Commensal Bacteroides Species Induce Colitis in Host-Genotype-Specific Fashion in a Mouse Model of Inflammatory Bowel Disease

Bloom, Seth M.; Bijanki, Vinieth N.; Nava, Gerardo M.; Sun, Lulu; Malvin, Nicole P.; Donermeyer, David L.; Dunne, W. Michael; Allen, Paul M.; Stappenbeck, Thaddeus S.

doi:10.1016/j.chom.2011.04.009

Cited by 488Gut microbiota and healthInflammatory Bowel DiseaseMicroscopic Colitis

Commensal Bacteroides Species Induce Colitis in Host-Genotype-Specific Fashion in a Mouse Model of Inflammatory Bowel Disease

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Bloom, Seth M., Bijanki, Vinieth N., Nava, Gerardo M., Sun, Lulu, Malvin, Nicole P., Donermeyer, David L., Dunne, W. Michael, Allen, Paul M. +1 more·2011·Cell Host & Microbe

DOI 10.1016/j.chom.2011.04.009PMC PMC3241010

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Abstract

The intestinal microbiota is important for induction of inflammatory bowel disease (IBD). IBD is associated with complex shifts in microbiota composition, but it is unclear whether specific bacterial subsets induce IBD and, if so, whether their proportions in the microbiota are altered during disease. Here, we fulfilled Koch's postulates in host-genotype-specific fashion using a mouse model of IBD with human-relevant disease-susceptibility mutations. From screening experiments we isolated common commensal Bacteroides species, introduced them into antibiotic-pretreated mice, and quantitatively reisolated them in culture. The bacteria colonized IBD-susceptible and -nonsusceptible mice equivalently, but induced disease exclusively in susceptible animals. Conversely, commensal Enterobacteriaceae were >100-fold enriched during spontaneous disease, but an Enterobacteriaceae isolate failed to induce disease in antibiotic-pretreated mice despite robust colonization. We thus demonstrate that IBD-associated microbiota alterations do not necessarily reflect underlying disease etiology. These findings establish important experimental criteria and a conceptual framework for understanding microbial contributions to IBD.

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Authors: Bloom, S. M., Bijanki, V. N., Nava, G. M., Sun, L., Malvin, N. P., Donermeyer, D. L., Dunne, W. M., Allen, P. M., & Stappenbeck, T. S.
Affiliations: Washington University in St. Louis (US)
Corresponding author: Stappenbeck, Thaddeus S.
ORCID: Bloom, Seth M.
Bijanki, Vinieth N.
Nava, Gerardo M.
Sun, Lulu
Malvin, Nicole P.
Donermeyer, David L.
Dunne, W. Michael
Allen, Paul M.
Stappenbeck, Thaddeus S.
Venue: Cell Host & Microbe
Publisher: Elsevier BV
Published: 2011-05
Volume: 9
Issue: 5
Pages: 390-403
ISSN: 1931-3128 (ISSN-L)
DOI: 10.1016/j.chom.2011.04.009
PMC: PMC3241010
OpenAlex: W2003525072
Cited by: 488
References: 69
Citations by year: 2026: 16 · 2025: 26 · 2024: 26 · 2023: 24 · 2022: 49 · 2021: 45 · 2020: 43 · 2019: 42 · 2018: 25 · 2017: 28 · 2016: 29 · 2015: 19 · 2014: 35 · 2013: 29 · 2012: 32
FWCI: 14.92
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 844 d)
Locations: Cell Host & Microbe (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Eli and Edythe Broad Foundation
National Institutes of Health
National Institute of Allergy and Infectious Diseases (R01AI024157, 5T32AI0071632, T32AI007163)
National Institute of Diabetes and Digestive and Kidney Diseases (DK-52574, P30DK052574)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
Health Sciences › Medicine › Epidemiology › Microscopic Colitis
Keywords: inflammatory bowel disease, Bacteroides, commensal bacteria, colitis, host genotype, gut microbiota, Enterobacteriaceae, Koch's postulates, bacterial colonization, etiology
MeSH terms: Animals, Bacteroides, Colitis, Disease Models, Animal, DNA, Bacterial, Genotype, Histocytochemistry, Molecular Sequence Data, Inflammatory Bowel Diseases, Sequence Analysis, DNA, Gastrointestinal Tract, Mice

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Commensal Bacteroides Species Induce Colitis in Host-Genotype-Specific Fashion in a Mouse Model of Inflammatory Bowel Disease

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