Cited by 380Neural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on BehaviorMotor Control and Adaptation

Influence of Reward Expectation on Behavior-Related Neuronal Activity in Primate Striatum

Hollerman, Jeffrey R., Tremblay, Léon, Schultz, Wolfram·1998·Journal of Neurophysiology

Abstract

Hollerman, Jeffrey R., Léon Tremblay, and Wolfram Schultz. Influence of reward expectation on behavior-related neuronal activity in primate striatum. J. Neurophysiol. 80: 947–963, 1998. Rewards constitute important goals for voluntary behavior. This study aimed to investigate how expected rewards influence behavior-related neuronal activity in the anterior striatum. In a delayed go-nogo task, monkeys executed or withheld a reaching movement and obtained liquid or sound as reinforcement. An initial instruction picture indicated the behavioral reaction to be performed and the reinforcer to be obtained after a subsequent trigger stimulus. Movements varied according to the reinforcers predicted by the instructions, suggesting that animals differentially expected the two outcomes. About 250 of nearly 1,500 neurons in anterior parts of caudate nucleus, putamen, and ventral striatum showed typical task-related activations that reflected the expectation of instructions and trigger, and the preparation, initiation, and execution of behavioral reactions. Strikingly, most task-related activations occurred only when liquid reward was delivered at trial end, rather than the reinforcing sound. Activations close to the time of reward showed similar preferences for liquid reward over the reinforcing sound, suggesting a relationship to the expectation or detection of the motivational outcome of the trial rather than to a “correct” or “end-of-trial” signal. By contrast, relatively few activations in the present task occurred irrespective of the type of reinforcement. In conclusion, many of the behavior-related neurons investigated in the anterior striatum were influenced by an upcoming primary liquid reward and did not appear to code behavioral acts in a motivationally neutral manner. Rather, these neurons incorporated information about the expected outcome into their behavior-related activity. The activations influenced by reward several seconds before its occurrence may constitute a neuronal basis for the retrograde effects of rewards on behavioral reactions.

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Crossref · 10.1152/jn.1998.80.2.947

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  • Dopamine neurons contrast strongly with non-dopamine neurons in the striatum and frontal cortex, which show wide varieties of activations and depressions at different time points before and after different stimuli and behavioural events.

    “In this respect, dopamine neurons contrast strongly with non-dopamine neurons in the striatum and frontal cortex, which show wide varieties of activations and depressions at different time points before and after different stimuli and behavioural events114,147–149.”

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Authors
Hollerman, J. R., Tremblay, L., & Schultz, W.
Affiliations
University of Fribourg (CH)
Venue
Journal of Neurophysiology
Published
1998-08-01
Volume
80
Issue
2
Pages
947-963
ISSN
  • 0022-3077 (ISSN-L)
  • 1522-1598
OpenAlex
W1924016629
Cited by
380
References
64
Citations by year
2026: 5 · 2025: 6 · 2024: 8 · 2023: 5 · 2022: 7 · 2021: 7 · 2020: 7 · 2019: 7 · 2018: 14 · 2017: 9 · 2016: 23 · 2015: 24 · 2014: 17 · 2013: 9 · 2012: 18
FWCI
7.30
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neurophysiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (1f32mh010282-01x1)
  • National Institute of Mental Health (MH-10282)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
Keywords
reward anticipation, caudate nucleus, putamen, ventral striatum, single-unit activity, go/no-go task, reaching movements, motivation
MeSH terms
Animals, Behavior, Animal, Conditioning, Psychological, Corpus Striatum, Electrophysiology, Eye Movements, Macaca fascicularis, Male, Movement, Neurons, Photic Stimulation, Psychomotor Performance, Reward

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