tager-Flusberg, H. B. (1992) · Child Development · doi:10.1111/j.1467-8624.1992.tb03604.x · Cited by 324 · see citing works
Parental psychiatric disorders associated with autism spectrum disorders in the offspring
Daniels, J. L., Forssen, U., Hultman, C. M., Cnattingius, S., Savitz, D. A., Feychting, M., & Sparen, P. (2008) · Pediatrics · doi:10.1542/peds.2007-2296 · Cited by 288 · see citing works
Friendship, loneliness and depression in adolescents with Asperger's Syndrome
Whitehouse, A. J. O., Durkin, K., Jaquet, E., & Ziatas, K. (2009) · Journal of Adolescence · doi:10.1016/j.adolescence.2008.03.004 · Cited by 286 · see citing works
Sterling, L., Dawson, G., Estes, A., & Greenson, J. (2008) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-007-0477-y · Cited by 263 · see citing works
Characteristics, correlates, and outcomes of childhood and adolescent depressive disorders
Rao, U., & Chen, L.-A. (2009) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2009.11.1/urao · Cited by 252 · see citing works
Little, L. (2002) · Issues in Comprehensive Pediatric Nursing · doi:10.1080/014608602753504847 · Cited by 250 · see citing works
Williams, S. B., O’Connor, E., Eder, M. L., & Whitlock, E. P. (2009) · PEDIATRICS · doi:10.1542/peds.2008-2415 · Cited by 235 · see citing works
Internalizing Disorders in Early Childhood: A Review of Depressive and Anxiety Disorders
Tandon, M., Cardeli, E., & Luby, J. L. (2009) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2009.03.004 · Cited by 226 · see citing works
Friendship and Internalizing Symptoms Among Children and Adolescents with ASD
Mazurek, M. O., & Kanne, S. M. (2010) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-010-1014-y · Cited by 218 · see citing works
Kerr, D., Lunkenheimer, E. S., & Olson, S. L. (2007) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2007.01776.x · Cited by 206 · see citing works
US Preventive Services Task Force (2009) · PEDIATRICS · doi:10.1542/peds.2008-2381 · Cited by 205 · see citing works
Kanne, S. M., Abbacchi, A. M., & Constantino, J. N. (2009) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-009-0694-7 · Cited by 203 · see citing works
Self-citationShtayermman, O. (2007) · Issues in Comprehensive Pediatric Nursing · doi:10.1080/01460860701525089 · Cited by 203 · see citing works
Vickerstaff, S., Heriot, S., Wong, M. L., Lopes, A., & Dossetor, D. R. (2006) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-006-0292-x · Cited by 202 · see citing works
Matson, J. L., Rush, K. S., Hamilton, M., Anderson, S. J., Bamburg, J. W., Baglio, C., Williams, D. E., & Kirkpatrick‐Sanchez, S. (1999) · Research in Developmental Disabilities · doi:10.1016/s0891-4222(99)00012-8 · Cited by 200 · see citing works
Tager-Flusberg, H. B. (1992) · Child Development · doi:10.2307/1130910 · Cited by 197 · see citing works
Affective disorders in people with autism: A review of published cases
Lainhart, J. E., & Folstein, S. E. (1994) · Journal of Autism and Developmental Disorders · doi:10.1007/bf02172140 · Cited by 189 · see citing works
Hurtig, T. M., Kuusikko, S., Mattila, M., Haapsamo, H., Ebeling, H. E., Jussila, K. K., Joskitt, L., Pauls, D. L., & Moilanen, I. K. (2009) · Autism · doi:10.1177/1362361309335719 · Cited by 176 · see citing works
Social attribution processes and comorbid psychiatric symptoms in children with Asperger syndrome
Meyer, J. A., Mundy, P. C., Hecke, A. V. V., & Durocher, J. S. (2006) · Autism · doi:10.1177/1362361306064435 · Cited by 175 · see citing works
Autism Spectrum Symptomatology in Children: The Impact of Family and Peer Relationships
Kelly, A. B., Garnett, M. S., Attwood, T., & Peterson, C. C. (2008) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-008-9234-8 · Cited by 167 · see citing works
Rapid Quantitative Assessment of Autistic Social Impairment by Classroom Teachers
