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Oxidative Stress, Inflammation, and Neuroprogression in Chronic PTSD
Open accessAbstract
Posttraumatic stress disorder is a serious and often disabling syndrome that develops in response to a traumatic event. Many individuals who initially develop the disorder go on to experience a chronic form of the condition that in some cases can last for many years. Among these patients, psychiatric and medical comorbidities are common, including early onset of age-related conditions such as chronic pain, cardiometabolic disease, neurocognitive disorders, and dementia. The hallmark symptoms of posttraumatic stress—recurrent sensory-memory reexperiencing of the trauma(s)—are associated with concomitant activations of threat- and stress-related neurobiological pathways that occur against a tonic backdrop of sleep disturbance and heightened physiological arousal. Emerging evidence suggests that the molecular consequences of this stress-perpetuating syndrome include elevated systemic levels of oxidative stress and inflammation. In this article we review evidence for the involvement of oxidative stress and inflammation in chronic PTSD and the neurobiological consequences of these processes, including accelerated cellular aging and neuroprogression. Our aim is to update and expand upon previous reviews of this rapidly developing literature and to discuss magnetic resonance spectroscopy as an imaging technology uniquely suited to measuring oxidative stress and inflammatory markers in vivo. Finally, we highlight future directions for research and avenues for the development of novel therapeutics targeting oxidative stress and inflammation in patients with PTSD.
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“ELS/CT may so lead to long-term molecular consequences in the basal antioxidant defenses with elevated systemic levels of OXS, stimulating inflammation and driving oxidative damage and accelerated cellular aging in both the CNS and the periphery of the organism (254, 255).”
From Developmental Trajectories of Early Life Stress and Trauma: A Narrative Review on Neurobiological Aspects Beyond Stress System Dysregulation (2019) · cites this paper as [255]
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Metadata
- Authors
- Miller, M. W., Lin, A. P., Wolf, E. J., & Miller, D. R.
- Affiliations
- Boston University (US)
- Corresponding author
- Miller, Mark W.
- Miller, Danielle R.
- Venue
- Harvard Review of Psychiatry
- Published
- 2018-03
- Volume
- 26
- Issue
- 2
- Pages
- 57-69
- ISSN
- 1067-3229 (ISSN-L)
- 1465-7309
- PMC
- PMC5843493
- OpenAlex
- W2762390890
- Cited by
- 237
- References
- 140
- Citations by year
- 2026: 20 · 2025: 33 · 2024: 26 · 2023: 33 · 2022: 49 · 2021: 31 · 2020: 25 · 2019: 10 · 2018: 8
- FWCI
- 1.88
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Harvard Review of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Veterans Affairs (I01 CX001586)
- National Institute of Mental Health (R21MH102834, T32MH019836)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
- Keywords
- chronic posttraumatic stress disorder, oxidative stress, inflammation, neuroprogression, magnetic resonance spectroscopy, inflammatory markers, sleep disorders, physiological arousal, neurobiological pathways, comorbidities, neurocognitive disorders, dementia, cardiometabolic disease, chronic pain
- MeSH terms
- Brain, Chronic Disease, Humans, Inflammation, Magnetic Resonance Spectroscopy, Stress Disorders, Post-Traumatic, Oxidative Stress
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