Constantino, J. N., LaVesser, P., Zhang, Y., Abbacchi, A. M., Gray, T., & Todd, R. D. (2007) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e318157cb23 · Cited by 167 · see citing works
Self-citationAutism: Preparing for Adulthood
Howlin, P. (1996) · Medical Entomology and Zoology · Cited by 163 · see citing works
Psychiatric Symptoms and Psychosocial Difficulties in Young Adults with Autistic Traits
Kanne, S. M., Christ, S. E., & Reiersen, A. M. (2009) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-008-0688-x · Cited by 155 · see citing works
Self-competence and emotional understanding in high-functioning children with autism
Capps, L. M., Sigman, M., & Yirmiya, N. (1995) · Development and Psychopathology · doi:10.1017/s0954579400006386 · Cited by 145 · see citing works
Constantino, J. N., Hudziak, J. J., & Todd, R. D. (2003) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000046811.95464.21 · Cited by 142 · see citing works
Self-citationHedley, D., & Young, R. (2006) · Autism · doi:10.1177/1362361306062020 · Cited by 139 · see citing works
Ghaziuddin, M., & Greden, J. F. (1998) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1026036514719 · Cited by 130 · see citing works
Predictors of Psychiatric Symptoms in Children with an Autism Spectrum Disorder
Gadow, K. D., DeVincent, C. J., & Schneider, J. (2008) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-008-0556-8 · Cited by 115 · see citing works
Social Attributions and Depression in Adolescents with Asperger Syndrome
Barnhill, G. P. (2001) · Focus on Autism and Other Developmental Disabilities · doi:10.1177/108835760101600112 · Cited by 114 · see citing works
MOTIVATION IN CHILDHOOD AUTISM: CAN THEY OR WON'T THEY?
Koegel, R. L., & Mentis, M. (1985) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1985.tb02259.x · Cited by 113 · see citing works
Life events and depression in children with pervasive developmental disorders
Ghaziuddin, M., Alessi, N. E., & Greden, J. F. (1995) · Journal of Autism and Developmental Disorders · doi:10.1007/bf02178296 · Cited by 104 · see citing works
Williamson, S., Craig, J., & Slinger, R. (2008) · Autism · doi:10.1177/1362361308091652 · Cited by 101 · see citing works
Pearson, D. A., Loveland, K. A., Lachar, D., Lane, D. M., Reddoch, S., Mansour, R., & Cleveland, L. A. (2006) · Child Neuropsychology · doi:10.1080/09297040600646847 · Cited by 99 · see citing works
Mazefsky, C. A., Folstein, S. E., & Lainhart, J. E. (2008) · Autism Research · doi:10.1002/aur.23 · Cited by 97 · see citing works
Anxiety and Depression in Children with HFASDs: Symptom Levels and Source Differences
Lopata, C. J., Toomey, J. A., Fox, J. D., Volker, M. A., Chow, S. Y., Thomeer, M. L., Lee, G. K., Rodgers, J. D., McDonald, C. A., & Smerbeck, A. M. (2010) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-010-9406-1 · Cited by 95 · see citing works
Association of Autistic-Like and Internalizing Traits During Childhood: A Longitudinal Twin Study
Hallett, V., Ronald, A., Rijsdijk, F. V., & Happe, F. G. E. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.09070990 · Cited by 92 · see citing works
Textbook of Autism Spectrum Disorders
Howlin, P. (2011) · Child and Adolescent Mental Health · doi:10.1111/j.1475-3588.2011.00640_8.x · Cited by 74 · see citing works
The Phenomenology of Depressive Illness in People with a Learning Disability and Autism
Perry, D. W., Marston, G., Hinder, S. A. J., Munden, A. C., & Roy, A. (2001) · Autism · doi:10.1177/1362361301005003004 · Cited by 56 · see citing works
Genetic and Environmental Covariation Between Autistic Traits and Behavioral Problems
Hoekstra, R. A., Bartels, M., Hudziak, J. J., Beijsterveldt, T. C. E. M. V., & Boomsma, D. I. (2007) · Twin Research and Human Genetics · doi:10.1375/twin.10.6.853 · Cited by 51 · see citing works
Wachtel, L. E., Griffin, M., & Reti, I. M. (2010) · Journal of Ect · doi:10.1097/yct.0b013e3181a744ec · Cited by 45 · see citing works
Hallett, V., Ronald, A., & Happe, F. G. E. (2009) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e31819f7116 · Cited by 40 · see citing works
Diagnosis and treatment of depression in patients with mental retardation
Janowsky, D. S., & Davis, J. M. (2005) · Current Psychiatry Reports · doi:10.1007/s11920-005-0062-z · Cited by 26 · see citing works
Chen, C., Chen, K.-H., Liu, C., Huang, S.-L., & Lin, K.-M. (2008) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2008.09.043 · Cited by 26 · see citing works
Textbook of Autism Spectrum Disorders
Achinivu, K. (2012) · Journal of Intellectual Disability Research · doi:10.1111/j.1365-2788.2011.01504.x · Cited by 24 · see citing works
Tsuji, H., Miyawaki, D., Kawaguchi, T., Matsushima, N., Horino, A., Takahashi, K., Suzuki, F., & Kiriike, N. (2009) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2008.01916.x · Cited by 24 · see citing works
Butzer, B., & Konstantareas, M. M. (2003) · Cited by 21 · see citing works
Behavioral Assessment and Treatment of Self-Injurious Behavior in Autism
Minshawi, N. F. (2008) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2008.06.012 · Cited by 20 · see citing works
Skinner, S. R., Ng, C., McDonald, A., & Walters, T. (2005) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.2005.tb07108.x · Cited by 19 · see citing works
Familial Risk Factors in Autism
Brimacombe, M. B., Ming, X., & Parikh, A. N. (2007) · Journal of Child Neurology · doi:10.1177/0883073807302609 · Cited by 15 · see citing works
CATATONIA IN HIGH-FUNCTIONING AUTISM SPECTRUM DISORDERS: CASE REPORT AND REVIEW OF LITERATURE
Takaoka, K., & Takata, T. (2007) · Psychological Reports · doi:10.2466/pr0.101.3.961-969 · Cited by 15 · see citing works
Depressive pseudodementia in a child with autism
Pollard, A. J., & Prendergast, M. (2004) · Developmental Medicine & Child Neurology · doi:10.1017/s0012162204000805 · Cited by 12 · see citing works
Depressive pseudodementia in a child with autism
Pollard, A. J., & Prendergast, M. (2004) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.2004.tb00510.x · Cited by 10 · see citing works
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An Overview of Autism Spectrum Disorder, Heterogeneity and Treatment Options
Masi, A., DeMayo, M. M., Glozier, N., & Guastella, A. J. (2017) · Neuroscience Bulletin · doi:10.1007/s12264-017-0100-y · Cited by 987 · see citing works
The Role of Emotion Regulation in Autism Spectrum Disorder
Mazefsky, C. A., Herrington, J., Siegel, M., Scarpa, A., Maddox, B. B., Scahill, L., & White, S. W. (2013) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2013.05.006 · Cited by 881 · see citing works
Prevalence of Depressive Disorders in Individuals with Autism Spectrum Disorder: A Meta-Analysis
Hudson, C. C., Hall, L., & Harkness, K. L. (2019) · Journal of Abnormal Child Psychology · doi:10.1007/s10802-018-0402-1 · Cited by 411 · see citing works
Co-occurring psychiatric conditions in autism spectrum disorder
Rosen, T. E., Mazefsky, C. A., Vasa, R. A., & Lerner, M. D. (2018) · International Review of Psychiatry · doi:10.1080/09540261.2018.1450229 · Cited by 325 · see citing works
Mazefsky, C. A., & White, S. W. (2014) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2013.07.002 · Cited by 323 · see citing works
Annual research review: re-thinking the classification of autism spectrum disorders
Lord, C., & Jones, R. M. (2012) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2012.02547.x · Cited by 290 · see citing works
Cross talk: the microbiota and neurodevelopmental disorders
Kelly, J. R., Minuto, C., Cryan, J. F., Clarke, G., & Dinan, T. G. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00490 · Cited by 271 · see citing works
Autism Spectrum Disorder: Defining Dimensions and Subgroups
Ousley, O., & Cermak, T. (2013) · Current Developmental Disorders Reports · doi:10.1007/s40474-013-0003-1 · Cited by 191 · see citing works
Storch, E. A., Sulkowski, M. L., Nadeau, J., Lewin, A. B., Arnold, E. B., Mutch, P. J., Jones, A. M., & Murphy, T. K. (2013) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-013-1795-x · Cited by 157 · see citing works
Depression in Youth with Autism Spectrum Disorder
Pezzimenti, F., Han, G. T., Vasa, R. A., & Gotham, K. (2019) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2019.02.009 · Cited by 144 · see citing works
Depression and its measurement in verbal adolescents and adults with autism spectrum disorder
Gotham, K., Unruh, K., & Lord, C. (2015) · Autism · doi:10.1177/1362361314536625 · Cited by 142 · see citing works
Gotham, K., Bishop, S. L., Brunwasser, S., & Lord, C. (2014) · Autism Research · doi:10.1002/aur.1377 · Cited by 149 · see citing works
Mutluer, T., Genç, H. A., Morey, A. Ö., Eser, H. Y., Ertinmaz, B., CAN, M., & Münir, K. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.856208 · Cited by 144 · see citing works
Mazefsky, C. A., Day, T. N., Siegel, M. S., White, S. W., Yu, L., & Pilkonis, P. A. (2016) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-016-2907-1 · Cited by 123 · see citing works
Gardiner, E., & Iarocci, G. (2017) · Autism Research · doi:10.1002/aur.1877 · Cited by 118 · see citing works
Taylor, J. L., & Gotham, K. O. (2016) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-016-9160-y · Cited by 116 · see citing works
The link between emotion regulation, social functioning, and depression in boys with ASD
Pouw, L. B. C., Rieffe, C. J., Stockmann, L., & Gadow, K. D. (2013) · Research in Autism · doi:10.1016/j.rasd.2013.01.002 · Cited by 112 · see citing works
Wigham, S., Barton, S., Parr, J. R., & Rodgers, J. (2017) · Journal of Mental Health Research in Intellectual Disabilities · doi:10.1080/19315864.2017.1299267 · Cited by 107 · see citing works
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Amorim, I. S., Lach, G., & Gkogkas, C. G. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00561 · Cited by 93 · see citing works
Uljarević, M., Richdale, A. L., McConachie, H., Hedley, D., Cai, R. Y., Merrick, H., Parr, J. R., & Le Couteur, A. (2018) · Autism Research · doi:10.1002/aur.1872 · Cited by 85 · see citing works
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Greenlee, J. L., Mosley, A. S., Shui, A. M., Veenstra-VanderWeele, J. M., & Gotham, K. O. (2016) · PEDIATRICS · doi:10.1542/peds.2015-2851i · Cited by 83 · see citing works
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Patel, S., Day, T. N., Jones, N., & Mazefsky, C. A. (2017) · Autism · doi:10.1177/1362361316633566 · Cited by 82 · see citing works
Montazeri, F., de Bildt, A. A., Dekker, V., & Anderson, G. M. (2019) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-019-03914-4 · Cited by 76 · see citing works
Hymas, R., Badcock, J. C., & Milne, E. (2022) · Review Journal of Autism and Developmental Disorders · doi:10.1007/s40489-022-00330-w · Cited by 72 · see citing works
Schiltz, H. K., McVey, A. J., Dolan, B. K., Willar, K. S., Pleiss, S. S., Karst, J. S., Carson, A. M., Caiozzo, C. N., Vogt, E. M., Yund, B. D., et al. (2017) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-017-3396-6 · Cited by 70 · see citing works
Metacognition in Autism Spectrum Disorder: Digital Technologies in Metacognitive Skills Training
Mitsea, E., Drigas, A. S., & Skianis, C. (2022) · Technium Social Sciences Journal · doi:10.47577/tssj.v31i1.6471 · Cited by 69 · see citing works
Solberg, B. S., Zayats, T., Posserud, M.-B., Halmøy, A., Engeland, A., Haavik, J., & Klungsøyr, K. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.04.021 · Cited by 64 · see citing works
Fluegge, K. (2016) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2016.08.013 · Cited by 67 · see citing works
Selective Mutism and Its Relations to Social Anxiety Disorder and Autism Spectrum Disorder
Muris, P., & Ollendick, T. H. (2021) · Clinical Child and Family Psychology Review · doi:10.1007/s10567-020-00342-0 · Cited by 73 · see citing works
Evidenced-Based Interventions for Children With Autism Spectrum Disorder
Will, M., Currans, K., Smith, J. D., Weber, S., Duncan, A. W., Burton, J. M., Kroeger-Geoppinger, K., Miller, V., Stone-Heaberlin, M., Mays, L., et al. (2018) · Current problems in pediatric and adolescent health care · doi:10.1016/j.cppeds.2018.08.014 · Cited by 70 · see citing works
Stavropoulos, K. K. M., Bolourian, Y., & Blacher, J. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7040071 · Cited by 57 · see citing works
Oakley, B. F. M., Loth, E., & Murphy, D. (2021) · International Review of Psychiatry · doi:10.1080/09540261.2021.1872506 · Cited by 59 · see citing works
Treatment of Depression in Individuals with Autism Spectrum Disorder: A Systematic Review
Menezes, M., Harkins, C., Robinson, M. F., & Mazurek, M. O. (2020) · Research in Autism Spectrum Disorders · doi:10.1016/j.rasd.2020.101639 · Cited by 55 · see citing works
Schwartzman, J. M., & Corbett, B. A. (2020) · Research in Autism Spectrum Disorders · doi:10.1016/j.rasd.2020.101613 · Cited by 53 · see citing works
Aller, M. I., Pecoraro, V., Paternain, A. V., Canals, S., & Lerma, J. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.2217-15.2015 · Cited by 50 · see citing works
Schwartzman, J. M., Williams, Z. J., & Corbett, B. A. (2021) · Autism · doi:10.1177/13623613211025895 · Cited by 51 · see citing works
Manter, M. A., Birtwell, K. B., Bath, J., Friedman, N. D. B., Keary, C. J., Neumeyer, A. M., Palumbo, M. L., Thom, R. P., Stonestreet, E., Brooks, H., et al. (2025) · BMC Medicine · doi:10.1186/s12916-024-03814-0 · Cited by 51 · see citing works
“A co-occurring diagnosis may be further complicated by the ways in which the symptoms and features overlap (e.g., social withdrawal) and by the atypical manifestation of depression symptoms in ASD [115].”
Wijnhoven, L. A. M. W., Niels, H., Creemers, D. H. M., Vermulst, A. A., Otten, R., & Engels, R. C. M. E. (2019) · Journal of Child and Adolescent Mental Health · doi:10.2989/17280583.2019.1608830 · Cited by 43 · see citing works
The positive impact of identity-affirming mental health treatment for neurodivergent individuals
Kroll, E., Lederman, M., Kohlmeier, J., Kumar, K., Ballard, J., Zant, I., & Fenkel, C. (2024) · Frontiers in Psychology · doi:10.3389/fpsyg.2024.1403129 · Cited by 41 · see citing works
Comorbid Behavioral Problems and Psychiatric Disorders in Autism Spectrum Disorders
Belardinelli, C., & Raza, M. (2016) · Journal of Childhood & Developmental Disorders · doi:10.4172/2472-1786.100019 · Cited by 44 · see citing works
Mood Stabilizers in Children and Adolescents With Autism Spectrum Disorders
Canitano, R. (2015) · Clinical Neuropharmacology · doi:10.1097/wnf.0000000000000096 · Cited by 37 · see citing works
Loneliness and Social Isolation in Children with Autism Spectrum Disorders
Kasari, C. L., & Sterling, L. (2013) · doi:10.1002/9781118427378.ch23 · Cited by 37 · see citing works
Trends in concept and nosology of autism spectrum disorder: A review
Gyawali, S., & Patra, B. N. (2019) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2019.01.021 · Cited by 35 · see citing works
Repetitive behaviors in Autism Spectrum Disorder: Associations with depression and anxiety symptoms
Muskett, A., Capriola-Hall, N. N., Radtke, S. R., Factor, R. S., & Scarpa, A. (2019) · Research in Autism · doi:10.1016/j.rasd.2019.101449 · Cited by 35 · see citing works
Shoji, H., Ikeda, K., & Miyakawa, T. (2023) · Molecular Brain · doi:10.1186/s13041-023-01020-2 · Cited by 34 · see citing works
Mathersul, D. C., McDonald, S., & Rushby, J. A. (2012) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2012.11.005 · Cited by 35 · see citing works
Psychosocial interventions for internalizing disorders in youth and adults with ASD
Keefer, A. J., White, S. W., Vasa, R. A., & Reaven, J. (2018) · International Review of Psychiatry · doi:10.1080/09540261.2018.1432575 · Cited by 34 · see citing works
Comorbidity of bipolar disorder and autism spectrum disorder – review paper
Dunalska, A., Rzeszutek, M., Dębowska, Z., & Bryńska, A. (2020) · Psychiatria Polska · doi:10.12740/pp/onlinefirst/122350 · Cited by 33 · see citing works
Loftus, T., Mathersul, D. C., Ooi, M., & Yau, S. H. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1079471 · Cited by 33 · see citing works
(ADDIRC), F. T. A. A. D. D. I. R. C., Lerner, M. D., Mazefsky, C. A., Weber, R. J., Transue, E., Siegel, M., & Gadow, K. D. (2018) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-017-3344-5 · Cited by 30 · see citing works
Muratori, F., Turi, M., Prosperi, M., Narzisi, A., Valeri, G., Guerrera, S., Santocchi, E., Apicella, F., Lattarulo, C., Calderoni, S., et al. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00107 · Cited by 29 · see citing works
Qigong in the treatment of children with autism spectrum disorder: A systematic review
Rodrigues, J. M., Mestre, M., & Fredes, L. I. (2019) · Journal of Chinese Integrative Medicine · doi:10.1016/j.joim.2019.04.003 · Cited by 29 · see citing works
Gandawijaya, J., Bamford, R. A., Burbach, J. P. H., & Oguro‐Ando, A. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.611379 · Cited by 29 · see citing works
Ringold, S. M., McGuire, R. W., Jayashankar, A., Kilroy, E., Butera, C. D., Harrison, L., Cermak, S. A., & Aziz‐Zadeh, L. (2022) · Brain Sciences · doi:10.3390/brainsci12091171 · Cited by 28 · see citing works
Constantino, J. N., Strom, S., Bunis, M., Nadler, C. B., Rodgers, T. A., LePage, J., Cahalan, C., Stockreef, A., Evans, L., Jones, R., et al. (2020) · Current Psychiatry Reports · doi:10.1007/s11920-020-1127-8 · Cited by 29 · see citing works
Self-citationHashikawa‐Hobara, N., Otsuka, A., Okujima, C., & Hashikawa, N. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.918953 · Cited by 27 · see citing works
Johnston, K. H. S., & Iarocci, G. (2017) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-017-3056-x · Cited by 26 · see citing works
Menezes, M., Robinson, L. A., Román, M. J. S., & Cook, B. L. (2018) · Review Journal of Autism and Developmental Disorders · doi:10.1007/s40489-018-0146-4 · Cited by 26 · see citing works
Stewart, T. M., Martin, K., Fazi, M., Oldridge, J., Piper, A., & Rhodes, S. M. (2022) · Psychology and Psychotherapy Theory Research and Practice · doi:10.1111/papt.12366 · Cited by 25 · see citing works
Depression and Employment Outcomes in Autistic Adults: A Systematic Review
Schwartzman, J. M., & Corbett, B. A. (2022) · Review Journal of Autism and Developmental Disorders · doi:10.1007/s40489-022-00331-9 · Cited by 24 · see citing works
Mazefsky, C. A., & White, S. W. (2014) · Wiley eBooks · doi:10.1002/9781118911389.hautc08 · Cited by 25 · see citing works
Validity of the patient health questionnaire 9-item in autistic youths: a pilot study
Pilunthanakul, T., Goh, T. J., Fung, D. S. S., Sultana, R., Allen, J. C., & Sung, M. (2021) · BMC Psychiatry · doi:10.1186/s12888-021-03556-w · Cited by 26 · see citing works
Rumney, H. L., & Macmahon, K. (2016) · Mental Health & Prevention · doi:10.1016/j.mhp.2016.12.001 · Cited by 24 · see citing works
Baraskewich, J., & McMorris, C. A. (2019) · Current Developmental Disorders Reports · doi:10.1007/s40474-019-0154-9 · Cited by 23 · see citing works
Serotonin 2A Receptor Gene (HTR2A) Regulatory Variants
Gadow, K. D., Smith, R. M., & Pinsonneault, J. K. (2014) · Cognitive and Behavioral Neurology · doi:10.1097/wnn.0000000000000028 · Cited by 23 · see citing works
Depression in young autistic people: A scoping review
Kim, S. Y., & Lecavalier, L. (2021) · Research in Autism · doi:10.1016/j.rasd.2021.101841 · Cited by 20 · see citing works
Shisa7 phosphorylation regulates GABAergic transmission and neurodevelopmental behaviors
Wu, K., Shepard, R., Castellano, D., Han, W., Tian, Q., Dong, L.-J., & Lu, W. (2021) · bioRxiv · doi:10.1038/s41386-022-01334-0 · Cited by 20 · see citing works
Autistic traits heighten sensitivity to rejection‐induced social pain
Lin, X., Zhuo, S., Liu, Z., Fan, J., & Peng, W. (2022) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14880 · Cited by 20 · see citing works
Burnley, A., Clair, M. S., Dack, C., Thompson, H., & Wren, Y. E. (2023) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-023-05946-3 · Cited by 22 · see citing works
Pascoe, M. I., Forbes, K., de la Roche, L., Derby, B., Psaradellis, E., Anagnostou, E. A., Nicolson, R., Georgiades, S., & Kelley, E. A. (2023) · Autism Research · doi:10.1002/aur.3015 · Cited by 24 · see citing works
Mammarella, I. C., Cardillo, R., & Semrud‐Clikeman, M. (2022) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2022.104242 · Cited by 19 · see citing works
McKenney, E. E., Brunwasser, S. M., Richards, J. K., Day, T. C., Kofner, B., McDonald, R. G., Williams, Z. J., Gillespie‐Lynch, K., Kang, E., Lerner, M. D., et al. (2023) · Autism in Adulthood · doi:10.1089/aut.2022.0078 · Cited by 19 · see citing works
Transcranial Magnetic Stimulation in a 15-Year-Old Patient With Autism and Comorbid Depression
Cristancho, P., Akkineni, K., Constantino, J. N., Carter, A. R., & Reardon, J. P. O. (2014) · Journal of Ect · doi:10.1097/yct.0000000000000156 · Cited by 18 · see citing works
Self-citationAutism Spectrum Disorders: A Research Review for School Counselors
Auger, R. W. (2013) · Professional School Counseling · doi:10.5330/psc.n.2013-16.256 · Cited by 17 · see citing works
Friedman, N. D. B., Politte, L. C., Nowinski, L. A., & McDougle, C. J. (2015) · Wiley eBooks · doi:10.1002/9781118753378.ch44 · Cited by 17 · see citing works
Autism Spectrum Disorder and Epilepsy: Pathogenetic Mechanisms and Therapeutic Implications
Giliberti, A., Frisina, A. M., Giustiniano, S., Carbonaro, Y., Roccella, M., & Nardello, R. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14072431 · Cited by 18 · see citing works
Rhodes, S., Eaton, C. B., Oldridge, J., Rodgers, J., Chan, S. W. Y., Skouta, E., McKechanie, A. G., Mackie, L., & Stewart, T. M. (2023) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2023.104516 · Cited by 16 · see citing works
Presentation of Depressive Symptoms in Autism Spectrum Disorders
Angel, L., Ailey, S. H., Delaney, K. R., & Mohr, L. D. (2023) · Western Journal of Nursing Research · doi:10.1177/01939459231190269 · Cited by 16 · see citing works
Cell Therapy Targets for Autism Spectrum Disorders: Hopes, Challenges and Future Directions
Larijani, B. A., Heravani, N. F., Alavi-Moghadam, S., Goodarzi, P., Rezaei–Tavirani, M., Payab, M., Gholami, M., Razi, F., & Arjmand, B. (2020) · Advances in experimental medicine and biology · doi:10.1007/5584_2020_491 · Cited by 14 · see citing works
Traverso, A., Ancora, C., Zanato, S., Raffagnato, A., & Gatta, M. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.644727 · Cited by 14 · see citing works
Absence of sex differences in mental rotation performance in autism spectrum disorder
Rohde, M. S., Georgescu, A. L., Vogeley, K. T., Fimmers, R., & Falter‐Wagner, C. M. (2017) · Autism · doi:10.1177/1362361317714991 · Cited by 14 · see citing works
Hadri, S. A., & Bouramoul, A. (2022) · Smart Health · doi:10.1016/j.smhl.2022.100371 · Cited by 13 · see citing works
Krieger, B., Piškur, B., Beurskens, A. J. H. M., & Moser, A. (2023) · Child Care Health and Development · doi:10.1111/cch.13155 · Cited by 13 · see citing works
Lupi, E., Tucci, F., Casula, L., Novello, R. L., Guerrera, S., Vicari, S., & Valeri, G. (2023) · Frontiers in Psychology · doi:10.3389/fpsyg.2023.1092164 · Cited by 16 · see citing works
Autism spectrum disorders : an epidemiological and clinical study
Mattila, M. (2013) · Cited by 12 · see citing works
Donaldson, A. L., Chabon, S. S., Lee‐Wilkerson, D., & Kapantzoglou, M. (2017) · Psychology in the Schools · doi:10.1002/pits.22083 · Cited by 13 · see citing works
Psychological Comorbidities in Autism Spectrum Disorder
Shaltout, E., Al-Dewik, N. I. E., Samara, M. M., Morsi, H. M., & Khattab, A. (2020) · Advances in neurobiology · doi:10.1007/978-3-030-30402-7_6 · Cited by 13 · see citing works
Kim, S. Y., & Lecavalier, L. (2021) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-021-05323-y · Cited by 12 · see citing works
Shirama, A., Stickley, A., Kamio, Y., Saito, A., Haraguchi, H., Wada, A., Sueyoshi, K., & Sumiyoshi, T. (2022) · BMC Psychiatry · doi:10.1186/s12888-022-04145-1 · Cited by 12 · see citing works
Children and Adolescents with ASD and Co-occurring Psychiatric Conditions
Reaven, J., & Wainer, A. (2015) · International review of research in developmental disabilities · doi:10.1016/bs.irrdd.2015.06.001 · Cited by 12 · see citing works
Cornelia de Lange and Ehlers-Danlos: comorbidity of two rare syndromes
Cravero, C., Guinchat, V., Barete, S., & Consoli, A. (2016) · BMJ Case Reports · doi:10.1136/bcr-2015-210925 · Cited by 11 · see citing works
Charlier, L., Cordeiro, L., Neto, J. L. C., Signini, É. D. F., da Silva, J. B., Corbellini, C., Lipka, A., & de Abreu, R. M. (2025) · Healthcare · doi:10.3390/healthcare13040439 · Cited by 11 · see citing works
Davidson, D. Z., Hilvert, E., Winning, A. M., & Giordano, M. (2021) · Child Psychiatry & Human Development · doi:10.1007/s10578-021-01139-0 · Cited by 10 · see citing works
The role of intellectual disability and emotional regulation in the autism–depression relationship
Sáez‐Suanes, G. P., García-Villamisar, D. A., & Armentia, A. D. P. (2023) · Autism · doi:10.1177/13623613231161881 · Cited by 10 · see citing works
Mylett, M. L., Boucher, T. Q., Scheerer, N. E., & Iarocci, G. (2023) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-023-06012-8 · Cited by 9 · see citing works
The social evolution of sleep: sex differences, intragenomic conflicts and clinical pathologies
Faria, G. S., Varela, S. A. M., & Gardner, A. (2019) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2018.2188 · Cited by 9 · see citing works
Mazefsky, C. A. (2012) · Perspectives on Language Learning and Education · doi:10.1044/lle19.2.38 · Cited by 8 · see citing works
- Authors
- Magnuson, K. M., & Constantino, J. N.
- Affiliations
- Washington University in St. Louis (US)
- Corresponding author
- Magnuson, Katherine M.
- ORCID
- Constantino, John N.
- Venue
- Journal of Developmental & Behavioral Pediatrics
- Published
- 2011-05
- Volume
- 32
- Issue
- 4
- Pages
- 332-340
- ISSN
- 0196-206X (ISSN-L)
- PMC
- PMC3154372
- OpenAlex
- W2079422843
- Cited by
- 193
- References
- 74
- Citations by year
- 2026: 5 · 2025: 19 · 2024: 15 · 2023: 23 · 2022: 16 · 2021: 15 · 2020: 12 · 2019: 13 · 2018: 12 · 2017: 12 · 2016: 12 · 2015: 9 · 2014: 11 · 2013: 11 · 2012: 7
- FWCI
- 0.79
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Developmental & Behavioral Pediatrics (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD42541, R01HD042541)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Keywords
- depression, autism spectrum disorder, comorbidities, children and adolescents, diagnostic assessment, phenotypic overlap, atypical depression, familial aggregation, genetic overlap, multiple informants, depression prevalence, neuropsychiatric comorbidity
- MeSH terms
- Child, Child Development Disorders, Pervasive, Depressive Disorder, Humans, Comorbidity
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